人类基因中mRNA聚腺苷化位点的预测

Jorng-Tzong Horng, Li-Ching Wu, Shun-Kai Liu, Cheng-Wei Chang, Tsung-Ming Chao, Rong-Hwei Yeh, Kuang-Fu Cheng
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引用次数: 0

摘要

mRNA聚腺苷化是人类基因的重要机制,与转录终止直接相关。选择性聚腺苷化改变了成熟mRNA 3'UTR的长度。由于3 ' utr已被证明含有控制mRNA功能的调控元件,选择性聚腺苷化在控制人类基因的表达中起着重要作用。多聚腺苷化位点的预测有助于基因的鉴定,并有助于我们了解选择性多聚腺苷化的机制。在本研究中,我们基于PET与基因组序列的比对分析,利用SVM构建了人类基因mRNA聚腺苷化位点预测系统。与早期的方法相比,PET序列更准确地映射到参考基因组。我们还分析了单位点型和多位点型序列PET序列数据集,发现在单位点型和多位点型PET序列比较时,每个核苷酸的频率不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Prediction of mRNA Polyadenylation Sites in Human Genes
mRNA polyadenylation is an essential mechanism in human genes and is direct linked to the termination of transcription. Alternative polyadenylation changes the length of the mature mRNA’s 3’UTR. Since 3’UTRs have been shown to contain regulatory elements that control mRNA functioning, alternative polyadenylation plays an important role in controlling the expression of human genes. Prediction of polyadenylation sites can help with the identification of genes and aid our understanding of the mechanisms of alternative polyadenylation. In this study, we constructed a system for mRNA polyadenylation site prediction in human genes using SVM and based on an analysis of the sequence alignment between pair-end diTags (PET) and genome sequences. The PET sequences were mapped to the reference genome more accurate compared to earlier methods. We also analyzed single-site type and multiple-site type sequences PET sequence datasets and found that the frequencies of each nucleotide were different when the single-site type and multiple-site type PET sequences were compared.
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