Progress in neurological surgery最新文献_第8页

Targeted Local Therapy for Management of Intracranial High-Grade Gliomas. 颅内高级别胶质瘤的局部靶向治疗。

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-07-10 DOI: 10.1159/000469688

Iddo Paldor, Kaisorn L Chaichana, Henry Brem, Betty M Tyler

引用次数: 9

Extracellular Vesicles as a Platform for Glioma Therapeutic Development. 细胞外囊泡作为神经胶质瘤治疗发展的平台。

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-07-10 DOI: 10.1159/000469689

David R Santiago-Dieppa, David D Gonda, Vincent J Cheung, Jeffery A Steinberg, Bob S Carter, Clark C Chen

引用次数: 6

Chemotherapy of High-Grade Astrocytomas in Adults. 成人高级别星形细胞瘤的化疗。

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-25 DOI: 10.1159/000467374

Vinay K Puduvalli, Nguyen Hoang

{"title":"Chemotherapy of High-Grade Astrocytomas in Adults.","authors":"Vinay K Puduvalli, Nguyen Hoang","doi":"10.1159/000467374","DOIUrl":"https://doi.org/10.1159/000467374","url":null,"abstract":"Malignant gliomas have been historically considered unresponsive to chemotherapy due to their intrinsic resistance to conventional anticancer medications and the role of the blood-brain barrier in preventing access of the cytotoxic agents to the tumor. However, recent studies have demonstrated the efficacy of specific drugs in subsets of patients with high-grade astrocytomas that has revived the enthusiasm for the role of systemic chemotherapy against these neoplasms. Temozolomide, a monofunctional alkylator, was the first chemotherapeutic agent to definitively improve survival in adults with newly diagnosed glioblastoma used in combination with radiation therapy with the most pronounced effect being in a subgroup of tumors with MGMT promoter methylation. Various other cytotoxic drugs and their combinations have been tested in this population with mostly anecdotal reports of benefit. Current efforts are directed towards identifying the subsets of patients most likely to benefit from chemotherapy and to determine the most effective treatment regimens likely to improve outcome. In addition, specific strategies in order to overcome resistance mechanisms to cytotoxic drugs and to disable cellular adaptive pathways are being explored to enhance cell kill and antitumor effects of chemotherapeutic agents.","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000467374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35786404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Chemotherapy of Diffuse Astrocytoma (WHO grade II) in Adults. 成人弥漫性星形细胞瘤(WHO分级II)的化疗。

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-25 DOI: 10.1159/000467375

Yoshitaka Narita

引用次数: 4

Surgery of Insular Gliomas. 脑岛胶质瘤的外科治疗。

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2017-12-14 DOI: 10.1159/000464393

Hugues Duffau

引用次数: 18

Surgery of Critically Located Intracranial Gliomas. 危重位置颅内胶质瘤的外科治疗。

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2017-12-14 DOI: 10.1159/000464396

Tomokatsu Hori, Atsushi Ishida, Yasuo Aihara, Seigo Matsuo, Haruko Yoshimoto, Hideki Shiramizu

引用次数: 3

Chemotherapy of Oligodendrogliomas. 少突胶质细胞瘤的化疗。

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-25 DOI: 10.1159/000467376

Jan Drappatz, Frank Lieberman

引用次数: 3

Physical and Psychological Rehabilitation of Patients with Intracranial Glioma. 颅内胶质瘤患者的生理和心理康复。

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-25 DOI: 10.1159/000467381

Julija Andrejeva, Olesya V Volkova

引用次数: 4

Alternating Electric Fields Therapy for Malignant Gliomas: From Bench Observation to Clinical Reality. 交变电场治疗恶性胶质瘤:从台架观察到临床实际。

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-07-10 DOI: 10.1159/000469690

Eric T Wong, Edwin Lok, Kenneth D Swanson

{"title":"Alternating Electric Fields Therapy for Malignant Gliomas: From Bench Observation to Clinical Reality.","authors":"Eric T Wong, Edwin Lok, Kenneth D Swanson","doi":"10.1159/000469690","DOIUrl":"https://doi.org/10.1159/000469690","url":null,"abstract":"Alternating electric fields of intermediate frequencies, also known as Tumor Treating Fields (TTFields or TTF) is a novel anticancer treatment modality that disrupts tumor cell mitosis at the metaphase-anaphase transition, leading to mitotic catastrophe, aberrant mitotic exit, and/or cell death. It is realized through alteration of the cytokinetic cleavage furrow by interference of proteins possessing large dipole moments, like septin heterotrimer complex and α/β-tubulin, and that results in disordered membrane contraction and failed cytokinesis. Aberrant mitotic exit also elicits immunogenic cell death, which may potentiate an immune response against treated tumors. Notably, in patients with recurrent glioblastoma multiforme (GBM) a prospective clinical trial demonstrated comparable overall survival and progression-free survival after TTFields therapy and best physician's choice chemotherapy. Moreover, it was shown that in patients with newly diagnosed GBM initially treated with standard chemoradiotherapy with daily temozolomide (TMZ), adjuvant TTFields combined with TMZ offered better survival than adjuvant TMZ alone. Therefore, TTFields therapy can be appreciated as a standard treatment option in cases of intracranial malignant gliomas, whereas future studies should establish its optimal combination with other existing anticancer modalities, which may offer additional survival benefits for patients.","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000469690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36299204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Rationale for Aggressive Resection and General Surgical Principles for Intracranial Gliomas. 颅内胶质瘤积极切除的基本原理及一般手术原则。

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2017-12-14 DOI: 10.1159/000464369

Ian E McCutcheon, Mikhail F Chernov

{"title":"Rationale for Aggressive Resection and General Surgical Principles for Intracranial Gliomas.","authors":"Ian E McCutcheon, Mikhail F Chernov","doi":"10.1159/000464369","DOIUrl":"https://doi.org/10.1159/000464369","url":null,"abstract":"Given the infiltrative nature of gliomas, controversy has long persisted over the value of their aggressive surgical removal. Nevertheless, in recent decades, the balance of opinion in neurosurgical oncology has shifted from a more nihilistic view that led to many patients' receiving stereotactic biopsy or very limited debulking of lesions for tissue diagnosis only, to more extensive tumor resections which relieve mass effect, lower intracranial pressure, reduce accompanying brain edema, and attenuate dependence on steroids. Achieving a clinically significant cytoreduction makes adjuvant therapy more successful, and ultimately helps to preserve or improve neurological function. Moreover, increased extent of brain tumor removal results in prolongation of progression-free survival and overall survival of patients and improves their quality of life. The beneficial effect of high resection rate may be noted even in selected cases of recurrent neoplasms. However, optimizing an aggressive surgical strategy for intracranial gliomas requires specific skills, availability of advanced intraoperative technological modalities, and the presence of a highly qualified multidisciplinary team of medical professionals for pre-, intra-, and postoperative care of such patients.","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000464369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35656388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3