Acta Urologica Japonica最新文献_第6页

[A Case of Long-Term Complete Remission by Pembrolizumab＋Axitinib, Cabozantinib for Papillary Renal Cell Carcinoma with Metastasis]. 【派姆单抗+阿西替尼、卡博赞替尼治疗转移性乳头状肾细胞癌长期完全缓解1例】。

Acta Urologica Japonica Pub Date : 2025-09-01 DOI: 10.14989/ActaUrolJap_71_9_289

Naoya Nakatake, Yushi Miyata, Tomohiro Kanaki, Takanori Kinjo, Wataru Nakata, Hitoshi Inoue

{"title":"[A Case of Long-Term Complete Remission by Pembrolizumab＋Axitinib, Cabozantinib for Papillary Renal Cell Carcinoma with Metastasis].","authors":"Naoya Nakatake, Yushi Miyata, Tomohiro Kanaki, Takanori Kinjo, Wataru Nakata, Hitoshi Inoue","doi":"10.14989/ActaUrolJap_71_9_289","DOIUrl":"10.14989/ActaUrolJap_71_9_289","url":null,"abstract":"A 46-year-old woman presented to a local clinic complaining of discomfort in the right upper quadrant. Abdominal ultrasound revealed a right renal mass, and she was referred for further evaluation and treatment. Contrast-enhanced computed tomography showed a 54 mm right renal tumor and a 12 mm enlarged lymph node in the aortocaval region. She was diagnosed with right renal cell carcinoma, staged as cT1bN1M0. Laparoscopic right nephrectomy and lymph node dissection were performed, confirming the diagnosis of papillary renal cell carcinoma type 2, pT1bpN1. At nine months after surgery, she developed retroperitoneal recurrence with invasion of the second lumbar vertebra. Pembrolizumab combined with axitinib was initiated. After six months of treatment, she achieved a complete response with no detectable lesions. However, 17 months after the initiation of treatment, new multiple liver metastases appeared, and the response was classified as progressive disease. Second-line treatment with cabozantinib was started, leading to complete tumor regression after 16 months, with a complete response confirmed. She has maintained a complete response for 39 months since starting cabozantinib.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 9","pages":"289-293"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Rare Case of Spontaneous Knotting of a Urethrally Inserted Cord in an Adolescent Patient]. [一例罕见的青少年患者尿道插入脊髓自发打结的病例]。

Acta Urologica Japonica Pub Date : 2025-09-01 DOI: 10.14989/ActaUrolJap_71_9_319

Sotaro Kayano, Eriko Nishi, Keiichiro Miyajima, Tatsuya Shimomura, Takahiro Kimura

引用次数: 0

[Paratesticular Rhabdomyosarcoma with Rapid Growth in an Infant : A Case Report]. [快速生长的婴儿睾丸旁横纹肌肉瘤1例报告]。

Acta Urologica Japonica Pub Date : 2025-09-01 DOI: 10.14989/ActaUrolJap_71_9_313

Wonseok Seo, Tetsuyuki Kurokawa, Hisato Kobayashi, Masaya Seki, So Inamura, Minekatsu Taga, Masato Fukushima, Yuzuru Ariga, Koji Suzuki, Akifumi Muramoto, Yoshiaki Imamura, Naoki Terada

{"title":"[Paratesticular Rhabdomyosarcoma with Rapid Growth in an Infant : A Case Report].","authors":"Wonseok Seo, Tetsuyuki Kurokawa, Hisato Kobayashi, Masaya Seki, So Inamura, Minekatsu Taga, Masato Fukushima, Yuzuru Ariga, Koji Suzuki, Akifumi Muramoto, Yoshiaki Imamura, Naoki Terada","doi":"10.14989/ActaUrolJap_71_9_313","DOIUrl":"https://doi.org/10.14989/ActaUrolJap_71_9_313","url":null,"abstract":"We report a case of paratesticular rhabdomyosarcoma in a one-year and nine-months old male infant. The patient presented with an asymptomatic enlargement of the right scrotum. Ultrasonography indicated a solid mass 3 cm in size in the right scrotum. Computed tomography and magnetic resonance imaging revealed a right testicular tumor with no distant metastases. Serum lactate dehydrogenase, human chorionic gonadotrophin beta, and alpha-fetoprotein were within normal limits. Although surgical treatment was scheduled based on the diagnosis of the testicular tumor, the patient had a high fever with a viral infection, and the surgery was postponed. The tumor rapidly progressed to 7 cm in size within one month. High orchiectomy was performed, and histopathological examination confirmed a paratesticular rhabdomyosarcoma. The patient received adjuvant chemotherapy with vincristine sulfate, actinomycin D, and cyclophosphamide. There was no recurrence one year post-surgery. Paratesticular rhabdomyosarcoma commonly occurs in the paratesticular tissues of pediatric patients. This case highlights the importance of the differential diagnosis of paratesticular rhabdomyosarcoma other than testicular tumor for painless scrotal masses in infants and the requirement for multidisciplinary management in pediatrics.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 9","pages":"313-318"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Vaginal and Vulval Secondary Extramammary Paget's Disease Associated with Urothelial Carcinoma in Situ : A Case Report]. [阴道和外阴继发性乳腺外佩吉特病合并尿路上皮原位癌1例报告]。

Acta Urologica Japonica Pub Date : 2025-09-01 DOI: 10.14989/ActaUrolJap_71_9_301

Hikaru Tsukada, Nozomi Hayakawa, Masahide Sasaki, Keisuke Matsubara, Ryuji Yamada, Naoto Aoki, Koichiro Aida, Ryuto Nakazawa, Kazunobu Shinoda, Masatomo Doi, Tatsuru Ohara, Nao Suzuki, Junki Koike, Eiji Kikuchi

{"title":"[Vaginal and Vulval Secondary Extramammary Paget's Disease Associated with Urothelial Carcinoma in Situ : A Case Report].","authors":"Hikaru Tsukada, Nozomi Hayakawa, Masahide Sasaki, Keisuke Matsubara, Ryuji Yamada, Naoto Aoki, Koichiro Aida, Ryuto Nakazawa, Kazunobu Shinoda, Masatomo Doi, Tatsuru Ohara, Nao Suzuki, Junki Koike, Eiji Kikuchi","doi":"10.14989/ActaUrolJap_71_9_301","DOIUrl":"https://doi.org/10.14989/ActaUrolJap_71_9_301","url":null,"abstract":"The patient is an 80-year-old woman who initially underwent transurethral resection of a bladder tumor (TURBT) 7 years ago for bladder cancer at another hospital and was diagnosed with urothelial carcinoma (UC), high grade, pT1, followed by 8 cycles of intravesical BCG instillation therapy. Subsequently, her voiding urine cytology began to show suspicion of malignancy. When voiding urine cytology started to show positive findings, two transurethral biopsies of bladder mucosae and one selective upper tract urine cytology were performed with no evidence of malignancy, so she was followed up as an outpatient. She began experiencing spontaneous pain near the urethra and pain on urination 5 years after the initial TURBT. At this time, cystoscopy revealed redness on the posterior bladder wall. Additionally, redness of the vagina and induration of the labia were observed, raising suspicion of Paget's disease or Bowen's disease. She underwent a biopsy of the vulvar, which revealed UC. Ultimately, biopsies of the bladder, urethra, and vulvovaginal regions were performed at our hospital to determine a treatment plan. Immunohistochemical staining of the vulva was positive for cytokeratins 7 and 20 and negative for GCDFP15, confirming a diagnosis of extramammary Paget disease secondary to bladder CIS. As a result, the patient underwent radical surgery, including removal of the vagina, uterus, bladder, and labia. Pathological findings showed extensive CIS in the vagina and labia majora. Herein, we report a very rare case of secondary extramammary Paget disease extending from bladder CIS to the vagina and labia.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 9","pages":"301-305"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Renal Myopericytoma]. 【肾肌外皮细胞瘤1例】。

Acta Urologica Japonica Pub Date : 2025-09-01 DOI: 10.14989/ActaUrolJap_71_9_295

Maki Nakamura, Yukiyoshi Hirayama, Ryo Katsube, Kaoru Kimura, Akinori Minami, Syunji Nishide, Tomohiro Hasaka, Chikako Nishihara, Toshihiro Asai, Keiichi Ishii, Sadanori Kamikawa

引用次数: 0

[Paratesticular Fibrous Pseudotumor Difficult to Differentiate from Testicular Tumor --Case Report-]. [难以与睾丸肿瘤鉴别的睾丸旁纤维性假瘤- 1例报告]。

Acta Urologica Japonica Pub Date : 2025-09-01 DOI: 10.14989/ActaUrolJap_71_9_307

Shimpei Yoshioka, Seiji Nagasawa, Yohei Kaizuka, Takashi Ito, Yoshikazu Togo

{"title":"[Paratesticular Fibrous Pseudotumor Difficult to Differentiate from Testicular Tumor --Case Report-].","authors":"Shimpei Yoshioka, Seiji Nagasawa, Yohei Kaizuka, Takashi Ito, Yoshikazu Togo","doi":"10.14989/ActaUrolJap_71_9_307","DOIUrl":"https://doi.org/10.14989/ActaUrolJap_71_9_307","url":null,"abstract":"A 74-year-old male patient presented with painless enlargement of the right scrotum that had persisted for three months. His past medical history included a gastrojejunostomy for metastatic gastric cancer and laparoscopic right inguinal hernia repair. Tumor markers were negative. However, an ultrasound examination revealed a mosaic-patterned mass measuring 4 cm in diameter within the scrotum, while an enhanced mass within the right scrotum was shown by contrast-enhanced computed tomography, raising suspicion of a malignant tumor. Consequently, a right high orchiectomy procedure was performed. Following surgery, histopathological examination results showed nodules composed of proliferating fibroblasts and collagen fibers surrounding the affected testis, which included bundles of smooth muscle and bony fragments within. Mild chronic inflammatory cell infiltration, including lymphocytes, plasma cells, and eosinophils, was also noted extending from the perivascular region to the stroma. As a result, a diagnosis of paratesticular fibrous pseudotumor was determined. Findings obtained in the present case revealed a rare condition and indicate that paratesticular fibrous pseudotumor should be considered as a differential diagnosis when a testicular tumor condition is suspected.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 9","pages":"307-311"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A Case of Prepubertal-Type Teratoma in a Male Adult : Importance of a Definitive Diagnosis by the Fish Method]. [1例男性成人青春期前型畸胎瘤：Fish法明确诊断的重要性]。

Acta Urologica Japonica Pub Date : 2025-08-01 DOI: 10.14989/ActaUrolJap_71_8_267

Toshiyasu Amano, Akitaka Aoki, Yuki Matsumoto, Tetsuya Imao, Shiori Ohshima, Midori Sato

{"title":"[A Case of Prepubertal-Type Teratoma in a Male Adult : Importance of a Definitive Diagnosis by the Fish Method].","authors":"Toshiyasu Amano, Akitaka Aoki, Yuki Matsumoto, Tetsuya Imao, Shiori Ohshima, Midori Sato","doi":"10.14989/ActaUrolJap_71_8_267","DOIUrl":"https://doi.org/10.14989/ActaUrolJap_71_8_267","url":null,"abstract":"Teratomas are broadly classified according to the presence or absence of germ cell neoplasia in situ (GCNIS), which is defined as neoplastic germ cell proliferation in the seminiferous tubules. Postpubertaltype teratoma is classified into a germ cell tumor derived from GCNIS, and it is malignant in adults. However, a prepubertal teratoma is classified as a germ cell tumor unrelated to GCNIS. It is common in children and has a benign course. We report a case in a 60-year-old man who had been aware of a nodule in his left scrotum for 15 years, and felt heaviness and pain from a few months before he visited a specialist. He visited a local urologist and was referred to our department under the diagnosis of a left testicular tumor in February 202X. In March 202X, he underwent a left high orchiectomy. A 12×5 mm white mass lesion was observed, and a pathological examination showed intestinal epithelial and bronchial epithelial structures. Additionally, no GCNIS was found in background seminiferous tubules. There was no amplification of chromosome 12 short arm as shown by the fluorescence in situ hybridization method. On the basis of these pathological findings, prepubertal-type teratoma was diagnosed in this patient.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 8","pages":"267-270"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Two Cases of Obstructive Pyelonephritis with Hyperammonemia Causing Impaired Consciousness]. [梗阻性肾盂肾炎伴高氨血症致意识障碍2例]。

Acta Urologica Japonica Pub Date : 2025-08-01 DOI: 10.14989/ActaUrolJap_71_8_271

Takao Haitani, Daisuke Takahashi, Shigeki Koterazawa, Shinya Somiya, Yoshihito Higashi, Masaaki Imamura

{"title":"[Two Cases of Obstructive Pyelonephritis with Hyperammonemia Causing Impaired Consciousness].","authors":"Takao Haitani, Daisuke Takahashi, Shigeki Koterazawa, Shinya Somiya, Yoshihito Higashi, Masaaki Imamura","doi":"10.14989/ActaUrolJap_71_8_271","DOIUrl":"https://doi.org/10.14989/ActaUrolJap_71_8_271","url":null,"abstract":"We herein report two cases of obstructive pyelonephritis with hyperammonemia causing impaired consciousness. One patient was a 79-year-old female. She was admitted for impaired consciousness and hematuria. Computed tomography (CT) revealed left hydronephrosis and hydroureter indicating obstructive pyelonephritis and her ammonia in the blood was a high level of 208 μg/dl. Her consciousness did not change immediately but improved 10 days after ureteral catheterization. The other patient was an 88-year-old female. She was also admitted for impaired consciousness and hematuria. CT revealed right hydronephrosis and an ureteral stone causing obstructive pyelonephritis and her ammonia level in the blood was a high level of 133 μg/dl. Her consciousness did not change immediately but improved 7 days after ureteral catheterization. Hyperammonemia in patients with obstructive pyelonephritis is a rare entity that can be occasionally observed. In patients with prolonged impaired consciousness due to urinary tract infections, clinicians should consider the possibility of hyperammonemia.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 8","pages":"271-275"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Testicular Sperm Extraction in an Unmarried Male Patient with Spinal Cord Injury : A Case Report]. 【未婚男性脊髓损伤患者睾丸精子抽取1例】。

Acta Urologica Japonica Pub Date : 2025-08-01 DOI: 10.14989/ActaUrolJap_71_8_277

Tetsuji Soda, Fumie Yoshioka, Yushi Miyata, Hiroshi Kiuchi, Kenichiro Sekii

{"title":"[Testicular Sperm Extraction in an Unmarried Male Patient with Spinal Cord Injury : A Case Report].","authors":"Tetsuji Soda, Fumie Yoshioka, Yushi Miyata, Hiroshi Kiuchi, Kenichiro Sekii","doi":"10.14989/ActaUrolJap_71_8_277","DOIUrl":"https://doi.org/10.14989/ActaUrolJap_71_8_277","url":null,"abstract":"Spinal cord injury (SCI) patients often develop erectile dysfunction and ejaculatory dysfunction, and prolonged post-injury time can be complicated by impaired spermatogenesis. To obtain sperm, penile vibratory stimulation, electroejaculation or testicular sperm extraction (TESE) are required, followed by cryopreservation of the spermatozoa. This is a large physical and financial burden for SCI patients who wish to have children. In this report, we describe a case in which conventional TESE was performed in an unmarried male SCI patient. The patient was a 32-year-old male who suffered a cervical subluxation in a traffic accident when he was 23 years old, resulting in sensory and motor paralysis of the lower half of his body and motor paralysis and contracture of his fingers. He was unmarried but wanted to preserve his sperm for future use. With the diagnosis of obstructive azoospermia, conventional TESE was considered necessary. However, due to the risk of autonomic hyperreflexia, general anesthesia was required. Conventional TESE under general anesthesia was performed and motile spermatozoa were obtained from one testis. The sperm was cryopreserved at a fertility clinic. The mean Johnsen's score of the tissue was 10.0. Since the patient was an unmarried male and the purpose of the procedure was sperm preservation for future use, Japanese medical insurance did not cover these examinations, hospitalization and surgery costs. The financial burden of performing TESE and sperm preservation in unmarried male SCI patients is considerable. Even if infertility treatment is covered by medical insurance in Japan, this is still an issue that should be considered.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 8","pages":"277-279"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Thoracoabdominal Approach for Retroperitoneal Liposarcoma Involving the Diaphragm : A Case Report]. 胸腹入路治疗累及膈肌的腹膜后脂肪肉瘤1例。

Acta Urologica Japonica Pub Date : 2025-08-01 DOI: 10.14989/ActaUrolJap_71_8_261

Kazuro Kikkawa, Toshifumi Takahashi, Kouhei Maruno, Ryota Nakayasu, Yuya Yamada, Masakazu Nakashima, Masahiro Tamaki, Noriyuki Ito

{"title":"[Thoracoabdominal Approach for Retroperitoneal Liposarcoma Involving the Diaphragm : A Case Report].","authors":"Kazuro Kikkawa, Toshifumi Takahashi, Kouhei Maruno, Ryota Nakayasu, Yuya Yamada, Masakazu Nakashima, Masahiro Tamaki, Noriyuki Ito","doi":"10.14989/ActaUrolJap_71_8_261","DOIUrl":"https://doi.org/10.14989/ActaUrolJap_71_8_261","url":null,"abstract":"An 81-year-old man presented to our hospital with left lower back pain. The computed tomographic scan revealed a retroperitoneal tumor with a heterogeneous contrast effect. Magnetic resonance imaging scan showed that the tumor was suspected to have invaded the left diaphragm, iliopsoas muscle, and pancreas, and an unclear boundary between the tumor and left kidney. Based on these findings, a left retroperitoneal sarcoma or renal carcinoma was suspected. A left retroperitoneal tumor resection, combined with left nephrectomy, was performed. A thoracoabdominal approach was chosen due to suspected diaphragmatic invasion and the need for an adequate operative field on the cephalic side of the kidney. The tumor was resected along with the left kidney, a portion of the diaphragm, and a portion of the iliopsoas muscle, without pancreatic resection. Pathological examination confirmed a dedifferentiated liposarcoma. No intraoperative or postoperative complications were encountered. Surgical resection with a negative surgical margin is crucial for the treatment of retroperitoneal liposarcoma. The thoracoabdominal approach provides excellent surgical exposure and allows for early vascular control. Although the thoracoabdominal approach is rarely used in urological surgery due to concern about the morbidity associated with violating the thoracic cavity, it can be performed effectively and safely for large or invasive retroperitoneal tumors in select cases requiring maximal surgical resection.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"71 8","pages":"261-265"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0