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Catastrophic antiphospholipid antibody syndrome provoked by eltrombopag.
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-03-22 DOI: 10.1136/pn-2025-004512
Bhargav Chandan Sumanth T, Aditya Vijayakrishnan Nair, Angel Miraclin T, George Abraham Ninan, Brunda K, Leena Rv, Harshad Arvind Vanjare, Joshi Nutan Damodar, Yamuna Naik, Appaswamy Thirumal Prabhakar, Ajith Sivadasan, Vivek Mathew, Sanjith Aaron
{"title":"Catastrophic antiphospholipid antibody syndrome provoked by eltrombopag.","authors":"Bhargav Chandan Sumanth T, Aditya Vijayakrishnan Nair, Angel Miraclin T, George Abraham Ninan, Brunda K, Leena Rv, Harshad Arvind Vanjare, Joshi Nutan Damodar, Yamuna Naik, Appaswamy Thirumal Prabhakar, Ajith Sivadasan, Vivek Mathew, Sanjith Aaron","doi":"10.1136/pn-2025-004512","DOIUrl":"https://doi.org/10.1136/pn-2025-004512","url":null,"abstract":"<p><p>Antiphospholipid antibody syndrome (APS) may rarely present with isolated thrombocytopenia that may be diagnosed and treated as immune thrombocytopenic purpura. A 32-year-old woman was given eltrombopag (a thrombopoietin receptor agonist) to treat presumed immune thrombocytopenic purpura. She developed catastrophic APS, with multiple ischaemic infarcts, microvascular coronary thrombosis and digital gangrene. She improved after stopping eltrombopag and starting immunotherapy (corticosteroids, intravenous immunoglobulin and rituximab) but was left with significant neurological morbidity.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visual allesthesia as manifestation of migraine aura. 视觉过敏是偏头痛先兆的表现。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-03-14 DOI: 10.1136/pn-2024-004381
Márcio Pinheiro Lima, José Luiz Pedroso, Orlando G P Barsottini, Flavio Moura Rezende Filho
{"title":"Visual allesthesia as manifestation of migraine aura.","authors":"Márcio Pinheiro Lima, José Luiz Pedroso, Orlando G P Barsottini, Flavio Moura Rezende Filho","doi":"10.1136/pn-2024-004381","DOIUrl":"10.1136/pn-2024-004381","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"174-175"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cavernous sinus thrombosis: then and now. 海绵窦血栓形成：过去和现在。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-03-14 DOI: 10.1136/pn-2024-004396
Christopher Y Itoh, Eelco F M Wijdicks
{"title":"Cavernous sinus thrombosis: then and now.","authors":"Christopher Y Itoh, Eelco F M Wijdicks","doi":"10.1136/pn-2024-004396","DOIUrl":"10.1136/pn-2024-004396","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"176-177"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Idiopathic pulmonary vein thrombosis: an under-recognised source of embolic stroke. 特发性肺静脉血栓：认识不足的栓塞性中风源头。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-03-14 DOI: 10.1136/pn-2024-004244
Y Muralidhar Reddy, Subhendu Parida, Manvitha Reddy, Johann Christopher, Lalitha Pidaparthi, Abhinay Kumar Gattu, J M K Murthy
{"title":"Idiopathic pulmonary vein thrombosis: an under-recognised source of embolic stroke.","authors":"Y Muralidhar Reddy, Subhendu Parida, Manvitha Reddy, Johann Christopher, Lalitha Pidaparthi, Abhinay Kumar Gattu, J M K Murthy","doi":"10.1136/pn-2024-004244","DOIUrl":"10.1136/pn-2024-004244","url":null,"abstract":"<p><p>Embolic stroke due to pulmonary vein thrombosis is rare but may be associated with lung and left atrial tumours, pulmonary surgery, atrial fibrillation and radiofrequency ablation. It is very rarely idiopathic. A 23-year-old man developed acute onset of a left partial third nerve palsy and left ataxic hemiparesis. His MR scan of the brain showed an acute infarct in the left midbrain and left thalamus. CT angiogram found no steno-occlusive disease and transthoracic echocardiogram was normal. However, a transoesophageal echocardiogram showed a hyperechoic mass projecting from the right inferior pulmonary vein, confirmed on cardiac MR scan to be a right inferior pulmonary vein thrombus. A cardiac loop recorder did not capture an atrial arrhythmia. CT scan of the chest found no significant abnormality in the pulmonary parenchyma. Investigations for hypercoagulable state were negative. He took dabigatran for 6 months with complete resolution of thrombus.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"150-154"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive screening instruments: reasons to be cheerful. 认知筛查工具：值得高兴的理由。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-03-14 DOI: 10.1136/pn-2024-004389
Timothy David Griffiths
{"title":"Cognitive screening instruments: reasons to be cheerful.","authors":"Timothy David Griffiths","doi":"10.1136/pn-2024-004389","DOIUrl":"10.1136/pn-2024-004389","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"187-188"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of small fibre neuropathies. 评估小纤维神经病。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-03-14 DOI: 10.1136/pn-2023-004054
Naveed Malek, Joseph Hutchinson, Asma Naz, Carla Cordivari
{"title":"Evaluation of small fibre neuropathies.","authors":"Naveed Malek, Joseph Hutchinson, Asma Naz, Carla Cordivari","doi":"10.1136/pn-2023-004054","DOIUrl":"10.1136/pn-2023-004054","url":null,"abstract":"<p><p>Small fibre neuropathies (SFNs) are common and can significantly affect patients' lives due to debilitating pain and autonomic symptoms. We explain the tests that neurologists can use to diagnose SFNs and how neurophysiologists perform and interpret them. This review focuses on neurophysiological tests that can be used to investigate SFNs, their sensitivity, specificity and limitations. Some of these tests are available only in specialist centres. However, newer technologies are emerging from scientific research that may make it easier to diagnose these conditions in the future.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"102-108"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Internal carotid artery aneurysm causing Horner's syndrome with the Harlequin sign. 颈内动脉瘤导致霍纳综合征，并伴有哈勒金征。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-03-14 DOI: 10.1136/pn-2024-004380
Kimberley Rose Monks, Aminah Iffah Jawaheer, Victoria Nowak
{"title":"Internal carotid artery aneurysm causing Horner's syndrome with the Harlequin sign.","authors":"Kimberley Rose Monks, Aminah Iffah Jawaheer, Victoria Nowak","doi":"10.1136/pn-2024-004380","DOIUrl":"10.1136/pn-2024-004380","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"170-171"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated optic nerve relapse in T-cell acute lymphoblastic leukaemia. T 细胞急性淋巴细胞白血病的孤立性视神经复发。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-03-14 DOI: 10.1136/pn-2024-004375
Isana Nakajima, Yuko Shirouchi, Yuka Morita, Hideki Tsuji
{"title":"Isolated optic nerve relapse in T-cell acute lymphoblastic leukaemia.","authors":"Isana Nakajima, Yuko Shirouchi, Yuka Morita, Hideki Tsuji","doi":"10.1136/pn-2024-004375","DOIUrl":"10.1136/pn-2024-004375","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"172-173"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain lipiodol contrast deposits 40 years after myelography. 脑脊髓造影术 40 年后的脑脂肪碘造影剂沉积。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-03-14 DOI: 10.1136/pn-2024-004329
José Blazer Costa, Vítor Mendes Ferreira, Manuel Salavisa, Filipa Serrazina
{"title":"Brain lipiodol contrast deposits 40 years after myelography.","authors":"José Blazer Costa, Vítor Mendes Ferreira, Manuel Salavisa, Filipa Serrazina","doi":"10.1136/pn-2024-004329","DOIUrl":"10.1136/pn-2024-004329","url":null,"abstract":"","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"168-169"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sporadic fatal insomnia. 零星致命性失眠。
IF 2.4
PRACTICAL NEUROLOGY Pub Date : 2025-03-14 DOI: 10.1136/pn-2024-004301
Marta Del Chicca, Elisabetta Belli, Valentina Nicoletti, Enrico Bergamin, Linda Giampietri, Alessia Pascazio, Michelangelo Maestri Tassoni, Filippo Baldacci, Gabriele Siciliano, Gloria Tognoni
{"title":"Sporadic fatal insomnia.","authors":"Marta Del Chicca, Elisabetta Belli, Valentina Nicoletti, Enrico Bergamin, Linda Giampietri, Alessia Pascazio, Michelangelo Maestri Tassoni, Filippo Baldacci, Gabriele Siciliano, Gloria Tognoni","doi":"10.1136/pn-2024-004301","DOIUrl":"10.1136/pn-2024-004301","url":null,"abstract":"<p><p>We describe a 63-year-old man diagnosed with sporadic Creutzfeldt-Jakob disease (sCJD), specifically sporadic fatal insomnia, confirmed through real-time quaking-induced conversion (RT-QuIC) analysis of cerebrospinal fluid and polysomnography. He presented with rapid cognitive decline, behavioural changes, sleep disturbances and dysautonomic symptoms. Initial MR imaging, electroencephalogram and cerebrospinal fluid analyses were inconclusive, highlighting the difficulty in diagnosing this rare subtype of CJD. Clinical evaluation is fundamental in defining the diagnosis of sCJD. When clinical suspicion is strong, the diagnostic work-up should be continued. In this case, the combination of comprehensive clinical evaluations and advanced diagnostic tools, including RT-QuIC and polysomnography, proved essential in making a definitive diagnosis.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":"159-163"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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