Indian Journal of Tuberculosis最新文献

{"title":"Revitalizing TB forums: A strategy to accelerate TB elimination","authors":"Padukudru Anand Mahesh , Raman Arora , Salil Bhargava , Rajendra P. Joshi , Mohammed Shiraz Ahmed , Mudassar Azeez Khan , Manoj Jain","doi":"10.1016/j.ijtb.2024.10.003","DOIUrl":"10.1016/j.ijtb.2024.10.003","url":null,"abstract":"","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 1","pages":"Pages 86-88"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in diagnosing primary tubercular chorioretinitis and ocular tuberculosis in resource-limited settings of Bangladesh","authors":"Ibrahim Khalil","doi":"10.1016/j.ijtb.2024.08.015","DOIUrl":"10.1016/j.ijtb.2024.08.015","url":null,"abstract":"<div><div>Tuberculosis is a pressing global health concern that affects not only the respiratory system but also various extrapulmonary sites. In addition to pulmonary symptoms, tuberculosis can also manifest outside the lungs. The ocular involvement of tuberculosis, often presenting as primary tuberculous chorioretinitis (PTCR), poses a significant diagnostic challenge for healthcare professionals. This review article sheds light on the intricate nature of diagnosing tuberculous infectious diseases in Bangladesh, highlighting the specific challenges faced in this setting. Despite commendable progress in tuberculosis control in Bangladesh, the advanced diagnosis of tuberculosis, particularly when it involves the eyes, presents formidable obstacles. This is especially true in cases of primary tuberculous chorioretinitis, which can pose a grave threat to vision and lead to life-threatening conditions, particularly in resource-poor settings. The article underscores the necessity for innovative and improvised diagnostic approaches to address the unique nature of these cases. Furthermore, the article delves into the implications of Mycobacterium tuberculosis infection in the eye, emphasizing its potential to cause severe blindness. To mitigate bias and enhance patient outcomes, the healthcare community must focus on raising public awareness, improving diagnostic techniques, and ensuring adherence to regulatory standards. This multifaceted approach is essential to effectively combat the challenges posed by tuberculosis, particularly in cases involving ocular manifestations.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 ","pages":"Pages S80-S84"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and epidemiological profile of pulmonary tuberculosis among elderly population residing in old age homes in Salem district, Tamilnadu","authors":"Shini Preetha Nirmalson ,&nbsp;Vijayakarthikeyan M ,&nbsp;Thenmozhi M.D","doi":"10.1016/j.ijtb.2024.08.019","DOIUrl":"10.1016/j.ijtb.2024.08.019","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis mostly affects adults in their most productive years. However, all age groups are at risk. One of the high risk groups for tuberculosis is the elderly population due to factors like physiological ageing related changes, presence of comorbidities and immunodeficiency.</div></div><div><h3>Objective</h3><div>1. To estimate the prevalence of pulmonary tuberculosis among the elderly population residing in selected old age homes.2. To assess the epidemiological profile of pulmonary tuberculosis among the elderly population residing in selected old age homes.</div></div><div><h3>Methodology</h3><div>An analytical cross sectional study was carried out among elderly inmates (N – 300) of selected 10 old age homes in Salem district of Tamilnadu. A pre tested semi-structured questionnaire was used as a study tool for data collection. Investigations like CBNAAT and X ray were carried out on individuals with presumptive symptoms.</div></div><div><h3>Results</h3><div>Among 300 participants, about 50.7% were between 61 and 70 Years and 60.7% were females. Nearly 4.3% were current smokers, 28.7% were hypertensive and 20.6% were diabetic About 15.6% had cough, 11.2% had fever and 4.8% had hemoptysis Prevalence of tuberculosis was 2.6% (260 per 10,000 popultion) in this study. Tuberculosis was reported more in Females, those with presumptive symptoms, underweight individuals, those living in dormitory and those with comorbidity.</div></div><div><h3>Conclusion</h3><div>The results indicate that the key population should be concentrated for routine screening for tuberculosis. Pro-active interventions to seek and diagnose TB disease among older adults are more effective than traditional passive case-finding as we march towards elimination of tuberculosis in India.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 ","pages":"Pages S55-S59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with delay of patients with cough to tuberculosis treatment centres in selected DOTS in South-West Nigeria","authors":"Olatunde Olayanju ,&nbsp;Idemudia Otaigbe ,&nbsp;Kolawole Sodeinde ,&nbsp;Olumide Abiodun ,&nbsp;Akindele Adebiyi","doi":"10.1016/j.ijtb.2023.08.009","DOIUrl":"10.1016/j.ijtb.2023.08.009","url":null,"abstract":"<div><h3>Background</h3><div>The recent gain in the fight against Tuberculosis is potentially being threatened by the delays in the diagnosis and treatment of infected patients. These patients continue to make contacts with other people in the community and spread the disease without knowing. Thus, there is a need to identify the factors associated with these delays and the possibility of mitigating them.</div></div><div><h3>Methods</h3><div>This was a cross-sectional study conducted in Ibadan, Nigeria. Three primary health care centres with high burden of tuberculosis were selected for this study. Patients with newly diagnosed tuberculosis was recruited, delays for presentation at the health centres were evaluated and associated factors were determined using their clinical records and a standard questionnaire.</div></div><div><h3>Results</h3><div>A total of 135 patients met the criteria for this study, and 68 (50.4%) of them were males. Two levels of delays were identified: delay between symptoms onset and presentation in health centres and delays between diagnosis and treatment commencement. Factors associated with these delays were: socio-economic status (p = 0.006), type of area of residence (p = 0.015), current smoking status (p = 0.016) and seeking treatment elsewhere before the current ailment (p = 0.037).</div></div><div><h3>Conclusions</h3><div>This study showed that socio-economic factors, area of residence, cigarette smoking and previous presentation at other health facilities were factors associated with delays at DOTS centres.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 1","pages":"Pages 25-31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47302495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical accuracy of IS6110-based molecular techniques for diagnosis of abdominal TB: A systematic review and meta-analysis","authors":"Hamidreza Zivarifar ,&nbsp;Forough Ahrari ,&nbsp;Nazanin Ataee","doi":"10.1016/j.ijtb.2025.01.008","DOIUrl":"10.1016/j.ijtb.2025.01.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Abdominal tuberculosis (TB) is one of the most common forms of extrapulmonary tuberculosis. It is mostly diagnosed with difficulty due to lower bacterial content. The present study evaluated the clinical accuracy of <em>IS6110</em>-based molecular techniques for diagnosing abdominal tuberculosis.</div></div><div><h3>Materials and methods</h3><div>We searched PubMed, Scopus, and ISI Web of Science databases to collect studies that investigated the accuracy of <em>IS6110</em>-based molecular techniques for diagnosing abdominal tuberculosis until October 2024. After evaluating the studies and compliance with the inclusion and exclusion criteria, the pooled sensitivity, specificity, diagnostic odds ratio, and the area under the curve (AUC), were measured.</div></div><div><h3>Results</h3><div>There are 20 eligible studies. The pooled sensitivity, specificity, as well as diagnostic odds ratio for <em>IS6110</em>-based molecular techniques was about 58% (95%CI: 54–61), 94% (95%CI: 92–96), as well as 35.11 (95 %CI: 16.91–72.87). The summary of the area under the curve (sROC) indicated the excellent efficacy of this method for diagnosing abdominal tuberculosis (sROC: 0.94). According to sub-group analysis, the diagnostic efficacy of intestinal TB is higher than peritoneal tuberculosis. Based on the specimen types, tissue samples have higher diagnostic accuracy than ascetic fluid samples. In addition, the clinical efficacy of both fresh and frozen samples for the detection of abdominal tuberculosis is higher than paraffin-embedded samples. However; there are significant heterogeneity rates in most cases.</div></div><div><h3>Conclusion</h3><div>The current study showed the clinical efficacy of <em>IS6110</em>-based molecular methods for rapid and accurate diagnosis of abdominal tuberculosis regardless of the molecular test, TB type, sample type, sample condition, and study design. However, the current results need to be further strengthened by additional investigations.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 ","pages":"Pages S85-S90"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis and sleep – An underexplored association?","authors":"Avishek Layek,&nbsp;Tejas Menon Suri","doi":"10.1016/j.ijtb.2025.02.007","DOIUrl":"10.1016/j.ijtb.2025.02.007","url":null,"abstract":"<div><div>Tuberculosis is a leading cause of infectious disease mortality worldwide. On the other hand, sleep is a vital determinant of human health and profoundly influences immunity and cardiometabolic health. Both tuberculosis and sleep disorders are highly prevalent conditions, especially in developing countries, which face a dual epidemic of communicable and non-communicable diseases. Sleep quality/disorders and tuberculosis may potentially have bidirectional relationships of public health significance. This article summarizes the current literature that explores the associations between sleep and tuberculosis, their pathophysiological basis, and potential future research avenues.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 ","pages":"Pages S91-S93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Lipoarabinomannan (LAM) in HIV sero-negative miliary tuberculosis patients","authors":"Om Pradeep Y,&nbsp;Ajantha P,&nbsp;Puri M M,&nbsp;Devika T,&nbsp;Sethi P","doi":"10.1016/j.ijtb.2024.11.002","DOIUrl":"10.1016/j.ijtb.2024.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis (TB) is the leading cause of death from infectious diseases worldwide next to COVID. Miliary presentation is a form of TB that can cause 100% mortality without treatment. Due to lack of a gold standard test, a systematic approach of high index of clinical suspicion and efforts at demonstrating <em>Mycobacterium tuberculosis</em> is imperative to early treatment initiation and mortality reduction. This study is designed to find the diagnostic value of urinary LAM using cage nanotechnology a new class of sandwich ELISA technique in HIV sero-negative miliary PTB patients.</div></div><div><h3>Results</h3><div>This is a case-control study done in a tertiary care hospital. Fifty HIV sero-negative patients with clinical presentation of miliary TB and fifty asymptomatic individuals as controls were enrolled. Mean urinary LAM value among the miliary TB patients was 1.82 ± 0.45 mg/L and control group was 0.48 ± 0.18 mg/L. Miliary TB patients had urinary LAM sensitivity and specificity of 98% and 96%.</div></div><div><h3>Conclusion</h3><div>The patients with urinary LAM values between 0.48 and 1.88 mg/L are most likely to have miliary TB. Patients with urinary LAM value of &gt;1.88 mg/L will be likely to have microbiologically confirmed miliary TB and urinary LAM values less than 0.48 mg/L are less likely to have microbiologically confirmed miliary TB.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 ","pages":"Pages S50-S54"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of comparison of medical thoracoscopic guided biopsy versus closed pleural biopsy for etiological diagnosis of undiagnosed exudative pleural effusions: A randomized controlled study","authors":"Sunil Kumar ,&nbsp;Dipti Gothi ,&nbsp;Umesh Chandra Ojha ,&nbsp;Nipun Malhotra ,&nbsp;Rahul Kumar ,&nbsp;Anshul Jain ,&nbsp;Mahismita Patro ,&nbsp;Divya Goyal ,&nbsp;Ram Babu Sah","doi":"10.1016/j.ijtb.2023.09.004","DOIUrl":"10.1016/j.ijtb.2023.09.004","url":null,"abstract":"<div><h3>Background</h3><div><span>Medical thoracoscopy (MT) has gained widespread acceptance in the diagnosis of undiagnosed exudative </span>pleural effusions. In developing countries, including India medical thoracoscopy is not widely available.</div></div><div><h3>Aims</h3><div>1. To analyze the yield of closed pleural biopsy (CPB) in comparison with MT in the diagnosis of undiagnosed exudative pleural effusions. 2. Comparison of complications between CPB and MT.</div></div><div><h3>Methodology</h3><div>This was a prospective randomized controlled study conducted in a tertiary care centre, from January 2020 to September 2021. The patients with undiagnosed exudative pleural effusions were included in the study. The enrolled patients were randomized into two groups, group A and group B. Total of 38 patients were taken, 19 patients in each group. Group A was subjected to MT. Group B was subjected to CPB with cope's needle. Ultrasound was used to mark the site of pleural effusion.</div></div><div><h3>Results</h3><div>Diagnostic yield was 78.9% in both MT and CPB group. CPB was significantly less painful procedure compared to MT. The duration of hospital stay was also significantly less in CPB as compared to MT (P &lt; 0.001). CPB was associated with 5.3% mortality and there was no mortality in MT group.</div></div><div><h3>Conclusions</h3><div>Our study recommends that, in the era of medical thoracoscopy, closed pleural biopsy still holds a significant role in the diagnosis of undiagnosed exudative pleural effusions especially where prevalence of tuberculosis is high. It is also a cost effective approach in developing countries like India.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 1","pages":"Pages 32-37"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46083381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isoniazid preventive therapy among HIV infected patients on antiretroviral therapy diagnosed with latent tuberculosis: A retrospective assessment of the outcome in Tanzania","authors":"Karol J Marwa ,&nbsp;Rachel Maingu","doi":"10.1016/j.ijtb.2023.07.005","DOIUrl":"10.1016/j.ijtb.2023.07.005","url":null,"abstract":"<div><h3>Background</h3><div>People infected with HIV are at a higher risk up to 20-folds of developing active TB<span> than those not infected with HIV. Isoniazid Preventive Therapy (IPT) is employed in HIV eligible individuals to prevent progression of active tuberculosis (TB) disease. However, there is limited data on the efficacy of IPT in clinical settings in Tanzania and other parts of the world. This study was carried to assess the real-time IPT effectiveness in preventing TB incidences among HIV infected individuals on antiretroviral therapy.</span></div></div><div><h3>Methods</h3><div>A retrospective cohort study was carried employing secondary data of 1000 HIV infected individuals receiving anti-retroviral therapy. TB incidence and associated factors were determined after a four years follow-up.</div></div><div><h3>Results</h3><div>A total of 1000 people were enrolled in the study. The mean age was 44.87 years. The incidence rate was 7.37/1000 person-years (PY) [95% confidence interval (CI) 3.96-13.71]. One percent (1%) of patients developed active tuberculosis within four years of follow up after receiving isoniazid tablets as part of IPT.</div></div><div><h3>Conclusion</h3><div>IPT has a high efficacy in preventing active TB development among HIV infected individuals on ART in clinical settings thus warranting the scale up of IPT services in the country.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 1","pages":"Pages 19-24"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46660820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculous meningitis in Bhubaneswar, Odisha, during 2016 to 2022","authors":"Chinmayee Mohanty ,&nbsp;Triyambakesh Mohanty ,&nbsp;Sarita Kar ,&nbsp;Sujeet Kumar ,&nbsp;Sunil Swick Rout ,&nbsp;Himadri Bhusan Bal ,&nbsp;Subrat Kumar Barik ,&nbsp;Jyotirmayee Turuk ,&nbsp;Dasarathi Das ,&nbsp;Sooman Sundaray ,&nbsp;Prasanta Kumar Hota ,&nbsp;Sanghamitra Pati ,&nbsp;Sidhartha Giri","doi":"10.1016/j.ijtb.2023.09.007","DOIUrl":"10.1016/j.ijtb.2023.09.007","url":null,"abstract":"<div><h3>Background</h3><div><span><span>The burden of tuberculous meningitis<span><span> varies substantially by location, and is influenced by the overall burden of tuberculosis in that geographical area, and the age structure<span> of the population. Conventional methods for diagnosis of tuberculous meningitis include </span></span>acid fast bacilli (AFB) smear and culture. AFB smear has low sensitivity and culture techniques are time consuming. During the last few years, rapid and sensitive molecular methods such as cartridge based </span></span>nucleic acid amplification technique (CBNAAT) is being used for the diagnosis of tuberculous meningitis. In this study, we evaluated the burden of tuberculosis and </span>rifampicin resistance in suspected cases of tuberculous meningitis in Bhubaneswar, Odisha, during February 2016 to December 2022 using CBNAAT.</div></div><div><h3>Methods</h3><div><span>Under the National Strategic Plan 2012–2017, CBNAAT machines were rolled out in 2016, of which 1 was installed in the National Reference Laboratory (NRL) for Tuberculosis in Bhubaneswar. For this study, retrospective data on CBNAAT testing of cerebrospinal fluid<span> (CSF) samples at the NRL was collected and analyzed from February 2016 to December 2022. All the demographic and laboratory data were entered in Excel 2010 (Microsoft office, USA) for data analysis. The age and sex distribution of the presumptive TB patients, proportion of samples referred from public and private health care facilities, proportion of </span></span><em>M. tuberculosis</em><span> positive CSF samples along with sensitivity to rifampicin was evaluated. The study was approved by the Institutional Human Ethics Committee.</span></div></div><div><h3>Results</h3><div>During February 2016 to December 2022, a total of 1627 CSF samples from presumptive TB meningitis patients were received in the NRL for CBNAAT testing. 60.7% (988/1627) of the presumptive TB patients were males. Of the 1627 patients, 3.1% (50/1627) were positive for <em>M. Tuberculosis</em> by CBNAAT. 56% (28/50) of the patients positive for tuberculous meningitis were males. The positivity for <em>M. tuberculosis</em> varied from 2.1% in 2017 to 5.1% in 2021. The CSF positivity for <em>M. tuberculosis</em> ranged from 0.7% in patients aged &gt;60 years to 6.1% in 15–30 years age group. Of the 50 <em>M. tuberculosis</em> positive samples, 6% (3/50) were resistant for rifampicin.</div></div><div><h3>Conclusion</h3><div>Our study which included more than 1600 samples over a period of approximately 7 years found a 3.1% positivity for <em>M. tuberculosis</em> in CSF samples using CBNAAT. 6% of the <em>M. tuberculosis</em> positive samples were resistant to rifampicin. Future studies involving data from other districts of Odisha will help provide a more accurate information on the prevalence of tuberculous meningitis in Odisha state.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 1","pages":"Pages 46-50"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135347715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}