Biologie Aujourd''hui最新文献

{"title":"Note de correction : Le récepteur de l’insuline a 50 ans – Revue des progrès accomplis - Biologie Aujourd’hui 216 (1-2), 7-28 (2022) https://doi.org/10.1051/jbio/2022007.","authors":"Pierre De Meyts","doi":"10.1051/jbio/2022015","DOIUrl":"https://doi.org/10.1051/jbio/2022015","url":null,"abstract":"","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":"216 1-2","pages":"71"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33438292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The pituitary gland unveiled: from the stimulation-secretion coupling to cellular networks wiring].","authors":"Patrice Mollard","doi":"10.1051/jbio/2022021","DOIUrl":"https://doi.org/10.1051/jbio/2022021","url":null,"abstract":"<p><p>The year 2021 ended with an event of great sadness: the death of Andrée Tixier-Vidal. She was not only a pioneer in cell biology but also the charismatic promoter of stimulating and successful multidisciplinary collaborations. Her achievements led to subsequent major discoveries on both the stimulation-secretion coupling of pituitary endocrine cells and the hitherto unknown organization of these cells into multicellular 3D networks which build-up highly organized pulses of pituitary hormones controlling basic body functions such as growth and reproduction.</p>","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":"216 3-4","pages":"83-87"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10741057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avant-Propos.","authors":"André Calas","doi":"10.1051/jbio/2022018","DOIUrl":"https://doi.org/10.1051/jbio/2022018","url":null,"abstract":"","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":"216 3-4","pages":"111-112"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10845723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[How oxytocin became overtime the attachment-mediating hormone].","authors":"Marie-José Freund-Mercier","doi":"10.1051/jbio/2022014","DOIUrl":"https://doi.org/10.1051/jbio/2022014","url":null,"abstract":"<p><p>Oxytocin is a pleiotropic molecule which, in addition to its facilitating action during parturition and milk ejection, is involved in social and prosocial behaviors such as attachment. This article presents, after a brief historical review, the action of oxytocin during the milk ejection reflex. Oxytocin is indeed essential for this vital function in mammals. It is both a neurohormone released into the bloodstream by the axon terminals of the posterior pituitary and a neuromodulator released in the hypothalamus by the soma and dendrites of oxytocinergic magnocellular neurons. In addition, oxytocin is also released by the axon terminals of parvocellular neurons and axon collaterals of magnocellular neurons in the brain. Both maternal attachment in rats and ewes and attachment between sexual partners in the prairie vole, one of the few monogamous rodent species, are mediated by central oxytocin. However, neither administering oxytocin into the brain nor increasing expression of the oxytocin receptor in the nucleus accumbens using a gene transfer technique converts polygamous voles to monogamous ones. Unfortunately, translation of animal data to human remains problematic due to still unsolved difficulties in modifying the level of oxytocin in the brain.</p>","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":"216 3-4","pages":"113-123"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9366905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of immunotoxicitiy in biomedical research and development].","authors":"Cathy Nguyen,&nbsp;Lars Petter Jordheim","doi":"10.1051/jbio/2022020","DOIUrl":"https://doi.org/10.1051/jbio/2022020","url":null,"abstract":"<p><p>Immunotoxicology aims at studying toxic effects of any substance on the immune system and its functions. In its various fields of application, this science is dependent on regulatory texts and guidelines. Studies are based on in vitro, ex vivo and in vivo techniques and are observational or functional allowing the identification of a toxic effect and its underlying mechanisms, respectively. Here, we review the various tests to perform in biomedical research and development, with a particular interest for the T-cell Dependent Antibody Response (TDAR) assay. We also briefly discuss the upcoming evolutions in this domain within a more ethically sound framework such as limiting the use of laboratory animals. These evolutions are represented by the development of relevant cell models.</p>","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":"216 3-4","pages":"167-181"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10741058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Intestinal gluconeogenesis: an insulin-mimetic function].","authors":"Gilles Mithieux","doi":"10.1051/jbio/2022003","DOIUrl":"https://doi.org/10.1051/jbio/2022003","url":null,"abstract":"<p><p>Intestinal gluconeogenesis (IGN) is a regulatory function of energy homeostasis. IGN-produced glucose is sensed by the gastrointestinal nervous system and sends a signal to regions of the brain regulating food intake and glucose control. IGN is activated by dietary protein and dietary fibre, and by gastric bypass surgery of obesity. Glutamine, propionate and succinate are the main substrates used for glucose production by IGN. Activation of IGN accounts for the well-known satiety effect of protein-enriched diets and the anti-obesity and anti-diabetes effects associated with fibre feeding and gastric bypass surgery. Genetic activation of IGN in mice shows the same beneficial effects, independently of any nutritional manipulation, including a marked prevention of hepatic steatosis under hypercaloric feeding. The activation of IGN could thus be the basis for new approaches to prevent or correct metabolic diseases in humans.</p>","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":" ","pages":"37-39"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40537596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avant-propos.","authors":"Yves Christen","doi":"10.1051/jbio/2022023","DOIUrl":"https://doi.org/10.1051/jbio/2022023","url":null,"abstract":"","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":"216 3-4","pages":"73"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10845722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Neurodegenerative diseases and brain aging].","authors":"Jean-Pierre Henry","doi":"10.1051/jbio/2022010","DOIUrl":"https://doi.org/10.1051/jbio/2022010","url":null,"abstract":"<p><p>Neurodegenerative diseases such as Alzheimer's, Parkinson's or Amyotrophic Lateral Sclerosis are generally of sporadic origin, but the risk of being affected increases dramatically with age. Progress in understanding brain aging contributes to define precisely the relationships between aging associated physiological and pathological processes. Aging is induced by various stresses, which turn somatic cells to a senescent state. Senescent cells cannot divide but acquire a typical phenotype and release chemicals that trigger inflammation. In the brain, glial cells such as astrocytes or microglia as well as neurons are affected. Dendritic branching declines, resulting in a decrease of synaptic plasticity and cognitive performances, associated with brain aging. Aging alters also glymphatic washing, the process by which brain catabolites are eliminated. The neurodegenerative diseases are proteinopathies resulting from pathological conformations of physiological proteins. Normally washed by the glymphatic flux, these proteins accumulate and aggregate in its absence and then trigger neuron death.</p>","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":" ","pages":"55-61"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40536539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prolactin and its receptor: From animal models to pituitary pathophysiology].","authors":"Emmanuelle Begon,&nbsp;Valérie Bernard","doi":"10.1051/jbio/2022019","DOIUrl":"https://doi.org/10.1051/jbio/2022019","url":null,"abstract":"<p><p>Prolactin (PRL) is a polypeptide hormone that is mainly synthesized and secreted by lactotroph cells of the anterior pituitary gland. The actions of prolactin are mediated by its transmembrane receptor, PRLR. The principal role attributed to PRL is to stimulate the proliferation and differentiation of the mammary cells required for lactation, but studies of animal models have assigned more than 300 separate actions to this hormone in various species. Hyperprolactinaemia is the prototypical pathological state associated with this hormone. Indeed, hyperprolactinaemia is the most common cause of amenorrhoea due to hypogonadotropic anovulation and is one of the most prevalent endocrine causes of infertility in women. In recent years, the study of conditional or complete Prlr ^-/- mouse models had improved the understanding concerning the regulation of gonadotroph and lactotroph axes. It is now demonstrated that prolactin exerts autocrine or paracrine actions on lactotroph cells in vivo. One of the major advances was to better understand, using mouse models, the impact of hyperprolactinemia on gonadotroph axis. It is now accepted that hypogonadotropic hypogonadism in patients with hyperprolactinemia is mediated by a decrease of hypothalamic kisspeptin secretion. Gonadotroph axis can be restored by intravenous administration of kisspeptin. However, the mechanisms of lactotroph tumorigenesis in Prlr ^-/- animals remain incompletely understood and transposable to the human species, since the only patient with biallelic PRLR loss-of-function mutation leading to complete prolactin resistance that has been described so far did not have pituitary adenoma visible on MRI.</p>","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":"216 3-4","pages":"105-110"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9366902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Oxytocin: a new target for neuroprotection?]","authors":"Olivier Baud,&nbsp;Marit Knoop,&nbsp;Alice Jacquens,&nbsp;Marie-Laure Possovre","doi":"10.1051/jbio/2022012","DOIUrl":"https://doi.org/10.1051/jbio/2022012","url":null,"abstract":"<p><p>Every year, 30 million infants worldwide are delivered after intra-uterine growth restriction (IUGR) and 15 million are born preterm. These two conditions are the leading causes of ante-/perinatal stress and brain injury responsible for neurocognitive and behavioral disorders affecting more than 9 million children each year. Most pharmacological candidates to prevent perinatal brain damage have failed to demonstrate substantial benefits. In contrast, environment enrichment based on developmental care, skin-to-skin contact and vocal/music exposure appear to exert positive effects on brain structure and function. However, mechanisms underlying these effects remain unknown. There is strong evidence that an adverse environment during pregnancy and the neonatal period can influence hormonal responses of the newborn with long-lasting neurobehavioral consequences in infancy and adulthood. In particular, excessive cortisol release in response to perinatal stress associated with prematurity or IUGR is recognized to induce brain-programming effects and neuroinflammation, a key predictor of subsequent neurological impairments. These deleterious effects are known to be balanced by oxytocin (OT), a neuropeptide released by the hypothalamus, which plays a role during the perinatal period and in social behavior. In addition, preclinical studies suggest that OT is able to regulate the central inflammatory response to injury in the adult brain. Using a rodent model of IUGR associated with developing white matter damage, we recently reported that carbetocin, a brain permeable OT receptor (OTR) agonist, induced a significant reduction of activated microglia, the primary immune cells of the brain. Moreover, this reduced microglia reactivity was associated with long-term neuroprotection. These findings make OT a promising candidate for neonatal neuroprotection through neuroinflammation regulation. However, the mechanisms linking endogenous OT and central inflammation response to injury have not yet been established. Further studies are needed to assess the protective role of OT in the developing brain through modulation of microglial activation, a key feature of brain injury observed in infants born preterm or growth-restricted. They are expected to have several impacts in the near future not only for improving knowledge of microglial cell physiology and reactivity during brain development, but also to design clinical trials testing interventions associated with endogenous OT release as a relevant strategy to alleviate neuroinflammation in neonates.</p>","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":"216 3-4","pages":"145-153"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10667803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}