Acta Urologica Japonica最新文献_第6页

[A Case of Immune Checkpoint Inhibitor-Related Gastritis and Severe Thrombocytopenia during Pembrolizumab and Axitinib Treatment]. [在 Pembrolizumab 和 Axitinib 治疗期间发生免疫检查点抑制剂相关性胃炎和严重血小板减少症的病例]。

Acta Urologica Japonica Pub Date : 2024-07-01 DOI: 10.14989/ActaUrolJap_70_7_213

Kosuke Ogawa, Daisuke Takahashi, Takuro Miyagawa, Ryuichiro Arakaki, Shinsuke Shibuya, Kazutoshi Okubo

{"title":"[A Case of Immune Checkpoint Inhibitor-Related Gastritis and Severe Thrombocytopenia during Pembrolizumab and Axitinib Treatment].","authors":"Kosuke Ogawa, Daisuke Takahashi, Takuro Miyagawa, Ryuichiro Arakaki, Shinsuke Shibuya, Kazutoshi Okubo","doi":"10.14989/ActaUrolJap_70_7_213","DOIUrl":"10.14989/ActaUrolJap_70_7_213","url":null,"abstract":"A 75-year-old female who was referred to our hospital with dizziness as the main complaint. Computed tomographic (CT) and positron emission tomography-CT scans indicated the presence of generalized lymphadenopathy and a 10 cm tumor in her left kidney. Further evaluation led to a diagnosis of Hodgkin’s lymphoma and left renal cell carcinoma. Due to her poor general condition secondary to the lymphoma, she was referred to our institution where chemotherapy was promptly initiated. After one year, metastases to the sternum and right hilar lymph nodes from the renal cancer were detected. Therefore, treatment for the lymphoma was discontinued, and combination therapy with Pembrolizumab and Axitinib for the renal carcinoma was started. Eight months after starting treatment for kidney cancer, the patient developed gastritis as an immune-related adverse event (irAE), which improved with high-dose steroid therapy. Subsequently, severe thrombocytopenia developed following the initiation of steroid therapy but improved upon discontinuation of Axitinib. Currently, treatment is ongoing with Cabozantinib without recurrence of either gastritis or thrombocytopenia.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"70 7","pages":"213-218"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Relationship between Serum Testosterone Levels and Diagnosis of Late-Onset Hypogonadism in Patients Visiting an Outpatient Clinic]. [门诊患者血清睾酮水平与晚发性性腺功能减退症诊断之间的关系]。

Acta Urologica Japonica Pub Date : 2024-07-01 DOI: 10.14989/ActaUrolJap_70_7_207

Hisanori Taniguchi, Seiji Shimada, Hidefumi Kinoshita, Tadashi Matsuda

{"title":"[Relationship between Serum Testosterone Levels and Diagnosis of Late-Onset Hypogonadism in Patients Visiting an Outpatient Clinic].","authors":"Hisanori Taniguchi, Seiji Shimada, Hidefumi Kinoshita, Tadashi Matsuda","doi":"10.14989/ActaUrolJap_70_7_207","DOIUrl":"10.14989/ActaUrolJap_70_7_207","url":null,"abstract":"The clinical practice manual for late-onset hypogonadism (LOH) was updated in 2022. This study analyzed the total and free testosterone levels of patients who visited our specialized hypogonadism outpatient clinic and examined the characteristics of patients eligible for androgen replacement therapy (TRT), using the 2007 guidelines and the new guidelines as references. Among a total of 770 patients that visited our clinic,11.9% (92/770) of the patients had total testosterone levels (＜250 ng/dl) that met the LOH diagnostic criteria of the new guidelines,and 39.2% (302/770) had free testosterone levels (＜7.5 pg/ml) that met the LOH diagnostic criteria. These patients represented 62.2% of the patients who underwent TRT,according to the 2007 guidelines. When patients who underwent TRT were divided into two groups depending on whether they met the diagnostic criteria in the new medical treatment guide,there was no significant difference in the subjective effectiveness rate of TRT and the improvement rate of Aging Males’Symptoms (AMS) score before and after TRT.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"70 7","pages":"207-211"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prognostic Factors for Recurrence in Patients with cT1 Renal Cell Carcinoma Upstaging to pT3a after Laparoscopic/Robot-Assisted Partial Nephrectomy]. [腹腔镜/机器人辅助肾部分切除术后 cT1 肾细胞癌上移至 pT3a 患者复发的预后因素]。

Acta Urologica Japonica Pub Date : 2024-07-01 DOI: 10.14989/ActaUrolJap_70_7_193

Takanari Kambe, Toshinari Yamasaki, Akihiko Nagoshi, Tasuku Fujiwara, Yuta Mine, Hiroki Hagimoto, Yuto Hattori, Yohei Abe, Daisuke Yamashita, Naofumi Tsutsumi, Mutsushi Kawakita

引用次数: 0

[A Case of Urethral Foreign Body from 40 Years Ago with Scrotum Abscess and Urethroscrotal Fistula]. [40 年前尿道异物伴阴囊脓肿和尿道瘘病例]。

Acta Urologica Japonica Pub Date : 2024-06-01 DOI: 10.14989/ActaUrolJap_70_6_185

Yohei Kaizuka, Tetsuro Yoshimoto, Yutaka Doi, Motohiro Taguchi

引用次数: 0

[Resumption of Enfortumab Vedotin Supported by Diagnosis of a Late- Onset Immune-Related Adverse Event in Metastatic Urothelial Carcinoma : A Case Report]. [转移性尿路上皮癌晚期免疫相关不良事件诊断支持恢复使用恩福单抗维多汀：病例报告]。

Acta Urologica Japonica Pub Date : 2024-06-01 DOI: 10.14989/ActaUrolJap_70_6_161

Takeru Fujimoto, Yoshio Sugino, Kazuma Soya, Kana Kohashiguchi, Sachiko Higashino, Fumihiro Uwamori, Yusuke Takei, Hiroshi Iwamura

引用次数: 0

[A Case of Metastatic Prostate Cancer with Neuroendocrine Differentiation with Long-Term Survival after Multidisciplinary Therapy]. [神经内分泌分化转移性前列腺癌多学科治疗后长期生存病例]。

Acta Urologica Japonica Pub Date : 2024-06-01 DOI: 10.14989/ActaUrolJap_70_6_173

Koki Fujita, Minoru Kato, Yuki Kosugi, Yoshimasa Sekido, Nanami Matsui, Kazuki Masuda, Shoma Yamamoto, Taisuke Matsue, Keiko Iguchi, Nao Yukimatsu, Taiyo Otoshi, Takeshi Yamasaki, Katsuyuki Kuratsukuri, Kenichi Kohashi, Junji Uchida

{"title":"[A Case of Metastatic Prostate Cancer with Neuroendocrine Differentiation with Long-Term Survival after Multidisciplinary Therapy].","authors":"Koki Fujita, Minoru Kato, Yuki Kosugi, Yoshimasa Sekido, Nanami Matsui, Kazuki Masuda, Shoma Yamamoto, Taisuke Matsue, Keiko Iguchi, Nao Yukimatsu, Taiyo Otoshi, Takeshi Yamasaki, Katsuyuki Kuratsukuri, Kenichi Kohashi, Junji Uchida","doi":"10.14989/ActaUrolJap_70_6_173","DOIUrl":"10.14989/ActaUrolJap_70_6_173","url":null,"abstract":"A 74-year-old man visited the urology clinic with the chief complaint of urinary retention in December 2014. Serum level of initial prostate specific antigen (PSA) was 50 ng/ml and he was diagnosed with Gleason Score 4＋4 prostate adenocarcinoma with regional lymphadenopathy (cT3aN1M0). PSA level had declined after the treatment with combined androgen blockade. In November 2018, he was diagnosed with castration resistant prostate cancer (CRPC) as local progression was detected by computed tomography (CT) while PSA level did not increase. Since local symptoms worsened, resulting in repeated hematuria after the treatment with enzalutamide, palliative radiation therapy to the prostate (45 Gy) was performed. Five months later, follow-up CT showed multiple metastasis in bilateral lung and left testicle. Serum level of neuron-specific enolase (NSE) was 24.4 ng/ml without an elevated in serum PSA level. He received rebiopsy of the prostate, but no malignant findings were observed. Consequently, bilateral orchiectomy was performed for diagnosis of left testicular tumor. Pathological examination revealed metastasis of neuroendocrine prostate cancer (NEPC). Chemotherapy using cisplatin and irinotecan was administered after orchiectomy. Complete response of lung lesions was achieved and serum level of NSE decreased within normal range. No recurrence has been confirmed for 4 years after the completion of chemotherapy.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"70 6","pages":"173-177"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Proliferative Cystitis Discovered as Protruding Lesion during Inspection of Secondary Infertility]. [在检查继发性不孕症时发现突出病变的增生性膀胱炎病例]。

Acta Urologica Japonica Pub Date : 2024-06-01 DOI: 10.14989/ActaUrolJap_70_6_167

Keita Okamoto, Kosuke Kojo, Masahiro Kurobe, Yoshimasa Nakazato, Hiromu Inai, Katsunori Uchida, Jun Miyazaki, Tatsuya Takayama

{"title":"[A Case of Proliferative Cystitis Discovered as Protruding Lesion during Inspection of Secondary Infertility].","authors":"Keita Okamoto, Kosuke Kojo, Masahiro Kurobe, Yoshimasa Nakazato, Hiromu Inai, Katsunori Uchida, Jun Miyazaki, Tatsuya Takayama","doi":"10.14989/ActaUrolJap_70_6_167","DOIUrl":"10.14989/ActaUrolJap_70_6_167","url":null,"abstract":"A 42-year-old man visited our hospital complaining of secondary infertility. An abdominal ultrasonography screening incidentally revealed a protruding lesion in the bladder. As the lesion extended from the prostatic urethra and bladder neck, there was a possibility of ejaculation dysfunction after resection of the lesion. Therefore, with the patient's informed consent, sperm cryopreservation was conducted for fertility preservation, and subsequently histological examination was performed by partial transurethral resection of bladder tumor. The pathological findings were proliferative cystitis including all three subtypes (glandularis, cystica, and papillary). Cyclooxygenase-2 immunostaining was positive in cytoplasm; weakly positive in cystic and papillary lesions, and strongly positive in glandular lesions. According to a literature review of massive proliferative cystitis, the patient was the 77th case in Japan. Novel postoperative immunological pharmacotherapies with cyclooxygenase-2 inhibitors have been introduced in recent years.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"70 6","pages":"167-171"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Xanthogranulomatous Pyelonephritis with Multiple Lymphadenopathy that was Difficult to Differentiate from Renal Tumor]. [黄疽性肾盂肾炎伴多发性淋巴结病难以与肾肿瘤鉴别的病例]。

Acta Urologica Japonica Pub Date : 2024-06-01 DOI: 10.14989/ActaUrolJap_70_6_149

Yuta Goto, Ei Shiomi, Mizuki Hisano, Shuhei Ishii, Takashi Ujiie, Yasuyuki Nakamura

{"title":"[A Case of Xanthogranulomatous Pyelonephritis with Multiple Lymphadenopathy that was Difficult to Differentiate from Renal Tumor].","authors":"Yuta Goto, Ei Shiomi, Mizuki Hisano, Shuhei Ishii, Takashi Ujiie, Yasuyuki Nakamura","doi":"10.14989/ActaUrolJap_70_6_149","DOIUrl":"10.14989/ActaUrolJap_70_6_149","url":null,"abstract":"A 74-year-old woman presented to our hospital with the main complaint of anorexia and weight loss for several months. Computed tomography (CT) revealed right urinary stone, hydronephrosis, multiple lymphadenopathy, and a mass in the right kidney. Considering these findings, she was suspected to have renal malignancy (kidney or renal pelvis cancer) with multiple lymph node metastases; therefore, nephrectomy was performed. Her pathological diagnosis was xanthogranulomatous pyelonephritis (XGPN). There was no postoperative renal function decline, and multiple lymphadenopathy also disappeared on CT 3 months after surgery. It was judged to be reactive swelling due to inflammation. XGPN is a pathological condition characterized by accumulation of mast cells and activated macrophages in the renal tissue; and, the renal tissue recognizes yellowish granulation growth because of repeating pyelonephritis due to urinary tract passing impairment. In some cases, it is difficult to differentiate XGPN from renal malignancy. Moreover, lymphadenopathy may be lymph node metastasis but may also present reactive enlargement due to the effect of inflammation, making it even more difficult to differentiate when accompanied by lymphadenopathy. We report this case in which it was difficult to differentiate XGPN from renal malignancy considering the scarcity of reports of XGPN accompanied by multiple lymphadenopathy.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"70 6","pages":"149-153"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The Association of Docetaxel Side Effects and Introduction of Subsequent Cabazitaxel for Castration-Resistant Prostate Cancer : A Clinical Study]. [多西他赛副作用与后续卡巴他赛治疗阉割耐药前列腺癌的关联：一项临床研究]。

Acta Urologica Japonica Pub Date : 2024-06-01 DOI: 10.14989/ActaUrolJap_70_6_141

Yuma Kujime, Mototaka Sato, Takahiro Maekawa, Shun Umeda, Makoto Matsushita, Norihide Tei, Osamu Miyake

{"title":"[The Association of Docetaxel Side Effects and Introduction of Subsequent Cabazitaxel for Castration-Resistant Prostate Cancer : A Clinical Study].","authors":"Yuma Kujime, Mototaka Sato, Takahiro Maekawa, Shun Umeda, Makoto Matsushita, Norihide Tei, Osamu Miyake","doi":"10.14989/ActaUrolJap_70_6_141","DOIUrl":"https://doi.org/10.14989/ActaUrolJap_70_6_141","url":null,"abstract":"The administration of cabazitaxel for patients with castration-resistant prostate cancer (CRPC) requires prior docetaxel therapy. Sequential chemotherapy may have to be discontinued due to docetaxelassociated side effects. This study investigated the relationship between treatment outcome of docetaxel and cabazitaxel and their associated side effects. We retrospectively analyzed 69 patients with CRPC who had been administered docetaxel withand without subsequent cabazitaxel at Toyonaka Municipal Hospital from October 2014 to June 2022. Twenty-eight patients (41%) discontinued docetaxel because of side effects, and the median number of docetaxel cycles at discontinuation was 2 (range : 1-11). Fourteen of these patients received no treatment following docetaxel. A comparison of the 28 patients who had discontinued docetaxel due to side effects with 41 patients who had not revealed a significant difference in the total numbers of chemotherapy cycles (2.5 vs 9 ; P＜0.001) and time to treatment failure (56 days vs 301 days ; P＝ 0.001), with a trend toward shorter overall survival from the start of docetaxel treatment (259 days vs 512 days ; P＝0.06). Multivariate analysis identified discontinuation of docetaxel due to side effects (OR＝0.07 ; P＜0.001) and lower hemoglobin (OR＝0.01 ; P＝0.001) as significant factors inhibiting the introduction of cabazitaxel. Reducing the side effects of docetaxel, including early drug switching, may allow more CRPC patients to be reached with cabazitaxel. Consequently, the resulting taxane-based chemotherapy may contribute to an additional survival advantage.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"70 6","pages":"141-147"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Granulocyte Colony-Stimulating Factor-Related Aortitis that Developed during the Treatment of Advanced Prostate Cancer with Neuroendocrine Differentiation]. [治疗神经内分泌分化的晚期前列腺癌期间出现的粒细胞集落刺激因子相关性大动脉炎病例]。

Acta Urologica Japonica Pub Date : 2024-06-01 DOI: 10.14989/ActaUrolJap_70_6_179

Tatsuya Hazama, Kohei Maruno, Toshifumi Takahashi, Yuya Yamada, Masakazu Nakashima, Kazuro Kikkawa, Masahiro Tamaki, Noriyuki Ito

{"title":"[A Case of Granulocyte Colony-Stimulating Factor-Related Aortitis that Developed during the Treatment of Advanced Prostate Cancer with Neuroendocrine Differentiation].","authors":"Tatsuya Hazama, Kohei Maruno, Toshifumi Takahashi, Yuya Yamada, Masakazu Nakashima, Kazuro Kikkawa, Masahiro Tamaki, Noriyuki Ito","doi":"10.14989/ActaUrolJap_70_6_179","DOIUrl":"10.14989/ActaUrolJap_70_6_179","url":null,"abstract":"An 81-year-old man with prostate cancer (cT3aN0M0), who had been undergoing hormonal therapy for 4 years and had maintained low prostate specific antigen levels, developed metastasized pelvic lymph nodes. A tissue biopsy revealed neuroendocrine differentiation of prostate cancer in the metastatic lymph nodes. Consequently, chemotherapy with carboplatin＋etoposide was initiated. During the first course, filgrastim was administered for 2 days due to a drop in his neutrophil count to 230/μl. During the second course, pegfilgrastim was administered as prophylaxis on day 4. However, on day 10 of the second course, he started to develop a fever and fatigue. Suspecting infection, antibiotics were administered, but failed to ameliorate his symptoms. On day 14, plain computed tomography revealed signs of aortic inflammation. Given the lack of improvement even after one week of antibiotic therapy, steroid treatment was initiated on the suspicion of granulocyte colony-stimulating factor (G-CSF) -induced aortitis, which rapidly improved his symptoms. Therefore, when encountering a case in which a fever remains unresponsive to antibiotics during chemotherapy with G-CSF agents, a differential diagnosis of aortic inflammation caused by G-CSF agents needs to be considered.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"70 6","pages":"179-183"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0