Development of Artificial Intra-articular Polyethylene Glycol (PEG) Lubricant for Survival of Total Knee Joint Patient (Preliminary Study for Clinical Application)

2011 IEEE 11th International Conference on Bioinformatics and Bioengineering Pub Date : 2011-10-24 DOI:10.1109/BIBE.2011.26

Y. Honda, M. Kobayashi, K. Matsumura, N. Nakajima, S. Hyon

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引用次数: 2

Abstract

We have developed polyethylene glycol (PEG) with excellent tribology as artificial joint lubricity agent for reducing the wear of UHMWPE. PEG of molecular weight two million was used. And the PEG lubricity agent samples prepared a kinds of 3wt% in this study. We performed mechanical experiment and observation of wear surface. The mechanical experiment for wear test on ultra-high molecular weight polyethylene (UHMWPE) and Co-Cr alloy of artificial joint : a control group and PEG group. The human symovial fluid and hyaluronic acid were prepared for the control group. The wear surface observation of UHMWPE was performed by scanning electron microscope (SEM). The mechanical experiment results suggested that the wear of control group less volume than that of PEG group. The SEM pictures showed the wear of control group progressing than that of PEG group. These results showed that PEG lubricant might be effective as an artificial lubricant in joint.

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人工关节内聚乙二醇(PEG)润滑剂的研制(临床应用初步研究)

我们开发了具有优异摩擦学性能的聚乙二醇(PEG)作为人工关节润滑剂，以降低超高分子量聚乙烯的磨损。采用分子量为200万的聚乙二醇。并在本研究中制备了3wt%的PEG润滑剂样品。对磨损表面进行了力学实验和观察。超高分子量聚乙烯(UHMWPE)和Co-Cr合金人工关节磨损试验的力学实验:对照组和PEG组。对照组制备人膜液和透明质酸。采用扫描电镜(SEM)对UHMWPE的磨损表面进行了观察。力学实验结果表明，对照组的磨损体积小于PEG组。SEM图显示，对照组的磨损程度明显大于PEG组。这些结果表明，聚乙二醇润滑剂可以作为一种有效的人工润滑剂用于关节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2011 IEEE 11th International Conference on Bioinformatics and Bioengineering

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