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PRACTICAL NEUROLOGY最新文献

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Acute monocular visual loss: time to call the stroke team? 急性单眼视力丧失：是时候呼叫卒中团队了吗？
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI: 10.1136/pn-2023-003998
Jacob Day, Housam Monla-Haidar, Vasant Raman, Stuart Weatherby
{"title":"Acute monocular visual loss: time to call the stroke team?","authors":"Jacob Day, Housam Monla-Haidar, Vasant Raman, Stuart Weatherby","doi":"10.1136/pn-2023-003998","DOIUrl":"10.1136/pn-2023-003998","url":null,"abstract":"<p><p>A man in his 90s presented with acute monocular loss of vision; the emergency department triage alerted the stroke team. He underwent urgent parallel assessments by the stroke and ophthalmology teams and was diagnosed with central retinal artery occlusion. The ultimate decision was made to manage him conservatively, rather than with intravenous thrombolysis, and his visual function has remained poor. We discuss the current evidence for using intravenous thrombolysis in people with central retinal artery occlusion and use this case to exemplify the practical issues that must be overcome if ongoing randomised clinical trials of central retinal artery occlusion confirm a definite benefit from using intravenous thrombolysis.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent tongue protrusion dystonia after cerebral infarction. 脑梗塞后持续性舌前伸肌张力障碍
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI: 10.1136/pn-2024-004120
Rana Alnasser Alsukhni, Hamsaraj Shetty, Tom A T Hughes
{"title":"Persistent tongue protrusion dystonia after cerebral infarction.","authors":"Rana Alnasser Alsukhni, Hamsaraj Shetty, Tom A T Hughes","doi":"10.1136/pn-2024-004120","DOIUrl":"10.1136/pn-2024-004120","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
General internal medicine: a neurology registrar's guide to making the most of medical attachments. 普通内科：神经病学注册医师充分利用医学实习的指南》。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI: 10.1136/pn-2024-004204
Neil Watson
{"title":"General internal medicine: a neurology registrar's guide to making the most of medical attachments.","authors":"Neil Watson","doi":"10.1136/pn-2024-004204","DOIUrl":"10.1136/pn-2024-004204","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methotrexate for the neurologist. 给神经科医生的甲氨蝶呤
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI: 10.1136/pn-2024-004156
Aaron Jesuthasan, Aravindhan Baheerathan, Stephen Auger, Rachel Dorsey, Robina Coker, Nowlan Selvapatt, Stuart Viegas
{"title":"Methotrexate for the neurologist.","authors":"Aaron Jesuthasan, Aravindhan Baheerathan, Stephen Auger, Rachel Dorsey, Robina Coker, Nowlan Selvapatt, Stuart Viegas","doi":"10.1136/pn-2024-004156","DOIUrl":"10.1136/pn-2024-004156","url":null,"abstract":"<p><p>The use of methotrexate in clinical practice has expanded significantly in recent years, as an effective chemotherapeutic agent as well as disease-modifying treatment for conditions such as rheumatoid arthritis, psoriasis and Crohn's disease. It is also used as a steroid-sparing agent for a range of inflammatory diseases of the central and peripheral nervous systems. Clinical neurologists must, therefore, know how to start and uptitrate methotrexate, its monitoring requirements and its potential toxicities. This review aims first to explore the evidence base for using methotrexate in various neurological diseases and second to discuss important practicalities around its use, ensuring its safe application and appropriate monitoring.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurotoxicology: a clinical systems-based review. 神经毒理学：基于临床系统的综述。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI: 10.1136/pn-2023-003983
Frederick W Vonberg, Peter G Blain
{"title":"Neurotoxicology: a clinical systems-based review.","authors":"Frederick W Vonberg, Peter G Blain","doi":"10.1136/pn-2023-003983","DOIUrl":"10.1136/pn-2023-003983","url":null,"abstract":"<p><p>Neurological disease caused by toxins is widespread but under-recognised. Despite increasing public interest and a growing number of novel potential neurotoxins, diagnosis of neurotoxic disease is often delayed or missed, resulting in poorer patient outcomes. This article discusses neurotoxic syndromes using a systems-based approach, focusing on environmental and occupational agents. We do not discuss recreational drugs, pharmaceutical agents or developmental neurotoxins in detail. We aim to provide neurologists with a working understanding of the scenarios in which a clinical presentation may be due to a neurotoxin and how to approach confirmation of the diagnosis.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute bilateral sensorineural hearing loss as presentation of leptomeningeal metastases. 急性双侧感音神经性听力损失是脑膜转移瘤的一种表现。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI: 10.1136/pn-2024-004167
Ayush Agarwal, Divyani Garg, Shikha Priya, Punith Saroja Bylappa, Ajay Garg, Shamim Ahmed Shamim, Anshuman Elhence, Divya M Radhakrishnan, Awadh Kishor Pandit, Achal K Srivastava
{"title":"Acute bilateral sensorineural hearing loss as presentation of leptomeningeal metastases.","authors":"Ayush Agarwal, Divyani Garg, Shikha Priya, Punith Saroja Bylappa, Ajay Garg, Shamim Ahmed Shamim, Anshuman Elhence, Divya M Radhakrishnan, Awadh Kishor Pandit, Achal K Srivastava","doi":"10.1136/pn-2024-004167","DOIUrl":"10.1136/pn-2024-004167","url":null,"abstract":"<p><p>We describe a rare occurrence of bilateral acute severe sensorineural hearing loss in a middle-aged man that heralded the diagnosis of metastatic gastric cancer.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'Ear of the lynx' sign: hereditary spastic paraplegia (HSP) type 11. 猞猁耳 "征：遗传性痉挛性截瘫（HSP）11 型。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI: 10.1136/pn-2024-004115
Jayaram Saibaba, Sunil K Narayan, Ramkumar Sugumaran
{"title":"'Ear of the lynx' sign: hereditary spastic paraplegia (HSP) type 11.","authors":"Jayaram Saibaba, Sunil K Narayan, Ramkumar Sugumaran","doi":"10.1136/pn-2024-004115","DOIUrl":"10.1136/pn-2024-004115","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurological manifestations in malignant melanoma. 恶性黑色素瘤的神经系统表现。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI: 10.1136/pn-2023-003966
H M M T B Herath, Nadiene G Lutchman, May Saleh, Leena Naidu, Shyama Balasuriya Alagoda, Stefen Brady, Sunil Wimalaratna
{"title":"Neurological manifestations in malignant melanoma.","authors":"H M M T B Herath, Nadiene G Lutchman, May Saleh, Leena Naidu, Shyama Balasuriya Alagoda, Stefen Brady, Sunil Wimalaratna","doi":"10.1136/pn-2023-003966","DOIUrl":"10.1136/pn-2023-003966","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to use podcasts in neurology. 如何在神经病学中使用播客。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI: 10.1136/pn-2024-004109
Fleur Mason, Josephine Mayer, Brian O'Toole, John Williamson, Amy Ross Russell
{"title":"How to use podcasts in neurology.","authors":"Fleur Mason, Josephine Mayer, Brian O'Toole, John Williamson, Amy Ross Russell","doi":"10.1136/pn-2024-004109","DOIUrl":"10.1136/pn-2024-004109","url":null,"abstract":"<p><p>Virtual learning resources such as podcasts and social media are increasingly used in medical education. Podcasts are one example of virtual learning, where prerecorded audio files are available to stream or download from the internet, usually without a fee and at any time. This gives listeners flexibility in when and where they engage with the educational material, enabling learning to be better tailored to individual needs. Podcasts are often enjoyed for their relaxed and conversational style. However, listeners must be aware of the lack of external peer review and incomplete coverage of information. There are also risks inherent to distant learning, including depersonalisation of medical education. We describe the roles that podcasts now play in neurological education, exploring some of the ways that they can be used to enhance neurological training both as a learner and educator and giving our top tips, based on our own experiences, for anyone keen to add to the expanding field of available podcasts.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arginine:glycine amidinotransferase (AGAT) deficiency: an easy-to-miss treatable adult-onset myopathy. 精氨酸：甘氨酸脒基转移酶（AGAT）缺乏症：一种易漏诊易治疗的成人型肌病。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI: 10.1136/pn-2023-003954
Yael Finezilber, Charlotte Massey, Jessica A Radley, Elaine Murphy
{"title":"Arginine:glycine amidinotransferase (AGAT) deficiency: an easy-to-miss treatable adult-onset myopathy.","authors":"Yael Finezilber, Charlotte Massey, Jessica A Radley, Elaine Murphy","doi":"10.1136/pn-2023-003954","DOIUrl":"10.1136/pn-2023-003954","url":null,"abstract":"<p><p>Arginine:glycine amidinotransferase (AGAT) deficiency is an ultrarare disorder of creatine metabolism, presenting with developmental delay, characteristic biochemical findings and muscle weakness. Most known cases have been identified and treated in early childhood. We describe a 27-year-old woman with learning difficulties and significant myopathy who was diagnosed through genetic investigation in adulthood. Treatment with creatine (10-15 g/day) led to a significant and rapid improvement of muscle strength. A literature review of the few reported adult cases confirms that progressive myopathy is a prominent feature that responds well to creatine supplementation. AGAT deficiency, a partially treatable condition, should be considered in the differential diagnosis of a genetic myopathy, particularly in people with developmental delay and progressive myopathy.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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