2011 IEEE 11th International Conference on Bioinformatics and Bioengineering最新文献_第6页

A Comparison Study of Virus Classification by Genome Sequences 病毒基因组序列分类的比较研究

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.47

Jing-doo Wang

引用次数: 4

Exploration of Chemical Space by Molecular Morphing 利用分子变形探索化学空间

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.38

D. Hoksza, D. Svozil

{"title":"Exploration of Chemical Space by Molecular Morphing","authors":"D. Hoksza, D. Svozil","doi":"10.1109/BIBE.2011.38","DOIUrl":"https://doi.org/10.1109/BIBE.2011.38","url":null,"abstract":"Many areas of chemical biology, such as drug discovery, rely heavily on chemical libraries offering compounds usable in the industrial processes. However, the \"universe\" containing all possible compounds, the so-called chemical space, is vast, and therefore, the libraries store only its representative parts. Thus, to explore the whole chemical space and to identify all its promising parts containing e.g., drug-like molecules computational methods have to be developed and employed. In this paper, we propose a method for traveling in the chemical space called Molpher. Given two molecules, Molpher is intended to find a sequence of related compounds, called path in the chemical space, leading from the starting molecule to the target one. The path is generated by iterative application of the so-called morphing operators corresponding to simple chemical operations such as adding or removing an atom or a bond. The molecules on the resulting path represent a focused library that can be used as a starting point for other experiments. We also propose a testbed for examining qualities of algorithms such as Molpher. The testbed is used to describe Molpher's qualities in terms of ability of finding a path in the space in the given time.","PeriodicalId":391184,"journal":{"name":"2011 IEEE 11th International Conference on Bioinformatics and Bioengineering","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116549578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Towards Continuous Electrocardiogram Monitoring Based on Rules and Ontologies 基于规则和本体的连续心电图监测

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.61

Tanatorn Tanantong, E. Nantajeewarawat, S. Thiemjarus

引用次数: 10

The Effect of Low-intensive Pulsed Ultrasound Waving on Hydroxyapatite in Simulated Body Fluid 低强度脉冲超声对模拟体液中羟基磷灰石的影响

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.27

H. Mukai, M. Kobayashi

引用次数: 4

Applying Brain Waves to Face Recognition 脑电波在人脸识别中的应用

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.23

Koun-Tem Sun, Min-Chi Chen, Tzu-Wei Huang

引用次数: 0

Development of Artificial Intra-articular Polyethylene Glycol (PEG) Lubricant for Survival of Total Knee Joint Patient (Preliminary Study for Clinical Application) 人工关节内聚乙二醇(PEG)润滑剂的研制(临床应用初步研究)

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.26

Y. Honda, M. Kobayashi, K. Matsumura, N. Nakajima, S. Hyon

引用次数: 2

An Improved Natural PCR-RFLP Primer Design Method 一种改进的自然PCR-RFLP引物设计方法

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.21

Li-Yeh Chuang, Yu-Da Lin, Hsueh-Wei Chang, Cheng-Hong Yang

引用次数: 0

Correlating Simulation and Experimental Data of Traction and Cell Speed as Functions of Substrate Stiffness 牵引和细胞速度作为基底刚度函数的相关仿真和实验数据

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI: 10.1109/BIBE.2011.43

Henry C. Wong, W. Tang

{"title":"Correlating Simulation and Experimental Data of Traction and Cell Speed as Functions of Substrate Stiffness","authors":"Henry C. Wong, W. Tang","doi":"10.1109/BIBE.2011.43","DOIUrl":"https://doi.org/10.1109/BIBE.2011.43","url":null,"abstract":"The mechanical interactions between cells and the extra cellular matrix (ECM) play important roles in many biological processes, including cell proliferation, migration, and differentiation. The cells can probe the stiffness of the ECM and alter their own function accordingly. The objective of this study was to investigate the applicability of a mathematical model by comparing the simulation results generated by the model with published experimental results for the migration of fibroblast, smooth muscle, and glioma cells on substrates. Cell -- substrate traction was assumed to be a nonlinear function of the Young's modulus of the substrate. Simulation parameters were determined so that the tractions and cell speeds agreed with the experimental results. It was shown that the mathematical model could predict the fibroblast migration speed by increasing the Young's modulus of the cell with that of the substrate. Simulation results showed that the smooth muscle cell speed exhibited a biphasic relationship with respect to the substrate stiffness for two fibronectin concentrations, where the limit of elasticity sensing decreased as the fibronectin concentration increased. The numerical results also predicted that the glioma cell migration speed increased with the substrate stiffness. This mathematical model could be used to predict the experimental data for the migration of these different cell types, and is particularly suited for modeling the smooth muscle and glioma cells.","PeriodicalId":391184,"journal":{"name":"2011 IEEE 11th International Conference on Bioinformatics and Bioengineering","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128508170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3