Clinical Neurology最新文献_第7页

[Negative myoclonus associated with high-dose trimethoprim-sulfamethoxazole for treating Nocardia brain abscess]. [大剂量甲氧苄啶-磺胺甲恶唑治疗诺卡菌脑脓肿伴阴性肌阵挛]。

Clinical Neurology Pub Date : 2026-05-26 Epub Date: 2026-04-11 DOI: 10.5692/clinicalneurol.cn-002225

Takahiro Makino, Kazuki Machino, Naoto Nakazawa, Ikuo Kamitsukasa

{"title":"[Negative myoclonus associated with high-dose trimethoprim-sulfamethoxazole for treating Nocardia brain abscess].","authors":"Takahiro Makino, Kazuki Machino, Naoto Nakazawa, Ikuo Kamitsukasa","doi":"10.5692/clinicalneurol.cn-002225","DOIUrl":"10.5692/clinicalneurol.cn-002225","url":null,"abstract":"A 77-year-old man was treated for Nocardia abscessus brain abscess with high-dose trimethoprim-sulfamethoxazole (TMP-SMX) and ceftriaxone (CTRX). During the treatment, he developed consciousness disturbance and negative myoclonus (NM) in all four limbs. Initially, we suspected CTRX-induced neurotoxicity because the clinical phenotype, characterized by NM, strongly resembled cephalosporin encephalopathy. However, we considered CTRX unlikely to be the cause because the patient's renal function was preserved, and NM appeared during the period when CTRX was withheld. Consequently, we suspected TMP-SMX as the causative agent, despite such symptoms being rare for this drug. Discontinuation of TMP-SMX alone, while continuing CTRX, resulted in the rapid disappearance of involuntary movements and improvement in consciousness. This clinical course confirmed the diagnosis of TMP-SMX-induced neurotoxicity. Although TMP-SMX encephalopathy typically presents with psychosis, high-dose administration can cause NM mimicking cephalosporin neurotoxicity. In cases under treatment with high-dose of TMP-SMX and preserved renal function, clinicians should consider that TMP-SMX can cause NM.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"325-329"},"PeriodicalIF":0.0,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Two cases of unilateral lesion of the inferior colliculus presenting with temporally changing, distinctive tinnitus and hearing impairment]. [单侧下丘病变2例，表现为时间变化，明显耳鸣和听力障碍]。

Clinical Neurology Pub Date : 2026-05-26 Epub Date: 2026-04-11 DOI: 10.5692/clinicalneurol.cn-002193

Ryutaro Hanyu, Yusuke Sakata, Hiroshi Matsuyama, Aki Sato, Shuichi Igarashi, Masayoshi Tada

{"title":"[Two cases of unilateral lesion of the inferior colliculus presenting with temporally changing, distinctive tinnitus and hearing impairment].","authors":"Ryutaro Hanyu, Yusuke Sakata, Hiroshi Matsuyama, Aki Sato, Shuichi Igarashi, Masayoshi Tada","doi":"10.5692/clinicalneurol.cn-002193","DOIUrl":"10.5692/clinicalneurol.cn-002193","url":null,"abstract":"We report two cases of unilateral lesion of the inferior colliculus presenting with distinctive tinnitus and hearing impairment. Case 1 was a 40-year-old woman under treatment for multiple sclerosis who developed sudden tinnitus in her bilateral ears, initially resembling a \"propeller\"-like sound, which evolved into high-pitched \"hyun-hyun\" tones and subsequently into sustained \"hyuun-hyuun\" tones. She also exhibited impaired perception of spoken language. Brain MRI revealed a new small lesion in the right inferior colliculus. Case 2 was a 49-year-old man who experienced sudden onset of tinnitus characterized by alternating cicada-like, bell-like, and electronic \"pyuun-pyuun\" sounds. MRI revealed a small hemorrhage in the right inferior colliculus. In both cases, the characteristics of tinnitus changed over time and was accompanied by impaired recognition of speech sounds. These findings suggest that unilateral inferior colliculus lesions, a relay nucleus of the auditory pathway, can cause temporally evolving tinnitus and selective hearing deficits, symptoms that have been rarely reported.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"293-298"},"PeriodicalIF":0.0,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Early-onset Alzheimer's disease with PSEN1 G206D mutation presenting with amnesia at an onset age of 29 years old]. 【早发性阿尔茨海默病伴PSEN1 G206D突变，发病年龄29岁，表现为健忘症】。

Clinical Neurology Pub Date : 2026-05-26 Epub Date: 2026-04-11 DOI: 10.5692/clinicalneurol.cn-002216

Kai Funakawa, Masanori Kurihara, Kensuke Takahashi, Ryoko Ihara, Toshiyuki Kakumoto, Kenji Ishibashi, Kenji Ishii, Yuki Fujii, Shunsuke Kobayashi, Atsushi Iwata

{"title":"[Early-onset Alzheimer's disease with PSEN1 G206D mutation presenting with amnesia at an onset age of 29 years old].","authors":"Kai Funakawa, Masanori Kurihara, Kensuke Takahashi, Ryoko Ihara, Toshiyuki Kakumoto, Kenji Ishibashi, Kenji Ishii, Yuki Fujii, Shunsuke Kobayashi, Atsushi Iwata","doi":"10.5692/clinicalneurol.cn-002216","DOIUrl":"10.5692/clinicalneurol.cn-002216","url":null,"abstract":"The patient was a 36-year-old woman with normal birth and development. The patient experienced gradual memory loss from the age of 29 years old. The patient showed irritability at 35, convulsion at 36, and was diagnosed to have early-onset dementia. Family history of early-onset dementia was suspected in her mother and her brother. Brain MRI showed atrophy mainly in parietal lobe and posterior cingulate cortes. Amyloid PET was positive and cerebrospinal fluid showed decreased amyloid-beta 42/40 ratio and increased phospho-tau 181, leading to a diagnosis of Alzheimer's disease (AD). Genomic analysis revealed known pathogenic variant c.617G>A (p.G206D) in PSEN1. The clinical presentation of very-early-onset memory loss followed by psychiatric symptoms and convulsion matched previous reports of the same variant. This patient represents the first reported case in Japan carrying the p.G206D variant and has the youngest age at onset among previously reported cases. This case highlights the importance of considering AD even in very-early-onset cases and detailed family history taking is important in earlier diagnosis.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"314-319"},"PeriodicalIF":0.0,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of vertebral artery dissection diagnosed using gadolinium-based contrast agent in a patient with iodine allergy]. [碘过敏患者用钆造影剂诊断椎动脉夹层1例]。

Clinical Neurology Pub Date : 2026-05-26 Epub Date: 2026-04-11 DOI: 10.5692/clinicalneurol.cn-002231

Shoichi Nakayasu, Rieko Motoka, Hideya Hayasshi, Naoto Kuwata, Yoshie Hara

引用次数: 0

[Behavioral variant frontotemporal dementia initially diagnosed by long-standing walking habit: an autopsy case]. [行为变异性额颞叶痴呆最初通过长期行走习惯诊断：一个尸检病例]。

Clinical Neurology Pub Date : 2026-05-26 Epub Date: 2026-04-21 DOI: 10.5692/clinicalneurol.cn-002218

Raita Kikuchi, Kenji Ishihara, Jun-Ichi Shiota, Mitsuru Kawamura, Mari Yoshida, Yasushi Iwasaki

引用次数: 0

[A case of anti-myelin-oligodendrocyte glycoprotein (MOG) antibody-associated disease without abnormal findings on spinal MRI and cerebrospinal fluid examination]. 【抗髓鞘-少突胶质细胞糖蛋白（MOG）抗体相关疾病1例，脊柱MRI和脑脊液检查未见异常】。

Clinical Neurology Pub Date : 2026-04-22 Epub Date: 2026-03-11 DOI: 10.5692/clinicalneurol.cn-002199

Rie Wakatsuki, Tomoyasu Bunai, Kouta Oka, Akiyuki Takenouchi, Kazuki Watanabe, Tomohiko Nakamura

引用次数: 0

[A case of progressive supranuclear palsy with progressive non-fluent agrammatic variant primary progressive aphasia who could sing fluently]. [进行性核上性麻痹伴进行性不流利语法变异原发性进行性失语症1例]。

Clinical Neurology Pub Date : 2026-04-22 Epub Date: 2026-03-14 DOI: 10.5692/clinicalneurol.cn-002124

Yasuko Mori, Keita Kitagawa, Nobuaki Yoshikura, Mika Otsuki, Takayoshi Shimohata

引用次数: 0

[A case of cerebellar-limited HIV-associated progressive multifocal leukoencephalopathy diagnosed with the aid of the shrimp sign]. [小脑局限性hiv相关进行性多灶性脑白质病1例，辅助虾征诊断]。

Clinical Neurology Pub Date : 2026-04-22 Epub Date: 2026-03-11 DOI: 10.5692/clinicalneurol.cn-002180

Himeko Ojio, Takeshi Kuroda, Tetsuhito Nohara, Kaoru Matsuoka, Takahide Wada, Hidetomo Murakami

引用次数: 0

[A female case of phospholipase A2 group VI-associated neurodegeneration with childhood onset and long-term follow-up until 49 years of age]. [1例女性磷脂酶A2组vi相关性神经退行性变，儿童期发病，长期随访至49岁]。

Clinical Neurology Pub Date : 2026-04-22 Epub Date: 2026-03-11 DOI: 10.5692/clinicalneurol.cn-002096

Masahiro Mimori, Kyoko Kanazawa, Wakiro Sato, Reiko Saika, Akihiro Yugeta, Yoshihisa Takiyama, Yuji Takahashi

{"title":"[A female case of phospholipase A2 group VI-associated neurodegeneration with childhood onset and long-term follow-up until 49 years of age].","authors":"Masahiro Mimori, Kyoko Kanazawa, Wakiro Sato, Reiko Saika, Akihiro Yugeta, Yoshihisa Takiyama, Yuji Takahashi","doi":"10.5692/clinicalneurol.cn-002096","DOIUrl":"10.5692/clinicalneurol.cn-002096","url":null,"abstract":"The patient was a 39-year-old woman. At the age of 7, she developed cognitive delay and gait disturbance due to flexion deformities of both toes. Her motor function progressively declined over the years, and she became bedridden at the age of 38. At 39, she was referred to our department and was clinically diagnosed with complicated spastic paraplegia. Genetic testing revealed compound heterozygous missense mutations in PLA2G6 (c.662C>T; p.L221P / c.991G>T; p.D331Y), leading to a diagnosis of phospholipase A2 group VI-associated neurodegeneration (PLAN). Despite the progressive nature of her condition, she remained out of hospital care for an extended period. At age 49, she was admitted for evaluation following an episode of impaired consciousness and was subsequently diagnosed with epilepsy. PLAN with early childhood onset is generally associated with a poor prognosis; however, the current case represents a rare example of prolonged survival without ventilatory support or enteral feeding. We conducted a literature review of similar PLAN subtypes and discussed the clinical course of the present case in that context.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"235-242"},"PeriodicalIF":0.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Febrile infection-related epilepsy syndrome (FIRES) with the claustrum sign in a 55-year-old woman: a case report]. [发热性感染相关癫痫综合征（FIRES）伴屏状体征的55岁妇女一例报告]。

Clinical Neurology Pub Date : 2026-04-22 Epub Date: 2026-03-11 DOI: 10.5692/clinicalneurol.cn-002145

Go Akao, Dai Ichikawa, Juichi Fujimori, Ichiro Nakashima

引用次数: 0