Clinical Neurology最新文献_第8页

[Clinical features of five Japanese cases with leucine-rich glioma inactivated-1 (LGI1) antibody-positive encephalitis]. [富亮氨酸胶质瘤灭活-1（LGI1）抗体阳性脑炎五例日本病例的临床特征]。

Clinical Neurology Pub Date : 2024-10-29 Epub Date: 2024-10-26 DOI: 10.5692/clinicalneurol.cn-001977

Naoki Moro, Masanori Nakajima, Hidenobu Shozawa, Kentaro Nagai, Ayumi Uchibori, Yaeko Ichikawa

{"title":"[Clinical features of five Japanese cases with leucine-rich glioma inactivated-1 (LGI1) antibody-positive encephalitis].","authors":"Naoki Moro, Masanori Nakajima, Hidenobu Shozawa, Kentaro Nagai, Ayumi Uchibori, Yaeko Ichikawa","doi":"10.5692/clinicalneurol.cn-001977","DOIUrl":"10.5692/clinicalneurol.cn-001977","url":null,"abstract":"We studied the clinical features of five Japanese cases with leucine-rich glioma inactivated-1 (LGI1) antibody-positive encephalitis. Their symptoms included seizures, hallucinations, memory impairment, apathy, anxiety, agitation, faciobrachial dystonic seizure (FBDS), and ictal piloerection. All five patients showed hippocampal fluid attenuated inversion recovery (FLAIR) hyperintensity on brain MRI even though their cell counts of cerebrospinal fluid (CSF) were normal range. Four patients had syndrome of inappropriate secretion of antidiuretic hormone. One patient with FBDS also showed basal ganglia lesion on her brain MRI. Sodium channel blockers apparently lowered the frequency of FBDS. One patient had a thyroid cancer and underwent thyroidectomy. Substantial response to immunotherapy was seen in four out of five cases. At follow-up ≥2 years, all five patients had never relapsed. In cases of limbic encephalitis with normal CSF cell counts and hyponatremia, we should consider LGI1 antibody-positive encephalitis and conduct immunotherapy immediately.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"714-718"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Utility of EEG in neurological emergencies and critical care]. [脑电图在神经系统急症和重症监护中的作用]。

Clinical Neurology Pub Date : 2024-10-29 Epub Date: 2024-10-26 DOI: 10.5692/clinicalneurol.cn-001928

Hajime Yoshimura

引用次数: 0

[A case of young onset cerebral amyloid angiopathy associated with dural grafting]. [一例与硬脑膜移植有关的年轻发病脑淀粉样血管病]。

Clinical Neurology Pub Date : 2024-10-29 Epub Date: 2024-10-21 DOI: 10.5692/clinicalneurol.cn-002006

Kengo Furutsuka, Aya Murakami, Haruka Iwamura, Kosuke Miyake, Akio Asai, Yusuke Yakushiji

{"title":"[A case of young onset cerebral amyloid angiopathy associated with dural grafting].","authors":"Kengo Furutsuka, Aya Murakami, Haruka Iwamura, Kosuke Miyake, Akio Asai, Yusuke Yakushiji","doi":"10.5692/clinicalneurol.cn-002006","DOIUrl":"10.5692/clinicalneurol.cn-002006","url":null,"abstract":"A 47-year-old man was admitted to our hospital because of sudden-onset motor aphasia and right hemiplegia. His past medical history was notable for left craniotomy and hematoma evacuation following a traumatic brain hemorrhage approximately 40 years earlier, for which dural grafting was performed. He also had a history of three lobar hemorrhages in the left hemisphere since the age of 42 years. Brain CT imaging revealed an acute left frontal lobar hemorrhage. His initial brain MRI conducted at our hospital demonstrated hemorrhagic findings with left hemisphere dominance, including acute and old lobar hemorrhage, cortical superficial siderosis, and cerebral microbleeds. Cerebrospinal fluid analyses demonstrated reduced levels of cerebral amyloid-β 42, and elevated total tau. His apolipoprotein E genotype was ε3/ε3. Whole-exome sequencing did not detect mutations in genes associated with Alzheimer's disease, including presenilin 1, presenilin 2, and amyloid precursor protein. These findings led to a clinical diagnosis of iatrogenic cerebral amyloid angiopathy (CAA) using recently proposed diagnostic criteria, which do not require pathological evaluation of the brain. Iatrogenic CAA should be considered as a cause of lobar hemorrhage in young patients, especially those with a past history of neurosurgery.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"736-741"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Primary intramedullary spinal cord lymphoma with long spinal cord lesion]. [原发性髓内脊髓淋巴瘤伴脊髓长段病变]。

Clinical Neurology Pub Date : 2024-10-29 Epub Date: 2024-10-21 DOI: 10.5692/clinicalneurol.cn-002008

Atsushi Hara, Hideo Aihara, Hiroaki Hirata, Tokiko Nakai, Toshiyuki Uehara

引用次数: 0

[Anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated cortical encephalitis with low signal in subcortical white matter on MRI FLAIR imaging]. [抗髓鞘少突胶质细胞糖蛋白（MOG）抗体相关性皮质脑炎，核磁共振 FLAIR 成像显示皮质下白质呈低信号]。

Clinical Neurology Pub Date : 2024-09-26 Epub Date: 2024-08-28 DOI: 10.5692/clinicalneurol.cn-001981

Ryoko Shibuya, Risako Furuta, Ryo Tanaka, Takamasa Nukui, Shunya Nakane, Yuji Nakatsuji

{"title":"[Anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated cortical encephalitis with low signal in subcortical white matter on MRI FLAIR imaging].","authors":"Ryoko Shibuya, Risako Furuta, Ryo Tanaka, Takamasa Nukui, Shunya Nakane, Yuji Nakatsuji","doi":"10.5692/clinicalneurol.cn-001981","DOIUrl":"10.5692/clinicalneurol.cn-001981","url":null,"abstract":"A 32-year-old male presented with unilateral orbital-temporal pulsatile headache, followed by fever in the 38°C range and nausea. The patient experienced two episodes of transient dysarthria and tinnitus, each lasting several minutes. MRI revealed swelling of the left cerebral cortex, enhancement of the leptomeninges, dilation of the left middle cerebral artery, and subcortical FLAIR hypointensity. The clinical presentation and MRI findings raised suspicions of myelin oligodendrocyte glycoprotein (MOG) antibody-associated cortical encephalitis. After two courses of steroid pulse therapy, the patient's headache subsided, and there was a significant improvement in the swelling of the left cerebral cortex. Subsequently, serum MOG antibody positivity was confirmed. While unilateral cortical FLAIR hyperintensity and increased blood flow can be observed in various diseases, MOG antibody-associated cortical encephalitis is notably characterized by subcortical FLAIR hypointensity, a finding more frequently observed in this condition compared to other diseases. In this case, the findings were useful for early diagnosis and intervention.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"654-657"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of metronidazole-induced encephalopathy that is difficult to differentiate from Wernicke encephalopathy]. [一例甲硝唑诱发的脑病，与韦尼克脑病难以区分]。

Clinical Neurology Pub Date : 2024-09-26 Epub Date: 2024-08-24 DOI: 10.5692/clinicalneurol.cn-001972

Takayuki Konishi, Junichi Uemura, Shinji Yamashita, Hitoshi Mori, Takeshi Inoue, Katsumi Kurokawa

{"title":"[A case of metronidazole-induced encephalopathy that is difficult to differentiate from Wernicke encephalopathy].","authors":"Takayuki Konishi, Junichi Uemura, Shinji Yamashita, Hitoshi Mori, Takeshi Inoue, Katsumi Kurokawa","doi":"10.5692/clinicalneurol.cn-001972","DOIUrl":"10.5692/clinicalneurol.cn-001972","url":null,"abstract":"Herein, we present the case of a 76-year-old man diagnosed with an iliopsoas abscess 3 months prior and consequently administered metronidazole. The patient visited our facility complaining of difficulty in speaking and feeling unsteady when walking. Neurological findings showed dysarthria, nystagmus, and bilateral cerebellar ataxia. Head MRI-FLAIR demonstrated symmetrical hyperintensities in the bilateral cerebellar dentate nuclei, red nucleus, periaqueductal of the midbrain, periventricular third ventricle, and the corpus callosum. Although Wernicke's encephalopathy was among the differential diagnoses based on the imaging findings, the thiamine level was normal and improvement in symptoms and hyperintensity on FLAIR within 5 days of discontinuing metronidazole led to the diagnosis of metronidazole-induced encephalopathy. Although there were many similarities in the imaging findings of metronidazole-induced encephalopathy and Wernicke's encephalopathy, Metronidazole-induced encephalopathy should be initially considered when midbrain red nucleus lesions are observed.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"637-641"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of numb chin syndrome caused by postcentral gyrus infarction]. [一例由中央后回梗塞引起的麻木下巴综合征]。

Clinical Neurology Pub Date : 2024-09-26 Epub Date: 2024-08-24 DOI: 10.5692/clinicalneurol.cn-001984

Naoki Sawada, Miki Ueda, Toshitaka Umemura, Mikiko Kamijo, Takashi Kameyama

引用次数: 0

[Repeated Bow hunter's stroke by artery-to-artery embolism from the vertebral artery dissecting aneurysm formed by head rotation: A case report]. [头部旋转形成的椎动脉夹层动脉瘤导致动脉对动脉栓塞引起的重复性猎弓者中风：病例报告]。

Clinical Neurology Pub Date : 2024-09-26 Epub Date: 2024-08-24 DOI: 10.5692/clinicalneurol.cn-001971

Junki Fukumoto, Mariko Hokari, Yusuke Sakata, Aki Sato, Shuichi Igarashi, Kenichi Morita

引用次数: 0

Herpes simplex encephalomyeloradiculitis initially presents with urinary retention. 单纯疱疹性脑脊髓膜炎最初表现为尿潴留。

Clinical Neurology Pub Date : 2024-09-26 Epub Date: 2024-08-24 DOI: 10.5692/clinicalneurol.cn-001998

Syuichi Tetsuka, Tomohiro Suzuki, Tomoko Ogawa, Ritsuo Hashimoto

{"title":"Herpes simplex encephalomyeloradiculitis initially presents with urinary retention.","authors":"Syuichi Tetsuka, Tomohiro Suzuki, Tomoko Ogawa, Ritsuo Hashimoto","doi":"10.5692/clinicalneurol.cn-001998","DOIUrl":"10.5692/clinicalneurol.cn-001998","url":null,"abstract":"Herpes simplex virus (HSV) infections necessitate careful management of urinary dysfunction and retention, which are underestimated conditions. Here, we present a rare case of HSV encephalomyeloradiculitis in a 76-year-old man, whose initial symptoms included urinary dysfunction and retention that alone lasted for approximately 1 week. Unlike in meningoencephalitis, high fever and headache were absent; however, the patient subsequently developed cauda equina syndrome and consciousness disturbance. Gadolinium-enhanced spinal MRI suggested enhanced cauda equina at the L2/3 level. Upon admission, he was treated for meningoencephalitis with acyclovir and steroid pulse therapy. Subsequent cerebrospinal fluid analysis result was positive for HSV DNA. A ‍brain MRI conducted 1 week after admission displayed high-intensity lesions in the white matter of the right temporal lobe, confirming HSV encephalomyeloradiculitis. These treatments were highly effective and gradually improved the patient's condition. He was discharged 1 month after hospitalization, and the urinary catheter was removed 2 weeks later. HSV infections can cause life-threatening encephalomyeloradiculitis. Therefore, both neurologists and urologists must pay attention to their occurrence and characteristics in clinical settings.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"658-663"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of Candida meningitis in a patient with CARD9 deficiency: an autopsy report]. [一例 CARD9 缺乏症患者的念珠菌脑膜炎：尸检报告]。

Clinical Neurology Pub Date : 2024-09-26 Epub Date: 2024-08-24 DOI: 10.5692/clinicalneurol.cn-001980

Takashi Katakami, Takehiro Ueda, Manabu Nagata, Kimiko Inoue, Yasuhumi Kageyama

引用次数: 0