South Dakota medicine : the journal of the South Dakota State Medical Association最新文献

{"title":"Phoenix Atherectomy in Calcified Common Femoral and Popliteal Artery Chronic Total Occlusion. A Retrospective Cohort Study.","authors":"Jacob R Devine, Tanner Berg, Joshua Schumacher, Quenton Steffen, Bhaskar Purushottam","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>To study the short-term safety, procedural success and efficacy of Phoenix atherectomy in calcified, high TASC CFA and PA chronic total occlusions.</p><p><strong>Methods: </strong>In this single center retrospective study, we included all patients who underwent Phoenix atherectomy for their calcified CFA and PA CTOs from 2021 to 2023 at Monument Health Rapid City Hospital, Rapid City, South Dakota.</p><p><strong>Results: </strong>The final cohort consisted of 51 patients, 22 presenting with chronic limb threatening ischemia and 29 with claudication and 51 limbs. Twelve CFA, 25 PA, 4 combined CFA and PA, 5 combined PA and superficial femoral artery [SFA], 5 combined CFA, SFA and PA CTOs were included, half of the lesions were severely calcified, 11 were TASC B, 37 were TASC C and 2 were TASC D lesions. Intravascular ultrasound was performed in half of the patients and drug coated balloons was used in all the patients. Procedural success was achieved in 100% of the patients [residual stenosis of less than 30%], one bail-out covered stenting for a distal popliteal artery perforation, no distal embolization protection devices was used and there were no embolization events. There were no immediate post procedural complications [less than 24 hours]. One death occurred 20 days later from an acute coronary syndrome. At 6 weeks follow-up, 60% had complete resolution of claudication and 40% achieved wound healing with no major amputation. Average peak systolic velocity of the CFA and PA was 214 cm/s and 91 cm/s, respectively with PSVR of less than 2.4 at 6 weeks' follow-up. Clinically driven target lesion revascularization occurred in 3 patients at 4, 5 and 6 months after the index procedure.</p><p><strong>Conclusions: </strong>Phoenix atherectomy can be used safely and effectively in calcified, high TASC common femoral and popliteal artery chronic total occlusions with extremely low rates of bail-out stenting and other complications and reasonable clinical efficacy.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"78 suppl 5","pages":"s25"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Medical Students' Perception of the Role of Artificial Intelligence in Healthcare.","authors":"Oluwafunke Oluwatosin Ogunremi, Alexandra Job, Ethan Noble, Joseph Reynen, Andrew Holmes, Valeriy Kozmenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Artificial intelligence (AI) holds the potential to unlock numerous advancements and positive changes in healthcare. However, concerns such as bias, privacy, and accountability are being considered alongside the potential benefits. A 28-question survey was distributed to medical students at the University of South Dakota Sanford School of Medicine (USD SSOM) to assess their perceptions of AI in healthcare. Responses were measured using a 5-point Likert scale and analyzed through regression analysis and ANOVA tests. Overall, medical students found AI's integration into healthcare to be neutral, with no significant difference in the overall view of AI between the four medical school cohorts. Aspects of this study, notably views on diagnostic radiology, highlight a dual perception of AI in healthcare: recognition of the potential to enhance diagnostic accuracy alongside concerns about possible job displacement. While medical students currently maintain a neutral stance toward AI in healthcare, there exists a foundational optimism that could be nurtured through education and practical experience. Emphasizing the importance and irreplaceable nature of human labor in the workforce may aid in easing the skepticism of those wary of integrating AI into healthcare.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"78 5","pages":"218-225"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Head and Neck Squamous Cell Carcinoma (HNSCC) Patient Outcomes Based on Rurality: A Retrospective Cohort Study.","authors":"Sarah Lane, Bailey Smith, Carly Brodersen, Schae Hanson, William Spanos, Steven Powell","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with head and neck squamous cell carcinoma (HNSCC) receiving chemoradiotherapy require ongoing treatment and follow-up, which may be influenced by distance to care. Rural patients often face limited access to specialized treatment centers, yet data on rurality's impact on compliance and outcomes remain limited. This study evaluates differences in treatment adherence and outcomes between rural and urban HNSCC patients.</p><p><strong>Methods: </strong>Retrospective chart review identified patients with HNSCC treated with chemoradiotherapy from 2010-2019 at Sanford Health in Sioux Falls, South Dakota; Fargo, North Dakota; and Bismark, North Dakota. Patients were classified as either rural (R) or urban (U) based on their home address using the Federal Office of Rural Health Policy (FORHP) definition. Differences in patient and disease characteristics were analyzed. Post-treatment complications (ototoxicity, osteoradionecrosis, and treatment compliance (major delays in radiation treatment [greater than 5 days] and prolonged time to complete radiation [greater than 52 days]) were compared between groups using chi-squared and t-tests.</p><p><strong>Results: </strong>132 patients met eligibility. Participants were predominantly male (80% U, 83.1% R), Medicare/ Medicaid (66.2% R, 60% U), Oropharynx (57.1% R, 61.8% U), and stage IV (84.4% R, 85.5% U). There was no significant difference in number of missed appointments (p=0.16), treatment breaks (p=0.15), prolonged time to complete radiation (p=0.67). Post-treatment complication rates were also similar: ototoxicity (R: 51.9%, U: 58.2%, p=0.49), osteoradionecrosis (R: 16.9%, U: 7.3%, p=0.1), and soft tissue necrosis (R: 35.1%, U: 27.3%, p=0.34).</p><p><strong>Conclusion: </strong>Rural and urban HNSCC patients showed no significant differences in treatment adherence or outcomes. These findings suggest that rural patients may have access to sufficient resources and support, enabling them to receive cancer treatment comparable to their urban counterparts. However, this study may be limited by its relatively small sample size, and further research is warranted to explore this topic in larger and more diverse populations.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"78 suppl 5","pages":"s31"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Spitz Tumor in a Pediatric Patient: A Case Report.","authors":"Joseph H Kelly, Linze Christensen, Marcus L Frohm","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Spitzoid neoplasms are a collection of melanocytic lesions distinguished from conventional nevi or melanoma by a unique set of histological and molecular features. These spitzoid proliferations - Spitz nevi, spitzoid melanocytoma, atypical Spitz tumors (ASTs), and spitzoid melanoma - range from benign to malignant. Morphology alone has been an insufficient prognostic tool, but immunohistochemical (IHC) stains prove useful for risk stratification. ASTs rarely metastasize beyond regional lymph nodes and treatment includes wide local excision (WLE) with or without sentinel lymph node (SNL) biopsy depending on histomolecular features. WLE of ASTs with negative margins is typically curative with excellent long-term survival and mortality rates close to zero in pediatric cases.</p><p><strong>Case: </strong>A 12-year-old male presented to their pediatrician for a well child check without pertinent symptoms. Examination revealed a 5 x 4 mm elliptical, raised, red papule with asymmetric brown/black discoloration. He was referred to dermatology for evaluation. Five months later the lesion had grown to 11 x 6 mm covered with a pink/black crust. A shave biopsy displayed atypical spitzoid melanocytic proliferation but lacked significant staining with PRAME or BRAF. An ALK stain did not highlight the melanocytes upon further evaluation. These IHC findings are most consistent with an atypical Spitz tumor. A WLE with 5 mm margins was performed and margins revealed no residual melanocytic proliferation.</p><p><strong>Conclusion: </strong>This case highlights the clinical, diagnostic, and management challenges of ASTs in pediatric patients. Although malignant potential is uncertain, ASTs often have an excellent prognosis with negative margins following WLE. In this case, IHC staining for PRAME and BRAF helped support the decision to defer SNL biopsy. This case underscores the importance of morphologic and molecular analysis to assess risk and guide management. Further research into molecular biomarkers may improve risk stratification and optimize treatment strategies for ASTs in pediatric patients.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"78 suppl 5","pages":"s28-s30"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faculty Perspectives on Inpatient Clinical Experiences in a Longitudinal Integrated Clerkship Curriculum: A Cross-Sectional Study.","authors":"Alan Sazama, Carly Cooper, Hannah DeHoogh-Kliewer, Christina Lusk, Nathan Popp, Jaymi Russo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>Longitudinal Integrated Clerkship (LIC) curricula have gained popularity among medical schools due to their demonstrated benefits in fostering improved relationships among patients, students, and faculty compared to traditional block schedules. The University of South Dakota Sanford School of Medicine (SSOM) adopted a comprehensive LIC curriculum for all campuses in 2014. SSOM encompasses four campuses distributed across the state. Faculty sufficiency has presented a persistent challenge, complicating student scheduling. Additionally, dissatisfaction among faculty regarding patient continuity has emerged as a key concern. To address this, inpatient clinical experiences were incorporated into the LIC curriculum in 2023.</p><p><strong>Methods: </strong>A pre- and post-implementation mixed-methods analysis was conducted to evaluate the impact of inpatient clinical experiences on faculty satisfaction. Participants included teaching faculty who completed anonymous online surveys evaluating their satisfaction with the LIC schedule and patient continuity. The first survey was conducted in December 2022 for faculty enrolled in the 2022-23 LIC cohort prior to the implementation of inpatient clinical experiences (ICE). Subsequent surveys were conducted in 2023 and 2024 after implementation of ICE.</p><p><strong>Results: </strong>In 2022, 79% of faculty expressed satisfaction with the traditional LIC schedule, yet 30% of faculty (N=92) reported dissatisfaction with patient continuity. Since the implementation of ICE weeks into the LIC, the 2024 faculty reported 73% (N=60) prefer the new hybrid model and 15% (N=12) prefer the traditional LIC. The hybrid model demonstrated a 29% (N=26) dissatisfaction rating for teaching continuity. However, 56% (N=48) of faculty reported satisfaction with student learning outcomes. Further qualitative and quantitative results from this survey will be shared regarding faculty satisfaction with student knowledge retention and teaching workload distribution.</p><p><strong>Conclusion: </strong>Initial findings for the incorporation of ICE into the LIC curriculum show faculty prefer a hybrid LIC over a traditional LIC. Results also showed satisfaction with student learning outcomes.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"78 suppl 5","pages":"s32-s33"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Study of Headache Treatment Between Rural and Urban Emergency Departments in South Dakota.","authors":"Logan Stacey, Alan Sazama, Benjamin Aaker","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Headaches are a common chief complaint in emergency departments (EDs), with rural patients facing unique challenges such as geographic isolation and limited access to care. This study aims to compare treatment efficacy for this top five ED chief complaint between rural and urban EDs.</p><p><strong>Methods: </strong>Patients treated for headaches from 2020-2023 were identified using diagnosis codes and electronic health records. Treatment plans and patient demographics were abstracted from identified charts. EDs were categorized as rural (populations under 50,000) or urban.</p><p><strong>Results: </strong>A total of 13,375 patients were included (6,165 urban, 7,210 rural). Pain reduction was similar between urban (3.78) and rural EDs (3.61) (p = 0.094). Urban EDs had longer visit times (2.95 hours vs. 2.60 hours in rural EDs). Medication use varied: opioids were more frequently used in rural EDs (8.3% vs. 3.6%), while NSAIDs, acetaminophen, and prokinetics showed similar use across both settings. Demographics differed slightly, with a higher percentage of Native American patients in rural EDs (10% vs. 5.5% urban).</p><p><strong>Conclusions: </strong>Treatment efficacy for headaches did not differ significantly between urban and rural EDs. Rural patients spent less time in the ED, likely due to lower patient volume, and opioid use was higher in rural locations.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"78 suppl 5","pages":"s36"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lean and Green Hand Office-Based Hand Surgery: Does it Work?","authors":"Robert Van Demark, Vanessa Smith, Tate Blankespoor, Ben Van Bockern","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>United States healthcare spending continues to increase every year with projected spending of $5.3 trillion for 2025. This spending represents 19.6% of the GDP. The United States also leads the world in waste production with the healthcare industry being the second largest producer of waste nationally. Implementing new strategies and techniques in the operating room can help reduce the cost and waste produced. Adopting a more Lean and Green approach to hand surgery can help to reduce waste and costs without compromising patient safety and satisfaction.</p><p><strong>Methods: </strong>A retrospective chart review of one surgeon's office-based cases was done. 437 cases performed over a 12-month period were reviewed. Study items included: infections, secondary procedures, patient satisfaction, and cost and waste savings seen with Lean and Green surgical packs. The patients were asked the following questions: how does the procedure compare to a dental visit, would you recommend to a friend or family member, and would you do office-based surgery again?</p><p><strong>Results: </strong>The superficial infection rate was 3.9% with no deep infections. The secondary procedure rate was 0.2% Using Lean and Green surgical packs, there were cost savings of $4,650 and a decrease in waste of 2,211 lbs (1.1 tons). Patient satisfaction with the procedure was high: 99% of patients rated the surgical experience as the same or better than visiting the dentist, 99% would recommend to a friend or family member, and 99% would do office-based surgery again.</p><p><strong>Conclusion: </strong>Wide-Awake local anesthesia office-based hand surgery is safe, cost effective with high patient satisfaction. By adding Lean and Green surgical packs, we saw both cost savings and a decrease in garbage associated with those cases. The combination of Lean and Green surgery with Wide-Awake office surgery is effective and will continue to be important in the future of healthcare delivery.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"78 suppl 5","pages":"s20-s21"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Student Perspectives on Inpatient Clinical Experiences in a Longitudinal Integrated Clerkship Curriculum: A Cross-Sectional Study.","authors":"Hannah DeHoogh-Kliewer, Carly Cooper, Christina Lusk, Nathan Popp, Jaymi Russo, Alan Sazama","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Longitudinal Integrated Clerkship (LIC) curriculum allows students to participate in rotations of all medical disciplines simultaneously. This model has gained popularity amongst medical schools and is evidenced to improve relationships between patients, students, and faculty compared to a traditional block schedule. The University of South Dakota Sanford School of Medicine (SSOM) implemented a comprehensive outpatient LIC curriculum for all campuses in 2014. The SSOM consists of 4 campuses (rural and urban) situated across the state, which leads to varying student experiences depending on site placement. To address issues of dissatisfaction with patient continuity and scheduling challenges, a hybrid inpatient and outpatient LIC was implemented in 2023.</p><p><strong>Methods: </strong>A pre- and post-mixed methods analysis regarding the implemented hybrid inpatient and outpatient clinical experiences was conducted with third-year medical students. Participants completed an anonymous online survey about satisfaction with patient continuity and scheduling. The first survey was conducted in December 2022 for students enrolled in the 2022-2023 LIC prior to the implementation of hybrid inpatient experiences and again in December 2024 for students enrolled in the 2024-2025 hybrid LIC.</p><p><strong>Results: </strong>In 2022, many students (82%) were satisfied with the standard LIC schedule. However, 38% of these students (N=52) reported dissatisfaction with patient continuity. After the implementation of inpatient experiences into the LIC, students in 2024 (N=50) reported 64% satisfaction with the schedule of the hybrid model. Amongst this cohort, 36% were dissatisfied with patient continuity in the hybrid LIC model. Of note, 70% of these students were satisfied with faculty continuity. When questioned about preferred curriculum model, 64% of students in 2024 prefer the hybrid LIC over traditional block schedule.</p><p><strong>Conclusion: </strong>Initial findings show that the implementation of inpatient clinical experiences in the LIC curriculum has decreased student satisfaction with scheduling and minimally improved satisfaction with patient continuity. Results also show that students prefer the hybrid LIC over a traditional block model.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"78 suppl 5","pages":"s24"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volar Locking Plates in a Non-Academic Setting: Complications of Distal Radius Fracture Fixation in 300 Cases.","authors":"Kyler A Hardie, Troy D Hollinsworth, Michaela J Derby, Paul F Thanel, Colton C Husby, Hillary A Becker, Matthew C Anderson, Li Cao, Robert Van Demark","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The volar locking plate is an increasingly common method to treat distal radius fractures. This study aimed to assess whether complication rates following volar locking plate fixation for distal radius fractures for patients in a rural, non-academic setting are comparable to post-operative complication rates reported at larger academic centers.</p><p><strong>Methods: </strong>A retrospective review of all patients who received volar locking plate fixation for distal radius fractures from January 2017 to February 2022 via the electronic medical record was performed at a single institution. A total of 300 patients were included in the study. Demographics, medical history, injury data, surgeon specialty and surgery data were collected along with any type of complications from surgery.</p><p><strong>Results: </strong>Overall, 79 complications were identified representing 26% of patients, with the most frequent being hardware removal due to discomfort (n=21, 7.0%) and stiffness (n=21, 7.0%), followed by median nerve neuropathy (n=15, 5.0%), and tendonitis/tenosynovitis (n=10, 3.3%). The mean age for all patients was 57 years, 81% of which were female. No significant difference was observed between complications and patient demographics, medical history, injury or surgery data. There was no significant difference in complications between hand fellowship trained surgeons (87% of cases, 23% complication rate) and non-hand orthopedic surgeons (13% of cases, 27% complication rate).</p><p><strong>Conclusion: </strong>The complication rate following volar locking plate fixation for distal radius fractures in our rural, non-academic setting (26%) is comparable to post-operative complication rates reported at larger academic centers (11-30%).</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"78 5","pages":"210-216"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Response to Pembrolizumab and Lenvatinib in pMMR Endometrial Cancers: A Retrospective Cohort Study.","authors":"Linze Christensen, Crystal Hattum, Tobias Meissner, Bing Xu, David Starks, Rachel Elsey","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Among women with endometrial cancer, mismatch repair proficient (pMMR) patients often exhibit diminished responses to immunotherapy (IO). This study aims to evaluate real-world outcomes of immunotherapy-containing regimens for this patient population.</p><p><strong>Methods: </strong>We analyzed charts of patients diagnosed with pMMR endometrial cancer who received an IO regimen between 01/01/2017-06/30/2024 for demographics, tumor characteristics, next-generation sequencing results, treatment dates and outcomes. Primary outcomes were PFS and OS of pembrolizumab/ lenvatinib (PL) and other IO-containing regimens in pMMR endometrial cancer.</p><p><strong>Results: </strong>Twenty-six patients met inclusion criteria: 18 received treatment with PL, 8 received a different IO-containing regimen (IO group). Median age in the PL group was 68 (range: 51-80). The quantity of patients with grade 1, 2, and 3 disease was 3, 4, and 10, respectively. Median prior lines of therapy was 2 (range: 0-4); 8 had previously received IO. Median PFS in the PL group was 126 days (range: 20-1652) compared with 368 days (range: 42-714) in the IO group (p=0.043). Patients with lower-grade endometrial cancers in the PL group saw significantly improved OS when compared with higher-grade cancers (p=0.022). Additionally, 1 patient with high TMB had numerically improved OS, though statistical significance was not reached (p=0.33). Discontinuation due to toxicity was low: 2 attributed to lenvatinib, and none due to pembrolizumab.</p><p><strong>Conclusions: </strong>In this real-world cohort of pMMR endometrial cancer patients treated with PL, the median PFS of 4.2 months was shorter than the 6.6 months reported in Study 309-KEYNOTE-775. Patients in the IO group had significantly longer PFS when compared with the PL group, though patients in the IO group had fewer prior lines of therapy. Small cohort sizes are a significant limitation of this analysis. Further study is needed to confirm whether the analyzed variables maintain potential significance in larger matched cohorts.</p>","PeriodicalId":39219,"journal":{"name":"South Dakota medicine : the journal of the South Dakota State Medical Association","volume":"78 suppl 5","pages":"s23"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}