Psiquiatria Biologica最新文献

{"title":"Biomarcadores sanguíneos, de orina y conductas autolesivas e intentos de suicidio repetidos en los adolescentes","authors":"Ping Wang,&nbsp;Chao Li,&nbsp;Marina Martin-Moratinos,&nbsp;Marcos Bella-Fernández,&nbsp;Pablo del Sol,&nbsp;Leticia Mallol,&nbsp;María Elena Hernández-Álvarez,&nbsp;Encarnación Donoso-Navarro,&nbsp;María Gil-Ligero,&nbsp;Silvia Rosado-Garcia,&nbsp;Antonio Sanchez-Lopez,&nbsp;Hilario Blasco-Fontecilla","doi":"10.1016/j.psiq.2024.100447","DOIUrl":"https://doi.org/10.1016/j.psiq.2024.100447","url":null,"abstract":"<div><p>There is partial evidence that elevated levels of blood β-endorphin are associated with suicidal addiction in adults, but hardly any data on adolescents. Blood β-endorphin, with an important role in addiction management mechanisms, can induce euphoria and happiness, reward and reinforce suicidal behavior. To test whether high repeaters of suicide attempts (5 or more suicide attempts) and self-injurious behaviors (20 or more episodes of self-injury) have higher biomarker levels, a sample of 43 patients aged 12-17 years attending the Psychiatric Emergency Department at the Hospital Universitario Puerta de Hierro Majadahonda is recruited. Ten present 5 or more suicide attempts, 35 present 20 or more self-injurious episodes and 10 present both characteristics, and most of the adolescents meet addiction criteria for self-injury and suicide. The results suggest that all patients with addiction to suicide also had addiction to self-injury. Blood ACTH, cortisol and β-endorphin and urine cortisol levels were very elevated, but did not differentiate heavy repeaters from the rest of the adolescents.</p></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"31 1","pages":"Article 100447"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140031429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aripiprazol: cuidado con la adicción patológica al juego","authors":"Pedro Moltó-Balado ,&nbsp;Roxana Reverté-Gil","doi":"10.1016/j.psiq.2023.100440","DOIUrl":"https://doi.org/10.1016/j.psiq.2023.100440","url":null,"abstract":"<div><p>Aripiprazole is an antipsychotic drug used in the treatment of various psychiatric illnesses. Among its various adverse effects, one very rare but serious one stands out. The development of addictive behaviours such as pathological gambling is a situation that can lead to negative consequences in the personal, social and financial life of patients. A case on aripiprazole and pathological gambling is presented to highlight this rare effect.</p></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"31 1","pages":"Article 100440"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139419149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersección de síntomas en el trastorno del espectro autista y trastornos psicóticos: a propósito de un caso","authors":"Sara Cabezas-Gutiérrez,&nbsp;Pablo Vázquez-Herrera,&nbsp;Batirtze Goitia-Aritxa","doi":"10.1016/j.psiq.2024.100442","DOIUrl":"https://doi.org/10.1016/j.psiq.2024.100442","url":null,"abstract":"<div><p>Autism spectrum disorder is a neurodevelopmental disorder with a current global prevalence of approximately 1%. It is common that the main symptoms of this disorder, such as deterioration in social interactions, restricted or atypical interests, and cognitive and verbal communication deficiencies, can be confused with symptoms of the psychotic sphere typical of schizophrenia. An adequate evaluation is necessary due that both entities can coexist with a variable prevalence of 12 to 50%. Moreover, both disorders can coexist with a variable prevalence of 12 to 50%. We present the clinical case of a woman who, at the age of 20, began follow-up in the mental health unit due to symptoms compatible with an obsessive-compulsive disorder along with a clinic characterized by apathy, anhedonia, abandonment of self-care and progressive functional deterioration. After several evaluation sessions, we diagnosed an autism spectrum disorder. We carry out a bibliographic review with which we conclude that the intersection of symptoms between autism and schizophrenia is common and clinical recommendations are provided to differentiate both clinical entities.</p></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"31 1","pages":"Article 100442"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139908299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relación entre la capacidad adquirida y el riesgo suicida","authors":"María Dolores Rus Guerrero,&nbsp;Zaira Morales Domínguez,&nbsp;Yolanda Torrico Linares,&nbsp;Esperanza Torrico Linares","doi":"10.1016/j.psiq.2024.100448","DOIUrl":"https://doi.org/10.1016/j.psiq.2024.100448","url":null,"abstract":"<div><p>The Interpersonal Theory of Suicide states that acquired capability refers to the fact that repeated exposure to pain leads to habituation to these experiences, which is what leads the individual, if he or she also has suicidal ideation, to commit suicide. Therefore, the aim of this study is to analyze the differences in the acquired capability on the basis of the existence or not of suicidal risk. The results support those found in other studies, showing that there are statistically significant differences between those at risk and those not at risk, with those at risk having the highest mean scores. Therefore, the acquired capability variable is shown to be a variable highly related to suicidal risk.</p></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"31 1","pages":"Article 100448"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140031420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trayectorias diagnósticas de los trastornos mentales en 10 años de seguimiento de una cohorte de niños y adolescentes","authors":"Sofía Abascal Peiró,&nbsp;Leire Izaguirre Gamir,&nbsp;Alberto Álvarez Gutiérrez,&nbsp;Alejandro Porras Segovia,&nbsp;Enrique Baca García,&nbsp;Juan José Carballo","doi":"10.1016/j.psiq.2024.100445","DOIUrl":"https://doi.org/10.1016/j.psiq.2024.100445","url":null,"abstract":"<div><p>Psychiatric disorders in childhood and adolescence may persist, change, remit or increase in adulthood. This study explores the diagnostic stability and trajectories of 311 children and adolescents aged 3-17 years into adulthood. Diagnostic stability is found to vary according to pathology. Diagnostic changes are more frequent in conduct disorder and affective disorders, while the highest diagnostic stability was found in learning difficulties, attention deficit learning disabilities, attention deficit hyperactivity disorder and autism spectrum disorders. Complete remission is more frequent in anxiety disorders. Psychiatric diagnoses have social, emotional and practical implications. Mental health resources need to be adapted to the needs of each age group.</p></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"31 1","pages":"Article 100445"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140031421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trayectoria del trastorno formal del pensamiento, desde la observación clínica al análisis computacional","authors":"Alvaro Cavieres ,&nbsp;Maria Francisca Alonso-Sanchez","doi":"10.1016/j.psiq.2023.100438","DOIUrl":"10.1016/j.psiq.2023.100438","url":null,"abstract":"<div><p>Properly understanding a psychopathological term requires knowledge of the disorder described, the contexts and concepts from which it was coined, and its modification over time. In the case of formal thought disorder, we describe its evolution from its incorporation into psychopathology for purely descriptive purposes and associated with the influence of associationism and the idea of a direct dependence between thought and language to the present day, in which the use of computational tools and hypotheses from linguistics have promoted its use as a diagnostic tool and prognostic marker, while simultaneously leading to the incorporation of new terminology.</p></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"31 1","pages":"Article 100438"},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138611851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¿Dios mío, por qué me has abandonado? Estrés, ansiedad, depresión y afrontamiento religioso en los estudiantes de Medicina","authors":"Hesed Virto-Farfan ,&nbsp;Dapne Vargas ,&nbsp;Pablo Grajeda","doi":"10.1016/j.psiq.2023.100427","DOIUrl":"https://doi.org/10.1016/j.psiq.2023.100427","url":null,"abstract":"<div><h3>Background</h3><p>Medical students present with elevated levels of stress, anxiety, and depression. Religious coping is an avenue for understanding and coping with negative life events that are related to the sacred. There are several studies of association between religious coping and levels of stress, anxiety and depression. The aim of the study was to determine the influence of religious coping on stress, anxiety and depression in medical students of the Universidad Andina del Cusco.</p></div><div><h3>Methods</h3><p>Analytical cross-sectional study in 317 medical students of the Universidad Andina del Cusco. The Depression, Anxiety and Stress Scale (DASS-21) was used to measure stressful states and the Abbreviated Religious Coping Scale (Brief RCOPE) to determine levels of positive and negative religious coping. For the expression of the results, prevalence and frequencies, Spearman's correlation and chi-square, p-value and 95% CI were calculated. All medical students who gave their informed consent and who regularly attended the 2020-I academic year were included.</p></div><div><h3>Results</h3><p>Of the participants, 51.5% were female. Mean age was 21.31 years. The 66.2% obtained scores of depression-moderate, severe or extremely-severe, 70.9% obtained scores of anxiety-moderate, severe or extremely-severe and 42.3% presented stress-moderate, severe or extremely-severe. Negative religious coping had a highly significant positive relationship with stress, anxiety and depression.</p></div><div><h3>Interpretation</h3><p>Negative religious coping was significantly (&lt;<!--> <!-->0.001) and positively associated with stress (0.252), anxiety (0.304) and depression (0.357), with high power (&gt;<!--> <!-->0.5). The study has clinical and public health implications.</p></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"30 3","pages":"Article 100427"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134656701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involuntary treatment in eating disorders: The coercion paradox","authors":"Pedro Miguel Mesquita Felgueiras ,&nbsp;Beatriz Fonseca Silva ,&nbsp;Odete Nombora ,&nbsp;João Correia ,&nbsp;Raquel Ribeiro Silva","doi":"10.1016/j.psiq.2023.100426","DOIUrl":"https://doi.org/10.1016/j.psiq.2023.100426","url":null,"abstract":"","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"30 3","pages":"Article 100426"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49850137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guía internacional para una dosificación más segura de la clozapina en adultos mediante el uso de 6 titulaciones personalizadas de dosis basados en la etnicidad, la proteína C reactiva y los niveles de clozapina","authors":"Jose de Leon ,&nbsp;Georgios Schoretsanitis ,&nbsp;Robert L. Smith ,&nbsp;Espen Molden ,&nbsp;Anssi Solismaa ,&nbsp;Niko Seppälä ,&nbsp;Miloslav Kopeček ,&nbsp;Patrik Švancer ,&nbsp;Ismael Olmos ,&nbsp;Carina Ricciardi ,&nbsp;Celso Iglesias-Garcia ,&nbsp;Ana Iglesias-Alonso ,&nbsp;Edoardo Spina ,&nbsp;Can-Jun Ruan ,&nbsp;Chuan-Yue Wang ,&nbsp;Gang Wang ,&nbsp;Yi-Lang Tang ,&nbsp;Shih-Ku Lin ,&nbsp;Hsien-Yuan Lane ,&nbsp;Yong Sik Kim ,&nbsp;Daniel J. Müller","doi":"10.1016/j.psiq.2023.100415","DOIUrl":"https://doi.org/10.1016/j.psiq.2023.100415","url":null,"abstract":"<div><p>This is the Spanish translation of an international guideline which proposes improving clozapine package inserts worldwide by using ancestry-based: 1) dosing and 2) titration. Adverse drug reaction (ADR) databases suggest clozapine: 1) is the third most toxic drug in the United States (US), and 2) produces worldwide pneumonia mortality four times greater than that of agranulocytosis or myocarditis. For trough steady-state clozapine serum concentrations, the therapeutic reference range is narrow, from 350 to 600 ng/mL with the potential for toxicity and ADRs as concentrations increase. Clozapine is mainly metabolized by CYP1A2 (female non-smokers require the lowest dose and male smokers the highest dose). Poor metabolizer (PM) status through phenotypic conversion is associated with co-prescription of inhibitors (including oral contraceptives and valproate), obesity or inflammation with C-reactive protein (CRP) elevations. People with ancestry from Asia (Pakistan to Japan) or the Americas’ original inhabitants have lower CYP1A2 activity and require lower clozapine doses to reach concentrations of 350 ng/ml. Daily doses of 300-600 mg/day are recommended in the US. Slow personalized titration may prevent early ADRs (including syncope, myocarditis and pneumonia). The core of this guideline consists of six personalized titration schedules for inpatients: 1) Asian/Amerindian ancestry with lower metabolism (in cases of obesity or valproate) needing minimum therapeutic dosages of 75-150 mg/day, 2) Asian/Amerindian ancestry with average metabolism needing 175-300 mg/day, 3) European/Western Asian ancestry with lower metabolism (in cases of obesity or valproate) needing 100-200 mg/day, 4) European/Western Asian ancestry with average metabolism needing 250-400 mg/day, 5) in the US of non-Asian/Amerindian ancestry with lower clozapine metabolism (in cases of obesity or valproate) needing 150-300 mg/day, and 6) in the US of non-Asian/Amerindian ancestry with average clozapine metabolism needing 300-600 mg/day. Baseline and weekly CRP monitoring for at least 4 weeks is required to identify any inflammation, including inflammation secondary to clozapine rapid titration.</p></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"30 3","pages":"Article 100415"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49906073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Síndrome de Cotard, más allá del delirio nihilista: a propósito de un caso","authors":"Sandra Sánchez Martínez ,&nbsp;Jair Montenegro Pérez ,&nbsp;Rosa Fontalvo Morales ,&nbsp;Pedro Gómez Mendez","doi":"10.1016/j.psiq.2023.100425","DOIUrl":"https://doi.org/10.1016/j.psiq.2023.100425","url":null,"abstract":"<div><p>The present article aims to expand the clinical and neuroimaging information of Cotard Syndrome, present therapeutic approaches, as well as the limitations in its practice. The case of a 54-year-old patient with a history of bipolar disorder who was admitted to a mental health institution with a depressive clinical presentation characterized by clinophilia, accompanied by nihilistic and guilt delusions, is presented. Pharmacological treatment was initiated with antipsychotics, antidepressants, and a mood stabilizer, resulting in the resolution of the condition and an improvement in the quality of life. Currently, much remains to be known about this clinical entity. Functional neuroimaging and clinical assessment will be the pillars that allow us to elucidate the physiopathological complexities and make advances in its classification, diagnosis, and comprehensive management.</p></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"30 3","pages":"Article 100425"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49906072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}