Targeted Local Therapy for Management of Intracranial High-Grade Gliomas.

Q2 Medicine

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-07-10 DOI:10.1159/000469688

Iddo Paldor, Kaisorn L Chaichana, Henry Brem, Betty M Tyler

引用次数: 9

Abstract

Systemic chemotherapy of malignant brain tumors has failed to achieve sufficient drug concentrations at the neoplasm site and frequently results in severe toxicities. Therefore, the local application of several anticancer agents, oncolytic viruses and vectors for gene therapy, immune-modifying preparations, and angiogenesis inhibitors has been investigated widely. Various modes of their administration were introduced, including intratumoral injections, implantation of reservoirs or pumps, convection-enhanced delivery, and use of nanocarriers, thermoreversible gels, microchips, and drug-loaded polymers. Many of these therapeutic approaches have shown promising results in management of high-grade gliomas.

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颅内高级别胶质瘤的局部靶向治疗。

恶性脑肿瘤的全身化疗未能在肿瘤部位达到足够的药物浓度，并且经常导致严重的毒性。因此，一些抗癌药物、溶瘤病毒和载体在基因治疗、免疫修饰制剂和血管生成抑制剂中的局部应用已被广泛研究。介绍了各种给药模式，包括肿瘤内注射、储存器或泵的植入、对流增强给药、纳米载体、热可逆凝胶、微芯片和载药聚合物的使用。许多这些治疗方法在高级别胶质瘤的治疗中显示出有希望的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in neurological surgery Medicine-Surgery

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期刊介绍： Published since 1966, this series has become universally recognized as the most significant group of books serving neurological surgeons. Volumes feature contributions from distinguished international surgeons, who brilliantly review the literature from the perspective of their own personal experience. The result is a series of works providing critical distillations of developments of central importance to the theory and practice of neurological surgery.