Journal of Pharmaceutical Research Science & Technology最新文献

{"title":"Revolutionizing Imaging and Diagnostics: Harnessing Metallic Nanoparticles and Nanocarriers for Cutting-Edge Theranostics","authors":"Sripathi Sowmya Priya, Neha Sharma, M.A.Jahangir","doi":"10.31531/jprst.1000173","DOIUrl":"https://doi.org/10.31531/jprst.1000173","url":null,"abstract":"The field of medical diagnostics and therapeutics is currently undergoing a transformative revolution, driven by the rapid advancements in nanotechnology. This paper explores the promising potential of metallic nanoparticles and nanocarriers in the realm of theranostics, a fusion of therapy and diagnostics, offering unprecedented opportunities for precision medicine and patient care. The integration of metallic nanoparticles and nanocarriers into medical applications has opened new frontiers for non-invasive imaging and targeted therapy. This review provides an in-depth analysis of metallic nanoparticles, including gold, silver, and magnetic nanoparticles, highlighting their unique physicochemical properties that make them ideal candidates for imaging and therapeutic purposes. Additionally, we discuss the evolution of nanocarriers, such as liposomes, micelles, and dendrimers, and their role in enhancing drug delivery, bioavailability, and treatment specificity. The versatility of metallic nanoparticles and nanocarriers in both imaging and therapeutic applications is showcased through their utilization in areas such as cancer diagnosis, drug delivery, and the management of neurological disorders. Furthermore, their potential to enable real-time monitoring of treatment responses and disease progression is explored, empowering clinicians with essential tools for personalized medicine. Challenges and considerations related to toxicity, biocompatibility, and regulatory hurdles are also discussed, shedding light on the need for further research and collaboration between scientists, clinicians, and regulatory bodies. As metallic nanoparticles and nanocarriers continue to evolve, they promise to revolutionize the landscape of medical diagnostics and therapy, ultimately improving patient outcomes and enhancing the effectiveness of healthcare practices. This paper serves as a comprehensive overview of the current state and future prospects of these groundbreaking technologies, contributing to the advancement of theranostics and its wide-reaching implications for the healthcare industry.","PeriodicalId":394015,"journal":{"name":"Journal of Pharmaceutical Research Science & Technology","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139280562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Observational Study of Type 2 Diabetes Mellitus Patients from a Small Town of Bihar, India","authors":"Ashwini Verma, Ashish Kumar, Mobashshir Heyat, M. Jahangir","doi":"10.31531/jprst.1000171","DOIUrl":"https://doi.org/10.31531/jprst.1000171","url":null,"abstract":"This study was conducted to describe the profile of patients with type 2 diabetes mellitus from a small town of Bihar, India. This study was conducted over 98 patients of Type 2 Diabetes Mellitus, who were taking treatment from a specialized diabetic hospital of Bihar Sharif, headquarter of Nalanda district of Bihar state, India. The study was conducted during January 2023 to March 2023. The patients were requested to complete a questionnaire including their risk profile (hypertension, obesity, dyslipidaemia, and glycaemic status), sociodemographic factors, general health, symptoms present, family history of diabetes, physical activity, diet control, medications (oral hypoglycemic agents, insulin injections, antihypertensives, etc.) and habits present (tobacco chewing, alcohol consumption and smoking). Blood pressure (BP), body mass index (BMI), fasting blood sugar (FBS) level and lipid profile were also included in the questionnaire. Overall, 98 type 2 diabetes mellitus (T2DM) patients with mean age of 60.23±7.50 years were studied. Out of 98 patients, 43 (43.87%) were male and 55 (56.12%) were female. Most of the T2DM patients (42.86%) were obese, and 70.40% had a positive family history of diabetes. 11.22% of patients had vision impairment. The mean FBS level was 188.11±71.10 mg/dl and good glycemic control (FBS level <100 mg/dl) was achieved only in 12.24% of the T2DM patients. 47.96% of study patients were also suffering from hypertension. This study concluded that many factors like family history of diabetes, obesity, uncontrolled glycaemic status, dyslipidaemia, hypertension and sedentary lifestyle were present among the Type 2 Diabetes Mellitus patients. This study will guide the healthcare professionals to develop a better roadmap for controlling and screening Type 2 Diabetes Mellitus in Bihar, India.","PeriodicalId":394015,"journal":{"name":"Journal of Pharmaceutical Research Science &amp; Technology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130654420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Licorice (Glycyrrhiza glabra L.) A Unique Herbaceous Plant: Review of its Medicinal Uses","authors":"Mohammad Makhmur Ahmad, M. Rashid","doi":"10.31531/jprst.1000169","DOIUrl":"https://doi.org/10.31531/jprst.1000169","url":null,"abstract":"Since the beginning of human civilization numerous plants have been used extensively as an essential medicinal source. The need for natural medications is steadily growing over time. One of the herbal plants that is most frequently used in foods, medicines, and extensive global study is licorice or sweetwood as Glycyrrhiza glabra belongs to family Fabaceae. It was used in traditional and complementary medicine to treat a variety of ailments such as allergies, liver toxicity, gastric ulcer, lung diseases, skin disorders, oral health issues such as tooth decay, and inflammation. The phytochemical constituents of licorice include various essential oils, sugars, inorganic salts, resins, amino acids, and nucleic acids. Licorice active substances such as triterpene, flavonoids, and saponins have been shown to exhibit biological activity. Licorice has been extensively researched in recent years to find its benefits, constituents and mechanism of action. This review summarizes the therapeutic and pharmacological benefits of licorice, as well as its applications in various health-related conditions along with its toxicity and maximum amounts of licorice consumption.","PeriodicalId":394015,"journal":{"name":"Journal of Pharmaceutical Research Science &amp; Technology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122080498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Pyrazole Derivative Incorporating Fluorine in the Aromatic Substitution for Physiological and Pharmacological Studies","authors":"R. Gautam","doi":"10.31531/jprst.1000168","DOIUrl":"https://doi.org/10.31531/jprst.1000168","url":null,"abstract":"Over the past decade, drug resistance has become a growing problem in the treatment of infectious diseases caused by bacteria, fungi and viruses. In particular, resistance of bacterial pathogens to current antibiotics has emerged as a measure of health problems. This is especially true in the case of infectious diseases such as pneumonia, meningitis and tuberculosis, which would once have been easily treated with antibiotics, is no longer so readily treated. At present, all widely used antibiotic, including some of the agent such as streptogramins and new generation fluoroquinolones are subjected to bacterial resistance. The search for new antimicrobial agent is one of the most challenging tasks to the medicinal chemist. A search for new antimicrobial compounds with potent and minor toxicity continues to be a region of exploration in medicinal chemistry. It has been well recognized that nitrogen containing heterocyclic molecule is a seat of diverse medicinal activities. Heterocyclic nucleus Pyrazole constitutes an important class of compounds for new drug development. The synthesis of these derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. Owing to the pharmacological importance of Pyrazole, and its derivatives, in the present work, it has been contemplated to combine various biologically active moieties with these heterocycles through active functional systems to form new molecular framework. Prompted by the therapeutic importance of these heterocyclic derivatives, in the present research work we have synthesized Pyrazole with fluorinated aromatic rings, and its derivatives through multistep reaction. Appropriate synthetic methodologies have been developed for the synthesis of new molecules. Their purification techniques have been established. All the newly synthesized compounds have been characterized by 1H NMR, 13C NMR, mass spectral, IR and elemental analyses. Also structures of a few molecules have been confirmed by X-ray crystallographic analysis. Further, the target molecules have been evaluated for their in vitro antibacterial and antifungal activity. From the pharmacological evaluation, it has been observed that some of Pyrazole, derivatives showed good antimicrobial activity","PeriodicalId":394015,"journal":{"name":"Journal of Pharmaceutical Research Science &amp; Technology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124770163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walatimine (Vanillyl Butyl Imine): A New Ketimine from Schiff Base Synthesis and Evaluation of its Antioxidant, Antibacterial and Antifungal Properties","authors":"O. Oladimeji, Joy Adesoji Olukoju, Sam Ogbu, Uforo Joseph Ubobo, E. Attih, O. Hakeem, Oladimeji","doi":"10.31531/jprst.1000170","DOIUrl":"https://doi.org/10.31531/jprst.1000170","url":null,"abstract":"Background of study: Vanillin is a white crystalline compound which is a phenolic aldehyde with a balsamic flavour. It is widely obtained from vanilla bean-pods amongst very many other sources. This compound and some of its derivatives possess diverse activities including anticancer, anti- inflammatory, antioxidant, antibacterial and antifungal amongst others. Hence, the import of this study. Objectives: The growing concerns about the deleterious actions of free radical oxygenated species (FROS) in the human body have become a huge concern to the scientific world. These chemical species continually devastate the human cells, tissues and organs leading to different pathophysiological conditions and neurodegenerative disorders. Also, the noticeable microbial resistance to antibiotics and antifungal drugs have prompted the search for lead compound(s) with the aim of chemically modifying its/their molecular structure(s) or synthesizing other compounds from reactions involving them such as Schiff base synthesis. The search for novel pharmaceutically active compounds with the aim of ameliorating these conditions led to the choice of vanillin. Methodology: Vanillin was subjected to the Schiff base synthesis. It was reacted separately with amines (aromatic and aliphatic amine) leading to the bases in the presence of acid. The melting points, refractive indices and optical rotations of the vanillin and the Schiff bases were obtained. The antioxidant activity (IC50) of the lead compound and bases was determined employing the DPPH (2, 2-diphenyl-1-picrylhydrazyl hydrate) bench-top assay test. Comparison of the obtained antioxidant activities was done to determine if any improvements could be noticed in the synthesized bases. Also, the agar-in-hole diffusion method was adopted for screening vanillin and the synthesized bases against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeriginosa and Candida albicans for antibacterial and antifungal activities respectively. Results: The identities of the synthesized Schiff bases have been revealed to be vanillyl butyl imine (W) a new ketimine referred to by the trivial name- Walatimine and vanillin-2,4-dinitrophenyl hydrazone (Vdnp) respectivelyusing a combination of physico-chemical determinations and IR spectral technique. Vanillin and (W) demonstrated marginal antioxidant activity of IC50 of 0.52 and 0.50 μg/mL respectively while Vdnp gave a remarkably significant IC50 of 0.48 and which compare favourably with 0.46 μg/mL elicited by Vitamin C (a standard antioxidant drug). The antibacterial and antifungal activities elicited by both W and Vdnp were concentration dependent. Furthermore, Vdnp was comparably more bacteriostatic than W against the test bacteria though it was inactive against Ps. aeriginosa. However, vanillyl butyl imine (W) was slightly more anti-candidal against C. albicans than vanillin-2,4-dinitrophenyl hydrazone (Vdnp). Conclusion: The results from this study indicate th","PeriodicalId":394015,"journal":{"name":"Journal of Pharmaceutical Research Science &amp; Technology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128097237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Formulation and Optimization of Peel-Off Face Mask Gel for the Symptomatic Treatment of Rosacea","authors":"T. Raju","doi":"10.31531/jprst.1000164","DOIUrl":"https://doi.org/10.31531/jprst.1000164","url":null,"abstract":"The aim of this research work was to design formulate and optimization peel off face mask for the treatment of Rosacea. Among the 4 different types of rosacea, this research work aims to develop a user-friendly symptomatic treatment for the types which affect the facial skin. The peel off mask was formulated using 4%, 6%, 8%, 10% and 12% polyvinyl alcohol (PVA) as a gelling agent and the main ingredient was chamomile oil. Evaluation of peel off mask included physical characteristics (organoleptic properties, homogeneity, viscosity, spreadability, film drying time), chemical characteristics (pH value), stability and antimicrobial activity. The variation in PVA affects the pH value, viscosity and film drying time significantly. Stability test showed that all peel off mask show no significant changes at room temperature with and without exposure to sunlight and at low temperature. The peel off mask containing chamomile oil using 10% PVA has the inhibitory effect against bacteria (S. aureus, E. coli) and fungi (C. albicans) as compared with the positive controls (clindamycin gel, gentamycin and clotrimazole gel). Variation in the concentration of PVA in the formula affected the physical, chemical characteristic and antimicrobial activity of the chamomile oil peel off gel face mask significantly. The preparation using 10% PVA was found to be the best formula with optimal results and better antimicrobial action","PeriodicalId":394015,"journal":{"name":"Journal of Pharmaceutical Research Science &amp; Technology","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125779006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Efficacy of Pippalyadi Basti and Lekhan Basti in the Management of Medoroga with Special Reference to Obesity – A Protocol","authors":"S. Wairagade","doi":"10.31531/jprst.1000165","DOIUrl":"https://doi.org/10.31531/jprst.1000165","url":null,"abstract":"Background: The conventional concept of etiopathogenesis, prognosis, and management of obesity is very similar and equally advanced to the Medoroga/Sthaulyaroga of Ayurveda, which was conceived in 1500 BC by Acharya Charaka. Overweight or obesity is mostly found in people with predominantly Kapha-type constitutions. According to Acharya Charak, apart from the genetic factors, diet (like shleshmakar, abhishayandi) & lifestyle (like avyayam, divaswapna) are the main contributing factors in the aetiopathogenesis of Medoroga. As per previous study Lekhana Basti was found to have moderate results in obesity. Pippalyadi has Chitraka and Pippali in addition to the other components of Lekahan basti so could have better results in correcting the vitiated Agni. Therefore, Pippalyadi basti is chosen for the current study. Objectives: • To evaluate efficacy of Pippalyadi Basti in the management of Medoroga. • To compare the efficacy with Lekhana Basti • Conceptual study of Medoroga in Ayurvedic texts and Obesity in modern medicine. • Effect of Pippalyadi Basti & Lekhan Basti on B.M.I. Methodology: D.Y. Patil Ayurved Hospital, Samhitas & modern books of medicine, Pharmacy attached to college for the preparations of the drugs, international & national medical journals and magazines, OPD, IPD , Labs , other provisions of the hospitals will be availed to do this intended work. Expected Results: Changes will be observed in objective outcomes. Conclusion: Conclusion will be drawn by suitably analyzing data.","PeriodicalId":394015,"journal":{"name":"Journal of Pharmaceutical Research Science &amp; Technology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125628805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Concise Review on Current Omicron Variants and Subvariants (SARS-Cov-2) and Effective Vaccines against them","authors":"M. Jahangir","doi":"10.31531/jprst.1000167","DOIUrl":"https://doi.org/10.31531/jprst.1000167","url":null,"abstract":"In late 2002 and early 2003, the SARS coronavirus and a new variant of the virus emerged in China and quickly spread around the globe. These viruses were easy to cultivate in tissue culture, which made it possible to study their genomic structure which were significantly different from human and animal coronavirus. The Covid-19 outbreak is a Group 2B Coronavirus. The genomic sequence of SARS-CoV-2 isolated from humans showed a similarity to SARS of 79.5%. The D614G mutation in the SARS-CoV-2 spikes was discovered at the beginning of March 2020. In the second wave of the SARS-COVID-2 epidemic in 2021, a number of novel COVID variants have been reported since the 2020 COVID outbreaks. The Omicron Variants, which were reported after the second wave in late 2021, is one of them. This concise review reports about Classification of new COVID-19 variants, Omicron variants and subvariants and their differences, and current vaccines in use against the newly mutated variants.","PeriodicalId":394015,"journal":{"name":"Journal of Pharmaceutical Research Science &amp; Technology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133462732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Pharmaceutical Coating to Avoid SARS-COVID-2","authors":"Vikrant Verma","doi":"10.31531/jprst.1000166","DOIUrl":"https://doi.org/10.31531/jprst.1000166","url":null,"abstract":"To prevent the spread of COVID-19 infection, there is an urgent global demand for the protection of daily handling surfaces from viral contamination. To combat the present pandemic, nanotechnologists and material scientists offer sustainable options for developing antiviral surface coatings for various substrates such as fabrics, plastics, metal, wood, and food. They develop or propose antiviral surfaces by coating them with nanomaterials that interact with the SARS-CoV-2 spike protein to prevent the virus from infecting the host cell. It was discovered that polymer nanocomposites made from nanoparticles can be used to create useful coating materials. The numerous elements of antiviral nanocoatings are discussed in this article, including the method of interaction with the Corona Virus, the various types of nanocoatings developed for diverse substrates.","PeriodicalId":394015,"journal":{"name":"Journal of Pharmaceutical Research Science &amp; Technology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131072120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Prebiotic Potential of Lepidium Sativum Seed Mucilage as a Nutraceutical Ingredient","authors":"Archana., Suresh Choudhary, Naresh Kalra","doi":"10.31531/jprst.1000163","DOIUrl":"https://doi.org/10.31531/jprst.1000163","url":null,"abstract":"The current study investigates the prebiotic potential of Lepidium sativum L. seeds mucilage on different lactobacilli strains. The quantification of the total reducing sugar in the mucilage was attained by Ultraviolet-Visible Spectrophotometric method. The mucilage exhibited efficient resistance against α-amylase and artificial gastric juice hydrolysis compared to standard prebiotic inulin. The mucilage also exhibited efficient activity necessary for the augmentation of almost all strains of lactobacilli. In vitro studies also exhibited that lactobacilli amount was at par to standard prebiotics (p<0.05) in the medium supplemented with the mucilage. The study led to conclude that the seed mucilage of Lepidium sativum exhibits efficient prebiotic activity and thereby can be used as a potential functional nutraceutical supplement.","PeriodicalId":394015,"journal":{"name":"Journal of Pharmaceutical Research Science &amp; Technology","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123282874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}