South Dakota medicine : the journal of the South Dakota State Medical Association最新文献

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2024 Scholars' Research Symposium Abstract: Effect of COVID-19 Pandemic on Routine Pediatric Vaccination Rates in 7 Upper Midwestern States. 摘要:2019冠状病毒病大流行对中西部7个州儿童常规疫苗接种率的影响。
Benjamin P Eastman
{"title":"2024 Scholars' Research Symposium Abstract: Effect of COVID-19 Pandemic on Routine Pediatric Vaccination Rates in 7 Upper Midwestern States.","authors":"Benjamin P Eastman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic stressed healthcare systems by increasing patient loads and creating shortages of both staffing and medical supplies. As a result, the process of administering routine pediatric vaccinations was affected. Multiple studies have reported ongoing decreases in vaccination opportunities. Completed vaccinations on the vaccination schedule for the pediatric population is a highly effective public health intervention and therefore should be maintained at high rates. Decreases in routine pediatric vaccinations could lead to the spread of multiple infectious diseases. The aim of this study is to assess the impact the COVID-19 pandemic had on routine pediatric vaccination rates in South Dakota and surrounding states.</p><p><strong>Methods: </strong>ChildVaxView, a publicly available and de-identified dataset, was utilized in this research. The initial focus of this study was the vaccination rates for the state of South Dakota. To give context for vaccination rates for this state, responses of participants from South Dakota as well as those from the surrounding states of Iowa, North Dakota, Nebraska, Minnesota, Montana, and Wyoming from 2012-2022 were utilized for this project. The data was divided into 2 cohorts: \"pre-pandemic vaccination\" and \"intra-pandemic vaccination\". The rates of 5 different vaccinations from these 7 states were analyzed. The basic analysis method was an independent samples test of proportions which compared the \"pre-pandemic\" and \"intra-pandemic\" vaccination rates. P-values ≤ 0.05 were considered statistically significant.</p><p><strong>Results: </strong>Responses compared the vaccination rates of the \"pre-pandemic\" period to the \"intra-pandemic\" period for all 7-states examined. OR values and 95% CI values are shown, where values less than 1 indicate higher \"intra-pandemic\" rates. In terms of 24-month PCV rates, Iowa (OR=0.76, 95%CI:0.60-0.97), Montana (OR=0.75, 95%CI:0.61-0.93), Nebraska (OR=0.77, 95%CI:0.61-0.99), and North Dakota (OR=0.77,95%CI:0.61-0.96) had higher \"intra-pandemic\" rates; Wyoming, South Dakota, and Minnesota showed no difference. For the 24-month polio vaccine, Montana had significantly higher \"intra-pandemic\" rates (OR=0.73,95%CI:0.54-0.98); the remaining states showed no difference. For the 24-month DTaP vaccine, North Dakota (OR=0.84, 95%CI:0.72-0.98), MT (OR=0.84, 95%CI:0.72-0.97), and Wyoming (OR=0.84, 95%CI:0.73-0.97) had significantly higher \"intra-pandemic\" vaccination rates, with no difference for the other states. The 6 surrounding states did not differ from South Dakota in polio vaccination rates \"pre-pandemic\" (p=0.54) nor \"intra-pandemic\" (p=0.36); there was additionally no difference between those states and South Dakota in the \"pre-\" vs \"intra-pandemic\" comparison (p=0.27). Similar results were seen for other vaccines.</p><p><strong>Conclusions: </strong>In this study, rates of a substantial proportion of pediatric vaccinations increased in t","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"77 9","pages":"396"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eczema Herpeticum: A Fatal Rash That Mimics Many. 疱疹性湿疹:一种致命的皮疹,模仿许多。
Amanda Ricke, Kristi Pond, Peter Paul Lim
{"title":"Eczema Herpeticum: A Fatal Rash That Mimics Many.","authors":"Amanda Ricke, Kristi Pond, Peter Paul Lim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Eczema herpeticum (EH) is a potentially life-threatening condition, especially in the pediatric population, that occurs among patients with atopic dermatitis (AD). AD is a chronic inflammatory skin disorder with a complex pathophysiology that predisposes patients to EH. Herpes simplex virus (HSV) 1 is implicated in 90 % of EH cases and often initially presents with gingivostomatitis. HSV 1 can also lead to more systemic disease such as keratoconjunctivitis, meningitis, encephalitis, and hepatitis. Rapid diagnosis of EH is vital, and prompt treatment is essential to preclude these complications. We describe a 5-month-old male with poorly controlled atopic dermatitis who presented with generalized polymorphic rash diagnosed with EH and superimposed MSSA cellulitis. This clinical scenario, while not uncommon, is often missed and underlies the importance of a strong clinical suspicion for EH among patients with AD presenting with complicated rash. EH is an infectious complication that is easily misdiagnosed causing treatment delays that lead to dire consequences. This report also includes an abridged review of literature on EH.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"77 9","pages":"412-417"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prescription for Connection: Engaging Generation Z Medical Students in Today's Learning Environment. 联系的处方:在今天的学习环境中吸引Z世代医学生。
Alan Sazama
{"title":"Prescription for Connection: Engaging Generation Z Medical Students in Today's Learning Environment.","authors":"Alan Sazama","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"77 9","pages":"386"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2024 Scholars' Research Symposium Abstract: Retrospective Cohort Study of Pediatric COVID-19 in a Rural Integrated Health System. 摘要:农村综合卫生系统儿童COVID-19回顾性队列研究。
Jamuna Buchanan
{"title":"2024 Scholars' Research Symposium Abstract: Retrospective Cohort Study of Pediatric COVID-19 in a Rural Integrated Health System.","authors":"Jamuna Buchanan","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The spread of the SARS-CoV-2 virus, which caused Coronavirus Disease 2019 (COVID-19), led to a global pandemic and public health crisis, which affected the physical health and mental well-being of Americans in every part of the country. Although the effect of the pandemic was ubiquitous, it has been more extensively studied in urban areas, which leads to an underscoring of the burden of COVID-19 in rural US. Health disparities adversely affect children in rural communities, each of which is unique and requires interventions based on regional needs. Characterization of COVID-19 disease in the pediatric population in rural areas is important for the development of protocols to address future surges of COVID-19 cases by the local health systems.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study is a retrospective, cross-sectional chart review of 86 children hospitalized with the diagnosis of COVID-19 at three different hospitals that are part of an integrated rural health system in North and South Dakota. The population demographics of the surveyed states included Caucasian (84.2% SD; 86.6% ND), Native American (8.6% SD; 4.9% ND), Black (2.6% SD; 3.6% ND), and Asian (1.8% SD; 1.7% ND). All the charts identified from the EMR by filtering for patients hospitalized between October 2020 and May 2021, with an age less than 18 years, and with the ICD-10 code for COVID-19 infection were reviewed. Patients with Multi-system Inflammatory Syndrome in Children were excluded.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;More than half of the patients identified as Caucasian (58%), (24%) as Native American, (12%) as Black/ African American, (5%) as Asian, and (1%) were unidentified. The median age was 12 years. Almost half of the patients, 42%, had a significant past medical history, defined as having one or more of the following diagnoses: asthma, diabetes mellitus, or immunodeficiency. The most common comorbidity was an elevated BMI&gt;25 noted in 31 patients of which 11 (13%) were overweight and 20 (23%) were obese. 18 patients (22%) were admitted to the ICU with a median length of ICU-stay of 3.5 days. 34 patients (40%) required oxygen supplementation with a median length duration of 3-days. 8 patients (9%) required intubation. The median length of mechanical ventilation support was 3-days. There were no deaths.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;It was interesting to note that in this study, pediatric patients with SARS-CoV-2 infection requiring hospitalization were disproportionately represented by minority groups (Native Americans, Blacks, and Asians) when compared to the proportion in the population. The predominance of Caucasian patients however was reflective of the general population of the surveyed states. Almost half the patients had one or more of the following diagnoses: asthma, diabetes mellitus, or immunodeficiency, risk factors previously identified for COVID-19. A common comorbidity among the patients studied was increased BMI, whi","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"77 9","pages":"394"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2024 Scholars' Research Symposium Abstract: Characteristics of Play Associated with Head Impact Severity During Tackling in Youth Football. 摘要:青少年足球铲球过程中与头部撞击严重程度相关的比赛特征。
Meaghan Sievers
{"title":"2024 Scholars' Research Symposium Abstract: Characteristics of Play Associated with Head Impact Severity During Tackling in Youth Football.","authors":"Meaghan Sievers","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>In the last decade, concussions and subconcussive brain trauma in football and other high impact sports have become of increasing concern. Tackling, in youth football, accounts for a high proportion of head impacts and injuries, including concussions. Thus, minimizing head impact severity during tackling may help in reducing concussion risk and subconcussive brain trauma. However, it is unknown how discrete aspects of play in youth football relate to head impact severity during tackling.</p><p><strong>Methods: </strong>25 youth tackle football players (12.9 ± 0.6 yr) wore helmets outfitted with the Head Impact Telemetry (HIT) System during two football seasons (64 practices and 18 games). Measures of head impact severity, including linear acceleration (LA) and rotational acceleration (RA), were collected at each session, along with videography. Videos and HIT System data were cross analyzed using a validated rubric to code each registered head impact based on several pre-identified characteristics of play. Sample distributions of play characteristics were compared using the nonparametric Mann-Whitney U test. Level of significance for all tests was α = 0.05.</p><p><strong>Results: </strong>There were 1025 head impacts identified for players making a tackle or being tackled. LA of head impacts was significantly greater (p = 0.017) for players making a tackle (n = 614; 21.70 [16.40-30.13] g) than players being tackled (n = 411; 20.50 [15.90-30.10] g). In comparing head impacts on tackles, LA was significantly greater (p = 0.010) for special teams (n = 39; 29.10 [21.40-39.70] g) over defense (n = 348; 22.50 [16.90-31.55] g), and RA was significantly greater (p = 0.003) for special teams (n = 39; 2241 [1223-3175] rad ∙ sec-1) over defense (n = 348; RA = 1618 [1004-2293] rad ∙ sec-1). While being tackled, player-to-ground head impacts LA values (n = 102; 25.85 [18.65-35.13] g) were significantly greater (p less than 0.001) than player-to-player head impacts (n = 308; 19.75 [14.95-26.68] g), and player-to-ground head impacts RA values (n = 102; 1687 [1108-2690] rad ∙ sec-1) were significantly greater (p less than 0.001) than player-to-player head impacts (n = 308; 1313 [906-1832] rad ∙ sec-1).</p><p><strong>Conclusions: </strong>There are certain characteristics of play in youth football that were associated with higher magnitude head impacts during tackling, including being the tackler, special teams plays and head contact to the ground while being tackled. These characteristics of play may serve as targets for mitigation efforts aimed at reducing head impact severity in youth football.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"77 9","pages":"410"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2024 Scholars' Research Symposium Abstract: Assessing and Monitoring Competency of Medical Students as Simulation Educators Using Novel Rubric. 摘要:应用新量表对医学生作为模拟教育者的胜任力进行评估与监测。
Jennifer Lindgren Boleyn
{"title":"2024 Scholars' Research Symposium Abstract: Assessing and Monitoring Competency of Medical Students as Simulation Educators Using Novel Rubric.","authors":"Jennifer Lindgren Boleyn","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Physicians are life-long learners and life-long educators. Through their entire careers, they educate patients, residents, medical students, and other health care professionals. There is currently no requirement for medical schools in the United States to provide courses in teaching or communication. Healthcare academia has recognized this need, which resulted in development of peer-assisted teaching and learning programs. USD SSOM has created a Medical Students as Simulation Educators (MSASE) program that teaches medical students the foundational concepts of adult education and how to effectively use them in simulation-based teaching. USD SSOM has demonstrated that learners' outcomes were similar whether they were taught by clinical faculty or by senior medical students. USD SSOM developed a novel Simulation Teaching Academic Competency Evaluation Rubric (STACER). STACER is a complex, multi-domain instrument that assesses multiple aspects of teaching. It allows for granular assessment and tracking of student-instructors' progress as educators.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;MSASE enrolls 12-18 medical students per year. These students complete asynchronous modules that cover history of healthcare simulation, educational theories, simulation modalities, feedback and debriefing, assessment, and high-fidelity simulation (HFS). After completing the didactic portion, MSASE students participate in teaching junior medical students under the supervision of clinical faculty. During teaching, MSASE students are evaluated with the use of STACER. STACER consists of three written assessments: (1) learner evaluation of student-educators, (2) student-educator's self-assessment, and (3) clinical faculty evaluation of student-educators.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was a statistically significant correlation between the student learners' engagement during debriefing, as opposed to during the activity itself, and the perceived value of the activity. There was a statistically significant negative correlation between the student learners' perceived judgment during the activity and their perceived value of the activity (p = 0.0013), with less judgement correlating to a higher perceived value. While learners and educators shared a positive perspective on the close relationship between pathophysiology and pharmacology, faculty expressed a more critical viewpoint. One notable discrepancy emerged regarding the three cohort's agreement with the statement, \"theoretical concepts were linked to clinically relevant examples.\"&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;STACER is an effective instrument to measure medical students' teaching competencies over time. This data supports the position held by most simulation scholars, emphasizing the importance of engaging debriefing as an integral part of simulation-based learning. Fostering a nonjudgmental learning environment can contribute to a more valuable learning experience. Lastly, this ","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"77 9","pages":"393"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2024 Scholars' Research Symposium Abstract: Oral Health Education Enhancement For South Dakota Medical Learners. 摘要:加强南达科他州医学学习者口腔健康教育。
Layne Hohn
{"title":"2024 Scholars' Research Symposium Abstract: Oral Health Education Enhancement For South Dakota Medical Learners.","authors":"Layne Hohn","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Medical education focuses on the biochemical origins, pathophysiologic pathways, diagnosis and treatment of human illnesses. While this educational training attempts to be all-encompassing, oral health and the associated pathologies are not commonly emphasized in medical training. Disparities in oral health have detrimental effects on systemic disease and impacts patient well-being. This project aimed to evaluate the integration of an oral health education pilot program into the medical school curriculum by assessing students' and residents' baseline understanding and perspectives of oral health, followed by a lecture on oral health basics. The goal was to enhance physicians' knowledge so they can help future patients recognize the impact good oral health care has on their overall health.</p><p><strong>Methods: </strong>27 Center for Family Medicine (CFM) residents, 15 USD pediatric residents, and 64 USD SSOM Pillar 2 (MS3) medical students received a lecture on oral health basics. Medical learners received a 10-question pre-lecture quiz to assess their baseline knowledge, followed by the same 10-question post-lecture quiz to assess knowledge gained. Students who attended in person also practiced the application of fluoride resin on oral cavity models and on one another. Lectures were given in various formats, with both the CFM and pediatric residents receiving the presentation through a live Zoom meeting. The Pillar 2 medical students were able attend the lecture, either in person or through Zoom, with 10 students attending the in-person lecture.</p><p><strong>Results: </strong>Of the 106 learners, 88 (83%) completed pre- and post-lecture questionnaires. Quiz results demonstrated that the session helped learners gain knowledge in oral health basics, pathology, and treatment, with almost a 20% increase in average quiz scores across all participants. Further statistical analysis, with paired t-tests, demonstrated that the increase in examination scores were all statistically significant with p less than 0.05 in all groups.</p><p><strong>Conclusions: </strong>The oral health education pilot program, using lecture presentation format over Zoom, was an effective method to increase both resident and student knowledge of oral health basics, pathology, and treatment. Considering the statistical increase in student performance and comfort level with performing essential examinations, this project also demonstrated that students and residents were engaged in the topic and emphasized the importance of oral health education. Based on the positive response to this pilot project, it is suggested that faculty consider integrating this into the medical school curriculum.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"77 9","pages":"399"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Combination of Bleeding Disorders in South Dakota: A Case Report. 南达科他州罕见的出血性疾病组合:一个病例报告。
Dallas Petroff, David Ring
{"title":"A Rare Combination of Bleeding Disorders in South Dakota: A Case Report.","authors":"Dallas Petroff, David Ring","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hemophilia A is a clotting disorder due to factor VIII deficiency, leading to prolonged bleeding. Acquired hemophilia A results from the immune system attacking factor VIII, typically occurring later in life. Factor V Leiden is a genetic mutation causing abnormal blood clot formation, primarily in veins. This mutation is inheritable and increases the risk of clotting. A combination of these conditions is extremely rare. Correct management of a patient with any bleeding disorder is imperative for a surgical case to prevent catastrophe. We present a surgical case involving both hemophilia A and Factor V Leiden.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"77 9","pages":"418-421"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2024 Scholars' Research Symposium Abstract: Sex-Split Analysis of Pathology and Motor-Behavioral Outcomes in a Mouse Model Of CLN8-Batten Disease. 摘要:CLN8-Batten病小鼠模型的病理和运动行为结果的性别分裂分析。
Andrew Holmes
{"title":"2024 Scholars' Research Symposium Abstract: Sex-Split Analysis of Pathology and Motor-Behavioral Outcomes in a Mouse Model Of CLN8-Batten Disease.","authors":"Andrew Holmes","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>CLN8-Batten disease is a rare neurodegenerative disorder characterized phenotypically by progressive deterioration of motor and cognitive abilities, visual symptoms, epileptic seizures, and premature death. Mutations in CLN8 result in characteristic Batten disease symptoms and brain-wide pathology including accumulation of lysosomal storage material, gliosis, and neurodegeneration. Recent investigations of other subtypes of Batten disease (CLN1, CLN3, CLN6) have emphasized the influence of biological sex on disease and treatment outcomes; however, little is known about sex differences in the CLN8 subtype.</p><p><strong>Methods: </strong>To determine the impact of sex on CLN8 disease burden and progression, a Cln8mnd mouse model was utilized to measure the impact and progression of histopathological and motor-behavioral outcomes between sexes. Immunohistochemistry staining utilized markers for intracellular storage materials, astrocytes, and microglial cells; sections were obtained of the thalamus and the somatosensory cortex of Cln8mnd mice.</p><p><strong>Results: </strong>Several notable sex differences were observed in the presentation of brain pathology, including Cln8mnd female mice consistently presenting with greater GFAP+ astrocytosis and CD68+ microgliosis in the somatosensory cortex and ventral posteromedial/ventral posterolateral nuclei of the thalamus when compared to Cln8mnd male mice. Female Cln8mnd mice experienced a diminished lifespan by 0.5 months compared to their male counterparts (p less than 0.05). Furthermore, sex differences in motor-behavioral assessments identified Cln8mnd female mice experience poorer motor performance in the Morris Water Maze assessment, reverse Morris Water Maze, and increased tremors.</p><p><strong>Conclusions: </strong>Female Cln8mnd mice perished earlier, performed worse on motor-behavioral assessments, and demonstrated marked microglial and astrocyte reactivity compared to their male counterparts. Taken together, the results provide further evidence of biological sex as a modifier of Batten disease progression and outcome, thus warranting consideration when conducting investigations and monitoring therapeutic impact.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"77 9","pages":"400"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2024 Scholars' Research Symposium Abstract: Development of an MD-MBA Program at University of South Dakota. 摘要:南达科他州大学医学硕士-工商管理硕士项目的发展。
Anna Myrmoe
{"title":"2024 Scholars' Research Symposium Abstract: Development of an MD-MBA Program at University of South Dakota.","authors":"Anna Myrmoe","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Over the last 20 years nationwide, the number of MD-MBA programs have seen an increase from 6 to 65 with an estimated annual enrollment of 500 students. Many of the healthcare challenges providers are witnessing are business challenges, varying from designing quality improvement initiatives to managing rising costs. Studies have shown those who obtained an MD-MBA degree were better prepared to face these challenges than their traditional counterparts. The aim of this study is to demonstrate a regional need and market demand for a joint degree program between the Sanford School of Medicine and the Beacom School of Business at the University of South Dakota.</p><p><strong>Methods: </strong>To generate a needs assessment for an MD-MBA degree, an IRB approved online survey was constructed and sent by email to physicians across the state of South Dakota. Recipients included members of the South Dakota State Medical Association, Sanford School of Medicine Alumni, and currently enrolled Sanford School of Medicine students. All submissions were kept confidential, and data was collected and stored in an Excel document.</p><p><strong>Results: </strong>The survey generated responses from 108 participants, 58 of which were current medical students and 54 were physician alumni or practicing physicians. Of the total respondents, 58% indicated they would apply or would have applied to an MD-MBA program if available. 84% of respondents agreed with the need for continued education in medicine and business to overcome the multifaceted challenges faced in healthcare. Survey questions requiring additional explanation of answer choices qualitatively demonstrated 92% of respondents strongly support a dual-degree and its benefits to the medical profession.</p><p><strong>Conclusions: </strong>Following submission of the study results in a comprehensive proposal for an MD-MBA program, the South Dakota Board of Regents approved and implemented the program, effective since Spring 2022. The MD-MBA program will allow for completion of training prior to beginning a medical career. Medical education at the university now provides healthcare industry support through healthcare provider acquisition of skills needed for meaningful and effective administrative capabilities.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"77 9","pages":"404"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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