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STK11 Adnexal Tumor: Expanding the Spectrum of Female Genital Tumors in Peutz-Jeghers Syndrome. STK11附件肿瘤：扩大Peutz-Jeghers综合征女性生殖器肿瘤的范围。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-09-24 DOI: 10.1016/j.path.2026.06.005
Jelena Mirkovic
{"title":"STK11 Adnexal Tumor: Expanding the Spectrum of Female Genital Tumors in Peutz-Jeghers Syndrome.","authors":"Jelena Mirkovic","doi":"10.1016/j.path.2026.06.005","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.005","url":null,"abstract":"<p><p>Serine-threonine kinase 11 (STK11) adnexal tumors are rare clinically aggressive neoplasms most commonly arising in the paratubal/paraovarian tissue. They are of uncertain histogenesis, characterized by STK11 genomic alterations, with a subset associated with Peutz-Jeghers syndrome. The spectrum of morphologic appearances is wide. Most commonly, cords and trabeculae in myxoid stroma are seen in addition to other components. They exhibit polyphenotypic immunoprofile with frequent expression of epithelial, mesothelial, sex cord, and smooth muscle marker desmin as well as hormone receptors, and loss of cytoplasmic STK11 expression.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"689-701"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive Biomarker Tests for Ovarian Cancer: A Primer for Pathologists. 卵巢癌的预测性生物标志物测试：病理学家的入门。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-26 DOI: 10.1016/j.path.2026.06.004
Barrett C Lawson, Ian S Hagemann
{"title":"Predictive Biomarker Tests for Ovarian Cancer: A Primer for Pathologists.","authors":"Barrett C Lawson, Ian S Hagemann","doi":"10.1016/j.path.2026.06.004","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.004","url":null,"abstract":"<p><p>Several biomarkers play a role in treatment selection for epithelial ovarian cancer. Homologous recombination deficiency (HRD) is a biomarker reflecting predisposing germline genetic changes as well as somatically acquired changes. Tumors with HRD may be eligible for poly-ADP(ribose) polymerase inhibitor therapy in the maintenance or recurrent setting. Expression of HER2 (ERBB2 gene product) or folate receptor alpha (FOLR1 gene product), assessed using immunohistochemical assays, is a biomarker for therapy with antibody-drug conjugates. Although the biomarker landscape in ovarian cancer remains relatively limited, these markers provide meaningful diagnostic and therapeutic guidance.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"529-539"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Atlas-Based Approach to Assigning International Federation of Gynecology and Obstetrics Stage to Different Presentations of Cervical Cancer. 一种基于atlas的方法来分配国际妇产科学联合会对宫颈癌不同表现的分期。
Surgical Pathology Clinics Pub Date : 2026-12-01 Epub Date: 2026-08-11 DOI: 10.1016/j.path.2026.06.010
Anjelica Hodgson, Kay J Park
{"title":"An Atlas-Based Approach to Assigning International Federation of Gynecology and Obstetrics Stage to Different Presentations of Cervical Cancer.","authors":"Anjelica Hodgson, Kay J Park","doi":"10.1016/j.path.2026.06.010","DOIUrl":"https://doi.org/10.1016/j.path.2026.06.010","url":null,"abstract":"<p><p>The International Federation of Gynecology and Obstetrics (FIGO) staging system for cervical carcinoma provides a globally accepted framework that guides treatment decisions and prognosticates disease. The 2018 update incorporates imaging and pathologic findings into the schema, reflecting advances in diagnostic modalities and improving stage accuracy. Despite these improvements, significant information gaps remain, and assigning an accurate FIGO stage may be challenging in several situations faced by pathologists. This article uses real world case examples for various clinical situations and presentations of cervical carcinoma, focusing on a practical approach and providing strategies to ensure accurate and clinically relevant FIGO stage designation.</p>","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 4","pages":"553-567"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Cutaneous Neoplasms with NUT Gene Fusions 伴有NUT基因融合的原发性皮肤肿瘤
Surgical Pathology Clinics Pub Date : 2026-03-01 Epub Date: 2025-11-25 DOI: 10.1016/j.path.2025.08.001
Nicolas Macagno MD, PhD , Mélanie Legrand MD, PhD , Thibault Kervarrec MD, PhD
{"title":"Primary Cutaneous Neoplasms with NUT Gene Fusions","authors":"Nicolas Macagno MD, PhD ,&nbsp;Mélanie Legrand MD, PhD ,&nbsp;Thibault Kervarrec MD, PhD","doi":"10.1016/j.path.2025.08.001","DOIUrl":"10.1016/j.path.2025.08.001","url":null,"abstract":"","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 1","pages":"Pages 1-12"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond Sweet Syndrome 超越甜蜜综合症
Surgical Pathology Clinics Pub Date : 2026-03-01 Epub Date: 2025-10-23 DOI: 10.1016/j.path.2025.09.003
Alexandra C. Hristov MD
{"title":"Beyond Sweet Syndrome","authors":"Alexandra C. Hristov MD","doi":"10.1016/j.path.2025.09.003","DOIUrl":"10.1016/j.path.2025.09.003","url":null,"abstract":"","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 1","pages":"Pages 163-174"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributors 贡献者
Surgical Pathology Clinics Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/S1875-9181(25)00082-0
{"title":"Contributors","authors":"","doi":"10.1016/S1875-9181(25)00082-0","DOIUrl":"10.1016/S1875-9181(25)00082-0","url":null,"abstract":"","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 1","pages":"Pages iii-iv"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forthcoming Issues 即将到来的问题
Surgical Pathology Clinics Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/S1875-9181(25)00084-4
{"title":"Forthcoming Issues","authors":"","doi":"10.1016/S1875-9181(25)00084-4","DOIUrl":"10.1016/S1875-9181(25)00084-4","url":null,"abstract":"","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 1","pages":"Page viii"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fusion-Associated Cutaneous Tumors with Melanocytic Differentiation 融合相关皮肤肿瘤伴黑素细胞分化
Surgical Pathology Clinics Pub Date : 2026-03-01 Epub Date: 2025-10-29 DOI: 10.1016/j.path.2025.08.002
Jennifer S. Ko MD, PhD
{"title":"Fusion-Associated Cutaneous Tumors with Melanocytic Differentiation","authors":"Jennifer S. Ko MD, PhD","doi":"10.1016/j.path.2025.08.002","DOIUrl":"10.1016/j.path.2025.08.002","url":null,"abstract":"","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 1","pages":"Pages 119-129"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blastic Plasmacytoid Dendritic Cell Neoplasm 母浆细胞样树突状细胞瘤
Surgical Pathology Clinics Pub Date : 2026-03-01 Epub Date: 2025-11-25 DOI: 10.1016/j.path.2025.08.008
Gabriel K. Griffin MD , Sam Sadigh MD
{"title":"Blastic Plasmacytoid Dendritic Cell Neoplasm","authors":"Gabriel K. Griffin MD ,&nbsp;Sam Sadigh MD","doi":"10.1016/j.path.2025.08.008","DOIUrl":"10.1016/j.path.2025.08.008","url":null,"abstract":"","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 1","pages":"Pages 131-144"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updates in Cutaneous Neoplasia 皮肤肿瘤的最新进展
Surgical Pathology Clinics Pub Date : 2026-03-01 Epub Date: 2025-10-23 DOI: 10.1016/j.path.2025.09.005
Eleanor Russell-Goldman MD, PhD
{"title":"Updates in Cutaneous Neoplasia","authors":"Eleanor Russell-Goldman MD, PhD","doi":"10.1016/j.path.2025.09.005","DOIUrl":"10.1016/j.path.2025.09.005","url":null,"abstract":"","PeriodicalId":39485,"journal":{"name":"Surgical Pathology Clinics","volume":"19 1","pages":"Pages ix-x"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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