Extracellular Vesicles as a Platform for Glioma Therapeutic Development.

Q2 Medicine

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-07-10 DOI:10.1159/000469689

David R Santiago-Dieppa, David D Gonda, Vincent J Cheung, Jeffery A Steinberg, Bob S Carter, Clark C Chen

引用次数: 6

Abstract

Normal and pathologic cells secrete extracellular vesicles (EV), which are defined as 30-2,000 nm spherical organelles. It has been found that EV mediate various biological functions including cellular remodeling and export of biomolecules, extracellular communication, immune stimulation and suppression, and modulation of the cellular microenvironment. EV secreted by human glioma cells contain a wealth of tumor-specific proteins and nucleic acids that can be isolated from patients with these neoplasms. Thus, EV contribute to the development of biomarkers, and additionally have certain therapeutic potential for possible use in neuro-oncology and neurosurgery.

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细胞外囊泡作为神经胶质瘤治疗发展的平台。

正常和病理细胞分泌细胞外囊泡(EV)，其定义为30-2,000 nm的球形细胞器。研究发现，EV介导多种生物功能，包括细胞重塑和生物分子输出、细胞外通讯、免疫刺激和抑制、细胞微环境调节等。由人类胶质瘤细胞分泌的EV含有丰富的肿瘤特异性蛋白质和核酸，可以从这些肿瘤患者中分离出来。因此，EV有助于生物标志物的发展，并且在神经肿瘤学和神经外科中具有一定的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in neurological surgery Medicine-Surgery

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期刊介绍： Published since 1966, this series has become universally recognized as the most significant group of books serving neurological surgeons. Volumes feature contributions from distinguished international surgeons, who brilliantly review the literature from the perspective of their own personal experience. The result is a series of works providing critical distillations of developments of central importance to the theory and practice of neurological surgery.