中国血吸虫病防治杂志最新文献

{"title":"[Correlation of mitochondrial genetic differentiation and spatial variables of <i>Oncomelania hupensis robertsoni</i> in Yunnan Province].","authors":"Y Zhang, J Song, Y Hao, Z Yang, X Shi, S Ning, H Wang, C Du, J Zhou, Z Zhang, K Li, S Li, Y Dong","doi":"10.16250/j.32.1915.2025124","DOIUrl":"https://doi.org/10.16250/j.32.1915.2025124","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Objective To analyze the potential spatial factors affecting the genetic differentiation of &lt;i&gt;Oncomelania hupensis robertsoni&lt;/i&gt; in Yunnan Province.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 13 administrative villages were selected from schistosomiasis-endemic areas of Yunnan Province as &lt;i&gt;O. hupensis&lt;/i&gt; snail sampling sites. At least 200 snails were collected in each site, and the spatial variable data of each site were recorded, including longitude, latitude and altitude. Thirty active and &lt;i&gt;Schistosoma japonicum&lt;/i&gt; uninfected &lt;i&gt;O. hupensis&lt;/i&gt; snails were selected from each sampling site by means of the crawling method and the cercarial shedding method. Genomic DNA was extracted from &lt;i&gt;O. hupensis&lt;/i&gt; snails. Following PCR amplification, purification of PCR amplification products and sequencing, the gene sequences of &lt;i&gt;O. hupensis&lt;/i&gt; snail samples were spliced and edited using the DNAstar software and the NCBI database to yield the complete mitochondrial sequences of &lt;i&gt;O. hupensis&lt;/i&gt; snails at each sampling site, and the mitochondrial genetic distance matrix of &lt;i&gt;O. hupensis robertsoni&lt;/i&gt; was calculated at each sampling site. The geographical coordinates of each sampling site were marked using the software ArcGIS 10.2, and the straight-line geographical distance between each sampling site was calculated. The altitude difference, longitude difference and latitude difference between each sampling site were calculated using the Excel software, and the correlation between the mitochondrial genetic distance matrix of &lt;i&gt;O. hupensis robertsoni&lt;/i&gt; and each spatial variable matrix was examined by using the Mantel test at 13 sampling sites in Yunnan Province.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among the 13 &lt;i&gt;O. hupensis&lt;/i&gt; snail sampling sites in Yunnan Province, the largest mitochondrial genetic distance of &lt;i&gt;O. hupensis robertsoni&lt;/i&gt; snail populations was seen between Anding Village, Nanjian Yi Autonomous County and Caizhuang Village, Midu County (26.244 2), and the largest geographical distance was seen between Dongyuan Village, Gucheng District and Cangling Village, Chuxiong County (272.64 km). The highest altitude difference was seen between Anding Village, Nanjian Yi Autonomous County and Dongyuan Village, Gucheng District (1 086.10 m), and the largest longitude difference was found between Qiandian Village, Eryuan County and Cangling Village, Chuxiong County (1.86°), while the largest latitude difference was measured between Leqiu Village, Nanjian Yi Autonomous County and Dongyuan Village, Gucheng District (1.81°). In addition, the mitochondrial genetic distance of &lt;i&gt;O. hupensis robertsoni&lt;/i&gt; snail populations was positively correlated with altitude at 13 snail sampling sites in Yunnan Province (&lt;i&gt;r&lt;/i&gt; = 0.542 8, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), and showed no significant correlations with geographical distance (&lt;i&gt;r&lt;/i&gt; = 0.093 4, &lt;i&gt;P&lt;/i&gt; &gt; 0.05), longitude (&lt;i&gt;r&lt;/i&gt; = -0.199 5, &lt;i&gt;P&lt;/i&gt; &gt; 0.05) or latitude","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"38 1","pages":"54-59"},"PeriodicalIF":0.0,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in techniques for assessment of schistosomiasis transmission risk: a global perspective and China's practice].","authors":"A Xu, H Zhu, J Xu, S Li","doi":"10.16250/j.32.1915.2025175","DOIUrl":"https://doi.org/10.16250/j.32.1915.2025175","url":null,"abstract":"<p><p>Based on review of global and Chinese schistosomiasis control progress and the evolution of control strategies, this article focuses on Chinese practical experiences of schistosomiasis control and systematically summarizes five key determinants for schistosomiasis transmission risk, including source of infections, intermediate host snails, high-risk populations, natural environments, and social factors. To address these risks and challenges associated with these determinants, the article reviews the advances in techniques for assessment of schistosomiasis transmission risk and their applications, including conventional risk assessment approaches, mathematical model-based tools for prediction of schistosomiasis transmission risk, and indicator-systembased techniques for assessment of schistosomiasis transmission risk. This review underscores the essential role of interdisciplinary integration and dynamic management in precision schistosomiasis control and recommends the intensification of verification of field adaptation and dynamic updates of indicator systems to promote the widespread application of assessment tools across diverse regions and contexts, so as to provide strategic guidance and methodological support to achieve the target for elimination of schistosomiasis across China in 2030.</p>","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"38 1","pages":"100-108"},"PeriodicalIF":0.0,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Single - molecule, real - time sequencing of ceftazidime - avibactam - resistant <i>Pseudomonas aeruginosa</i> and the mechanism of resistance to ceftazidime - avibactam].","authors":"L Wan, W Liu, Y Zhou, H Weng, X Cai, C Mao","doi":"10.16250/j.32.1915.2025203","DOIUrl":"https://doi.org/10.16250/j.32.1915.2025203","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To perform single-molecule, real-time sequencing of ceftazidime-avibactam (CAZ-AVI)-resistant &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; and to investigate the mechanism underlying ceftazidime-avibactam resistance in &lt;i&gt;P. aeruginosa&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The susceptibility of 89 &lt;i&gt;P. aeruginosa&lt;/i&gt; isolates randomly sampled from clinical specimens in Sanming First Hospital Affiliated to Fujian Medical University from November 2021 through July 2023 to common antimicrobial agents was tested, and the minimum inhibitory concentration (MIC) of CAZ-AVI was determined against &lt;i&gt;P. aeruginosa&lt;/i&gt; with a broth microdilution assay, with CAZ-AVI MICs of 8 mg/L and lower defined as susceptible and 16 mg/L and higher as resistant. The expression of drug-resistant genes &lt;i&gt;ampC&lt;/i&gt;, &lt;i&gt;oxa-488&lt;/i&gt;, &lt;i&gt;oprD&lt;/i&gt;, &lt;i&gt;mexA&lt;/i&gt;, &lt;i&gt;oxa-10&lt;/i&gt;, &lt;i&gt;oxa-14&lt;/i&gt;, &lt;i&gt;vim&lt;/i&gt; and &lt;i&gt;tem&lt;/i&gt; was quantified in &lt;i&gt;P. aeruginosa&lt;/i&gt; using a real-time quantitative reverse transcription PCR (qPCR) assay. CAZ-AVI-susceptible and -resistant &lt;i&gt;P. aeruginosa&lt;/i&gt; isolates from the same case were selected for PacBio single-molecule, real-time sequencing, and sequencing results were subjected to genome structure and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional annotations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The 89 &lt;i&gt;P. aeruginosa&lt;/i&gt; isolates showed a relatively high level of resistance to meropenem (75.28%) and imipenem (74.16%) and the highest susceptibility to amikacin (91.01%). There were 49 CAZ-AVI-resistant &lt;i&gt;P. aeruginosa&lt;/i&gt; isolates and 40 susceptible isolates. qPCR assay detected lower &lt;i&gt;oprD&lt;/i&gt; gene expression in CAZ-AVI-resistant &lt;i&gt;P. aeruginosa&lt;/i&gt; isolates [0.104 (2.385)] than in susceptible isolates [0.551 (17.885)] (&lt;i&gt;Z&lt;/i&gt; = -2.958, &lt;i&gt;P&lt;/i&gt; &lt; 0.01), and there were no significant differences between CAZ-AVI-susceptible and -resistant &lt;i&gt;P. aeruginosa&lt;/i&gt; isolates in terms of &lt;i&gt;ampC&lt;/i&gt;, &lt;i&gt;oxa-488&lt;/i&gt;, &lt;i&gt;mexA&lt;/i&gt; or &lt;i&gt;tem&lt;/i&gt; gene expression (all &lt;i&gt;P&lt;/i&gt; values &gt; 0.05), while &lt;i&gt;oxa-10&lt;/i&gt;, &lt;i&gt;oxa-14&lt;/i&gt; and &lt;i&gt;vim&lt;/i&gt; gene was expressed in few &lt;i&gt;P. aeruginosa&lt;/i&gt; isolates. There were 1 729, 3 936, 3 737 and 3 955 genes in CAZ-AVI-resistant &lt;i&gt;P. aeruginosa&lt;/i&gt; isolates PA-762 and PA-M174 and susceptible isolates PA-885 and PA-808 that were annotated to GO terms, with the highest numbers of genes enriched in the molecular function of catalytic activity, high numbers of genes enriched in biological processes of metabolic process, single-organism process and cellular process, and high numbers of genes enriched in cellular components of cell and cell membranes. There were 1 803, 4 084, 3 915 and 4 066 genes in the PA-762, PA-M174, PA-885 and PA-808 isolates enriched in the KEGG signaling pathway, and the majority of genes were enriched in four primary signaling pathways of metabolism, genetic information processing, environmental information processing and cellular process, with the highest","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"37 5","pages":"530-536"},"PeriodicalIF":0.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ownership of insecticide-treated nets in African countries from 2010 to 2023].","authors":"M Tao, J He, X Liu, C Chen, W Ding, H Li","doi":"10.16250/j.32.1915.2025080","DOIUrl":"https://doi.org/10.16250/j.32.1915.2025080","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the situation of insecticide-treated nets (ITNs) ownership in malaria-endemic African countries from 2010 to 2023, so as to provide insights into China's deeper participation in malaria control in Africa.</p><p><strong>Methods: </strong>The study period from 2010 to 2023 was divided into three phases: the baseline phase (from 2010 to 2015), the middle phase (from 2016 to 2019), and the final phase (from 2020 to 2023), a total of 11 African countries with at least one Demographic and Health Survey (DHS) in each phase were included. Data pertaining to ITNs in 33 surveys of the above 11 African counties from 2010 to 2023 were captured from the DHS database, and the proportions of sources of ITNs and ITN ownership in each phase (number of ITNs ownership per person, overall ownership rate, and ownership rate per two residents) were calculated. The differences in numbers of ITNs per person between urban and rural areas and specified by socioeconomic status were analyzed.</p><p><strong>Results: </strong>The proportions of ITNs from distribution campaigns were 60.24% to 94.01% and 50.46% to 85.04% in 11 African countries in the middle and final phases, respectively. The median numbers (interquartile range) of INTs ownership per person were 0.22 (0.50), 0.33 (0.50) and 0.33 (0.50) in the baseline, middle, and final phases, and the overall ownership rates [95% confidence interval (<i>CI</i>)] were 59.77% (59.50%, 60.05%), 70.32% (70.06%, 70.57%), and 69.21% (68.95%, 69.47%), while the ownership rates per two residents were 26.91% (26.66%, 27.16%), 38.07% (37.80%, 38.34%), and 36.56% (36.29%, 36.84%), respectively. The number of ITNs per person showed a significant increase followed by a significant decrease in 7 countries during all three phases (<i>H</i> = 102.518 to 2 327.440, all <i>P</i> < 0.05; <i>Z</i> = -48.886 to -4.653, all <i>P</i> < 0.016 7 after Bonferroni correction). In 33 surveys, there were 31 (<i>Z</i> = -26.719 to -2.472, <i>P</i> < 0.05) and 28 surveys (<i>Z</i> = -27.316 to -4.068, <i>P</i> < 0.001) with significant differences in numbers of ITNs ownership per person between households in urban and rural areas and with different socioeconomic status, including 20 surveys with a significantly higher number of ITNs ownership per person in households in rural areas than in urban areas, and 17 surveys with a significantly higher number of ITNs ownership per person among the poorest households than among the richest households.</p><p><strong>Conclusions: </strong>There are substantial disparities in ITNs ownership in 11 African countries. Intensified co-operation on malaria prevention and control measures, such as ITNs, is recommended between China and African countries to build a global community of health for all.</p>","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"37 5","pages":"494-505"},"PeriodicalIF":0.0,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidemiological characteristics and control measures of dengue fever in Zhongshan City in 2024].","authors":"M Wang, L Luo, X Chen, W Shi, C Chen, Y Mai","doi":"10.16250/j.32.1915.2025037","DOIUrl":"https://doi.org/10.16250/j.32.1915.2025037","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the epidemiological characteristics and control measures of dengue fever in Zhongshan City in 2024, so as to provide insights into optimization of dengue fever control strategies in the city.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data pertaining to dengue fever cases in Zhongshan City in 2024 were collected from the Infectious Disease Reporting System of China Disease Prevention and Control Information System, and the epidemiological characteristics of the cases were analyzed using a descriptive statistical method. The density of &lt;i&gt;Aedes albopictus&lt;/i&gt; mosquito was monitored across all 23 townships (subdistricts) using Breteau index (BI) and mosquito ovitrap index (MOI) at midmonth each month from March to December 2024. In addition, the climatic characteristics, case reporting patterns, and corresponding control measures were analyzed during different phases of dengue fever epidemics in Zhongshan in 2024. Furthermore, real-time quantitative reverse transcription PCR (RT-qPCR) assay was employed to serotype the dengue virus among local dengue fever cases with unknown sources of infections. The dengue virus envelope (&lt;i&gt;E&lt;/i&gt;) gene was sequenced using Sanger sequencing among dengue fever cases without apparent epidemiological links. A phylogenetic tree was constructed using the neighbor-joining method to infer major transmission chains during the dengue fever epi demics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 952 dengue fever cases were reported in Zhongshan City in 2024, including 879 local cases, 57 domestically imported cases from other regions, and 16 overseas imported cases, representing the largest outbreak in nearly two decades. The first local dengue fever case was reported on July 5, and the last one was detected on December 19, with all townships and subdistricts affected. Mosquito monitoring data indicated that both MOI and BI rose rapidly from March to May, and then remained at high levels with fluctuations, and began to decline in October. The dengue fever epidemic was categorized into five distinct phases in Zhongshan, including non-epidemic, pre-epidemic, early-epidemic, peak, and receding stages. During the pre-epidemic and early-epidemic phases, key measures included enhancing sensitivity of case detection, implementing isolation and treatment of hospitalized cases, and carrying out standardized vector control measures in affected communities. In the peak phase, the strategy shifted towards targeted mosquito control in key communities and clinical rescue and treatment emphasized on \"preventing severe cases and deaths\". Among 481 local cases with unknown sources of infections, RT-qPCR assay revealed that 68.8% (331/481) were infected with dengue virus type I and 31.2% (150/481) with type II among local dengue fever cases in Zhongshan City in 2024. Phylogenetic analysis revealed two major transmission chains: one originating from imported cases within Guangdong Province around Zhongshan C","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"37 5","pages":"555-560"},"PeriodicalIF":0.0,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Economic burden of echinococcosis patients in endemic areas of western China: a meta-analysis].","authors":"Z Yin, G Shi, W Rena, T Kaisaier, W Ma, S Adili, J Zhao","doi":"10.16250/j.32.1915.2025020","DOIUrl":"10.16250/j.32.1915.2025020","url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate the economic burden of echinococcosis patients in western China using meta-analysis, so as to provide insights into formulation of effective echinococcosis control strategies and optimization of medical resource allocation.</p><p><strong>Methods: </strong>Articles pertaining to the economic burden of echinococcosis patients in western China were retrieved in international and Chinese databases, including PubMed, Web of Science, CNKI, Wanfang Data, and VIP Chinese Science and Technology Periodicals Full-Text Database. Studies were screened according to inclusion and exclusion criteria, and the basic characteristics of included articles, characteristics of included studies, and echinococcosis patients' economic burden were extracted. A meta-analysis was performed using the software R package. The pooled effect size and heterogeneity were examined using a random effects model, and subgroup analyses were conducted.</p><p><strong>Results: </strong>A total of 13 articles were enrolled, including 12 Chinese publications and one English publication, and all were retrospective studies. Included studies covered 4 western provinces (autonomous regions) of China, including Ningxia Hui Autonomous Region, Xinjiang Uygur Autonomous Region, Sichuan Province, and Qinghai Province, which involved 11 282 echinococcosis patients, and the study period spanned from 2006 to 2023. Meta-analysis showed that the pooled direct medical costs of echinococcosis patients were 24 730 [95% confidence interval (<i>CI</i>): (13 040, 36 430)] Yuan in endemic areas of western China, appearing a significant heterogeneity (<i>I</i>² = 79.95%, <i>P</i> < 0.01). Subgroup analyses showed the pooled direct medical costs of 9 090 [95% <i>CI</i>: (-4 970, 23 150)] Yuan for echinococcosis patients in Ningxia Hui Autonomous Region and 18 140 [95% <i>CI</i>: (8 440, 27 840)] Yuan in Xinjiang Uygur Autonomous Region, and pooled direct medical costs of 9 470 [95% <i>CI</i>: (-1 850, 20 790)] Yuan for cystic echinococcosis patients prior to 2007 and 15 270 [95% <i>CI</i>: (560, 24 030)] Yuan after 2007, respectively. There were high heterogeneities in the pooled direct medical costs for echinococcosis patients in terms of date of publication (<i>I</i>² = 82.05%, <i>P</i> < 0.001), treatment modality (<i>I</i>² = 83.28%, <i>P</i> < 0.001) and type of echinococcosis (<i>I</i>² = 72.63%, <i>P</i> < 0.001). In addition, the pooled indirect medical costs and direct non-medical costs were 5 670 Yuan and 4 000 Yuan for echinococcosis patients in western regions of China, respectively.</p><p><strong>Conclusions: </strong>Echinococcosis patients suffer from a high economic burden in endemic areas of western China, and there are disparities in the direct medical costs for echinococcosis patients depending on disease type, study areas and study period.</p>","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"37 5","pages":"506-516"},"PeriodicalIF":0.0,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnostic value of serum Mac-2 binding protein for the severity of schistosomiasis-induced liver fibrosis].","authors":"J Wu, M Luo, S Xie, R Zhu, H Xu, L Tang, F Hu, S Ding","doi":"10.16250/j.32.1915.2025118","DOIUrl":"https://doi.org/10.16250/j.32.1915.2025118","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the value of serum Mac-2 binding protein (M2BP) for assessment of the severity of schisto somiasis-induced liver fibrosis, so as to provide insights into non-invasive diagnosis and disease surveillance of liver fibrosis caused by schistosomiasis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 234 individuals with a history of &lt;i&gt;Schistosoma japonicum&lt;/i&gt; infection were sampled from Xinhua Village, Lushan City, Jiangxi Province from 2019 to 2020, and 234 serum samples were collected from all participants. All participants received B-ultrasound examinations of the liver. Serum samples were categorized into four groups (grades 0, Ⅰ, Ⅱ and Ⅲ schistosomiasis-induced liver fibrosis groups) according to B-ultrasound examination results, and then, each group was randomly divided into a receiver operating characteristic (ROC) curve group and an efficacy assessment group at a ratio of 7∶3. Serum M2BP concentration was measured in four groups using the enzyme-linked immunosorbent assay (ELISA), and differences in serum M2BP concentrations were compared with analysis of variance and Spearman correlation analysis. Serum M2BP concentration was subjected to ROC curve analysis among individuals with different grades of schistosomiasis-induced liver fibrosis in the ROC curve group to determine the optimal diagnostic threshold of M2BP concentration at different fibrosis grades, and the area under the ROC curve (AUC) was calculated to evaluate the diagnostic performance. The diagnostic accuracy was verified by comparing the accordance rate and &lt;i&gt;Kappa&lt;/i&gt; consistency test in the efficacy assessment group.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among 234 serum samples, there were 79 samples with grade 0 schistosomiasis-induced liver fibrosis, 87 samples with Grade Ⅰ, 46 samples with Grade Ⅱ and 22 samples with Grade Ⅲ according to the B-ultrasound examinations. The mean serum M2BP concentrations were (0.40 ± 0.31) [95% confidence interval (&lt;i&gt;CI&lt;/i&gt;): (0.33, 0.47)], (0.64 ± 0.48) [95% &lt;i&gt;CI&lt;/i&gt;: (0.53, 0.74)], (1.76 ± 0.58) [95% &lt;i&gt;CI&lt;/i&gt;: (1.59, 1.93)] μg/mL and (2.56 ± 0.93) [95% &lt;i&gt;CI&lt;/i&gt;: (2.14, 2.97)] μg/mL in the four groups, respectively (&lt;i&gt;F&lt;/i&gt; = 150.796, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), and the severity of schistosomiasis-induced liver fibrosis significantly positively correlated with serum M2BP concentration (&lt;i&gt;rs&lt;/i&gt; = 0.715, &lt;i&gt;P&lt;/i&gt; &lt; 0. 001). The sample sizes of grades 0, Ⅰ, Ⅱ and Ⅲ schistosomiasis-induced liver fibrosis sera were randomly allocated as follows: 55 versus 24, 61 versus 26, 32 versus 14, and 15 versus 7 in the ROC curve and efficacy assessment groups, respectively, and the serum M2BP concentrations were (0.39 ± 0.29) μg/mL and (0.42 ± 0.36) μg/mL (&lt;i&gt;F&lt;/i&gt; = 0.196, &lt;i&gt;P&lt;/i&gt; &gt; 0.05), (0.59 ± 0.47) μg/mL and (0.75 ± 0.51) μg/mL (&lt;i&gt;F&lt;/i&gt; = 1.967, &lt;i&gt;P&lt;/i&gt; &gt; 0.05), (1.73 ± 0.59) μg/mL and (1.85 ± 0.57) μg/mL (&lt;i&gt;F&lt;/i&gt; = 0.417, &lt;i&gt;P&lt;/i&gt; &gt; 0.05), and (2.46 ± 0.64) μg/mL and (2.76 ± 1.41) μg/mL (&lt;i&gt;F&lt;/i&gt; = 0.491, &lt;i&gt;P&lt;/i&gt;","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"38 1","pages":"38-43"},"PeriodicalIF":0.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Strategies and practices for joint prevention and control of cross - border infectious diseases between Guangxi Zhuang Autonomous Region, China and Vietnam].","authors":"J Cai, J Meng, L Hu, Z Jiang, G Lan","doi":"10.16250/j.32.1915.2024294","DOIUrl":"https://doi.org/10.16250/j.32.1915.2024294","url":null,"abstract":"<p><p>This article discusses the important role and practical experience of Guangxi Zhuang Autonomous Region as a bridgehead between China and the Association of Southeast Asian Nations (ASEAN) in the joint prevention and control of cross-border infectious diseases between China and Vietnam. The cross-border transmission of infectious diseases has been effectively managed in Guangxi Zhuang Autonomous Region through a package of strategies, including government leadership, construction of the joint prevention and control mechanism, establishment of dialogue platforms, collaboration of scientific researches, and personnel exchange and training; however, there are still challenges. Further deepening of collaboration is required to meet future needs for infectious disease prevention and control.</p>","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"37 5","pages":"451-454"},"PeriodicalIF":0.0,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidemiological characteristics of dengue fever in Guangzhou City in 2024].","authors":"B Dai, W Liu, R Zhen, W Zhang, Y Lu, Y Liu","doi":"10.16250/j.32.1915.2025058","DOIUrl":"https://doi.org/10.16250/j.32.1915.2025058","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the epidemiological characteristics and effectiveness of emergency responses to epidemic foci in Guangzhou City in 2024, so as to optimization of the dengue fever control strategy in Guangzhou City.</p><p><strong>Methods: </strong>All data pertaining to dengue fever cases in Guangzhou City in 2024 were collected from the National Notifiable Infectious Disease Surveillance Information Reporting System. The temporal, spatial and population distributions of dengue fever cases and sources of infections were descriptively analyzed, and the effectiveness of emergency responses to epidemic foci of dengue fever was evaluated through standard space index (SSI), the interval from disease onset to case reporting and the percentage of isolation in hospital.</p><p><strong>Results: </strong>A total of 3 656 dengue fever cases were reported in Guangzhou City in 2024, including 3 102 local cases and 554 imported cases. Of all cases, 67.86% (2 481 cases) occurred at ages of 20 to 59 years, and the three most common occupations included housework/unemployment (793 cases, 21.69%), business servants (744 cases, 20.35%) and retirees (669 cases, 18.30%). The peak of dengue fever epidemics was concentrated during the period from the 39th to the 45th weeks in 2024, when a total of 2 317 local cases were reported, accounting for 74.69% of all local cases in 2024. Dengue fever cases were reported across all 11 districts in Guangzhou City in 2024, with local cases concentrated in Baiyun District (754 cases, 24.31%), Liwan District (398 cases, 12.83%), Panyu District (365 cases, 11.77%), Haizhu District (332 cases, 10.70%) and Tianhe District (328 cases, 10.57%). Imported dengue fever cases were predominantly domestically imported (492 cases, 88.81%), with the majority imported from Foshan City (377 cases), and overseas imported cases were predominantly imported from southeastern Asian countries. The mean proportion of case isolation in hospital was 9.16% (284/3 102), and the mean interval from disease onset to case reporting was (3.99 ± 2.70) days, while the percentages of mosquito density meeting the required standard were 61.68% (462/ 749) and 66.32% (126/190) on the 4th and 7th day of emergency responses to epidemic foci, respectively.</p><p><strong>Conclusions: </strong>The prevention and control cycle of dengue fever in Guangzhou in 2024 took longer than in previous years, with a larger scale of the epidemic. Although some progress has been made in epidemic management, there are still problems such as unsustainable mosquito vector control and low hospitalization isolation rates for cases. Further optimization of control measures in mosquito vector control, case monitoring and management is required to improve the effectiveness of dengue fever control measures.</p>","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"37 5","pages":"549-554"},"PeriodicalIF":0.0,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Antibacterial activity of the antifungal peptide Mt6 - 21DLeu derived from <i>Musca domestica</i> against <i>Acinetobacter baumannii</i> and the underlying mechanisms].","authors":"X Hua, T Qiu, X Wang, R Tang, D Kong","doi":"10.16250/j.32.1915.2025081","DOIUrl":"https://doi.org/10.16250/j.32.1915.2025081","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the antibacterial activity of the antifungal peptide Mt6-21DLeu derived from &lt;i&gt;Musca domestica&lt;/i&gt; against &lt;i&gt;Acinetobacter baumannii&lt;/i&gt; (AB) and unravel its underlying mechanisms, so as to provide insights into development of novel agents against AB.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The minimum inhibitory concentrations (MICs) of Mt6-21DLeu, &lt;i&gt;M. domestica&lt;/i&gt;-derived antifungal peptide-1 (MAF-1A), and polymyxin B were determined against &lt;i&gt;Staphylococcus aureus&lt;/i&gt;, &lt;i&gt;Bacillus subtilis&lt;/i&gt;, &lt;i&gt;Escherichia coli&lt;/i&gt;, &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;, &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; and AB using the broth microdilution assay, and the antibacterial activity of Mt6-21DLeu and polymyxin B was dynamically assessed against AB over 24 hours with time-kill curves. The inhibitory effects of Mt6-21DLeu and polymyxin B on biofilm formation in AB at concentrations of 1/4 × MIC, 1/2 × MIC and MIC, and the eradication effects of Mt6-21DLeu and polymyxin B on mature biofilms in AB at concentrations of MIC, 2 × MIC, and 4 × MIC were evaluated using crystal violet staining. Structural changes in the cell membrane of AB were observed 3 hours post-exposure to Mt6-21DLeu at concentrations of MIC and 2 × MIC using scanning electron microscopy, and alterations in the cell membrane permeability of AB were analyzed 3 hours post-treatment with Mt6-21DLeu at concentrations of MIC and 2 × MIC by means of fluorescence microscopy and propidium iodide (PI) staining. Intracellular reactive oxygen species (ROS) levels in AB were measured 3 hours post-treatment with Mt6-21DLeu at concentrations of MIC, 2 × MIC, and 4 × MIC using flow cytometry. The survival of &lt;i&gt;Caenorhabditis elegans&lt;/i&gt; exposed to Mt6-21DLeu at concentrations of MIC, 2 × MIC, and 4 × MIC was monitored for 7 consecutive days, and survival curves were plotted to evaluate the &lt;i&gt;in vivo&lt;/i&gt; toxicity of Mt6-21DLeu. In addition, &lt;i&gt;C. elegans&lt;/i&gt; infected with AB and treated with Mt6-21DLeu at a concentration of 4 × MIC served as the treatment group, and uninfected &lt;i&gt;C. elegans&lt;/i&gt; served as the control group, while infected but untreated &lt;i&gt;C. elegans&lt;/i&gt; served as the infection group. The &lt;i&gt;in vivo&lt;/i&gt; antibacterial efficacy of Mt6-21DLeu at a concentration of 4 × MIC was evaluated by comparing the survival curves and bacterial load among the three groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The MICs of MAF-1A were all &gt;128 μg/mL against &lt;i&gt;S. aureus&lt;/i&gt;, &lt;i&gt;B. subtilis&lt;/i&gt;, &lt;i&gt;E. coli&lt;/i&gt;, &lt;i&gt;K. pneumoniae&lt;/i&gt;, &lt;i&gt;P. aeruginosa&lt;/i&gt;, and AB. In contrast, the MICs of Mt6-21DLeu were &gt;128, 32, 8, 8, 16, and 4 μg/mL against these strains, respectively, and the MIC of Mt6-21DLeu against AB was close to that of polymyxin B (2 μg/mL). Time-kill curve analysis showed that both Mt6-21DLeu at concentrations of MIC and 2 × MIC and polymyxin B at a concentration of MIC inhibited AB growth over the 24-hour study period. The biofilm biomass in AB was (52.38 ± 6.92)%, (40.88 ± 9.17)% a","PeriodicalId":38874,"journal":{"name":"中国血吸虫病防治杂志","volume":"37 5","pages":"482-493"},"PeriodicalIF":0.0,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}