Biologie Aujourd''hui最新文献_第3页

[Disruptors of thyroid hormones: Which consequences for human health and environment?] [甲状腺激素干扰物:对人类健康和环境的后果?]］

Biologie Aujourd''hui Pub Date : 2023-01-01 Epub Date: 2023-11-29 DOI: 10.1051/jbio/2023036

Patricia Rannaud-Bartaire, Jean-Baptiste Fini

{"title":"[Disruptors of thyroid hormones: Which consequences for human health and environment?]","authors":"Patricia Rannaud-Bartaire, Jean-Baptiste Fini","doi":"10.1051/jbio/2023036","DOIUrl":"10.1051/jbio/2023036","url":null,"abstract":"Endocrine disruptors (EDs) of chemical origin are the subject of numerous studies, some of which have led to measures aimed at limiting their use and their impact on the environment and human health. Dozens of hormones have been described and are common to all vertebrates (some chemically related messengers have also been identified in invertebrates), with variable roles that are not always known. The effects of endocrine disruptors therefore potentially concern all animal species via all endocrine axes. These effects are added to the other parameters of the exposome, leading to strong, multiple and complex adaptive pressures. The effects of EDs on reproductive and thyroid pathways have been among the most extensively studied over the last 30 years, in a large number of species. The study of the effects of EDs on thyroid pathways and brain development goes hand in hand with increasing knowledge of 1) the different roles of thyroid hormones at cellular or tissue level (particularly developing brain tissue) in many species, 2) other hormonal pathways and 3) epigenetic interactions. If we want to understand how EDs affect living organisms, we need to integrate results from complementary scientific fields within an integrated, multi-model approach (the so-called translational approach). In the present review article, we aim at reporting recent discoveries and discuss prospects for action in the fields of medicine and research. We also want to highlight the need for an integrated, multi-disciplinary approach to studying impacts and taking appropriate action.","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":"217 3-4","pages":"219-231"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Which place has experimentation in ethology?] 哪个地方有动物行为学实验?］

Biologie Aujourd''hui Pub Date : 2023-01-01 Epub Date: 2023-11-29 DOI: 10.1051/jbio/2023027

Michel Kreutzer

引用次数: 0

Françoise Dieterlen et Biologie Aujourd’hui. francoise Dieterlen和今天的生物学。

Biologie Aujourd''hui Pub Date : 2023-01-01 DOI: 10.1051/jbio/2023007

Evelyne Vila

引用次数: 0

[How studies on curare contributed to the development of neurophysiological research in Brazil]. [curare研究如何促进巴西神经生理学研究的发展]。

Biologie Aujourd''hui Pub Date : 2023-01-01 Epub Date: 2023-11-29 DOI: 10.1051/jbio/2023025

Roberto Pereira Santos, Antonio Egídio Nardi, Marleide da Mota Gomes

引用次数: 0

[Legal aspects of alternative methods to animal testing]. [动物试验替代方法的法律方面]。

Biologie Aujourd''hui Pub Date : 2023-01-01 Epub Date: 2023-11-29 DOI: 10.1051/jbio/2023034

Aloïse Quesne

引用次数: 0

Hommage à Françoise Dieterlen. 向弗朗索瓦·迪特伦致敬。

Biologie Aujourd''hui Pub Date : 2023-01-01 DOI: 10.1051/jbio/2023012

Yves Christen

引用次数: 0

Potentialité hématopoïétique de l’allantoïde avant la vascularisation chez la souris. 小鼠血管化前尿囊造血潜能。

Biologie Aujourd''hui Pub Date : 2023-01-01 Epub Date: 2023-07-06 DOI: 10.1051/jbio/2023011

Catherine Corbel, Josselyne Salaün

引用次数: 0

[Ketamine in antidepressant treatment: a revolution?] 氯胺酮在抗抑郁治疗中的应用:一场革命?］

Biologie Aujourd''hui Pub Date : 2023-01-01 Epub Date: 2023-11-29 DOI: 10.1051/jbio/2023023

Philippe Fossati

引用次数: 0

[Multigenerational epigenetic inheritance in human: the past, present and perspectives]. [人类多代表观遗传:过去、现在和前景]。

Biologie Aujourd''hui Pub Date : 2023-01-01 Epub Date: 2023-11-29 DOI: 10.1051/jbio/2023032

Fatima Smagulova

{"title":"[Multigenerational epigenetic inheritance in human: the past, present and perspectives].","authors":"Fatima Smagulova","doi":"10.1051/jbio/2023032","DOIUrl":"10.1051/jbio/2023032","url":null,"abstract":"Nowadays, a growing body of evidence suggests that the developmental programs of each individual could be modified. The acquired new phenotypic changes could be persistent throughout the individual's life and even transmitted to the next generation. While the exact mechanism for that preservation is not well understood yet, there are many evidences showing that epigenetic alterations, which are robust and dynamic in response to the influence of the environmental factors, could be responsible for that inheritance. A growing number of external factors such as social stress, environmental pollution and climate changes make adaptation to these environmental changes rather challenging. According to the Developmental Origin of Human Disease theory, formulated by David Barker, environmental conditions experienced during the first phases of development can have long term effects on later phases of life. This phenomenon is linked to the biological plasticity of development, which allows reprogramming of physiological functions in response to different stimuli. Consequently, in utero exposure to environmental pollutants can increase predisposition to different pathologies that can occur both in early and later phases of life not only in the living generation but also in subsequent ones. Here, we have summarised some findings in human epigenetic research studies performed for the past few years which address the question whether transgenerational effects observed in model organisms could also occur in humans.","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":"217 3-4","pages":"233-243"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Alternative methods to animal testing: the need for funding and dissemination]. [动物试验的替代方法:资金和传播的需要]。

Biologie Aujourd''hui Pub Date : 2023-01-01 Epub Date: 2023-11-29 DOI: 10.1051/jbio/2023033

Louis Schweitzer, Nikita Bachelard

{"title":"[Alternative methods to animal testing: the need for funding and dissemination].","authors":"Louis Schweitzer, Nikita Bachelard","doi":"10.1051/jbio/2023033","DOIUrl":"10.1051/jbio/2023033","url":null,"abstract":"The use of animals for scientific purposes brings a moral conflict between the necessity for human health and animal rights. Indeed, science has shown that most animals used in research are sentient beings, capable of suffering. Based on the principle of the 3Rs, the European legislation encourages the development of alternative methods to animal testing. French and European public opinions support the development of alternatives and broadly reject the use of animals for scientific purposes when alternatives exist. However, alternative methods to animal testing are still lacking. In order to drastically reduce the use of animals to this end, significant fundings are necessary. As far as this matter is concerned, France comes at the bottom of the class, but the creation of its 3Rs centre gathering all major scientific institutes and launching calls for fundings is a step into the right direction. The European Union funds projects of alternative methods, so do other private stakeholders, such as companies and NGOs. Another matter is the dissemination of alternative methods to scientists so they are aware of these methods. Some French research teams develop innovative methods and try to disseminate them. French and European platforms bring together creators, users and regulators to that end. Funding and disseminating alternative methods to animal testing should be a priority.","PeriodicalId":39068,"journal":{"name":"Biologie Aujourd''hui","volume":"217 3-4","pages":"183-191"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0