PRACTICAL NEUROLOGY最新文献

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Neurological aspects of drug misuse. 药物滥用的神经学方面。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-05-27 DOI: 10.1136/pn-2023-003796
Robin S Howard, Paul Holmes, Paul Dargan
{"title":"Neurological aspects of drug misuse.","authors":"Robin S Howard, Paul Holmes, Paul Dargan","doi":"10.1136/pn-2023-003796","DOIUrl":"https://doi.org/10.1136/pn-2023-003796","url":null,"abstract":"<p><p>The misuse of illicit drugs and prescription medications may cause neurological complications from overdose, withdrawal and long-term chronic misuse. Drug-use disorder has become particularly important and complex because of different patterns of presentation associated with new psychoactive substances and the growing misuse of opioids, synthetic cannabinoids and stimulants. We review worldwide demographic data of drug-use disorder and discuss the individual classes of agents, newer developments relating to understanding the mechanisms of action and the patterns of administration, usage, toxicity and withdrawal. We consider the difficulties in assessment and the specific acute syndromes of toxicity that present with neurological manifestations. We review the neurological patterns of longer-term complications and consider the effects of drug misuse-related trauma, infection, seizures, stroke, toxic leucoencephalopathy, cognitive impairment, movement disorders and neuromuscular complications. The neurological consequences of drug-use disorder disproportionately affect the young and can have devastating effects on innocent lives. It is essential that neurologists recognise acute toxicity early and understand the longer-term consequences of drug-use disorder.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treating anxiety and depression in people with epilepsy. 治疗癫痫患者的焦虑和抑郁。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-05-27 DOI: 10.1136/pn-2024-004424
Emanuele F Osimo, Paul C Fletcher, Thomas E Cope
{"title":"Treating anxiety and depression in people with epilepsy.","authors":"Emanuele F Osimo, Paul C Fletcher, Thomas E Cope","doi":"10.1136/pn-2024-004424","DOIUrl":"https://doi.org/10.1136/pn-2024-004424","url":null,"abstract":"<p><p>The major barriers to detecting, diagnosing and treating depression in the epilepsy clinic are a lack of confidence and a lack of time. Patients with epilepsy have a significantly increased risk of anxiety and depression, and an increased risk of suicide, so conversations about mood should be considered as routine as conversations about SUDEP (sudden unexpected death in epilepsy). Neurologists should feel confident in prescribing serotonin reuptake inhibitors and should know how to refer to local next-stage mental health services if required. Access to psychological well-being services is better than most people are aware of, and self-referral is possible. We would encourage neurologists to strongly consider mental health when prescribing antiseizure medications, especially levetiracetam, and to disseminate such considerations to acute medical, anaesthetic and neurosurgical colleagues. We provide some simple, practical advice to equip neurologists and epilepsy nurses to talk to patients about their mental health and to take initial steps towards treatment.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cortical deafness following embolic strokes. 栓塞性中风后的皮质性耳聋。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-05-24 DOI: 10.1136/pn-2025-004559
Giovanni Siconolfi, Cristiano Pecchioli, Petra Vukoja, Fabrizio Vecchio, Francesco Iodice, Antonio Marrone, Alberto Pierallini, Paolo Maria Rossini
{"title":"Cortical deafness following embolic strokes.","authors":"Giovanni Siconolfi, Cristiano Pecchioli, Petra Vukoja, Fabrizio Vecchio, Francesco Iodice, Antonio Marrone, Alberto Pierallini, Paolo Maria Rossini","doi":"10.1136/pn-2025-004559","DOIUrl":"https://doi.org/10.1136/pn-2025-004559","url":null,"abstract":"<p><p>Cortical deafness is exceedingly rare and is caused by bilateral failure of the auditory cortices, due to structural damage such as ischaemic stroke, while the peripheral and brainstem auditory structures remain unaffected. We describe a woman who acutely developed bilateral neurosensorial hypoacusis following a bilateral cardioembolic ischaemic stroke, due to takotsubo cardiomyopathy, affecting the primary auditory areas of the temporal lobes. She partially recovered over several months, with noticeably improved auditory function and gradual normalisation of auditory brainstem responses and evoked potentials. Her language comprehension markedly improved, with substantially enhanced ability to process and understand spoken language. Nevertheless, mild language impairments persisted. We explore the neurophysiological assessment of cortical deafness and its prognosis.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 38-year-old man with unsteadiness and difficulty walking. 38岁男性,身体不稳,行走困难。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-05-23 DOI: 10.1136/pn-2024-004352
Aye Moe, Charles Fry, Mark R Baker, Yi Shiau Ng
{"title":"A 38-year-old man with unsteadiness and difficulty walking.","authors":"Aye Moe, Charles Fry, Mark R Baker, Yi Shiau Ng","doi":"10.1136/pn-2024-004352","DOIUrl":"https://doi.org/10.1136/pn-2024-004352","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cold Comfort Farm by Stella Gibbons. 斯特拉-吉本斯(Stella Gibbons)的《冷酷舒适农场》。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-05-15 DOI: 10.1136/pn-2024-004338
Matthew D Smith
{"title":"Cold Comfort Farm by Stella Gibbons.","authors":"Matthew D Smith","doi":"10.1136/pn-2024-004338","DOIUrl":"10.1136/pn-2024-004338","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"292"},"PeriodicalIF":2.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central nervous system vasculopathy: inherited or acquired? The DADA2 conundrum. 中枢神经系统血管病:遗传还是获得性?DADA2难题。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-05-15 DOI: 10.1136/pn-2024-004441
Sowmya Saravanan, Rajeswari Aghoram, Sunil K Narayan, Jayaram Saibaba, R Madhan
{"title":"Central nervous system vasculopathy: inherited or acquired? The DADA2 conundrum.","authors":"Sowmya Saravanan, Rajeswari Aghoram, Sunil K Narayan, Jayaram Saibaba, R Madhan","doi":"10.1136/pn-2024-004441","DOIUrl":"10.1136/pn-2024-004441","url":null,"abstract":"<p><p>Young people with stroke require detailed investigation because uncommon causes are more likely. A 19-year-old woman presented with multiple cortical and subcortical infarcts, arterial aneurysms, anaemia and hypertension. Further evaluation identified a systemic vasculopathy secondary to a deficiency of adenosine deaminase 2, a rare treatable monogenic disorder.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"250-252"},"PeriodicalIF":2.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infratentorial superficial siderosis due to a spinal dural tear. 由硬脊膜撕裂引起的幕下浅表性铁沉着症。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-05-15 DOI: 10.1136/pn-2024-004382
Sarah Katherine Morgan, Kuhilan Gounder, Constantine Phatouros, Tom Jenkins
{"title":"Infratentorial superficial siderosis due to a spinal dural tear.","authors":"Sarah Katherine Morgan, Kuhilan Gounder, Constantine Phatouros, Tom Jenkins","doi":"10.1136/pn-2024-004382","DOIUrl":"10.1136/pn-2024-004382","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"278-280"},"PeriodicalIF":2.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunoglobulin use in neurology: a practical approach. 免疫球蛋白在神经病学中的应用:实用方法。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-05-15 DOI: 10.1136/pn-2022-003655
Mahima Kapoor, Anthony Khoo, Michael P T Lunn, Stephen Reddel, Aisling S Carr
{"title":"Immunoglobulin use in neurology: a practical approach.","authors":"Mahima Kapoor, Anthony Khoo, Michael P T Lunn, Stephen Reddel, Aisling S Carr","doi":"10.1136/pn-2022-003655","DOIUrl":"10.1136/pn-2022-003655","url":null,"abstract":"<p><p>Human immunoglobulin, delivered either intravenously (IVIg) or subcutaneously, is used to treat a range of immune-mediated neurological disorders. It has a role in acute or subacute inflammatory disease control and as a maintenance therapy in chronic disease management. This review considers mechanisms of IVIg action and the evidence for IVIg in neurological conditions. We use Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) as frameworks to demonstrate an approach to IVIg use in acute and chronic dysimmune neurological conditions across two different healthcare systems: the UK and Australia. We highlight the benefits and limitations of IVIg and focus on practical considerations such as informed consent, managing risks and adverse effects, optimal dosing and monitoring response. We use these basic clinical practice principles to discuss the judicious use of an expensive and scarce blood product with international relevance.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"228-240"},"PeriodicalIF":2.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beriberi following sleeve gastrectomy. 袖状胃切除术后的脚气病
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-05-15 DOI: 10.1136/pn-2024-004219
Bernard Liem, Xin You Tai, Faye Begeti, Farheen Fazal Fathima, Monika Hofer, Lucy Matthews, Simon Rinaldi, David L H Bennett, Martin R Turner
{"title":"Beriberi following sleeve gastrectomy.","authors":"Bernard Liem, Xin You Tai, Faye Begeti, Farheen Fazal Fathima, Monika Hofer, Lucy Matthews, Simon Rinaldi, David L H Bennett, Martin R Turner","doi":"10.1136/pn-2024-004219","DOIUrl":"10.1136/pn-2024-004219","url":null,"abstract":"<p><p>Bariatric surgery is being undertaken more frequently in response to rising levels of obesity but is increasingly also requested as a cosmetic choice. Nutritional deficiencies are a recognised consequence of gastrectomy, with potentially severe and permanent neurological sequelae. We present two cases of acute, severe polyneuropathy following sleeve gastrectomy. Severe thiamine deficiency was considered in both cases but with delayed proof and a significant initial differential diagnosis. Neurologists must have a high index of suspicion for the peripheral as well as central presentations of thiamine deficiency to avoid permanent disability. We also call for explicit information resources warning of the risk and signs of thiamine deficiency to be provided routinely to patients after gastrectomy.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"268-272"},"PeriodicalIF":2.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Action-induced finger and wrist clonus. 动作诱发的手指和手腕阵挛。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-05-15 DOI: 10.1136/pn-2024-004420
Yoshimitsu Shimatani, Munenori Iwamoto, Seio Okada, Yuki Takeda, Kakuya Nagata, Hiroyuki Ishihara
{"title":"Action-induced finger and wrist clonus.","authors":"Yoshimitsu Shimatani, Munenori Iwamoto, Seio Okada, Yuki Takeda, Kakuya Nagata, Hiroyuki Ishihara","doi":"10.1136/pn-2024-004420","DOIUrl":"10.1136/pn-2024-004420","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"273-274"},"PeriodicalIF":2.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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