Acta Urologica Japonica最新文献_第8页

[Superior Vena Cava Syndrome and Trousseau Syndrome in a Patient with Metastatic Urothelial Carcinoma Treated with Enfortumab Vedotin : A Case Report]. [上腔静脉综合征和Trousseau综合征在转移性尿路上皮癌患者中的应用：1例报告]。

Acta Urologica Japonica Pub Date : 2025-06-01 DOI: 10.14989/ActaUrolJap_71_6_191

Takuya Hida, Naoko Fujita, Takaya Murashima, Masato Fujii, Takahiro Nagai, Chie Onizuka, Koshiro Nishimoto, Atsuro Sawada, Shoichiro Mukai, Toshiyuki Kamoto

引用次数: 0

[Comprehensive Genomic Profiling Tests for Japanese Patients with Metastatic Castration-Resistant Prostate Cancer : A Single-Institution Experience]. [日本转移性去势抵抗性前列腺癌患者的综合基因组分析测试：单一机构的经验]。

Acta Urologica Japonica Pub Date : 2025-06-01 DOI: 10.14989/ActaUrolJap_71_6_171

Shiori Miyachi, Takeshi Sasaki, Momoko Kato, Shinichiro Higashi, Satoru Masui, Kouhei Nishikawa, Takumi Fujiwara, Takahito Kitajima, Yotaro Hashizume, Katsunori Uchida, Hiroshi Imai, Masatoshi Watanabe, Yoshinaga Okugawa, Takahiro Inoue

{"title":"[Comprehensive Genomic Profiling Tests for Japanese Patients with Metastatic Castration-Resistant Prostate Cancer : A Single-Institution Experience].","authors":"Shiori Miyachi, Takeshi Sasaki, Momoko Kato, Shinichiro Higashi, Satoru Masui, Kouhei Nishikawa, Takumi Fujiwara, Takahito Kitajima, Yotaro Hashizume, Katsunori Uchida, Hiroshi Imai, Masatoshi Watanabe, Yoshinaga Okugawa, Takahiro Inoue","doi":"10.14989/ActaUrolJap_71_6_171","DOIUrl":"10.14989/ActaUrolJap_71_6_171","url":null,"abstract":"Comprehensive genomic profiling for metastatic castration-resistant prostate cancer (mCRPC) is rapidly becoming widespread. This study sought to investigate the gene alteration profiles of Japanese patients with mCRPC. We retrospectively reviewed 80 consecutive mCRPC patients who underwent comprehensive genomic profiling tests at our institution between 2021 and 2022. All patients underwent next-generation sequencing (NGS) : FoundationOne® CDx (F1-CDx) or FoundationOne® Liquid CDx (F1L-CDx). F1LCDx was indicated for cases in which tissue specimens were older than 5 years or could not be analyzed using F1-CDx. The median patient age was 74 years. Thirty-five and 45 patients received F1-CDx and F1LCDx, respectively. At least one pathogenic variant was found in 35 (100%) who received F1-CDx and 43 (95%) who received F1L-CDx. In total, 11 and 1 patients had pathogenic variants of BRCA2 and BRCA1, respectively. Among them, 4 cases (33%) were found to be germline variants. TP53, CDK12, and PTEN were found in ＞ 20% of cases who received F1-CDx. DNMT3A, TP53, AR, and TET2 were found in ＞ 20% of cases who received F1L-CDx. The proportion of gene alteration subtypes of amplification and loss in F1L-CDx was less common than that in F1-CDx. Pathogenic variants were successfully detected in almost all F1-CDx and F1L-CDx cases in our mCRPC cohort. The total proportion of BRCA1/2 pathogenic variant patients was similar to those in previous reports.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 6","pages":"171-179"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Partial Nephrectomy for Juxtaglomerular Cell Tumor in the Renal Hilum]. [肾门肾小球旁细胞瘤部分切除1例]。

Acta Urologica Japonica Pub Date : 2025-06-01 DOI: 10.14989/ActaUrolJap_71_6_181

Sena I, Teppei Yamamoto, Kazuyoshi Iijima, Akio Miyamoto, Yukiko Kusama, Tomomi Haba, Takashi Hagimoto, Masashi Koshiba, Haruaki Kato

引用次数: 0

[A Case of Urothelial Carcinoma of Renal Pelvis Intraoperatively Diagnosed during Robot-Assisted Ureterocalicostomy]. [机器人辅助输尿管造口术中诊断肾盂尿路上皮癌1例]。

Acta Urologica Japonica Pub Date : 2025-06-01 DOI: 10.14989/ActaUrolJap_71_6_187

Yoshitaka Motoki, Toueki Yanagi, Shinpei Yoshioka, Masato Tomono, Motohiro Taguchi, Kimihiro Shimatani, Yusuke Yamada, Shuken Go, Akihiro Kanematsu, Shingo Yamamoto, Takashi Yamasaki, Seiichi Hirota

引用次数: 0

[Pyonephrosis Caused by Ureteral Stricture Due to Syphilitic Granuloma: A Case Report]. [梅毒肉芽肿致输尿管狭窄致脓肾1例]。

Acta Urologica Japonica Pub Date : 2025-05-01 DOI: 10.14989/ActaUrolJap_71_5_145

Seigo Machiya, Haruto Honda, Makoto Ishii, Hiromu Horitani, Sayaka Horii, Masao Kobayashi, Yutaka Ono, Shigeru Nakamori

引用次数: 0

[A Case of Ureteral Sciatic Hernia Treated by Laparoscopic Vesicoureterl Neoanastomosis]. [腹腔镜输尿管输尿管吻合术治疗输尿管坐骨疝1例]。

Acta Urologica Japonica Pub Date : 2025-05-01 DOI: 10.14989/ActaUrolJap_71_5_159

Kanji Nagahama, Toru Kanno, Kazuto Imai, Norihiko Masuda, Takahiro Maruyama, Haruki Imura, Keita Hanada, Takakazu Matsushita, Toshiya Akao

{"title":"[A Case of Ureteral Sciatic Hernia Treated by Laparoscopic Vesicoureterl Neoanastomosis].","authors":"Kanji Nagahama, Toru Kanno, Kazuto Imai, Norihiko Masuda, Takahiro Maruyama, Haruki Imura, Keita Hanada, Takakazu Matsushita, Toshiya Akao","doi":"10.14989/ActaUrolJap_71_5_159","DOIUrl":"10.14989/ActaUrolJap_71_5_159","url":null,"abstract":"Pelvic herniation of the ureter through anatomical musculoskeletal foramina stands out as one of the rarest causes of ureteric obstruction. The herniation of the ureter through the sciatic foramen presents as a particularly uncommon variant of this condition. A 62-year-old woman was referred to our hospital from a family practioner with symptoms of fever and septic shock. Subsequent computed tomography imaging revealed left hydroureteronephrosis without clear evidence of ureteral stones or ureteral tumors and that the lower part of the ureter was shifted to the outside of the cavum pelvis minor from the greater sciatic foramen. She was diagnosed with ureterosciatic hernia, and a left retrograde ureteral stent was indwelled. Her hemodynamic status improved and the ureteral stent was removed after ureteral migration became normal. However, three months later, left ureterosciatic hernia recurred. Therefore, we performed laparoscopic vesicoureteral neoanastomosis and native tissue repair of hernia by uterine appendages. The postoperative course was uneventful. We believe this is a durable repair although longer follow-up is needed to establish the longevity of our treatment modality.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 5","pages":"159-164"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pathophysiology of Semen Parameter Deterioration Associated with Varicocele --Evaluation of Total Antioxidant Capacity in Seminal Plasma and Serum-]. 精索静脉曲张相关精液参数恶化的病理生理学——精浆和血清总抗氧化能力的评估。

Acta Urologica Japonica Pub Date : 2025-05-01 DOI: 10.14989/ActaUrolJap_71_5_137

Masaki Kimura, Kazuki Takei, Kazuki Yanagida, Itsuki Yoshimura, Ichiro Takada, Tomoyuki Kaneko, Tohru Nakagawa

{"title":"[Pathophysiology of Semen Parameter Deterioration Associated with Varicocele --Evaluation of Total Antioxidant Capacity in Seminal Plasma and Serum-].","authors":"Masaki Kimura, Kazuki Takei, Kazuki Yanagida, Itsuki Yoshimura, Ichiro Takada, Tomoyuki Kaneko, Tohru Nakagawa","doi":"10.14989/ActaUrolJap_71_5_137","DOIUrl":"https://doi.org/10.14989/ActaUrolJap_71_5_137","url":null,"abstract":"Varicocele is a frequent cause of male infertility. On the contrary, the majority of men who have varicocele show normal semen parameters. This study aimed to clarify the pathophysiology of abnormal semen findings associated with varicocele by evaluating the total antioxidant capacity in seminal plasma and serum. Sixty patients with clinical varicocele were included in this study. Of the 60 patients, 22 men had scrotal pain caused by varicocele with normal semen parameters, and 38 men had abnormal semen parameters as defined by the 2010 World Health Organization criteria. Before the investigation, semen samples were collected. Total antioxidant capacity in serum and seminal plasma was analyzed by colorimetric assay and the relationship between semen parameters and total antioxidant capacity was evaluated. Positive associations were found between antioxidant capacity in seminal plasma and concentration (r＝0.364, P＝0.004), motility (r＝0.254, P＝0.050), and total motile sperm count (r＝0.468, P＜0.001). In multivariate analysis, higher total motile sperm count showed a significant positive relationship with higher total antioxidant capacity in seminal plasma (P＝0.001). Our results indicated that the total antioxidant capacity of seminal plasma might affect varicocele-related male infertility.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 5","pages":"137-143"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Cut-to-the-light Incision for Ureteroileal Anastomotic Obstruction after Robot-Assisted Radical Cystectomy and Ileal Conduit]. [机器人辅助根治性膀胱切除术及回肠导管术后输尿管输尿管吻合口梗阻的切开式切口1例]。

Acta Urologica Japonica Pub Date : 2025-05-01 DOI: 10.14989/ActaUrolJap_71_5_155

Ryunosuke Murofushi, Daiki Ikarashi, Yasushi Nozaki, Moe Toyoshima, Ei Shiomi, Tomohiko Matsuura, Shigekatsu Maekawa, Renpei Kato, Mitsugu Kanehira, Jun Sugimura, Wataru Obara

引用次数: 0

[A Case of Thrombocytopenia as an Adverse Effect of Mycophenolate Mofetil before Blood Type-Incompatible Living-Donor Renal Transplantation]. 【血型不相容活体肾移植前使用霉酚酸酯所致血小板减少一例】。

Acta Urologica Japonica Pub Date : 2025-05-01 DOI: 10.14989/ActaUrolJap_71_5_149

Suguru Ito, Kazutoshi Okubo, Yoshiyuki Okada, Kosuke Ogawa, Yukari Tanaka, Noriyuki Ito, Hitomi Miyata, Toru Matsugasumi, Masakatsu Hishizawa

{"title":"[A Case of Thrombocytopenia as an Adverse Effect of Mycophenolate Mofetil before Blood Type-Incompatible Living-Donor Renal Transplantation].","authors":"Suguru Ito, Kazutoshi Okubo, Yoshiyuki Okada, Kosuke Ogawa, Yukari Tanaka, Noriyuki Ito, Hitomi Miyata, Toru Matsugasumi, Masakatsu Hishizawa","doi":"10.14989/ActaUrolJap_71_5_149","DOIUrl":"https://doi.org/10.14989/ActaUrolJap_71_5_149","url":null,"abstract":"We present a patient who developed thrombocytopenia before blood type-incompatible living-donor renal transplantation, which inhibited proper evaluation and treatment of thrombocytopenia. A 45-year-old woman with kidney failure of unknown etiology who was on peritoneal dialysis for 2 years was admitted after receiving immunosuppressive drugs at an outpatient clinic. The platelet count gradually decreased and eventually reached a level that could interfere with surgery. Mycophenolate mofetil was considered the cause of thrombocytopenia. Thus, it was discontinued, which increased the platelet count. The patient also received platelet transfusion, and renal transplantation was successfully performed as planned. The patient did not develop hemorrhage after the transplantation. The pretransplantation administration of mycophenolate mofetil was suspected to have caused thrombocytopenia in this patient. Hence, sudden decline in platelet count before surgery should be promptly investigated to identify potential causes in order of their likelihood. It is important to confirm that there is no evidence of platelet consumption or destruction.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 5","pages":"149-153"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Transverse Testicular Ectopia with Complete Descent to the Bottom of the Contralateral Scrotum]. 睾丸横向异位伴完全下降至对侧阴囊底部1例。

Acta Urologica Japonica Pub Date : 2025-04-01 DOI: 10.14989/ActaUrolJap_71_4_127

Shinya Abe, Kazuma Hiramatsu, Toshihide Hosomi, Takashi Matsuoka, Yuki Kamiyama, Naofumi Tsutsumi, Takehiko Segawa

引用次数: 0