Indian Journal of Tuberculosis最新文献

{"title":"Tuberculosis notification in India-current trends and the road ahead","authors":"Ravindra Nath, Vidushi Rathi, Pranav Ish","doi":"10.1016/j.ijtb.2023.08.010","DOIUrl":"10.1016/j.ijtb.2023.08.010","url":null,"abstract":"","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"71 2","pages":"Pages 114-116"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41995200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“TB - Mindedness”-the only way to beat “the great mimicker”: A case series with atypical presentation of female genital tuberculosis","authors":"Ashmita Saha,&nbsp;Nilanchali Singh,&nbsp;Deepika kashyap,&nbsp;Anshul Kulshrestha,&nbsp;Avir Sarkar,&nbsp;Jai B. Sharma,&nbsp;Kallol Kumar Roy","doi":"10.1016/j.ijtb.2023.04.027","DOIUrl":"10.1016/j.ijtb.2023.04.027","url":null,"abstract":"<div><h3>Background</h3><p>Incidence of Tuberculosis (TB) cases in India reported in 2019 is 193 per 1 lakh population [National Tuberculosis Elimination Plan (NTEP)]. In India, annual extra pulmonary TB<span> burden is 20–25%, of which 4% of cases are of urogenital origin (Revised National TB Control Programme, 2019; World Health Organization, 2019). The Ministry of Health and Family Welfare has made a target of eliminating tuberculosis by 2025 under the NTEP by the process of identification, notification and treatment of cases. Tuberculosis being a leading cause of infertility in developing countries, employing best clinical practices and being “TB-minded” will also save the patient of enormous anxiety and uncertainity and also decrease the time gap between clinical presentation and diagnosis to optimize fertility outcome.</span></p></div><div><h3>Methodology</h3><p><span><span>A prospective cohort study of cases presenting with unusual findings and ultimately being diagnosed as </span>genital tuberculosis was conducted in the </span>gynaecology OPD, AIIMS, New Delhi, from November 2020 to November 2021 (1 year). Patients were investigated judiciously, diagnosis made and followed up for their response to anti tuberculosis therapy (ATT).</p></div><div><h3>Results</h3><p><span>This data comprises of conglomerate of ten cases with unconventional exhibition of genital tuberculosis. 70% of the cases presented with pain lower abdomen not specifically related to menstrual cycle<span> and often confused with IBD<span>. Tubo ovarian mass (70%) mimicking as simple ovarian cyst, </span></span></span>ovarian carcinoma<span> or endometriosis was the most common clinical finding we came across.</span></p></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"71 2","pages":"Pages 179-184"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46145933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between serum isoniazid concentration and therapeutic response in patients of pulmonary tuberculosis in Central India: A prospective observational study","authors":"P. Ponmani ,&nbsp;Ratinder Jhaj ,&nbsp;Ajay Kumar Shukla ,&nbsp;Alkesh Kumar Khurana ,&nbsp;Prashant Pathak","doi":"10.1016/j.ijtb.2023.04.022","DOIUrl":"10.1016/j.ijtb.2023.04.022","url":null,"abstract":"<div><h3>Background</h3><p>Tuberculosis (TB), an infectious disease caused by <span><em>Mycobacterium tuberculosis</em></span><span><span> is one of the top ten causes of death worldwide. Isoniazid (INH) is an important component of anti-tuberculosis therapy (ATT). Low isoniazid levels can serve as a risk factor for the development of treatment failure, relapse of disease and acquired secondary resistance. Hence, serum level of isoniazid becomes a critical factor in determining the treatment outcome of patients on ATT. This study aimed to evaluate the correlation between serum isoniazid concentration and therapeutic response </span>in patients<span> of pulmonary tuberculosis in Central India.</span></span></p></div><div><h3>Methods</h3><p>This was a prospective single cohort observational study conducted at a tertiary care hospital. Therapeutic response in newly diagnosed patients of pulmonary TB was determined based the microbiological, clinical and radiological parameters. Serum INH levels were estimated based on a spectrophotometric method using nano-spectrophotometer.</p></div><div><h3>Results</h3><p>In this study, patients had a significant improvement in treatment outcome as evident by a significant decrease in the TB score I at end of IP (p = 0.001) and a significant decline in the Timika score at end of CP (p = 0.001). Although all patients converted to sputum negative at end of CP, 20% remained positive at end of IP. Lower INH levels were seen in 13.3% of the study population. Higher INH levels were observed in sputum converters, patients with low TB score I and low Timika score, although no statistically significant difference was noted (p &gt; 0.05).</p></div><div><h3>Conclusion</h3><p>In this study, we could not find any statistically significant association between serum INH levels and therapeutic outcome of the patients. Further studies on a larger population could provide better understanding about the prevalence of low serum isoniazid levels among the Indian population and establish its relationship with therapeutic outcome. Also, the usage of a comparatively less expensive spectrophotometric method of analysis makes this feasible in almost every district hospital without the need of high-performance liquid chromatography which is costlier and needs more expertise.</p></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"71 2","pages":"Pages 153-162"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48573288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary mucormycosis diagnosed by ultrasound guided percutaneous biopsy: A case series","authors":"Rajesh Kumar Yadav,&nbsp;Saurabh Karmakar,&nbsp;Abdul Raouf Wani,&nbsp;Vinay V","doi":"10.1016/j.ijtb.2023.10.001","DOIUrl":"10.1016/j.ijtb.2023.10.001","url":null,"abstract":"<div><p><span><span>Pulmonary mucormycosis is a rare but highly lethal </span>fungal infection<span><span>, usually affecting immunocompromised patients<span>. Pulmonary mucormycosis was also a critical problem that complicated the later part of the clinical course of COVID-19 in India. Early diagnosis of the disease, combined with aggressive treatment, is crucial for patient survival. Fibreoptic </span></span>bronchoscopy<span><span> is a useful procedure for diagnosis of pulmonary mucormycosis, but image-guided percutaneous biopsy efficiently samples lesions abutting the chest wall. Biopsy is more yielding than cultures and imaging guided biopsy is required for lesions that cannot be microbiologically confirmed by fibreoptic bronchoscopy. We present a case series of four patients of pulmonary mucormycosis in whom ultrasound guided biopsy clinched the diagnosis. All the four patients were poor surgical candidates and underwent medical management with </span>antifungal agents, and had successful clinical recovery and radiological resolution. Our case series illustrates the utility of ultrasound guided percutaneous biopsy as a diagnostic tool for sampling cavitatory disease due to pulmonary mucormycosis, when fibreoptic bronchoscopy failed to yield a diagnosis and the beneficial role antifungal agents as </span></span></span>salvage therapy in poor surgical candidates.</p></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"71 2","pages":"Pages 225-231"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135707808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTIVENESS OF FDA VITAL STAINING IN FOLLOW UP OF DR PTB PATIENTS ON LONGER TREATMENT REGIMEN UNDER NTEP","authors":"A.S.W.A.T.H.Y. S A, Dr ANUJ.K. Bhatnagar, Dr M. Hanif","doi":"10.1016/j.ijtb.2024.04.011","DOIUrl":"https://doi.org/10.1016/j.ijtb.2024.04.011","url":null,"abstract":"","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"15 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The uptake and utilization of Nikshay Poshan Yojana: Lessons from an urban setting in India","authors":"Gauri A Oka, Prasad D. Pore, Prakash P. Doke","doi":"10.1016/j.ijtb.2024.04.004","DOIUrl":"https://doi.org/10.1016/j.ijtb.2024.04.004","url":null,"abstract":"","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"63 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finger printing-RFLP analysis of chromosomal IS6110 insertion sequence and PCR diagnosis of pulmonary tuberculosis, isolated from patients in El Hajeb region of Morocco","authors":"Adil Essahale ,&nbsp;Fouad Nia ,&nbsp;Anis Sfendla ,&nbsp;Mohieddine Moumni","doi":"10.1016/j.ijtb.2023.03.020","DOIUrl":"10.1016/j.ijtb.2023.03.020","url":null,"abstract":"<div><p>Tuberculosis (TB) is one of the contagious diseases caused by <em>M. tuberculosis</em><span> (MTB) bacteria. Prompt diagnosis is one of the active solutions to control the spread of this infection. Besides, a targeted, specific and non-complex diagnosis can prove promising in this type of epidemic. This study was designed to compare the efficiencies of a diagnosis by Ziehl-Neelsen staining (ZN) and by the polymerase chain reaction<span> (PCR) technique. Samples presented smear-positive pulmonary TB were subjected to Chromosomal restriction fragment length polymorphism of IS6110 (IS6110-RFLP) for fingerprinting profile determination.</span></span></p><p><span>The results showed that out of 100 sputum samples of </span><strong>suspected case</strong>, 53 were positive. Numbers of positive individuals for tuberculosis obtained by the different diagnostic techniques, to know, (ZN staining; culture and PCR) were respectively: 6, 25 and 22. Chromosomal RFLP fingerprinting profile revealed the presence of five different genotypes obtained from seven tested isolates.</p><p>These results suggest that molecular techniques are alternative tool for fast and specific diagnosis of pulmonary MTB from sputum.</p></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"71 2","pages":"Pages 117-122"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44187459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroids and pericardial TB: “Friend or Foe”","authors":"Jyoti Bajpai,&nbsp;Shobhit Shah,&nbsp;Akshyaya Pradhan,&nbsp;Surya Kant","doi":"10.1016/j.ijtb.2024.02.001","DOIUrl":"10.1016/j.ijtb.2024.02.001","url":null,"abstract":"","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"71 2","pages":"Pages 111-113"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nebulized dexmedetomidine prior to flexible bronchoscopy in reducing procedural cough episodes a randomized double blind clinical trial. (NCT: CTRI/2022/07/044389, NICOBAR group of investigators)","authors":"Jahanvi Grover, Mohit Garg, P. Singh, Savita Verma, Dhruva Chaudhry, Puneet Saxena, Aman Ahuja, Geetika Arya","doi":"10.1016/j.ijtb.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.ijtb.2024.04.003","url":null,"abstract":"","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"28 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140761620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes mellitus and human immunodeficiency virus (HIV) infection in people with tuberculosis in Odisha, India","authors":"Sidhartha Giri ,&nbsp;Priyanka Sahu ,&nbsp;Srikanta Kanungo ,&nbsp;Himadri Bhusan Bal ,&nbsp;Sujeet Kumar ,&nbsp;Sarita Kar ,&nbsp;Triyambakesh Mohanty ,&nbsp;Jyotirmayee Turuk ,&nbsp;Dasarathi Das ,&nbsp;Prasanta Kumar Hota ,&nbsp;Sanghamitra Pati","doi":"10.1016/j.ijtb.2023.04.021","DOIUrl":"10.1016/j.ijtb.2023.04.021","url":null,"abstract":"<div><h3>Background</h3><p><span>Modelling studies have indicated that approximately 20% of all tuberculosis (TB) cases may suffer from diabetes mellitus (DM). DM increases the risk of developing active TB disease by 2–3 times. People living with HIV (PLHIV) are more likely to develop TB disease, and TB is a leading cause of hospitalization and death among PLHIV. Despite the substantial burden of DM and HIV in India, few studies have evaluated the prevalence of DM and HIV among active cases of TB, and its impact on the treatment outcome for TB. This study evaluated the burden of HIV and DM in TB cases from Odisha during 2019, and its impact on the </span>TB treatment outcome.</p></div><div><h3>Methods</h3><p><span>The study utilized data on TB patients of Odisha during 2019, from the NIKSHAY portal, the health management information system (HMIS) of TB in India. This is a retrospective observational registry-based </span>cohort study, which evaluated a linkage between socio-demographic predictors, clinical diagnostic and treatment predictors, time of treatment predictors, and co-morbidity with TB. Data were retrieved electronically in Microsoft-Excel and analysis was done using STATA 16 (StataCorp. 2019, College Station, TX: StataCorp LLC).</p></div><div><h3>Results</h3><p>Data for 47,831 TB cases of Odisha as study population was extracted from the Nikshay application for the year 2019. The highest prevalence (31.1%, 14,863/47,831) of TB was observed among young participants aged 15–30 years, whereas the prevalence was least among children &lt;14 years (4.4%, 2124/47,831). Males had a higher prevalence of TB (66.7%, 31,878/47,831). Of the 47,831 TB cases included in the study, 7.6% (3659/47,831) had diabetes mellitus (DM), along with TB. 1.2% (571/47,831) had HIV along with TB, while only 0.08% (37/47,831) had both DM and HIV along with TB. 88.2% (3148/3569) of cases with DM and TB had a favorable outcome, compared to 82.3% (449/541) of cases with HIV and TB. People with TB who did not have DM had a significantly higher favorable outcome (OR 1.6, 95% CI 1.5–1.8) compared to those with TB and DM. Similarly, TB cases who did not have HIV infection had a significantly higher favorable outcome (OR 2.4, 95% CI 1.9–3.0) compared to those with TB and HIV.</p></div><div><h3>Conclusion</h3><p>Our study showed that presence of DM and/or HIV in TB patients had an impact on the TB treatment outcome. There is a crucial need to prevent comorbidities such as DM and HIV from occurring and to prioritize early diagnosis and management of these conditions.</p></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"71 2","pages":"Pages 147-152"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45430022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}