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DNA Methylation Profiling: Current and Emerging Uses in Gynecologic Pathology. DNA甲基化分析：当前和新出现的应用在妇科病理学。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-05 DOI: 10.1016/j.path.2026.06.003
Wei Gu, Brooke E Howitt
{"title":"DNA Methylation Profiling: Current and Emerging Uses in Gynecologic Pathology.","authors":"Wei Gu, Brooke E Howitt","doi":"10.1016/j.path.2026.06.003","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.003","url":null,"abstract":"<p><p>DNA methylation profiling is emerging as a powerful ancillary molecular tool for tumor classification in gynecologic pathology. This article provides a practical overview of the technology and its emerging applications, with emphasis on diagnostically challenging settings including rare mesenchymal neoplasms (eg, uterine tumors resembling ovarian sex cord tumor, SMARCA4-deficient uterine sarcoma) and lineage-ambiguous tumors. Beyond classification, methylation profiling enables copy number analysis, tumor microenvironment deconvolution, epigenetic age estimation, and cell-free DNA-based detection, with growing relevance to gynecologic pathology, albeit mostly in research setting. Current barriers include limited access, incomplete classifier development for gynecologic entities, and the need for clinical validation.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"605-616"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human papillomavirus-independent, TP53 Wild-type Vulvar Intraepithelial Neoplasia and Its Mimics. 不依赖人乳头瘤病毒的TP53野生型外阴上皮内瘤变及其模拟物。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-05 DOI: 10.1016/j.path.2026.06.013
Yuna Kang, Stephanie Lynn Skala
{"title":"Human papillomavirus-independent, TP53 Wild-type Vulvar Intraepithelial Neoplasia and Its Mimics.","authors":"Yuna Kang, Stephanie Lynn Skala","doi":"10.1016/j.path.2026.06.013","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.013","url":null,"abstract":"<p><p>High-risk human papillomavirus-independent, p53-wild-type vulvar intraepithelial neoplasia (HPVi(p53wt) VIN) is a squamous cell carcinoma precursor lesion with altered squamous maturation but minimal to no cytologic atypia. Use of p16 and p53 immunohistochemical stains is strongly encouraged for accurate subclassification of VIN lesions due to the potential for overlapping morphologic features. Additionally, there are a number of benign and inflammatory mimics of HPVi(p53wt) VIN. For lesions that cannot be definitively classified as either neoplastic or inflammatory/reactive/benign, descriptive diagnoses or \"vulvar aberrant maturation\" are appropriate.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"667-688"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhabdomyosarcoma of the Cervix/Vagina and Its Mimics. 宫颈/阴道横纹肌肉瘤及其模拟。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-05 DOI: 10.1016/j.path.2026.06.012
Kyle M Devins
{"title":"Rhabdomyosarcoma of the Cervix/Vagina and Its Mimics.","authors":"Kyle M Devins","doi":"10.1016/j.path.2026.06.012","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.012","url":null,"abstract":"<p><p>Rhabdomyosarcomas form a morphologically and genomically heterogeneous family of malignant mesenchymal tumors defined by skeletal muscle differentiation. In the gynecologic tract, the same morphologic subtypes defined at extragenital sites may be encountered, but there are unique genetic associations and differential diagnostic concerns which should be addressed. This article aims to clarify the pathologic assessment of gynecologic rhabdomyosarcomas and their mimics, particularly in the cervix and vagina.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"637-646"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic and Prognostic Roles of Universal Estrogen Receptor Testing in Endometrial Carcinoma. 通用雌激素受体检测在子宫内膜癌中的诊断和预后作用。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-11 DOI: 10.1016/j.path.2026.06.006
Jutta Huvila
{"title":"Diagnostic and Prognostic Roles of Universal Estrogen Receptor Testing in Endometrial Carcinoma.","authors":"Jutta Huvila","doi":"10.1016/j.path.2026.06.006","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.006","url":null,"abstract":"<p><p>Estrogen receptor (ER) immunohistochemical evaluation has emerged as a key variable in the risk assessment of endometrial carcinoma. In the most common molecular subtype of endometrial carcinomas, the no specific molecular profile, ER is used in conjunction with stage, grade, and lymphovascular space invasion (LVSI) for risk assessment and guiding adjuvant treatments. Additionally, ER is a useful tool for aiding primary site and histotype assessment and has a role in predicting response to hormonal therapies for endometrial carcinoma. These applications of ER immunostaining will be reviewed.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"541-552"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real World Application of Digital Pathology in Gynecologic Pathology Reporting. 数字病理学在妇科病理报告中的实际应用。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-13 DOI: 10.1016/j.path.2026.06.014
Gareth Bryson, Sarah Bell, Donna O'Dwyer
{"title":"Real World Application of Digital Pathology in Gynecologic Pathology Reporting.","authors":"Gareth Bryson, Sarah Bell, Donna O'Dwyer","doi":"10.1016/j.path.2026.06.014","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.014","url":null,"abstract":"<p><p>Digital pathology (DP) is being implemented at scale with the hope of increasing efficiency and quality of pathology reporting. In this article, we share our experiences of this technological transformation from the perspective of practicing gynecologic pathologists. Herein, we outline what we see at the real-life advantages of DP and a digital workflow, using examples specific to gynecologic pathology. We also highlight some of the challenges, both for system deployment and configuration and for diagnostic reporting with a brief discussion of artificial intelligence applications of digital gynecologic pathology.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"589-603"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pitfalls, Problems, and Dilemmas in Applying the FIGO 2023 Staging System for Endometrial Cancer. FIGO 2023分期系统应用于子宫内膜癌的陷阱、问题和困境
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-26 DOI: 10.1016/j.path.2026.06.007
Amy S Joehlin, Stephanie M McGregor
{"title":"Pitfalls, Problems, and Dilemmas in Applying the FIGO 2023 Staging System for Endometrial Cancer.","authors":"Amy S Joehlin, Stephanie M McGregor","doi":"10.1016/j.path.2026.06.007","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.007","url":null,"abstract":"<p><p>The publication of FIGO 2023 staging for endometrial carcinoma (EC) fundamentally changed pathologic staging of EC by incorporating histologic subtypes, extent of lymphovascular space invasion, and molecular classification. In this article, the authors discuss the new staging system, the dilemmas with molecular classification, and clinical application details of histologic examination as they relate to the staging practices of surgical pathologists.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"569-587"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaginal Epithelial Pathology: A Review with Emphasis on Recent Developments. 阴道上皮病理学：综述，重点是最近的发展。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-06 DOI: 10.1016/j.path.2026.06.011
Karen L Talia, Richard Wing-Cheuk Wong, W Glenn McCluggage
{"title":"Vaginal Epithelial Pathology: A Review with Emphasis on Recent Developments.","authors":"Karen L Talia, Richard Wing-Cheuk Wong, W Glenn McCluggage","doi":"10.1016/j.path.2026.06.011","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.011","url":null,"abstract":"<p><p>Primary vaginal carcinoma is rare and far less common than vaginal metastases, which usually originate from neighboring organs. Primary carcinomas are predominantly squamous in type and human papillomavirus (HPV)-associated while primary adenocarcinomas are mostly HPV-independent; as glands are normally absent in the vagina, a congenital or acquired glandular precursor lesion is a prerequisite for their development, although this is not always identified. A variety of rare benign squamous and glandular lesions may also occur at this site. In this article the spectrum of vaginal squamous and glandular neoplasia, precursor and rare non-neoplastic lesions is discussed, with emphasis on recent developments.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"647-666"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometrial Biopsies in Patients with Infertility: An Update for Pathologists. 不孕症患者的子宫内膜活检：病理学家的最新进展。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-24 DOI: 10.1016/j.path.2026.06.008
Vinita Parkash, Na Niu, Lubna Pal
{"title":"Endometrial Biopsies in Patients with Infertility: An Update for Pathologists.","authors":"Vinita Parkash, Na Niu, Lubna Pal","doi":"10.1016/j.path.2026.06.008","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.008","url":null,"abstract":"<p><p>Pathological evaluation of endometrial biopsies has been a clinically relevant tool in the management of patients with unexplained infertility and recurrent pregnancy loss. In this article, we provide a practical, morphology-based framework for the interpretation of endometrial biopsies in this population. Chronic endometritis (CE) has attracted the most clinical and investigative attention in recent years. The evolving clinical picture and histological criteria for CE and the significant unresolved questions surrounding diagnostic thresholds are discussed.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"703-715"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uterine Adenosarcoma: Unusual Presentations and Mimics. 子宫腺肉瘤：不寻常的表现和模仿。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-05 DOI: 10.1016/j.path.2026.06.009
Timothy A Dinh, David B Chapel
{"title":"Uterine Adenosarcoma: Unusual Presentations and Mimics.","authors":"Timothy A Dinh, David B Chapel","doi":"10.1016/j.path.2026.06.009","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.009","url":null,"abstract":"<p><p>Uterine adenosarcoma is an uncommon biphasic neoplasm composed of malignant stroma and benign non-neoplastic epithelium. Most adenosarcomas show canonical low-grade morphology, which must be distinguished from various benign uterine polyps. A subset of adenosarcomas shows sarcomatous overgrowth, myometrial invasion, vascular invasion, heterologous differentiation, or marked nuclear atypia. These findings are prognostically adverse and may raise the differential with other uterine sarcomas. This article provides an overview of the clinicopathologic features of uterine adenosarcoma, with a particular focus on challenging presentations and histologic mimics.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"617-636"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Patient-centered Care in Diagnostic Gynecologic Pathology. 推进以患者为中心的妇科病理诊断护理。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-09-15 DOI: 10.1016/j.path.2026.07.001
Joseph Rabban, Zehra Ordulu
{"title":"Advancing Patient-centered Care in Diagnostic Gynecologic Pathology.","authors":"Joseph Rabban, Zehra Ordulu","doi":"10.1016/j.path.2026.07.001","DOIUrl":"https://doi.org/10.1016/j.path.2026.07.001","url":null,"abstract":"","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"xi-xii"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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