Design, Formulation and Optimization of Peel-Off Face Mask Gel for the Symptomatic Treatment of Rosacea

Abstract

The aim of this research work was to design formulate and optimization peel off face mask for the treatment of Rosacea. Among the 4 different types of rosacea, this research work aims to develop a user-friendly symptomatic treatment for the types which affect the facial skin. The peel off mask was formulated using 4%, 6%, 8%, 10% and 12% polyvinyl alcohol (PVA) as a gelling agent and the main ingredient was chamomile oil. Evaluation of peel off mask included physical characteristics (organoleptic properties, homogeneity, viscosity, spreadability, film drying time), chemical characteristics (pH value), stability and antimicrobial activity. The variation in PVA affects the pH value, viscosity and film drying time significantly. Stability test showed that all peel off mask show no significant changes at room temperature with and without exposure to sunlight and at low temperature. The peel off mask containing chamomile oil using 10% PVA has the inhibitory effect against bacteria (S. aureus, E. coli) and fungi (C. albicans) as compared with the positive controls (clindamycin gel, gentamycin and clotrimazole gel). Variation in the concentration of PVA in the formula affected the physical, chemical characteristic and antimicrobial activity of the chamomile oil peel off gel face mask significantly. The preparation using 10% PVA was found to be the best formula with optimal results and better antimicrobial action