Clinical Microbiology Newsletter最新文献_第8页

A special invitation to authors 对作者的特别邀请

Clinical Microbiology Newsletter Pub Date : 2022-03-15 DOI: 10.1016/j.clinmicnews.2022.03.002

引用次数: 0

An Easily Digestible Review of Helicobacter pylori Diagnostics 幽门螺杆菌诊断方法综述

Clinical Microbiology Newsletter Pub Date : 2022-03-15 DOI: 10.1016/j.clinmicnews.2022.03.001

Kamran N. Azad Ph.D., Susan E. Realegeno Ph.D., Ron M. Kagan Ph.D., Dale A. Schwab Ph.D., Hollis J. Batterman M.D., Elizabeth M. Marlowe Ph.D.

引用次数: 2

Bacteriophages: Potential Biocontrol Agents and Treatment Options for Bacterial Pathogens 噬菌体:细菌性病原体的潜在生物防治剂和治疗方案

Clinical Microbiology Newsletter Pub Date : 2022-03-01 DOI: 10.1016/j.clinmicnews.2022.02.002

N. Harshitha, Aishwarya Rajasekhar, Suman Saurabh, Rohit Sonalkar, M. Tejashwini, Susweta Das Mitra

{"title":"Bacteriophages: Potential Biocontrol Agents and Treatment Options for Bacterial Pathogens","authors":"N. Harshitha, Aishwarya Rajasekhar, Suman Saurabh, Rohit Sonalkar, M. Tejashwini, Susweta Das Mitra","doi":"10.1016/j.clinmicnews.2022.02.002","DOIUrl":"10.1016/j.clinmicnews.2022.02.002","url":null,"abstract":"<div><p><span><span>The global report on antibiotic resistance<span> by the World Health Organization features the burden of antimicrobial resistance and the emerging risk of a post-antibiotic era, where therapeutic options will no longer exist for previously treatable diseases. The search for alternative avenues to combat multidrug-resistant (MDR) pathogens<span><span> has sparked interest in the use of bacteriophages for the treatment of bacterial infections. The unique ability of bacteriophages to infect and kill bacteria without affecting </span>mammalian cells makes them a promising avenue as biocontrol agents against bacterial pathogens. </span></span></span>Phage therapy in both animal and human models has shown promising results. Further, the phage-derived proteins (lytic enzymes), such as </span>endolysins<span>, that are the key weapons used by phages to degrade the bacterial cell have been explored by the scientific community as viable therapeutic options themselves. This review focuses on the prospects of phage therapy; an overview of diverse phages isolated against MDR pathogens; phage-derived proteins as antibacterial agents; phage cocktail development; phage and antibiotic combinational therapy; and the application of phages as biocontrol agents in agriculture, veterinary science, synthetic biology, and aquaculture. The review emphasizes the therapeutic use of phages and how they might be applied on a large scale if certain limitations and challenges can be overcome.</span></p></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49596606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Direct-to-Consumer Testing (DTC): Destined to Connect or Disrupt. Buyer Be Aware (An Infectious Disease Perspective) 直接面向消费者的测试(DTC):注定要连接或中断。买家要注意(传染病视角)

Clinical Microbiology Newsletter Pub Date : 2022-02-15 DOI: 10.1016/j.clinmicnews.2022.02.001

Teofilo Borunda Duque Pharm.D., M.S. , Monique Dodd Pharm.D., Ph.C., MLS(ASCP)CM , Ramisha Ali Pharm.D. , Richard VanNess M.S. , David G. Grenache Ph.D., D(ABCC)

{"title":"Direct-to-Consumer Testing (DTC): Destined to Connect or Disrupt. Buyer Be Aware (An Infectious Disease Perspective)","authors":"Teofilo Borunda Duque Pharm.D., M.S. , Monique Dodd Pharm.D., Ph.C., MLS(ASCP)CM , Ramisha Ali Pharm.D. , Richard VanNess M.S. , David G. Grenache Ph.D., D(ABCC)","doi":"10.1016/j.clinmicnews.2022.02.001","DOIUrl":"10.1016/j.clinmicnews.2022.02.001","url":null,"abstract":"<div><p>Direct-to-consumer (DTC) testing continues to be a subject of debate throughout the medical community. DTC testing may be viewed as expanding access to health care<span><span>. Additionally, caution is needed in defining the role of DTC testing in the overall health care<span> continuum of the consumer, particularly with limited provider resources. The recent COVID-19 pandemic resulted in a shift of consumer health care expectations and triggered providers to restructure their </span></span>health care delivery services to create a more consolidated care model. There are several benefits from DTC testing that can help address this new restructure of health care, such as easy access to an available product and decreased person-to-person contact. However, there have been controversies regarding ethical considerations, appropriate specimen sampling, and evidence-based practices. This article provides an overview of DTC testing, advantages and concerns, considerations around infectious disease, and the potential role of the clinical laboratory to ensure safe and effective DTC testing services.</span></p></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43182635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A special invitation to authors 对作者的特别邀请

Clinical Microbiology Newsletter Pub Date : 2022-02-01 DOI: 10.1016/j.clinmicnews.2022.01.004

引用次数: 0

Current Protocols in Laboratory Diagnosis, Genotyping, and Treatment of Burkholderia pseudomallei 假踝伯克霍尔德菌实验室诊断、基因分型和治疗的最新方案

Clinical Microbiology Newsletter Pub Date : 2022-02-01 DOI: 10.1016/j.clinmicnews.2022.01.003

AbdelRahman M. Zueter , Hana M. Sawan , Amani Zaiter , Azian Harun

引用次数: 2

Tick Talk: Powassan, Heartland, and Bourbon Viruses 蜱虫谈话:波瓦桑病毒、心脏地带病毒和波旁病毒

Clinical Microbiology Newsletter Pub Date : 2022-01-15 DOI: 10.1016/j.clinmicnews.2022.01.001

Heba H. Mostafa MBBCh, Ph.D., D(ABMM) , Amy B. Dean Ph.D.

引用次数: 1

A special invitation to authors 对作者的特别邀请

Clinical Microbiology Newsletter Pub Date : 2022-01-15 DOI: 10.1016/j.clinmicnews.2022.01.002

引用次数: 0

Current Methods and Role of Next-Generation Sequencing in the Diagnosis of Antimicrobial Resistance in Tuberculosis 新一代测序技术在结核病耐药诊断中的作用及现状

Clinical Microbiology Newsletter Pub Date : 2022-01-01 DOI: 10.1016/j.clinmicnews.2021.12.001

Marie-Claire Rowlinson Ph.D., D(ABMM), Kimberlee A. Musser Ph.D.

{"title":"Current Methods and Role of Next-Generation Sequencing in the Diagnosis of Antimicrobial Resistance in Tuberculosis","authors":"Marie-Claire Rowlinson Ph.D., D(ABMM), Kimberlee A. Musser Ph.D.","doi":"10.1016/j.clinmicnews.2021.12.001","DOIUrl":"https://doi.org/10.1016/j.clinmicnews.2021.12.001","url":null,"abstract":"<div><p>Rapid diagnosis of tuberculosis (TB) and identification of antimicrobial resistance<span> (AR) are critical to improving patient outcomes, especially for multidrug- and extensively drug-resistant TB (DR-TB) infections. Diagnosis can take weeks with traditional culture and growth-based antimicrobial susceptibility<span> testing, delaying appropriate treatment, impacting transmission of resistant strains, and leading to additional health care costs. Next-generation sequencing (NGS) techniques are revolutionizing the diagnostic laboratory and provide rapid, comprehensive, and accurate detection of AR in one test. With NGS, the whole genome can be sequenced in as little as 4 days from identification of TB in a positive culture. Subsequent bioinformatic analysis of sequence data assesses nucleotide changes compared to a wild-type reference genome and can identify mutations known to cause AR. Additionally, data can be analyzed to determine the species and provide a genotype. Targeted NGS methods designed to detect DR-TB directly from clinical specimens hold promise for the future.</span></span></p></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90031996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How To Successfully Design and Implement a Clinical Trial To Evaluate the Clinical Impact of New Diagnostic Assays for Testing Positive Blood Culture Bottles 如何成功设计和实施临床试验以评估检测阳性血液培养瓶的新诊断方法的临床影响

Clinical Microbiology Newsletter Pub Date : 2021-12-15 DOI: 10.1016/j.clinmicnews.2021.11.005

Robin Patel , Ritu Banerjee

引用次数: 0