Clinical Microbiology Newsletter最新文献_第8页

Sickeningly Sweet: Infectious Complications of Diabetes 令人作呕的甜蜜:糖尿病的传染性并发症

Clinical Microbiology Newsletter Pub Date : 2023-01-01 DOI: 10.1016/j.clinmicnews.2023.01.001

Rong Mei Zhang M.D. , Alexis M. McKee M.D. , Neil W. Anderson M.D.

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Don't Be So Negative; Let's Have a Positive Perspective! A Review of Novel Antibiotics Targeting Gram-Positive Bacteria 不要那么消极;让我们有一个积极的观点!针对革兰氏阳性菌的新型抗生素研究进展

Clinical Microbiology Newsletter Pub Date : 2022-12-15 DOI: 10.1016/j.clinmicnews.2022.12.001

Mimi R. Precit Ph.D., D(ABMM), M(ASCP)CM , Emily A. Snavely Ph.D., D(ABMM) , Rachael M. Liesman Ph.D., D(ABMM)

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Clinical Microbiology Newsletter Pub Date : 2022-12-15 DOI: 10.1016/j.clinmicnews.2022.12.002

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Recent Advances in Direct Blood Culture Phenotypic Antimicrobial Susceptibility Testing 直接血培养表型药敏试验的最新进展

Clinical Microbiology Newsletter Pub Date : 2022-12-01 DOI: 10.1016/j.clinmicnews.2022.11.005

Elizabeth M. Garrett Ph.D., D(ABMM), April M. Bobenchik Ph.D., D(ABMM)

{"title":"Recent Advances in Direct Blood Culture Phenotypic Antimicrobial Susceptibility Testing","authors":"Elizabeth M. Garrett Ph.D., D(ABMM), April M. Bobenchik Ph.D., D(ABMM)","doi":"10.1016/j.clinmicnews.2022.11.005","DOIUrl":"10.1016/j.clinmicnews.2022.11.005","url":null,"abstract":"<div>Increasing rates of antibiotic resistance make selecting empiric therapy challenging for the treatment of sepsis and suspected bloodstream infections (BSIs). The time to initiation of effective therapy for BSIs is critical for positive patient outcomes. Recent advances in rapid diagnostics for the detection of BSIs directly from positive blood culture include rapid organism identification and rapid antimicrobial susceptibility testing (AST). Rapid AST methods include genotypic and phenotypic methods or a combination of both and provide important information to aid in the prompt initiation of effective therapy. Genotypic AST methods allow rapid direct detection of a resistance mechanism but may fail to accurately predict a full susceptibility profile, whereas phenotypic AST provides comprehensive results but is not rapid if conventional methods are used. Efforts to decrease the turnaround time of phenotypic AST are an important advancement for the treatment of BSIs. Here, we review currently available and in-development phenotypic methods for AST directly from positive blood culture and their potential benefits for antimicrobial stewardship and patient care.</div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"44 23","pages":"Pages 209-216"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43479249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Clinical Microbiology Newsletter Pub Date : 2022-12-01 DOI: 10.1016/j.clinmicnews.2022.11.006

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Monkeypox: Clinical Considerations, Epidemiology, and Laboratory Diagnostics 猴痘:临床考虑、流行病学和实验室诊断

Clinical Microbiology Newsletter Pub Date : 2022-11-15 DOI: 10.1016/j.clinmicnews.2022.11.003

Lucas J. Osborn Ph.D. , Diana Villarreal M.D., Ph.D. , Noah Wald-Dickler M.D. , Jennifer Dien Bard Ph.D.

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Clinical Microbiology Newsletter Pub Date : 2022-11-15 DOI: 10.1016/j.clinmicnews.2022.11.004

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Discontinuation of DNA Probes for Identification of Dimorphic Fungi Growing in Culture: What's a Lab To Do? 停止使用DNA探针鉴定培养中的二形真菌:实验室该怎么做?

Clinical Microbiology Newsletter Pub Date : 2022-11-01 DOI: 10.1016/j.clinmicnews.2022.11.001

Tanis C. Dingle , Philippe J. Dufresne

{"title":"Discontinuation of DNA Probes for Identification of Dimorphic Fungi Growing in Culture: What's a Lab To Do?","authors":"Tanis C. Dingle , Philippe J. Dufresne","doi":"10.1016/j.clinmicnews.2022.11.001","DOIUrl":"10.1016/j.clinmicnews.2022.11.001","url":null,"abstract":"<div>The most common dimorphic fungi isolated from clinical specimens in North America are Coccidioides immitis, Coccidioides posadasii, Blastomyces dermatitidis species complex, and Histoplasma capsulatum. These organisms are typically definitively identified at reference or public health laboratories, as they are risk group 3 (RG3) pathogens requiring additional biosafety considerations compared to risk group 2 (RG2) pathogens. Reference and public health laboratories have been using organism-specific DNA probes since the early 1990s as the primary method of confirming the identification of morphologically suspect dimorphic fungi growing in culture. At the end of November 2021, manufacturing of these probes was discontinued, leaving clinical laboratories responsible for dimorphic fungus identification with the task of validating and implementing a new identification method for these pathogens. Here, we discuss alternatives to DNA probes for identification of Coccidioides spp., B. dermatitidis species complex, and H. capsulatum growing in culture, including the strengths and limitations of each method.</div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"44 21","pages":"Pages 191-197"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48491573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Diagnostic Stewardship: the Central Role of Clinical Microbiology Laboratories 诊断管理:临床微生物实验室的中心作用

Clinical Microbiology Newsletter Pub Date : 2022-10-15 DOI: 10.1016/j.clinmicnews.2022.10.004

Daniel A. Green M.D., Maxwell D. Weidmann M.D., Ph.D., Mahavrat S. Srivastava-Malick M.D.

{"title":"Diagnostic Stewardship: the Central Role of Clinical Microbiology Laboratories","authors":"Daniel A. Green M.D., Maxwell D. Weidmann M.D., Ph.D., Mahavrat S. Srivastava-Malick M.D.","doi":"10.1016/j.clinmicnews.2022.10.004","DOIUrl":"10.1016/j.clinmicnews.2022.10.004","url":null,"abstract":"<div>Diagnostic stewardship aims to improve diagnostic test utilization through evidence-based practices to improve care, quality, safety, and costs. Diagnostic stewardship is a collaborative effort that brings together multidisciplinary groups that have a common interest in promoting and ensuring best testing practices. For infectious disease testing, clinical microbiology laboratories are perhaps best positioned within their health care systems to lead these efforts, as they are not only diagnostic experts, but also directly oversee many of the tools and choices available to improve test performance and utilization. While some interventions may not fall under the direct purview of clinical microbiology laboratories, their expertise is nevertheless essential to inform these efforts, as well. Multiple stewardship strategies have been evaluated, providing laboratories with several opportunities to implement evidence-based practice changes to improve quality and outcomes. Further research is needed to continue advancing practice for well-established and emerging tests alike.</div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"44 20","pages":"Pages 179-189"},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49503889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A special invitation to authors 对作者的特别邀请

Clinical Microbiology Newsletter Pub Date : 2022-10-15 DOI: 10.1016/j.clinmicnews.2022.10.005

引用次数: 0