Pediatric Endocrinology, Diabetes and Metabolism最新文献

{"title":"Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study","authors":"Marta Hetman, Ewa Barg, Sylwia Placzkowska","doi":"10.5114/pedm.2023.131513","DOIUrl":"https://doi.org/10.5114/pedm.2023.131513","url":null,"abstract":"AMA Hetman M, Barg E, Placzkowska S. Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):134-142. doi:10.5114/pedm.2023.131513. APA Hetman, M., Barg, E., & Placzkowska, S. (2023). Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study. Pediatric Endocrinology Diabetes and Metabolism, 29(3), 134-142. https://doi.org/10.5114/pedm.2023.131513 Chicago Hetman, Marta, Ewa Barg, and Sylwia Placzkowska. 2023. \"Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study\". Pediatric Endocrinology Diabetes and Metabolism 29 (3): 134-142. doi:10.5114/pedm.2023.131513. Harvard Hetman, M., Barg, E., and Placzkowska, S. (2023). Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study. Pediatric Endocrinology Diabetes and Metabolism, 29(3), pp.134-142. https://doi.org/10.5114/pedm.2023.131513 MLA Hetman, Marta et al. \"Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study.\" Pediatric Endocrinology Diabetes and Metabolism, vol. 29, no. 3, 2023, pp. 134-142. doi:10.5114/pedm.2023.131513. Vancouver Hetman M, Barg E, Placzkowska S. Comparative analysis of obesity prevalence, antioxidant and oxidant status in children with Down syndrome – a sibling-controlled study. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):134-142. doi:10.5114/pedm.2023.131513.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135706356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary guidelines in diabetes – why are they so difficult to follow?","authors":"Beata Sińska, Alicja Kucharska","doi":"10.5114/pedm.2023.132024","DOIUrl":"https://doi.org/10.5114/pedm.2023.132024","url":null,"abstract":"","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135706385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital hypothyroidism due to thyroid ectopy not detected in neonatal screening - case report.","authors":"Anna Stępniewska,&nbsp;Małgorzata Wójcik,&nbsp;Jerzy B Starzyk","doi":"10.5114/pedm.2022.118322","DOIUrl":"https://doi.org/10.5114/pedm.2022.118322","url":null,"abstract":"<p><p>Newborn screening for congenital hypothyroidism (CH) has been highly effective in preventing devastating neurodevelopmental and physical sequelae in affected infants. We report a case of an ectopic thyroid gland located in the submandibular area detected at the age of 3 months, which was missed by congenital hypothyroidism screening test based on twice-repeated TSH measurement in dried blood spots. The diagnosis of subclinical hypothyroidism was confirmed on the basis of blood test performed in the endocrine clinic: TSH 26.3 µIU/ml (N: < 10 µIU/ml), with FT4 14.7 pmol/l (N: 10-25 pmol/l) and fT3 6.9 pmol/l (N: 3-8 pmol/l). Ultrasonography and scintigraphy revealed ectopically located thyroid tissue in the sublingual area. In the case of doubtful results of a neonatal screening test or in any case of suspected congenital hypothyroidism, the diagnosis should be supplemented with ultrasound examination of the neonate's neck and followed by scintigraphy if necessary.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 1","pages":"53-56"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/f8/PEDM-29-47556.PMC10226458.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9580637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial","authors":"Hosein Shabani-Mirzaee, Zahra Haghshenas, Armen Malekiantaghi, Mohsen Vigeh, Fazeleh Mahdavi, Kambiz Eftekhari","doi":"10.5114/pedm.2023.132025","DOIUrl":"https://doi.org/10.5114/pedm.2023.132025","url":null,"abstract":"AMA Shabani-Mirzaee H, Haghshenas Z, Malekiantaghi A, Vigeh M, Mahdavi F, Eftekhari K. The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):128-133. doi:10.5114/pedm.2023.132025. APA Shabani-Mirzaee, H., Haghshenas, Z., Malekiantaghi, A., Vigeh, M., Mahdavi, F., & Eftekhari, K. (2023). The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial. Pediatric Endocrinology Diabetes and Metabolism, 29(3), 128-133. https://doi.org/10.5114/pedm.2023.132025 Chicago Shabani-Mirzaee, Hosein, Zahra Haghshenas, Armen Malekiantaghi, Mohsen Vigeh, Fazeleh Mahdavi, and Kambiz Eftekhari. 2023. \"The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial\". Pediatric Endocrinology Diabetes and Metabolism 29 (3): 128-133. doi:10.5114/pedm.2023.132025. Harvard Shabani-Mirzaee, H., Haghshenas, Z., Malekiantaghi, A., Vigeh, M., Mahdavi, F., and Eftekhari, K. (2023). The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial. Pediatric Endocrinology Diabetes and Metabolism, 29(3), pp.128-133. https://doi.org/10.5114/pedm.2023.132025 MLA Shabani-Mirzaee, Hosein et al. \"The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial.\" Pediatric Endocrinology Diabetes and Metabolism, vol. 29, no. 3, 2023, pp. 128-133. doi:10.5114/pedm.2023.132025. Vancouver Shabani-Mirzaee H, Haghshenas Z, Malekiantaghi A, Vigeh M, Mahdavi F, Eftekhari K. The effect of oral probiotics on glycated haemoglobin levels in children with type 1 diabetes mellitus – a randomized clinical trial. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):128-133. doi:10.5114/pedm.2023.132025.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135706138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late diagnosis of DiGeorge syndrome in a 13-year-old male with subclinical course of the disease - case report and literature review.","authors":"Aleksandra Janina Wylazłowska, Małgorzata Grabarczyk, Marta Gorczyca, Paweł Matusik","doi":"10.5114/pedm.2023.132030","DOIUrl":"10.5114/pedm.2023.132030","url":null,"abstract":"<p><p>DiGeorge syndrome is associated with microdeletion of chromosome 22q11. Hypoplasia of the thymus, hypoparathyroidism, facial malformations and cardiac defects as well as learning difficulties are typical features of the disease. On the other hand hypocalcemia related to hypoparathyroidism is not present in every patient and can develop later and be persistent or transient and is often masked by the other signs or symptoms. We described a 13-year-old boy diagnosed with DiGeorge syndrome, after a few years of nonspecific signs and symptoms, and a microarray examination performed because myopathy was suspected on the basis of elevated creatine kinase activity. Only after molecular confirmation of DiGeorge syndrome the patient was referred to a pediatric endocrinologist and proper therapy started. Looking back to his medical history, low calcium levels were at least 2 times reported in the medical records, the child had learning difficulties, speech disturbances, and submucosal cleft palate suspicion. In conclusion it is important to educate general practitioners and pediatricians to check the serum calcium levels in patients presenting with nonspecific, muscular signs and symptoms.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 4","pages":"259-266"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market","authors":"Irena Mańkiewicz-Żurawska, Wanda Lutogniewska, Eliza Skała-Zamorowska, Przemysława Jarosz-Chobot","doi":"10.5114/pedm.2023.132026","DOIUrl":"https://doi.org/10.5114/pedm.2023.132026","url":null,"abstract":"AMA Mańkiewicz-Żurawska I, Lutogniewska W, Skała-Zamorowska E, Jarosz-Chobot P. Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):166-174. doi:10.5114/pedm.2023.132026. APA Mańkiewicz-Żurawska, I., Lutogniewska, W., Skała-Zamorowska, E., & Jarosz-Chobot, P. (2023). Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market. Pediatric Endocrinology Diabetes and Metabolism, 29(3), 166-174. https://doi.org/10.5114/pedm.2023.132026 Chicago Mańkiewicz-Żurawska, Irena, Wanda Lutogniewska, Eliza Skała-Zamorowska, and Przemysława Jarosz-Chobot. 2023. \"Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market\". Pediatric Endocrinology Diabetes and Metabolism 29 (3): 166-174. doi:10.5114/pedm.2023.132026. Harvard Mańkiewicz-Żurawska, I., Lutogniewska, W., Skała-Zamorowska, E., and Jarosz-Chobot, P. (2023). Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market. Pediatric Endocrinology Diabetes and Metabolism, 29(3), pp.166-174. https://doi.org/10.5114/pedm.2023.132026 MLA Mańkiewicz-Żurawska, Irena et al. \"Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market.\" Pediatric Endocrinology Diabetes and Metabolism, vol. 29, no. 3, 2023, pp. 166-174. doi:10.5114/pedm.2023.132026. Vancouver Mańkiewicz-Żurawska I, Lutogniewska W, Skała-Zamorowska E, Jarosz-Chobot P. Nutrition analysis – with particular focus on carbohydrate content in kefirs and natural yoghurts in the Polish consumer market. Pediatric Endocrinology Diabetes and Metabolism. 2023;29(3):166-174. doi:10.5114/pedm.2023.132026.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135706344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings","authors":"Melike Arslan, Emine Nüket Ünsal, Nihal Durmaz, Onur Akin, Sevinç Odabaşi Güneş, Necati Balamtekin","doi":"10.5114/pedm.2023.131161","DOIUrl":"https://doi.org/10.5114/pedm.2023.131161","url":null,"abstract":"AMA Arslan M, Ünsal E, Durmaz N, Akin O, Güneş S, Balamtekin N. Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings. Pediatric Endocrinology Diabetes and Metabolism. 2023. doi:10.5114/pedm.2023.131161. APA Arslan, M., Ünsal, E., Durmaz, N., Akin, O., Güneş, S., & Balamtekin, N. (2023). Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings. Pediatric Endocrinology Diabetes and Metabolism. https://doi.org/10.5114/pedm.2023.131161 Chicago Arslan, Melike, Emine Nüket Ünsal, Nihal Durmaz, Onur Akin, Sevinç Odabaşi Güneş, and Necati Balamtekin. 2023. \"Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings\". Pediatric Endocrinology Diabetes and Metabolism. doi:10.5114/pedm.2023.131161. Harvard Arslan, M., Ünsal, E., Durmaz, N., Akin, O., Güneş, S., and Balamtekin, N. (2023). Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings. Pediatric Endocrinology Diabetes and Metabolism. https://doi.org/10.5114/pedm.2023.131161 MLA Arslan, Melike et al. \"Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings.\" Pediatric Endocrinology Diabetes and Metabolism, 2023. doi:10.5114/pedm.2023.131161. Vancouver Arslan M, Ünsal E, Durmaz N, Akin O, Güneş S, Balamtekin N. Evaluation of the nutritional status of children with type 1 diabetes and their healthy siblings. Pediatric Endocrinology Diabetes and Metabolism. 2023. doi:10.5114/pedm.2023.131161.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"293 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135600790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric obesity - time to act as early as possible.","authors":"Joanna Szczyrska","doi":"10.5114/pedm.2023.133122","DOIUrl":"10.5114/pedm.2023.133122","url":null,"abstract":"<p><p>There has been a global increase in the average body mass index (BMI) in children and an alarming trend of increasing weight among the youngest children in recent decades. Childhood excess weight and obesity result in premature adult mortality and morbidity. Obesity is not only a risk factor for other diseases but is also a complex, multifactorial disease in its own right, linked to a genetic predisposition influenced by an increasingly permissive environment from intrauterine life throughout childhood and adolescence into adulthood. Knowledge of the prevalence of obesity from the earliest life stages and its trajectory is essential to raise awareness of the risks at each stage and to indicate the potential age of prevention and intervention. Taking effective anti-obesity measures in children, both preventive and therapeutic, is now a necessity, with successful interventions used to decrease body weight and thus reduce health consequences. Identified risk factors in the first 1,000 days of life and even earlier, before conception, suggest that this is a key period for the development of overweight and obesity, and it appears to be the best time for preventive action. The growing phenomenon of obesity among children requires not only prevention but also integral treatment. Lifestyle change intervention programs are considered key to the treatment of childhood obesity. Obesity trajectories, the higher effectiveness of applied interventions observed in younger age groups, and the dependence of the risk of developing complications on the duration of obesity confirm the need for early diagnosis and treatment of obesity in children from an early age. The main aim should be to prevent the onset of obesity, thus reducing the future health, social, and financial consequences.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 4","pages":"267-273"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic consequences of recombinant human growth hormone therapy in patients with Turner syndrome.","authors":"Maria Gnacińska,&nbsp;Hanna Magnuszewska,&nbsp;Krzysztof Sworczak","doi":"10.5114/pedm.2022.123204","DOIUrl":"https://doi.org/10.5114/pedm.2022.123204","url":null,"abstract":"<p><strong>Introduction: </strong>Turner syndrome (TS) predisposes to metabolic complications. Currently, TS patients are treated with recombinant human growth hormone (rGH) as standard therapy. The long-term effect of this therapy on carbohydrate metabolism remains unclear. Aim of the study: To assess possible metabolic alterations following rGH therapy.</p><p><strong>Material and methods: </strong>Material and methods: We enrolled 53 TS participants, comprising 37 patients who finished rGH therapy (group 1) and 16 patients who did not receive growth promoting therapy (group 2). Several anthropometric measurements were made. Carbohydrate and lipid metabolism, adipokines, and hs-CRP were assessed basing on laboratory test. The following indices were calculated: HOMA-IR, HOMA-b, QUICKI, and Matsuda.</p><p><strong>Results: </strong>There were no statistically significant differences between the 2 groups in terms of BMI or WHR. There was a statistically significant lower mean percentage of fat tissue in group 1 compared to group 2 (27.46% vs. 31.75%). Insulin resistance and sensitivity indices were not statistically different between groups. Using the Matsuda index, more patients who met criteria of insulin resistance were found in group 2 than in group 1 (56.25% vs. 37.84%); however, this difference was not statistically significant (p = 0.2). No statistically significant differences were found in lipid profile, adipokines, and hsCRP between groups.</p><p><strong>Conclusions: </strong>rGH therapy leads to a beneficial change in body composition of TS patients despite unchanged BMI. A decrease in body fat persists for several years after finishing rGH treatment; rGH treatment is connected with a trend toward increased insulin sensitivity.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 1","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/ee/PEDM-29-49374.PMC10226455.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9575314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are menstrual disorders in adolescent girls related to metabolic disorders?","authors":"Elżbieta Foryś,&nbsp;Adrianna Baran,&nbsp;Aleksandra Dziurdzia,&nbsp;Ewelina Jarosz-Wójcik,&nbsp;Paweł Matusik,&nbsp;Aneta Gawlik,&nbsp;Ryszard Tomaszewski,&nbsp;Agnieszka Zachurzok","doi":"10.5114/pedm.2023.125364","DOIUrl":"https://doi.org/10.5114/pedm.2023.125364","url":null,"abstract":"<p><strong>Introduction: </strong>Menstrual disorders in adolescent girls are a common clinical problem. They are often accompanied by lipid and glucose metabolism disturbances. The aim of the study was to investigate to what extent the metabolic profile of adolescent girls relates to the severity of their menstrual disorders.</p><p><strong>Material and methods: </strong>The study included 165 girls with menstrual disturbances and 49 regularly menstruating girls (REG) without clinical hyperandrogenism, matched for age and BMI. The subjects from the study group were divided into 2 subgroups: OLIGO - 111 girls with oligomenorrhea and SA - 54 girls with secondary amenorrhoea. In all girls, hormonal, lipid, and carbohydrate metabolism profiles were assessed.</p><p><strong>Results: </strong>In the SA subgroup concentrations of total cholesterol (TC) and LDL were significantly higher than in the REG and OLIGO groups. Triglyceride (TG) concentration was also the highest in the SA group and significantly higher than in the REG group. The prevalence of lipid metabolism disorders was higher in the SA group (65%) vs. the REG (40%) and OLIGO (51%) groups. The subgroups did not differ significantly in terms of fasting and OGTT glucose and insulin as well as HOMA-IR. TyG index was significantly higher in the OLIGO and SA groups than in the REG group. BMI z-score correlated with TG, LDL, fasting and 120' OGTT glucose and insulin, HOMA-IR, and TyG and negatively with HDL. No relationship between hormonal concentration and metabolic disturbances was found.</p><p><strong>Conclusions: </strong>Adolescent girls with menstrual disorders are insulin resistant, regardless of PCOS diagnosis. The severity of menstrual disorders may be related to the incidence of lipid disorders in adolescent girls.</p>","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"29 2","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/fd/PEDM-29-50193.PMC10411084.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}