Pediatric Endocrinology, Diabetes and Metabolism最新文献

{"title":"Premature pubarche during minipuberty - literature review and two case reports.","authors":"Anna Rakuś-Kwiatosz,&nbsp;Elżbieta Budzyńska,&nbsp;Iwona Beń-Skowronek","doi":"10.5114/pedm.2023.129343","DOIUrl":"https://doi.org/10.5114/pedm.2023.129343","url":null,"abstract":"<p><strong>Introduction: </strong>Isolated premature pubarche (PP) in infancy may be the reason for many diagnostic difficulties. This is due to the low incidence and, therefore, the limited number of studies on this subject and the lack of strict laboratory standards because of the physiological variability of gonadotropic hormone and androgen concentrations during minipuberty.</p><p><strong>Material and methods: </strong>We aimed to present current knowledge about PP in infancy based on the literature review and 2 cases of male infants with scrotal hair during minipuberty.</p><p><strong>Results: </strong>Isolated hair in the pubic region in a boy during the period of minipuberty requires differential diagnosis. After excluding serious aetiology, it seems to be a mild, self-limiting variant of precocious puberty. The phenomenon is probably a result of increased sensitivity of the hair follicles to transiently increased androgen concentration.</p><p><strong>Conclusions: </strong>Isolated pubic hair in infancy as a mild, self-limiting variant of precocious puberty in infants should be a diagnosis of exclusion. The condition resolves spontaneously, but it absolutely requires further follow-up to exclude serious aetiology in the case of puberty progression.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 2","pages":"112-117"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/57/PEDM-29-51056.PMC10411085.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41142870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential bacteriophages to overcome bacterial infection of Alcaligenes faecalis in diabetic ulcer.","authors":"Erlia Narulita,&nbsp;Vivi Indah Nur Cahyati,&nbsp;Riska A Febrianti,&nbsp;Mochammad Iqbal","doi":"10.5114/pedm.2023.125363","DOIUrl":"https://doi.org/10.5114/pedm.2023.125363","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes is a non-contagious disease, but it can cause various complications. One of the most common complications of diabetes is diabetic ulcers. Diabetic ulcers are infections that occur in the legs of diabetics due to the destruction of the deepest skin tissue. Recent studies have reported the presence of Alcaligenes faecalis with extensive drug resistance (XDR) properties as a cause of diabetic ulcers. Bacteriophages are known to have the ability to infect bacteria specifically so that they can be used as an alternative solution for treating diabetic ulcers. The purpose of this study was to determine the characteristics of bacteriophages capable of infecting Alcaligenes faecalis bacteria.</p><p><strong>Material and methods: </strong>The method used is the spot test method, host range, and identification of nucleic acid types.</p><p><strong>Results: </strong>The results showed that the 6 bacteriophages isolated, namely AFaV1, AFaV2, AFaV3, AFaV4, AFaV5, and AFaV6, had cloudy plaques with a diameter of ±3 mm. AFaV1, AFaV2, and AFaV4 isolates could infect all bacteria used; they were Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus. Meanwhile, bacteriophage isolates AFaV3, AFaV5, and AFaV6 could infect Klebsiella pneumoniae and Staphylococcus aureus bacteria only. The nucleic acid types of the 6 bacteriophage samples were dsDNA with band length > 1 Kb.</p><p><strong>Conclusions: </strong>The 6 isolates that were isolated had the ability to infect by forming a prophage that could inhibit the growth of Alcaligenes faecalis and other pathogenic bacteria in diabetic ulcers.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 2","pages":"61-66"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/4c/PEDM-29-50192.PMC10411081.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 diabetes – What’s new in prevention and therapeutic strategies?","authors":"Aleksandra Pilśniak, Ewa Otto-Buczkowska","doi":"10.5114/pedm.2023.132028","DOIUrl":"https://doi.org/10.5114/pedm.2023.132028","url":null,"abstract":"AMA Pilśniak A, Otto-Buczkowska E. Type 1 diabetes – What’s new in prevention and therapeutic strategies?. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):196-201. doi:10.5114/pedm.2023.132028. APA Pilśniak, A., & Otto-Buczkowska, E. (2023). Type 1 diabetes – What’s new in prevention and therapeutic strategies?. Pediatric Endocrinology Diabetes and Metabolism, 29(3), 196-201. https://doi.org/10.5114/pedm.2023.132028 Chicago Pilśniak, Aleksandra, and Ewa Otto-Buczkowska. 2023. \"Type 1 diabetes – What’s new in prevention and therapeutic strategies?\". Pediatric Endocrinology Diabetes and Metabolism 29 (3): 196-201. doi:10.5114/pedm.2023.132028. Harvard Pilśniak, A., and Otto-Buczkowska, E. (2023). Type 1 diabetes – What’s new in prevention and therapeutic strategies?. Pediatric Endocrinology Diabetes and Metabolism, 29(3), pp.196-201. https://doi.org/10.5114/pedm.2023.132028 MLA Pilśniak, Aleksandra et al. \"Type 1 diabetes – What’s new in prevention and therapeutic strategies?.\" Pediatric Endocrinology Diabetes and Metabolism, vol. 29, no. 3, 2023, pp. 196-201. doi:10.5114/pedm.2023.132028. Vancouver Pilśniak A, Otto-Buczkowska E. Type 1 diabetes – What’s new in prevention and therapeutic strategies?. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):196-201. doi:10.5114/pedm.2023.132028.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 diabetes mellitus prevention.","authors":"Lidia Groele, Agnieszka Szypowska","doi":"10.5114/pedm.2023.134130","DOIUrl":"10.5114/pedm.2023.134130","url":null,"abstract":"","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 4","pages":"209-213"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study","authors":"Marta Hetman, Ewa Barg, Sylwia Placzkowska","doi":"10.5114/pedm.2023.131513","DOIUrl":"https://doi.org/10.5114/pedm.2023.131513","url":null,"abstract":"AMA Hetman M, Barg E, Placzkowska S. Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):134-142. doi:10.5114/pedm.2023.131513. APA Hetman, M., Barg, E., & Placzkowska, S. (2023). Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study. Pediatric Endocrinology Diabetes and Metabolism, 29(3), 134-142. https://doi.org/10.5114/pedm.2023.131513 Chicago Hetman, Marta, Ewa Barg, and Sylwia Placzkowska. 2023. \"Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study\". Pediatric Endocrinology Diabetes and Metabolism 29 (3): 134-142. doi:10.5114/pedm.2023.131513. Harvard Hetman, M., Barg, E., and Placzkowska, S. (2023). Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study. Pediatric Endocrinology Diabetes and Metabolism, 29(3), pp.134-142. https://doi.org/10.5114/pedm.2023.131513 MLA Hetman, Marta et al. \"Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study.\" Pediatric Endocrinology Diabetes and Metabolism, vol. 29, no. 3, 2023, pp. 134-142. doi:10.5114/pedm.2023.131513. Vancouver Hetman M, Barg E, Placzkowska S. Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):134-142. doi:10.5114/pedm.2023.131513.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135706356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary guidelines in diabetes – why are they so difficult to follow?","authors":"Beata Sińska, Alicja Kucharska","doi":"10.5114/pedm.2023.132024","DOIUrl":"https://doi.org/10.5114/pedm.2023.132024","url":null,"abstract":"","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135706385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital hypothyroidism due to thyroid ectopy not detected in neonatal screening - case report.","authors":"Anna Stępniewska,&nbsp;Małgorzata Wójcik,&nbsp;Jerzy B Starzyk","doi":"10.5114/pedm.2022.118322","DOIUrl":"https://doi.org/10.5114/pedm.2022.118322","url":null,"abstract":"<p><p>Newborn screening for congenital hypothyroidism (CH) has been highly effective in preventing devastating neurodevelopmental and physical sequelae in affected infants. We report a case of an ectopic thyroid gland located in the submandibular area detected at the age of 3 months, which was missed by congenital hypothyroidism screening test based on twice-repeated TSH measurement in dried blood spots. The diagnosis of subclinical hypothyroidism was confirmed on the basis of blood test performed in the endocrine clinic: TSH 26.3 µIU/ml (N: < 10 µIU/ml), with FT4 14.7 pmol/l (N: 10-25 pmol/l) and fT3 6.9 pmol/l (N: 3-8 pmol/l). Ultrasonography and scintigraphy revealed ectopically located thyroid tissue in the sublingual area. In the case of doubtful results of a neonatal screening test or in any case of suspected congenital hypothyroidism, the diagnosis should be supplemented with ultrasound examination of the neonate's neck and followed by scintigraphy if necessary.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 1","pages":"53-56"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/f8/PEDM-29-47556.PMC10226458.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9580637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial","authors":"Hosein Shabani-Mirzaee, Zahra Haghshenas, Armen Malekiantaghi, Mohsen Vigeh, Fazeleh Mahdavi, Kambiz Eftekhari","doi":"10.5114/pedm.2023.132025","DOIUrl":"https://doi.org/10.5114/pedm.2023.132025","url":null,"abstract":"AMA Shabani-Mirzaee H, Haghshenas Z, Malekiantaghi A, Vigeh M, Mahdavi F, Eftekhari K. The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):128-133. doi:10.5114/pedm.2023.132025. APA Shabani-Mirzaee, H., Haghshenas, Z., Malekiantaghi, A., Vigeh, M., Mahdavi, F., & Eftekhari, K. (2023). The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial. Pediatric Endocrinology Diabetes and Metabolism, 29(3), 128-133. https://doi.org/10.5114/pedm.2023.132025 Chicago Shabani-Mirzaee, Hosein, Zahra Haghshenas, Armen Malekiantaghi, Mohsen Vigeh, Fazeleh Mahdavi, and Kambiz Eftekhari. 2023. \"The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial\". Pediatric Endocrinology Diabetes and Metabolism 29 (3): 128-133. doi:10.5114/pedm.2023.132025. Harvard Shabani-Mirzaee, H., Haghshenas, Z., Malekiantaghi, A., Vigeh, M., Mahdavi, F., and Eftekhari, K. (2023). The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial. Pediatric Endocrinology Diabetes and Metabolism, 29(3), pp.128-133. https://doi.org/10.5114/pedm.2023.132025 MLA Shabani-Mirzaee, Hosein et al. \"The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial.\" Pediatric Endocrinology Diabetes and Metabolism, vol. 29, no. 3, 2023, pp. 128-133. doi:10.5114/pedm.2023.132025. Vancouver Shabani-Mirzaee H, Haghshenas Z, Malekiantaghi A, Vigeh M, Mahdavi F, Eftekhari K. The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):128-133. doi:10.5114/pedm.2023.132025.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135706138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late diagnosis of DiGeorge syndrome in a 13-year-old male with subclinical course of the disease - case report and literature review.","authors":"Aleksandra Janina Wylazłowska, Małgorzata Grabarczyk, Marta Gorczyca, Paweł Matusik","doi":"10.5114/pedm.2023.132030","DOIUrl":"10.5114/pedm.2023.132030","url":null,"abstract":"<p><p>DiGeorge syndrome is associated with microdeletion of chromosome 22q11. Hypoplasia of the thymus, hypoparathyroidism, facial malformations and cardiac defects as well as learning difficulties are typical features of the disease. On the other hand hypocalcemia related to hypoparathyroidism is not present in every patient and can develop later and be persistent or transient and is often masked by the other signs or symptoms. We described a 13-year-old boy diagnosed with DiGeorge syndrome, after a few years of nonspecific signs and symptoms, and a microarray examination performed because myopathy was suspected on the basis of elevated creatine kinase activity. Only after molecular confirmation of DiGeorge syndrome the patient was referred to a pediatric endocrinologist and proper therapy started. Looking back to his medical history, low calcium levels were at least 2 times reported in the medical records, the child had learning difficulties, speech disturbances, and submucosal cleft palate suspicion. In conclusion it is important to educate general practitioners and pediatricians to check the serum calcium levels in patients presenting with nonspecific, muscular signs and symptoms.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 4","pages":"259-266"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric obesity - time to act as early as possible.","authors":"Joanna Szczyrska","doi":"10.5114/pedm.2023.133122","DOIUrl":"10.5114/pedm.2023.133122","url":null,"abstract":"<p><p>There has been a global increase in the average body mass index (BMI) in children and an alarming trend of increasing weight among the youngest children in recent decades. Childhood excess weight and obesity result in premature adult mortality and morbidity. Obesity is not only a risk factor for other diseases but is also a complex, multifactorial disease in its own right, linked to a genetic predisposition influenced by an increasingly permissive environment from intrauterine life throughout childhood and adolescence into adulthood. Knowledge of the prevalence of obesity from the earliest life stages and its trajectory is essential to raise awareness of the risks at each stage and to indicate the potential age of prevention and intervention. Taking effective anti-obesity measures in children, both preventive and therapeutic, is now a necessity, with successful interventions used to decrease body weight and thus reduce health consequences. Identified risk factors in the first 1,000 days of life and even earlier, before conception, suggest that this is a key period for the development of overweight and obesity, and it appears to be the best time for preventive action. The growing phenomenon of obesity among children requires not only prevention but also integral treatment. Lifestyle change intervention programs are considered key to the treatment of childhood obesity. Obesity trajectories, the higher effectiveness of applied interventions observed in younger age groups, and the dependence of the risk of developing complications on the duration of obesity confirm the need for early diagnosis and treatment of obesity in children from an early age. The main aim should be to prevent the onset of obesity, thus reducing the future health, social, and financial consequences.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 4","pages":"267-273"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}