Acta Urologica Japonica最新文献_第3页

[PEMBROLIZUMAB-ASSOCIATED MYOCARDITIS FOLLOWED BY STEROID MYOPATHY IN A PATIENT WITH RENAL CELL CARCINOMA]. [肾细胞癌患者的派姆单抗相关性心肌炎并发类固醇肌病]。

Acta Urologica Japonica Pub Date : 2026-04-01 DOI: 10.82687/actaurojp.72.4_125

Yuki Nagano, Yukiyoshi Hirayama, Kouhei Iwamoto, Katsuya Takahashi, Kaoru Kimura, Syunji Nishide, Tomohiro Hasaka, Chikako Nishihara, Toshihiro Asai, Keiichi Ishii, Sadanori Kamikawa

{"title":"[PEMBROLIZUMAB-ASSOCIATED MYOCARDITIS FOLLOWED BY STEROID MYOPATHY IN A PATIENT WITH RENAL CELL CARCINOMA].","authors":"Yuki Nagano, Yukiyoshi Hirayama, Kouhei Iwamoto, Katsuya Takahashi, Kaoru Kimura, Syunji Nishide, Tomohiro Hasaka, Chikako Nishihara, Toshihiro Asai, Keiichi Ishii, Sadanori Kamikawa","doi":"10.82687/actaurojp.72.4_125","DOIUrl":"10.82687/actaurojp.72.4_125","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) are increasingly used as adjuvant therapy in high-risk renal cell carcinoma (RCC), but may cause serious immune-related adverse events, such as myocarditis. We report a rare case of myocarditis followed by steroid-induced myopathy during adjuvant pembrolizumab therapy. A 74-year-old man underwent partial and radical nephrectomy for bilateral clear cell RCC (pT1b and pT3a). Pembrolizumab was initiated postoperatively. On day 22, he developed exertional fatigue and cardiac enzyme levels were elevated. Myocardial biopsy confirmed myocarditis, and corticosteroid pulse therapy was started. Although cardiac markers improved initially, they rose again, requiring a second steroid pulse and higher maintenance doses. After 27 days of steroid therapy, the patient developed severe proximal muscle weakness. Myasthenia gravis and other autoimmune diseases were excluded. Steroid-induced myopathy was diagnosed, and steroid tapering plus rehabilitation led to functional recovery. He was later discharged without recurrence of myocarditis. This case highlights the importance of early detection and treatment of ICI-related myocarditis and awareness of secondary complications such as steroid myopathy. Multidisciplinary care is essential in managing these rare but serious conditions.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"72 4","pages":"125-129"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A CASE OF CASTRATION-RESISTANT PROSTATE CANCER ASSOCIATED WITH HEREDITARY BREAST-OVARIAN CANCER SYNDROME SHOWING LONG-TERM RESPONSE TO A POLY-ADP RIBOSE POLYMERASE INHIBITOR]. [一例与遗传性乳腺癌综合征相关的去势抵抗性前列腺癌对多聚腺苷核糖聚合酶抑制剂有长期反应]。

Acta Urologica Japonica Pub Date : 2026-04-01 DOI: 10.82687/actaurojp.72.4_131

Tetsuya Imamura, Yuuka Tsuji, Kaho Deguchi, Yoshinaga Okugawa

{"title":"[A CASE OF CASTRATION-RESISTANT PROSTATE CANCER ASSOCIATED WITH HEREDITARY BREAST-OVARIAN CANCER SYNDROME SHOWING LONG-TERM RESPONSE TO A POLY-ADP RIBOSE POLYMERASE INHIBITOR].","authors":"Tetsuya Imamura, Yuuka Tsuji, Kaho Deguchi, Yoshinaga Okugawa","doi":"10.82687/actaurojp.72.4_131","DOIUrl":"10.82687/actaurojp.72.4_131","url":null,"abstract":"The patient was a 69-year-old male. Eight years ago, he underwent radical prostatectomy for locally advanced prostate cancer at another hospital, and then underwent endocrine therapy due to biochemical recurrence. Five years later, progression to castration-resistant prostate cancer was confirmed, and abiraterone treatment was started. Macroscopic hematuria persisted, so he visited our department. Magnetic resonance imaging revealed a mass at the bladder neck. A tissue biopsy was performed, and prostate cancer was identified. The patient was diagnosed with local recurrence at the prostatectomy site. Salvage radiotherapy with a total dose of 70. 2 Gy was promptly administered. The recurrent lesion subsequently disappeared on imaging ; however, shortly thereafter, multiple liver metastases were detected on computed tomography. Treatment with docetaxel was initiated. The liver metastases promptly disappeared thereafter, and the prostate specific antigen (PSA) level decreased to 0.001 ng/ml. Since then, 17 courses were administered. Docetaxel was effective ; however, the patient's bone marrow function, indicated that the treatment was approaching its limit, and a gene panel test, Foundation One-CDx, was performed. Inactivating mutations in BRCA2 were identified. The diagnosis made was prostate cancer associated with hereditary breast and ovarian cancer syndrome. The patient was started on olaparib, a poly (ADP-ribose) polymerase inhibitor. To date, his PSA level has remained below 0.001 ng/ml. He has been taking the medication for more than 42 months without any side effects, and imaging studies have consistently shown a complete response.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"72 4","pages":"131-135"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Testicular Leydig Cell Tumor Incidentally Detected on Computed Tomography : A Case Report]. 计算机断层扫描偶然发现睾丸间质细胞瘤1例。

Acta Urologica Japonica Pub Date : 2026-03-01 DOI: 10.82687/actaurojp.72.3_103

Kazuki Shiobara, Shinsuke Mizoguchi, Toru Inakawa, Ryo Ishiyama, Arisa Wada, Hiroshi Kobayashi

{"title":"[Testicular Leydig Cell Tumor Incidentally Detected on Computed Tomography : A Case Report].","authors":"Kazuki Shiobara, Shinsuke Mizoguchi, Toru Inakawa, Ryo Ishiyama, Arisa Wada, Hiroshi Kobayashi","doi":"10.82687/actaurojp.72.3_103","DOIUrl":"10.82687/actaurojp.72.3_103","url":null,"abstract":"A 58-year-old man was referred to our department for further evaluation of an incidental right intratesticular mass detected on abdominal and pelvic contrast-enhanced computed tomography performed for an unrelated condition. The mass measured approximately 13 mm and was not clearly palpable on physical examination. Scrotal magnetic resonance imaging showed a well-defined, lobulated, and multinodular mass within the right testis. As a malignant testicular tumor could not be excluded, a right high inguinal orchiectomy was performed for diagnostic and therapeutic purposes. Macroscopically, the excised specimen contained a solid yellow-white mass measuring 16×13×12 mm. Histopathological examination revealed proliferation of tumor cells with round nuclei and eosinophilic cytoplasm. Immunohistochemical staining showed that the tumor cells were positive for calretinin, focally positive for Melan-A, and negative for SALL4. Based on these findings, the diagnosis of a Leydig cell tumor of the testis was made. The patient's postoperative course was uneventful, and no evidence of local recurrence or distant metastasis was observed during 9 months of follow-up. Leydig cell tumors are rare, accounting for approximately 1-3% of all testicular tumors. To our knowledge, this case represents the 128th reported case of testicular Leydig cell tumor in Japan. We report this rare case and provide a review of the literature.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"72 3","pages":"103-107"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Single-Institution Experience with 25 Cases of Extragonadal Germ Cell Tumors]. [单院25例生殖道外生殖细胞瘤的治疗体会]。

Acta Urologica Japonica Pub Date : 2026-03-01 DOI: 10.82687/actaurojp.72.3_97

Takehiro Yamane, Takeshi Sano, Takeyuki Watanabe, Takashi Matsuoka, Yuki Kita, Jin Kono, Kimihiko Masui, Takayuki Goto, Atsuro Sawada, Shusuke Akamatsu, Takashi Kobayashi

引用次数: 0

[A Case of Emphysematous Cystitis with Air Bubbles in the Vena Cava, Pulmonary Artery and Brachiocephalic Vein]. 肺气肿性膀胱炎伴腔静脉、肺动脉、头臂静脉气泡1例。

Acta Urologica Japonica Pub Date : 2026-03-01 DOI: 10.82687/actaurojp.72.3_113

Satoshi Kondo, Syuya Kandori, Takuma Kanazawa, Satoka Kinase, Ryutaro Ishitsuka, Tsuyoshi Endo, Masakazu Tsutsumi, Hiroyuki Nishiyama

{"title":"[A Case of Emphysematous Cystitis with Air Bubbles in the Vena Cava, Pulmonary Artery and Brachiocephalic Vein].","authors":"Satoshi Kondo, Syuya Kandori, Takuma Kanazawa, Satoka Kinase, Ryutaro Ishitsuka, Tsuyoshi Endo, Masakazu Tsutsumi, Hiroyuki Nishiyama","doi":"10.82687/actaurojp.72.3_113","DOIUrl":"10.82687/actaurojp.72.3_113","url":null,"abstract":"A 78-year-old woman came to our emergency room because of loss of consciousness. Blood tests showed an elevated inflammatory response, and a computed tomography (CT) scan showed emphysematous cystitis. In addition, air bubbles were observed in the inferior vena cava, pulmonary artery, and brachiocephalic vein. We considered that they came from emphysematous cystitis. After admission to our hospital, we started antibiotics, placed a urethral catheter, and controlled the hyperglycemia. The patient's emphysematous cystitis resolved, and a CT scan performed on the 9th day of her hospitalization showed the disappearance of air bubbles. Emphysematous cystitis is caused by the accumulation of gas produced by gas-producing bacteria in the bladder wall or bladder cavity. It is a relatively rare disease with a high mortality rate of about 2-7%. Emphysematous cystitis with air bubbles in the venous system is rare. To our knowledge this is the first report of air bubbles in the brachiocephalic vein. In this report, we describe a case of emphysematous cystitis with air bubbles in the inferior vena cava, pulmonary artery and brachiocephalic vein.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"72 3","pages":"113-116"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Negative Pressure Wound Therapy for Fournier's Gangrene in the Inguinal Region : A Case Report]. 负压创面治疗腹股沟区富尼耶坏疽1例

Acta Urologica Japonica Pub Date : 2026-03-01 DOI: 10.82687/actaurojp.72.3_109

Kaho Deguchi, Tetsuya Imamura, Shusuke Morikawa

引用次数: 0

[Bladder Pain Syndrome Associated with Detrusor Underactivity and Bladder Outlet Obstruction : A Case Report]. 膀胱疼痛综合征伴逼尿肌活动不足和膀胱出口梗阻1例。

Acta Urologica Japonica Pub Date : 2026-03-01 DOI: 10.82687/actaurojp.72.3_117

Nodoka Kozen, Yuki Kyoda, Kohei Hashimoto, Ko Kobayashi, Toshiaki Tanaka, Naoya Masumori

引用次数: 0

[A Case of Cellular Angioﬁbroma Presenting as a Giant Scrotal Tumor]. 细胞血管纤维瘤表现为巨大的阴囊肿瘤1例。

Acta Urologica Japonica Pub Date : 2026-02-01 DOI: 10.82687/actaurojp.72.2_83

Akihiro Hoshiyama, Kasumi Kanai, Yuka Kono, Keiyu Matsumoto, Jin Kono, Satoshi Ishitoya, Yasumasa Shichiri, Tomoko Okuno, Kenichi Kohashi

引用次数: 0

[A Case of Urethral Calculi Treated by Transurethral Surgery Due to Mesh Exposure in the Urethra Following a Tension-Free Vaginal Tape Procedure]. [一例经尿道手术治疗尿道结石，原因是阴道无张力胶带手术后尿道网暴露]。

Acta Urologica Japonica Pub Date : 2026-02-01 DOI: 10.82687/actaurojp.72.2_89

Yuji Yata, Sumire Santo, Takuya Hagiwara, Junya Hara, Kazuaki Yamaga, Hakaru Masumoto, Tomohiro Hongo, Takashi Yoshioka, Tomoya Yamasaki, Kei Fujio, Hideo Otsuki

{"title":"[A Case of Urethral Calculi Treated by Transurethral Surgery Due to Mesh Exposure in the Urethra Following a Tension-Free Vaginal Tape Procedure].","authors":"Yuji Yata, Sumire Santo, Takuya Hagiwara, Junya Hara, Kazuaki Yamaga, Hakaru Masumoto, Tomohiro Hongo, Takashi Yoshioka, Tomoya Yamasaki, Kei Fujio, Hideo Otsuki","doi":"10.82687/actaurojp.72.2_89","DOIUrl":"10.82687/actaurojp.72.2_89","url":null,"abstract":"A 66-year-old female patient visited another hospital complaining of frequent urination. Computed tomography scan revealed a 3 cm urethral stone, and she was referred to our hospital for surgery. The patient had a history of tension-free vaginal tape (TVT) surgery for stress urinary incontinence approximately 15 years ago. When transurethral lithotripsy was initiated, the lower end of the stone was found near the external urethral meatus, and an attempt to push it into the bladder was unsuccessful. When fragmentation of the stone was performed using a Ho-YAG laser, exposure of the mesh, presumably from the previous TVT surgery, was detected. A loop electrocautery was used to remove as much of the exposed mesh and the stone as possible. Cystoscopic observation was not possible, but no stone recurrence or mesh-related complications have been noted six months after the surgery. Cases of urethral stones caused by mesh exposure in the urethra after TVT are rare, and we report this case together with a literature review.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"72 2","pages":"89-92"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clinical Experience with Colovesical and Rectovesical Fistulas : A Case Series from Rakuwakai Otowa Hospital]. [膀胱瘘和直肠膀胱瘘的临床经验：Rakuwakai Otowa医院病例系列]。

Acta Urologica Japonica Pub Date : 2026-02-01 DOI: 10.82687/actaurojp.72.2_75

Kazuto Imai, Norihiko Masuda, Kanji Nagahama, Toshiya Akao

{"title":"[Clinical Experience with Colovesical and Rectovesical Fistulas : A Case Series from Rakuwakai Otowa Hospital].","authors":"Kazuto Imai, Norihiko Masuda, Kanji Nagahama, Toshiya Akao","doi":"10.82687/actaurojp.72.2_75","DOIUrl":"10.82687/actaurojp.72.2_75","url":null,"abstract":"Colovesical and rectovesical fistulas are relatively rare, and there is no consensus on the gold standard for diagnostic workup and treatment. Here we retrospectively analyzed clinical courses from four patients with colovesical or rectovesical fistulas diagnosed at our hospital between January 2024 and December 2024. Among the four cases, three were male, and one was female. Fever was the chief complaint in three of the four cases, and sigmoid diverticulitis was identified as the underlying disease in two cases. All patients underwent abdominal plain CT scan and cystoscopy. CT scan revealed intravesical air in all cases. In one case, there was a discrepancy between the fistula location identified on CT and cystoscopic findings. One patient underwent laparoscopic sigmoidectomy as curative treatment, with an uneventful postoperative course. In the three cases managed conservatively, laparoscopic colostomy was performed, and postoperative complications such as urinary tract infection and urethral catheter obstruction occurred. In our case series, cystoscopy was useful for assessing the fistula location accurately. Preoperative evaluation with cystoscopy should be considered, especially in patients scheduled for curative surgery.","PeriodicalId":39291,"journal":{"name":"Acta Urologica Japonica","volume":"72 2","pages":"75-78"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0