Human papillomavirus-independent, TP53 Wild-type Vulvar Intraepithelial Neoplasia and Its Mimics.

Q1 Medicine

Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-05 DOI:10.1016/j.path.2026.06.013

Yuna Kang, Stephanie Lynn Skala

引用次数: 0

Abstract

High-risk human papillomavirus-independent, p53-wild-type vulvar intraepithelial neoplasia (HPVi(p53wt) VIN) is a squamous cell carcinoma precursor lesion with altered squamous maturation but minimal to no cytologic atypia. Use of p16 and p53 immunohistochemical stains is strongly encouraged for accurate subclassification of VIN lesions due to the potential for overlapping morphologic features. Additionally, there are a number of benign and inflammatory mimics of HPVi(p53wt) VIN. For lesions that cannot be definitively classified as either neoplastic or inflammatory/reactive/benign, descriptive diagnoses or "vulvar aberrant maturation" are appropriate.

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不依赖人乳头瘤病毒的TP53野生型外阴上皮内瘤变及其模拟物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgical Pathology Clinics Medicine-Surgery

CiteScore

4.40

自引率

0.00%

发文量

期刊介绍： This newest addition to the Clinics Series keeps you current on the information that is essential to every practicing surgical pathologist, from the latest techniques and approaches to detailed discussions on differential diagnosis. It devotes each and every issue exclusively to surgical pathology and its associated problems and is enhanced by abundant full-color images. Each issue focuses on a single topic-and is overseen by Guest Editors who are experts in their field-providing information of practical value on service while also offering material that increases understanding.