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Diffusion Tensor Imaging of the Basal Ganglia for Functional Neurosurgery Applications. 基底神经节弥散张量成像在功能性神经外科中的应用。
Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-12 DOI: 10.1159/000480766
Francesco Sammartino, Mojgan Hodaie
{"title":"Diffusion Tensor Imaging of the Basal Ganglia for Functional Neurosurgery Applications.","authors":"Francesco Sammartino,&nbsp;Mojgan Hodaie","doi":"10.1159/000480766","DOIUrl":"https://doi.org/10.1159/000480766","url":null,"abstract":"<p><p>Since its introduction, diffusion tensor imaging (DTI) has become an important tool in neuroscience given its unprecedented ability to image brain white matter in vivo. The interest in understanding the mechanisms of action of Deep Brain Stimulation in different targets and indications, together with the constant drive towards the improvement in long-term clinical outcomes, has found a logical complement in the application of tractography in this field. Diffusion tensor imaging has been traditionally associated with an increased susceptibility to MRI artifacts, and expensive computational resources. Recent advances have however improved these restrictions, allowing for countless applications in Neurosurgery, as demonstrated by the large number of original research papers published in the last decade. In this chapter, we review the current status of the implementation of DTI during DBS of the basal ganglia, discussing the findings, potential challenges and the expected improvements in surgical outcomes deriving by the routine use of tractography in functional neurosurgery.</p>","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000480766","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35735741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Perspectives of Personalized Chemotherapy of Gliomas Based on Molecular Tumor Profiling. 基于分子肿瘤谱的胶质瘤个体化化疗展望。
Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-25 DOI: 10.1159/000467378
Riccardo Soffietti, Federica Franchino, Michela Magistrello, Alessia Pellerino, Roberta Rudà
{"title":"Perspectives of Personalized Chemotherapy of Gliomas Based on Molecular Tumor Profiling.","authors":"Riccardo Soffietti,&nbsp;Federica Franchino,&nbsp;Michela Magistrello,&nbsp;Alessia Pellerino,&nbsp;Roberta Rudà","doi":"10.1159/000467378","DOIUrl":"https://doi.org/10.1159/000467378","url":null,"abstract":"<p><p>Histopathological typing and grading are the cornerstones of the World Health Organization classification of the central nervous system tumors. It provides clinicians with information on the natural course of the disease and thus guides therapeutic choices. Nonetheless, patients with histologically identical tumors may have different outcomes and response to therapy. In recent years, extensive research has been done on three molecular markers in adult gliomas, namely MGMT promoter methylation, 1p/19q co-deletion, and IDH1/IDH2 mutations. These markers may have either a prognostic or a predictive value, differentiation of which is often difficult as both can coexist. At present, MGMT promoter methylation is considered as a predictive marker for response of glioblastoma to chemotherapy with temozolomide, particularly in elderly patients, 1p/19q co-deletion is a molecular signature of oligodendroglial tumors and predictive marker for response of anaplastic gliomas to PCV chemotherapy, and IDH1/IDH2 mutations have a strong favorable prognostic value across all glioma histopathological grades.</p>","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000467378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35787737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Palliative and Supportive Care of Patients with Intracranial Glioma. 颅内胶质瘤患者的姑息治疗和支持性护理。
Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-25 DOI: 10.1159/000467383
Andrea Pace, Veronica Villani
{"title":"Palliative and Supportive Care of Patients with Intracranial Glioma.","authors":"Andrea Pace,&nbsp;Veronica Villani","doi":"10.1159/000467383","DOIUrl":"https://doi.org/10.1159/000467383","url":null,"abstract":"<p><p>Clinicians dealing with patients affected by malignant brain tumors are frequently involved in providing palliative and supportive care, particularly at the end of life. It requires a multidisciplinary approach by a well-trained specialized neuro-oncology team. Early initiation of palliative care integrated with standard anticancer therapy may be effective for symptom management and results in improvement of the quality of life. However, studies specifically addressing these issues are very limited, thus do not allow the creation of any reliable evidence-based guidelines. Therefore, there is a definite need for improvement in the quality of palliative and supportive care in neuro-oncology and for specific education for its providers.</p>","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000467383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35787741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Drug Delivery for Movement Disorders. 运动障碍的药物递送。
Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-12 DOI: 10.1159/000481108
Neil Barua, Steven Gill
{"title":"Drug Delivery for Movement Disorders.","authors":"Neil Barua,&nbsp;Steven Gill","doi":"10.1159/000481108","DOIUrl":"https://doi.org/10.1159/000481108","url":null,"abstract":"<p><p>There has been substantial research interest in delivering therapeutic neurotrophic factors directly to the brain for the treatment of Parkinson's Disease (PD) and other movement disorders. Direct infusion of glial cell-line derived neurotrophic factor has been investigated in both pre-clinical models and clinical trials. In this chapter we discuss past and present research investigating the potential of direct drug delivery to the brain for the treatment of PD and other movement disorders.</p>","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000481108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35734657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Gene Therapy for Parkinson's Disease. 帕金森病的基因治疗。
Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-12 DOI: 10.1159/000481109
Vivek Sudhakar, R Mark Richardson
{"title":"Gene Therapy for Parkinson's Disease.","authors":"Vivek Sudhakar,&nbsp;R Mark Richardson","doi":"10.1159/000481109","DOIUrl":"https://doi.org/10.1159/000481109","url":null,"abstract":"<p><p>Gene therapy is a clinical tool that may eventually provide therapeutic benefit to patients suffering from movement disorders through a few potential mechanisms: direct correction of the pathogenic mechanism, neuroprotection, neurorestoration or symptom control. The therapeutic mechanism is therefore dependent on knowledge of disease pathogenesis and the required temporal and spatial specificities of gene expression. An additional critical challenge is achieving the most complete transduction of the target structure while avoiding leakage into neighboring regions or perivascular spaces. Although critical clinical work is ongoing to optimize the direct intracerebral delivery of transgenes to the brain, the field has recently entered a new technological era, where interventional-MRI-guided convection-enhanced delivery is the gold standard for verifying accurate vector delivery in real-time.</p>","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000481109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35734658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Deep Brain Stimulation of the Subthalamic Nucleus and Globus Pallidus for Parkinson's Disease. 脑深部刺激丘脑下核和苍白球治疗帕金森病。
Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-12 DOI: 10.1159/000481105
Philip S Lee, Donald J Crammond, R Mark Richardson
{"title":"Deep Brain Stimulation of the Subthalamic Nucleus and Globus Pallidus for Parkinson's Disease.","authors":"Philip S Lee,&nbsp;Donald J Crammond,&nbsp;R Mark Richardson","doi":"10.1159/000481105","DOIUrl":"https://doi.org/10.1159/000481105","url":null,"abstract":"<p><p>The concept of deep brain stimulation (DBS) for Parkinson's disease (PD) was introduced over 20 years ago, but our understanding of the nuances of this procedure continues to improve. The average motor outcomes of internal segment of the globus pallidus (GPi) and subthalamic nucleus (STN) DBS appear to be similar, although GPi DBS may allow greater recovery of verbal fluency and may provide greater relief of depression symptoms and improvement in the quality of life, and STN DBS appears more likely to result in decrease in levodopa equivalent doses. Despite the lack of consensus on whether STN or GPi DBS is most appropriate for a given clinical phenotype, the general expansion of patient selection criteria to include younger and older patients and the advent of real-time imaging-confirmed that DBS electrode placement are making life-changing treatment available to greater numbers of movement disorder patients.</p>","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000481105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35735167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Current and Expected Advances in Deep Brain Stimulation for Movement Disorders. 脑深部电刺激治疗运动障碍的当前和预期进展。
Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-12 DOI: 10.1159/000481106
Ausaf A Bari, Jasmine Thum, Diana Babayan, Andres M Lozano
{"title":"Current and Expected Advances in Deep Brain Stimulation for Movement Disorders.","authors":"Ausaf A Bari,&nbsp;Jasmine Thum,&nbsp;Diana Babayan,&nbsp;Andres M Lozano","doi":"10.1159/000481106","DOIUrl":"https://doi.org/10.1159/000481106","url":null,"abstract":"<p><p>Deep brain stimulation (DBS) has become an established treatment for medically refractory movement disorders including Parkinson's disease, essential tremor, and dystonia. The field of DBS continues to evolve with advances in patient selection, target identification, electrode and pulse generator technology, and the development of more effective stimulation paradigms such as closed-loop stimulation. Furthermore, as the safety and efficacy of DBS improves through better hardware design and deeper understanding of its mechanisms of action, the indications for DBS will continue to expand to cover a wider range of disorders. Finally, the recent approval of MR-guided focused ultrasound for the treatment of essential tremor and potentially other movement disorders heralds a resurgence in lesion creation as a viable alternative to DBS for selected patients.</p>","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000481106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35735168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Patient Evaluation and Selection for Movement Disorders Surgery: The Changing Spectrum of Indications. 运动障碍手术的患者评估和选择:适应症的变化谱。
Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-12 DOI: 10.1159/000480910
Steffen Paschen, Günther Deuschl
{"title":"Patient Evaluation and Selection for Movement Disorders Surgery: The Changing Spectrum of Indications.","authors":"Steffen Paschen,&nbsp;Günther Deuschl","doi":"10.1159/000480910","DOIUrl":"https://doi.org/10.1159/000480910","url":null,"abstract":"<p><p>This report summarizes the state-of-the-art and controversies around patient selection for deep brain stimulation (DBS) for various conditions. Parkinson's disease (PD): several class I studies have shown superiority of DBS over best medical treatment for advanced PD with fluctuations and further inclusion criteria. One class I study suggests that PD patients with early motor complications might gain more quality of life if operated within 3 years after the onset of fluctuations. The subthalamic nucleus (STN) is still the standard target. STN DBS has an impact on impulse control disorders though the exact mechanism is unclear. Tremor: essential tremor (ET) patients found to be eligible for DBS surgery should first be treated with primidone, propranolol, and with a combined therapy preoperatively. Second-line drugs (i.e., topiramate and gabapentin) may be useful. No class I studies exist for DBS treatment of ET. The optimal target of DBS in ET might be the posterior subthalamic area. Dystonia: there is class I evidence for primary generalized and segmental dystonia and for some botulinum-resistant focal dystonias. The impact of age, symptom duration, and DYT-mutation status in primary dystonia on the outcome of DBS surgery clearly demands more studies. DBS has a role in SCGE-mutation positive myoclonus dystonia and tardive dystonia. Finally, neurostimulation in secondary dystonia might be considered in selected patients based on an individual patient's approach.</p>","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000480910","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35735742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Medical Management of Movement Disorders. 运动障碍的医学管理。
Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-01-12 DOI: 10.1159/000480747
Marina Picillo, Renato P Munhoz
{"title":"Medical Management of Movement Disorders.","authors":"Marina Picillo,&nbsp;Renato P Munhoz","doi":"10.1159/000480747","DOIUrl":"https://doi.org/10.1159/000480747","url":null,"abstract":"<p><p>Pharmacological treatment is the cornerstone in the management of movement disorders. Although most available treatment options have no impact on the underlying process of each movement disorder, symptomatic therapies can significantly improve patient's quality of life and level of disability. Here, we review the current knowledge on clinical symptomatic management of Parkinson's disease (both early and advanced stages), essential tremor, dystonia, and chorea. Ideally, treatment should be carried out by specialists with reasonable experience in movement disorders, as it needs to be tailored for each patient depending on several appraisals, including but not limited to patients' needs, compliance issues, potential side effects, caregiver support, and presence of comorbidities. When medications fail to improve patient's disability, stereotactic surgery is a well-established option for most of these disorders.</p>","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000480747","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35735801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Surgical Management of Gliomas in Eloquent Cortex. 雄辩皮层胶质瘤的外科治疗。
Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2017-12-14 DOI: 10.1159/000464391
Sherise D Ferguson, Ian E McCutcheon
{"title":"Surgical Management of Gliomas in Eloquent Cortex.","authors":"Sherise D Ferguson,&nbsp;Ian E McCutcheon","doi":"10.1159/000464391","DOIUrl":"https://doi.org/10.1159/000464391","url":null,"abstract":"<p><p>Gliomas located in eloquent cortex impose a unique surgical obstacle. The oncological benefit of aggressive resection must be balanced with preservation of functional tissue and optimization of surgical outcome. Technical advances in preoperative functional imaging, refinement of intraoperative mapping, and conceptual understanding of cerebral plasticity have significantly improved the outcome of this patient population.</p>","PeriodicalId":39342,"journal":{"name":"Progress in neurological surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000464391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35656391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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