2011 IEEE 11th International Conference on Bioinformatics and Bioengineering最新文献_第2页

Principal Component Analysis Method for Detection and Classification of ECG Beat 心电拍检测与分类的主成分分析方法

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.59

Yun-Chi Yeh, Tung-Chien Chiang, Hong-Jhih Lin

引用次数: 8

Downstream Exploration of DNA-Bound Searching Proteins: A Diffusion-Reaction Model dna结合搜索蛋白的下游探索:扩散反应模型

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.11

Michael L. Mayo, E. Perkins, P. Ghosh

引用次数: 1

Epileptic Seizure Detection for Multichannel EEG Signals with Support Vector Machines 基于支持向量机的多通道脑电信号癫痫发作检测

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.13

Chia-Ping Shen, Chih-Min Chan, Feng-Sheng Lin, M. Chiu, Jeng-Wei Lin, J. Kao, C. C. Chen, F. Lai

引用次数: 32

The Development of the Dry Cleaning and Surface Treatment All-in-one Equipment Used for Biochip 生物芯片干洗机和表面处理一体机的研制

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.55

Chi-Sang Lau, Fun-jou Chen

{"title":"The Development of the Dry Cleaning and Surface Treatment All-in-one Equipment Used for Biochip","authors":"Chi-Sang Lau, Fun-jou Chen","doi":"10.1109/BIBE.2011.55","DOIUrl":"https://doi.org/10.1109/BIBE.2011.55","url":null,"abstract":"The surface treatment and cleaning for biochips has been a long existing problem to the biological scientists. We provided a fast, reliable and low cost method to solve this difficulty. We proposed a method using a high density hot Ozone vapor to clean the organic pollutant on the slide surface. Further, we added a Chemical Vapor Deposit system (CVD) in the operating chamber to process the surface energy treatment with the biochips. In this way, the hydrophilic or hydrophobic character of biochip surface could be controlled. A nozzle of CVD system is a long metal capillary needle used to inject chemistry liquid into the reaction chamber directly. Different from the common CVD systems, we used the chemical vapor guiding pipe, so there is no liquid jam in the guiding pipe. Moreover, we can get a high quality coated thin film by steaming the hot vapor to the slides in a sealed vessel without any vacuum equipment. The features of this system are fast, low cost, and easy to be operated. All processes are completely integrated in one chamber. The producing period of the biochips may be reduced from ten hours to one hour.","PeriodicalId":391184,"journal":{"name":"2011 IEEE 11th International Conference on Bioinformatics and Bioengineering","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131149271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Prediction of mRNA Polyadenylation Sites in Human Genes 人类基因中mRNA聚腺苷化位点的预测

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.64

Jorng-Tzong Horng, Li-Ching Wu, Shun-Kai Liu, Cheng-Wei Chang, Tsung-Ming Chao, Rong-Hwei Yeh, Kuang-Fu Cheng

{"title":"A Prediction of mRNA Polyadenylation Sites in Human Genes","authors":"Jorng-Tzong Horng, Li-Ching Wu, Shun-Kai Liu, Cheng-Wei Chang, Tsung-Ming Chao, Rong-Hwei Yeh, Kuang-Fu Cheng","doi":"10.1109/BIBE.2011.64","DOIUrl":"https://doi.org/10.1109/BIBE.2011.64","url":null,"abstract":"mRNA polyadenylation is an essential mechanism in human genes and is direct linked to the termination of transcription. Alternative polyadenylation changes the length of the mature mRNA’s 3’UTR. Since 3’UTRs have been shown to contain regulatory elements that control mRNA functioning, alternative polyadenylation plays an important role in controlling the expression of human genes. Prediction of polyadenylation sites can help with the identification of genes and aid our understanding of the mechanisms of alternative polyadenylation. In this study, we constructed a system for mRNA polyadenylation site prediction in human genes using SVM and based on an analysis of the sequence alignment between pair-end diTags (PET) and genome sequences. The PET sequences were mapped to the reference genome more accurate compared to earlier methods. We also analyzed single-site type and multiple-site type sequences PET sequence datasets and found that the frequencies of each nucleotide were different when the single-site type and multiple-site type PET sequences were compared.","PeriodicalId":391184,"journal":{"name":"2011 IEEE 11th International Conference on Bioinformatics and Bioengineering","volume":"430 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131580219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Segmentation of the Pectoral Muscle Boundary in Breast MR Images 乳腺MR图像中胸肌边界的分割

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.60

Myungeun Lee, Yanjuan Chen, Soohyung Kim, Jong Hyo Kim

引用次数: 3

Analysis of SNP Interaction Combinations to Determine Breast Cancer Risk with PSO 分析SNP相互作用组合确定患PSO的乳腺癌风险

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.52

Li-Yeh Chuang, Ming-Cheng Lin, Hsueh-Wei Chang, Cheng-Hong Yang

{"title":"Analysis of SNP Interaction Combinations to Determine Breast Cancer Risk with PSO","authors":"Li-Yeh Chuang, Ming-Cheng Lin, Hsueh-Wei Chang, Cheng-Hong Yang","doi":"10.1109/BIBE.2011.52","DOIUrl":"https://doi.org/10.1109/BIBE.2011.52","url":null,"abstract":"Many association studies analyze the genotype frequencies of case and control data to predict susceptibility to diseases and cancers. An increasing number of studies has shown that the risk of getting diseases and cancers is associated with the co-occurrence of some contain single nucleotide polymorphisms (SNPs). Determining the disease-causing SNPs has become an important objective. In order to study the SNPSNP interaction in breast cancer, we used a particle swarm optimization (PSO) algorithm to compute the difference between the control and case data and performed a feature selection from different SNP combinations with their corresponding genotypes. The best combination of SNP-SNP interactions is the maximal difference of co-occurrences between the control and case groups. In this study, we explored the SNP interaction of 19 SNPs in 372 controls and 398 cases of breast cancer association using simulated SNP data of breast cancers. The odds ratio (OR) were used to evaluate the breast cancer risk in terms of the best combination of SNP-SNP interactions. Compared to their corresponding non-SNP combinations, the estimated OR of the best predicted SNP combination with genotypes for breast cancer is significantly greater than 1 (about 1.771 and 2.417, confidence interval (CI): 1.223-4.371, p","PeriodicalId":391184,"journal":{"name":"2011 IEEE 11th International Conference on Bioinformatics and Bioengineering","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125216990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Clinical Characteristics Change and the Heart Rate Variability of Subjects with Metabolic Syndrome in the Weight Loss Program 减肥计划中代谢综合征患者的临床特征变化和心率变异性

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.66

Ching-I Lin, Wan‐Teng Lin, M. Fan, M. Lin, Chang-Hai Tsai, F. Tsai, Wei-Jen Ting, Chih-Yang Huang, Y. Tsai

{"title":"Clinical Characteristics Change and the Heart Rate Variability of Subjects with Metabolic Syndrome in the Weight Loss Program","authors":"Ching-I Lin, Wan‐Teng Lin, M. Fan, M. Lin, Chang-Hai Tsai, F. Tsai, Wei-Jen Ting, Chih-Yang Huang, Y. Tsai","doi":"10.1109/BIBE.2011.66","DOIUrl":"https://doi.org/10.1109/BIBE.2011.66","url":null,"abstract":"The purpose of this study was to evaluate whether a weight loss program, including nutrition education and physical fitness, has a positive effects on heart rate variability (HRV) in subjects with metabolic syndrome. Twelve female volunteers with metabolic syndrome, who aged between 30 and 60 years, and resided at Jiantan, Taiwan, were studied. All subjects participated in the weight loss program for 3 months comprised of the nutrition education and aerobic exercise (three times a week). The blood tests and HRV of subjects were determined, and the data were analyzed statistically using dependent sample t-test. The results of this study showed that the average of the waist circumference and the level of fasting plasma glucose and total cholesterol was significantly reduced in all subjects after having a 3-month weight loss program (P<0.05). Moreover, the three parameter values (total power, high frequency and low frequency) of HRV in those subjects increase significantly, compared to their baseline values (P<0.05). In our study, we concludes that a 3-month weight loss program combined with the nutrition education and aerobic exercise improves the body composition, the value of fasting glucose, the level of total cholesterol and the function of autonomic nervous system in the subjects with metabolic syndrome. Keywords—weight-control program; metabolic syndrome; heart rate variability; nutrition education; aerobic exercise","PeriodicalId":391184,"journal":{"name":"2011 IEEE 11th International Conference on Bioinformatics and Bioengineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129537577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational Tools for SNP Interactions - How Good Are They? SNP相互作用的计算工具-它们有多好?

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.53

F. R. B. Araujo, K. Guimaraes

{"title":"Computational Tools for SNP Interactions - How Good Are They?","authors":"F. R. B. Araujo, K. Guimaraes","doi":"10.1109/BIBE.2011.53","DOIUrl":"https://doi.org/10.1109/BIBE.2011.53","url":null,"abstract":"It is no trivial task to sift through huge amounts of SNP data to detect interactions between SNPs that can be relevant to identify propensity for a certain disease or a phenotype trait of interest, especially because many times it also involves the influence of environmental aspects. In a previous work, we analyzed the impact of different epistatic models on the accuracy of exhaustive computational methods. Those methods have good accuracy, but they are by nature, highly computationally demanding, hence not well suited for large population size or large number of SNPs, as found in genome-wide studies. In this paper, we report the results of a comparative study of methods for detecting epistatic interactions, based on recent trends, namely greedy and Bayesian computational approaches. Our experiments reveal that all methods have better performance in scenarios with higher values for heritability and minor allele frequency (MAF). In general, in terms of accuracy, BOOST outperformed the other methods studied. Even presenting an statistically significantly better performance, BOOST could not reach 40% accuracy when there were 50 or more SNPs, for cases with heritability 0.01 and MAF 0.2, even with a large number of individuals. Keywords-SNPs; Interactions; Computational Approaches;","PeriodicalId":391184,"journal":{"name":"2011 IEEE 11th International Conference on Bioinformatics and Bioengineering","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132051678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

U-healthcare System Deployment u -医疗保健系统部署

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.30

S. Yeh, Wu-Yuin Hwang, T. Huang, Wen-Kang Liu

引用次数: 0