Pediatric Endocrinology, Diabetes and Metabolism最新文献

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Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market 营养分析-特别关注在波兰消费市场的酸奶和天然酸奶中的碳水化合物含量
Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2023-01-01 DOI: 10.5114/pedm.2023.132026
Irena Mańkiewicz-Żurawska, Wanda Lutogniewska, Eliza Skała-Zamorowska, Przemysława Jarosz-Chobot
{"title":"Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market","authors":"Irena Mańkiewicz-Żurawska, Wanda Lutogniewska, Eliza Skała-Zamorowska, Przemysława Jarosz-Chobot","doi":"10.5114/pedm.2023.132026","DOIUrl":"https://doi.org/10.5114/pedm.2023.132026","url":null,"abstract":"AMA Mańkiewicz-Żurawska I, Lutogniewska W, Skała-Zamorowska E, Jarosz-Chobot P. Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):166-174. doi:10.5114/pedm.2023.132026. APA Mańkiewicz-Żurawska, I., Lutogniewska, W., Skała-Zamorowska, E., & Jarosz-Chobot, P. (2023). Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market. Pediatric Endocrinology Diabetes and Metabolism, 29(3), 166-174. https://doi.org/10.5114/pedm.2023.132026 Chicago Mańkiewicz-Żurawska, Irena, Wanda Lutogniewska, Eliza Skała-Zamorowska, and Przemysława Jarosz-Chobot. 2023. \"Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market\". Pediatric Endocrinology Diabetes and Metabolism 29 (3): 166-174. doi:10.5114/pedm.2023.132026. Harvard Mańkiewicz-Żurawska, I., Lutogniewska, W., Skała-Zamorowska, E., and Jarosz-Chobot, P. (2023). Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market. Pediatric Endocrinology Diabetes and Metabolism, 29(3), pp.166-174. https://doi.org/10.5114/pedm.2023.132026 MLA Mańkiewicz-Żurawska, Irena et al. \"Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market.\" Pediatric Endocrinology Diabetes and Metabolism, vol. 29, no. 3, 2023, pp. 166-174. doi:10.5114/pedm.2023.132026. Vancouver Mańkiewicz-Żurawska I, Lutogniewska W, Skała-Zamorowska E, Jarosz-Chobot P. Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):166-174. doi:10.5114/pedm.2023.132026.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135706344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings 1型糖尿病儿童及其健康兄弟姐妹的营养状况评估
Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2023-01-01 DOI: 10.5114/pedm.2023.131161
Melike Arslan, Emine Nüket Ünsal, Nihal Durmaz, Onur Akin, Sevinç Odabaşi Güneş, Necati Balamtekin
{"title":"Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings","authors":"Melike Arslan, Emine Nüket Ünsal, Nihal Durmaz, Onur Akin, Sevinç Odabaşi Güneş, Necati Balamtekin","doi":"10.5114/pedm.2023.131161","DOIUrl":"https://doi.org/10.5114/pedm.2023.131161","url":null,"abstract":"AMA Arslan M, Ünsal E, Durmaz N, Akin O, Güneş S, Balamtekin N. Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings. Pediatric Endocrinology Diabetes and Metabolism. 2023. doi:10.5114/pedm.2023.131161. APA Arslan, M., Ünsal, E., Durmaz, N., Akin, O., Güneş, S., & Balamtekin, N. (2023). Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings. Pediatric Endocrinology Diabetes and Metabolism. https://doi.org/10.5114/pedm.2023.131161 Chicago Arslan, Melike, Emine Nüket Ünsal, Nihal Durmaz, Onur Akin, Sevinç Odabaşi Güneş, and Necati Balamtekin. 2023. \"Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings\". Pediatric Endocrinology Diabetes and Metabolism. doi:10.5114/pedm.2023.131161. Harvard Arslan, M., Ünsal, E., Durmaz, N., Akin, O., Güneş, S., and Balamtekin, N. (2023). Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings. Pediatric Endocrinology Diabetes and Metabolism. https://doi.org/10.5114/pedm.2023.131161 MLA Arslan, Melike et al. \"Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings.\" Pediatric Endocrinology Diabetes and Metabolism, 2023. doi:10.5114/pedm.2023.131161. Vancouver Arslan M, Ünsal E, Durmaz N, Akin O, Güneş S, Balamtekin N. Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings. Pediatric Endocrinology Diabetes and Metabolism. 2023. doi:10.5114/pedm.2023.131161.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"293 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135600790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic consequences of recombinant human growth hormone therapy in patients with Turner syndrome. 重组人生长激素治疗对特纳综合征患者的代谢影响。
Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2023-01-01 DOI: 10.5114/pedm.2022.123204
Maria Gnacińska, Hanna Magnuszewska, Krzysztof Sworczak
{"title":"Metabolic consequences of recombinant human growth hormone therapy in patients with Turner syndrome.","authors":"Maria Gnacińska,&nbsp;Hanna Magnuszewska,&nbsp;Krzysztof Sworczak","doi":"10.5114/pedm.2022.123204","DOIUrl":"https://doi.org/10.5114/pedm.2022.123204","url":null,"abstract":"<p><strong>Introduction: </strong>Turner syndrome (TS) predisposes to metabolic complications. Currently, TS patients are treated with recombinant human growth hormone (rGH) as standard therapy. The long-term effect of this therapy on carbohydrate metabolism remains unclear. Aim of the study: To assess possible metabolic alterations following rGH therapy.</p><p><strong>Material and methods: </strong>Material and methods: We enrolled 53 TS participants, comprising 37 patients who finished rGH therapy (group 1) and 16 patients who did not receive growth promoting therapy (group 2). Several anthropometric measurements were made. Carbohydrate and lipid metabolism, adipokines, and hs-CRP were assessed basing on laboratory test. The following indices were calculated: HOMA-IR, HOMA-b, QUICKI, and Matsuda.</p><p><strong>Results: </strong>There were no statistically significant differences between the 2 groups in terms of BMI or WHR. There was a statistically significant lower mean percentage of fat tissue in group 1 compared to group 2 (27.46% vs. 31.75%). Insulin resistance and sensitivity indices were not statistically different between groups. Using the Matsuda index, more patients who met criteria of insulin resistance were found in group 2 than in group 1 (56.25% vs. 37.84%); however, this difference was not statistically significant (p = 0.2). No statistically significant differences were found in lipid profile, adipokines, and hsCRP between groups.</p><p><strong>Conclusions: </strong>rGH therapy leads to a beneficial change in body composition of TS patients despite unchanged BMI. A decrease in body fat persists for several years after finishing rGH treatment; rGH treatment is connected with a trend toward increased insulin sensitivity.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 1","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/ee/PEDM-29-49374.PMC10226455.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9575314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Elevated level of testosterone in amniotic fluid during prenatal stress and its association with development of Attention-Deficit/Hyperactivity Disorder (ADHD) like symptoms in toddlers. 产前应激时羊水中睾酮水平的升高及其与幼儿注意力缺陷/多动症(ADHD)类似症状发展的关系。
Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2023-01-01 DOI: 10.5114/pedm.2023.132031
Tamar Kacharava, Ketevan Nemsadze, Ketevan Inasaridze
{"title":"Elevated level of testosterone in amniotic fluid during prenatal stress and its association with development of Attention-Deficit/Hyperactivity Disorder (ADHD) like symptoms in toddlers.","authors":"Tamar Kacharava, Ketevan Nemsadze, Ketevan Inasaridze","doi":"10.5114/pedm.2023.132031","DOIUrl":"10.5114/pedm.2023.132031","url":null,"abstract":"<p><strong>Aim of the study: </strong>To investigate the \"prenatal testosterone hypothesis\", according to which, high level of testosterone associated with the development of ADHD like symptoms in younger children, and to investigate whether maternal stress during pregnancy in-creases the risk of developing ADHD like symptoms in early childhood.</p><p><strong>Design: </strong>This was a prospective study with three measurement periods: the first one during pregnancy (12 to 25 weeks of gestation); the second period involved the assessment of infants of this pregnancy at the age of 6 months and the third one the assessment of the same infants at the age of 18 months. The research plan is approved by \"David Tvildiani Medical University\" Research Ethics Committee. The study does not contain serious predictable risks as the expected benefit overweighs them.</p><p><strong>Material and methods: </strong>The study group is presented by 40 pregnant women and 40 infants of these pregnancies. Pregnant women were asked about their perceived stress levels, critical life events of the past year and pregnancy-specific stress levels using standardized questionnaires. Child's temperament and behavioral regulation were assessed using the questionnaires. Amniotic fluid was collected undergoing amniocentesis. Total testosterone in amniotic fluid was measured by radioimmunoassay.</p><p><strong>Results: </strong>Although statistically significant relationship was identified between hyperactivity, also impulsiveness symptoms and pre-natal stress, no statistically significant relationship was identified between testosterone level and hyperactivity, also impulsivity symptoms, as well as between testosterone level and prenatal stress level.</p><p><strong>Conclusions: </strong>The performed study did not support the \"hypothesis about prenatal testosterone\", because there was a significant negative correlation between the frequency of hyperactivity symptoms and testosterone level.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 4","pages":"248-252"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are menstrual disorders in adolescent girls related to metabolic disorders? 青春期女孩的月经失调与代谢紊乱有关吗?
Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2023-01-01 DOI: 10.5114/pedm.2023.125364
Elżbieta Foryś, Adrianna Baran, Aleksandra Dziurdzia, Ewelina Jarosz-Wójcik, Paweł Matusik, Aneta Gawlik, Ryszard Tomaszewski, Agnieszka Zachurzok
{"title":"Are menstrual disorders in adolescent girls related to metabolic disorders?","authors":"Elżbieta Foryś,&nbsp;Adrianna Baran,&nbsp;Aleksandra Dziurdzia,&nbsp;Ewelina Jarosz-Wójcik,&nbsp;Paweł Matusik,&nbsp;Aneta Gawlik,&nbsp;Ryszard Tomaszewski,&nbsp;Agnieszka Zachurzok","doi":"10.5114/pedm.2023.125364","DOIUrl":"https://doi.org/10.5114/pedm.2023.125364","url":null,"abstract":"<p><strong>Introduction: </strong>Menstrual disorders in adolescent girls are a common clinical problem. They are often accompanied by lipid and glucose metabolism disturbances. The aim of the study was to investigate to what extent the metabolic profile of adolescent girls relates to the severity of their menstrual disorders.</p><p><strong>Material and methods: </strong>The study included 165 girls with menstrual disturbances and 49 regularly menstruating girls (REG) without clinical hyperandrogenism, matched for age and BMI. The subjects from the study group were divided into 2 subgroups: OLIGO - 111 girls with oligomenorrhea and SA - 54 girls with secondary amenorrhoea. In all girls, hormonal, lipid, and carbohydrate metabolism profiles were assessed.</p><p><strong>Results: </strong>In the SA subgroup concentrations of total cholesterol (TC) and LDL were significantly higher than in the REG and OLIGO groups. Triglyceride (TG) concentration was also the highest in the SA group and significantly higher than in the REG group. The prevalence of lipid metabolism disorders was higher in the SA group (65%) vs. the REG (40%) and OLIGO (51%) groups. The subgroups did not differ significantly in terms of fasting and OGTT glucose and insulin as well as HOMA-IR. TyG index was significantly higher in the OLIGO and SA groups than in the REG group. BMI z-score correlated with TG, LDL, fasting and 120' OGTT glucose and insulin, HOMA-IR, and TyG and negatively with HDL. No relationship between hormonal concentration and metabolic disturbances was found.</p><p><strong>Conclusions: </strong>Adolescent girls with menstrual disorders are insulin resistant, regardless of PCOS diagnosis. The severity of menstrual disorders may be related to the incidence of lipid disorders in adolescent girls.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 2","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/fd/PEDM-29-50193.PMC10411084.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predisposition to atherosclerosis in children and adults with trisomy 21: biochemical and metabolomic studies 21三体儿童和成人动脉粥样硬化易感性:生化和代谢组学研究
Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2023-01-01 DOI: 10.5114/pedm.2023.131162
Marta Hetman, Karolina Mielko, Sylwia Placzkowska, Aleksandra Bodetko, Piotr Młynarz, Ewa Barg
{"title":"Predisposition to atherosclerosis in children and adults with trisomy 21: biochemical and metabolomic studies","authors":"Marta Hetman, Karolina Mielko, Sylwia Placzkowska, Aleksandra Bodetko, Piotr Młynarz, Ewa Barg","doi":"10.5114/pedm.2023.131162","DOIUrl":"https://doi.org/10.5114/pedm.2023.131162","url":null,"abstract":"Introduction Atherosclerosis, a precursor to cardiovascular disease (CVD), is deeply intertwined with lipid metabolism. The metabolic process in the Down syndrome (DS) population remain less explored. Aim of the study: This study examines the lipid profiles of DS in comparison to their siblings (CG), aiming to uncover potential atherosclerotic and CVD risks. Material and methods The study included 42 people with DS (mean age 14.17 years) and the CG – 20 individuals (mean age 15.92 years). Anthropometric measurements: BMI, BMI SDS, and TMI were calculated. Lipid profile (LP) and metabolomics were determined. Results LP: DS display significantly reduced HDL (DS vs. CG: 47±10 vs. 59 ±12 mg/dl; p = 0.0001) and elevated LDL (104 ±25 vs. 90 ±22 mg/dl; p = 0.0331). Triglycerides, APO A1, and APO B/APO A1 ratio corroborate with the elevated risk of CVD in DS. Despite no marked differences in: TCH and APO B, the DS group demonstrated a concerning BMI trend. Of 31 identified metabolites, 12 showed statistical significance (acetate, choline, creatinine, formate, glutamine, histidine, lysine, proline, pyroglutamate, threonine, tyrosine, and xanthine). However, only 8 metabolites passed the FDR validation (acetate, creatinine, formate, glutamine, lysine, proline, pyroglutamate, xanthine). Conclusions Down syndrome individuals show distinct cardiovascular risks, with decreased HDL and increased LDL levels. Combined with metabolomic disparities and higher BMI and TMI, this suggests an increased atherosclerosis risk compared to controls.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135706355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Availability of psychological care in pediatric diabetes centers - a real need? 儿童糖尿病中心心理护理的可用性——一个真正的需求?
Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2023-01-01 DOI: 10.5114/pedm.2023.126358
Olga Kamińska-Jackowiak, Anna Malatyńska, Agata Chobot, Katarzyna A Gajewska
{"title":"Availability of psychological care in pediatric diabetes centers - a real need?","authors":"Olga Kamińska-Jackowiak,&nbsp;Anna Malatyńska,&nbsp;Agata Chobot,&nbsp;Katarzyna A Gajewska","doi":"10.5114/pedm.2023.126358","DOIUrl":"https://doi.org/10.5114/pedm.2023.126358","url":null,"abstract":"<p><p>The role of a multidisciplinary diabetes team (MDT) in the treatment of a person with diabetes is emphasized by both Polish and international recommendations. The importance of the availability of psychological care for the well-being and mental health of individuals (and their caregivers), as well as for diabetes management and medical outcomes, is a subject of numerous analyzes. Despite the recommendations and research showing the benefits of psychological intervention and support, there is a scarcity of data on the real availability of such care, both in Poland as well as worldwide.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 1","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/57/PEDM-29-50489.PMC10226459.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9581129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subclinical hypothyroidism in children and adolescents as mild dysfunction of the thyroid gland: a single-center study. 儿童和青少年甲状腺功能减退亚临床表现为甲状腺轻度功能障碍:一项单中心研究。
Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2023-01-01 DOI: 10.5114/pedm.2023.124266
Kamila Szeliga, Aleksandra Antosz, Karolina Skrzynska, Barbara Kalina-Faska, Aneta Gawlik
{"title":"Subclinical hypothyroidism in children and adolescents as mild dysfunction of the thyroid gland: a single-center study.","authors":"Kamila Szeliga,&nbsp;Aleksandra Antosz,&nbsp;Karolina Skrzynska,&nbsp;Barbara Kalina-Faska,&nbsp;Aneta Gawlik","doi":"10.5114/pedm.2023.124266","DOIUrl":"https://doi.org/10.5114/pedm.2023.124266","url":null,"abstract":"<p><strong>Introduction: </strong>Subclinical hypothyroidism (SH) is a biochemical diagnosis made when a serum thyroid-stimulating hormone (TSH) is ele-vated with circulating thyroid hormone levels within their reference ranges.</p><p><strong>Aim of the study: </strong>Aim of our prospective non-randomized study was to evaluate the course of SH.</p><p><strong>Material and methods: </strong>All patients with suspicion of SH referred to the Endocrinology Outpatient Clinic between 2014 and 2018 were recruited to prospective study.</p><p><strong>Results: </strong>A total of 130 patients with SH were recruited for this study. Thirty-five (26.9%) patients were followed up without levothy-roxine (L-T4) (SH-T0 group) and therapy with L-T4 was randomly introduced in 95/130 (73.1%) SH children (SH-T1 group). We did not find statistical differences in hSDS and BMI Z-score between the SH-T0 and SH-T1 groups (p = 0.761 and p = 0.843, respectively). Introducing L-T4 in patients with short stature did not affect the linear growth at the end of FU ex-pressed as hSDS. OH developed in six children (6.3%) in the SH-T1 group. After conducting a multivariate logistic regres-sion, we found that the baseline TSH concentration and BMI Z-score are possible predictors of OH.</p><p><strong>Conslusions: </strong>Our study confirmed a low risk of progression of SH to overt hypothyroidism. The majority of patients remains SH or resolved for nor-mal thyroid function. The L-T4 therapy did not effect on linear growth and body weight. The main predictor of worsening to hypothyroidism were a higher TSH level and Z-score BMI.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 2","pages":"97-103"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/45/07/PEDM-29-49969.PMC10411089.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41160059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differences in the clinical picture at the onset of diagnosis of severe autoimmune hypothyroidism in children depending on the time of diagnosis: before or during the SARS-CoV-2 pandemic. 儿童严重自身免疫性甲状腺功能减退症发病时的临床表现因诊断时间而异:是在SARS-CoV-2大流行之前还是期间。
Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2023-01-01 DOI: 10.5114/pedm.2023.133123
Jessica Munarin, Gerdi Tuli
{"title":"Differences in the clinical picture at the onset of diagnosis of severe autoimmune hypothyroidism in children depending on the time of diagnosis: before or during the SARS-CoV-2 pandemic.","authors":"Jessica Munarin, Gerdi Tuli","doi":"10.5114/pedm.2023.133123","DOIUrl":"10.5114/pedm.2023.133123","url":null,"abstract":"<p><strong>Introduction: </strong>There are few data about effects of COVID-19 on thyroid disease presentation in children, due to difficulties in healthcare services access.</p><p><strong>Aim of the study: </strong>To assess the differences in hypothyroidism presentation before and during the COVID-19 pandemic.</p><p><strong>Material and methods: </strong>All paediatric patients with autoimmune hypothyroidism (AIT) diagnosed from January 2017 to December 2022 were analysed.</p><p><strong>Results: </strong>A total of 150 subjects were enrolled (94 in before and 56 during the pandemic period). Severe AIT was detected in 7.4% before and 12.5% during the pandemic. Age at the onset in the pre-pandemic period was lower ( p = 0.04). Diagnosis delay (time elapsed from onset of symptoms and diagnosis) was significantly different between the before and during the pandemic groups ( p = 0.02). In the pre-pandemic period the TSH value was 447.7 ±59.1, and it was 713.7 ±104.4 mUI/l during the pandemic ( p = 0.04), whereas mean fT4 values were 2.66 ±0.34 and 0.58 ±0.08 ng/l, respectively ( p = 0.0002). Significantly greater thyroid volume and bone age delay SDS were observed during the pandemic ( p = 0.04). Neurological symptoms were mostly observed during the pandemic, especially slow speech and impaired school performance.</p><p><strong>Conclusions: </strong>A higher rate of severe AIT was observed during the pandemic period, mostly related to difficulties in access to healthcare services. The diagnosis delay led to a more severe biochemical thyroid hormone profile, goitre, and more frequent presence of bone age delay and neurological symptoms at the onset. Recognizing hypothyroidism and recalling symptoms in child-hood, even if often non-specific, is fundamental for avoiding diagnosis delay.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 4","pages":"253-258"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenocortical carcinoma – 12-year observation period in a single centre. Case report with literature review 肾上腺皮质癌:单中心12年观察期。病例报告并文献复习
Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2023-01-01 DOI: 10.5114/pedm.2023.132131
Patrycja Dasiewicz, Elżbieta Moszczyńska, Danuta Perek, Dariusz Polnik, Maria Stepaniuk, Joanna Trubicka, Wiesława Grajkowska
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