Tokai Journal of Experimental and Clinical Medicine最新文献

{"title":"Case of Pilomatricoma After Coronavirus Disease 2019 Vaccination.","authors":"Manabu Nakazono,&nbsp;Mayu Kawai,&nbsp;Akiko Mizukami,&nbsp;Akio Kondoh,&nbsp;Hanako Yamaoka,&nbsp;Tomotaka Mabuchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The coronavirus disease 2019 (COVID-19), which is an infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), spread worldwide including Japan. This COVID-19 pandemic has changed the way of life around the world. To prevent the spread of infection, several COVID-19 vaccines were rapidly developed and their vaccination is recommended. While safety and effectiveness of these vaccines have been shown, various adverse reactions occur with a certain frequency. Pilomatricoma is a benign subcutaneous tumor. Cause of pilomatricoma is unclear, however, an external insult could be a cause of part of pilomatricoma. Herein, we report a rare case of pilomatricoma after COVID-19 vaccination. Pilomatricoma should be included in the differential diagnoses of nodular lesions arising after vaccination sites, including the COVID-19 vaccine.</p>","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"48 1","pages":"10-12"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Disseminated Cutaneous Sporotrichosis Mimicking Sarcoidosis, that Required Four Biopsies to Diagnose.","authors":"Michio Tokuyama,&nbsp;Hanako Yamaoka,&nbsp;Shiho Tamiya,&nbsp;Tomotaka Mabuchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 69-year-old Japanese woman visited Tokai University Oiso hospital with cutaneous ulcers on her left upper arm that appeared in January 2013, and on her right nose that appeared in December of 2013. Neither the two biopsies and tissue culture from the arm lesion nor the biopsy and tissue culture from the nose lesion detected any organism. In December of 2013, she was diagnosed as cutaneous sarcoidosis at Oiso hospital and treated with oral prednisolone for six months, however, did not show improvement. In June of 2014, third skin biopsy and culture from her left upper arm was done at our hospital, and also could not detect any organism. After six months of continuing treatment with oral steroids and steroid injections, the cutaneous ulcers became enlarged, with purulent exudate, requiring a fourth skin biopsy and culture from left upper arm, which finally detected Sporotrichosis. After one-month administration of itraconazole, in January of 2015, cutaneous ulcers of both the arm and nose shrunk. Sporotrichosis mimics sarcoidosis as well as other skin conditions clinically and histologically, therefore recognizing the importance of carrying out multiple skin biopsies and cultures are imperative to prevent misdiagnosis and improper treatments and possible dissemination.</p>","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"48 1","pages":"5-9"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical glucocorticoids іn dermatological practice: the problem of efficiency and safety","authors":"T. Iermolenko, О. Faizullin, O. Doroshenko","doi":"10.35339/ekm.2023.92.1.ifd","DOIUrl":"https://doi.org/10.35339/ekm.2023.92.1.ifd","url":null,"abstract":"The problem of choosing the optimal glucocorticoids for topical use regularly arises for any physician involved in the treatment of dermatological diseases. When solving this problem, the doctor should take into account the nature, severity and localization of the pathological process, the patient's age, as well as the potency and the safety profile of the drug itself. One of the most common approaches to making the optimal choice of glucocorticoids for topical use, which is designed to reduce potential risks, involves administration the least active drugs at the beginning of the treatment, if they are ineffective, they switch to the use of more active drugs, and further the most active drugs. An obvious disadvantage of this approach is the duration of the procedure of the empirical selection of the drug, which can significantly impede treatment. The emergence of VI generation glucocorticoids, such as mometasone furoate, methylprednisolone aceponate and prednicarbate. The therapeutic potential of these drugs combines high activity and safety of use. It has changed the situation significantly and helped to solve the problem of the safe use of glucocorticoid drugs in pediatric and geriatric practice for the treatment of severe forms of dermatological diseases wich requires administration of the active glucocorticoids. The paper contains an overview of the main classification systems that are applied to glucocorticoids intended for use in dermatological practice, and a short analysis of literary data regarding the experience of the clinical use of VI generation glucocorticoids. The article also contains a retrospective overview of development of main approaches to improving the pharmacotherapeutic properties of topical glucocorticoids. Special attention is paid on the analysis of the influence of peculiarities of the chemical structure of drugs into pharmacokinetic and pharmacodynamic parameters. Keywords: corticosteroid-responsive dermatoses, mometasone furoate, methylprednisolone aceponate, prednicarbate.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77265867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the pathogenesis of obesity-associated osteoarthritis","authors":"O. Buryanov, V. Kvasha, V.O. Kuprii, E. O. Skobenko, O.E. Skobenko","doi":"10.35339/ekm.2023.92.1.bkk","DOIUrl":"https://doi.org/10.35339/ekm.2023.92.1.bkk","url":null,"abstract":"Osteoarthritis (OA) is a multifactorial disease that is initiated by the interaction of genetic and environmental factors (metabolic, mechanical, including traumatic), which leads to a violation of the properties of cartilage tissue with the subsequent spread of the pathological process to all structural elements of the joint and leads to the development of persistent inflammation. Osteoarthritis is one of the most common dystrophic-degenerative joint diseases, which occurs in 6.4–12.0% of the planet's population. The purpose of the study is to determine modern views on the peculiarities of the pathogenesis of obesity-associated osteoarthritis based on the study of literary sources. An analysis of literature sources was carried out by using the MEDLINE database, Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL, EMBASE, Science Citation Index (Web of Science), Science direct and Scopus by searching: osteoarthritis, obesity, osteoarthritis associated with obesity. The subject of assessment is the pathogenetic relationship of these diseases. The mechanical factor in the development of osteoarthritis is a proven factor in general and in excess body weight in particular. Such a relationship is confirmed by many studies, and the content is that the mediator of the relationship between obesity and OA is biomechanical factors, which are implemented through the redistribution of increased body weight to the supporting joints. The use of modern technological research methods provides an opportunity to deepen the understanding of the complex molecular relationship between OA and obesity. Adipokines have the potential to identify an additional pathogenetic link in the development and progression of OA in obese patients, which forms a potentially new approach in the development and implementation of methods for the prevention and therapy of OA in obese patients. However, views on the correlations of adipokines with OA are quite different (direct, inverse, and even absent), which requires further study.\u0000\u0000Keywords: osteoarthritis, obesity, adipokinins, leptin, apodenectin, resistin.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74928301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning ability and spatial memory status in rats during the acute period of mild blast-induced traumatic brain injury","authors":"Y. Kozlova, N. Tryasak","doi":"10.35339/ekm.2023.92.1.ktz","DOIUrl":"https://doi.org/10.35339/ekm.2023.92.1.ktz","url":null,"abstract":"The mild blast-induced brain traumatic injury like a battle fatigue, leads to neurological disability, including due to a violation of spatial memory. The presented work is the result of a blast-induced brain traumatic injury study on a self-developed device. For the experiment, 15 white Wistar rats were used and were divided into 3 groups: rats of Experimental group exposed by air shock wave (26–36 кPа); Sham group (anesthesia with halothane and fixation in a horizontal position) and Intact group. The ability to learning (food reinforcement) and the spatial memory state (time to search for food, vertical locomotor activity) were studied in the complex maze during the first 5 days of the posttraumatic period. To assess the emotional state, we counted the number and observed the quality of grooming acts. All researches were conducted in compliance with modern standards for humane attitude of animals. The results of our study clearly indicate a violation of spatial memory, which was manifested in the time of searching lengthening of the feeder and in the increase of vertical locomotor activity in the rats of the experimental group, while the animals clearly remembered that they were looking for food. The analysis of grooming showed qualitative changes in the form of incomplete and prolonged acts. Such changes indicate the development of anxiety in rats with mild blast-induced traumatic brain injury. This, in turn, led to deterioration of the spatial orientation and memory formation. Thus, the consequence of a mild blast-induced traumatic brain injury in the acute period is changes in the cognitive function of the brain in the form of deterioration of spatial memory, which was aggravated by a disturbance of emotionality in the form of anxiety. At the same time, the memory regarding the presence of food was formed adequately.\u0000\u0000Keywords: explosion, central nervous system, cognitive function, memory, maze.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83200991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the causes, frequency and localization of injuries among pole acrobatics athletes","authors":"H.P. Antonova","doi":"10.35339/ekm.2023.92.1.ant","DOIUrl":"https://doi.org/10.35339/ekm.2023.92.1.ant","url":null,"abstract":"Pole acrobatics is a popular sport and fitness activity that has undergone some stigmatization but is now recognized as a form of fitness, sport, and circus art. The aim of this study was to identify the causes and frequency of injuries among pole acrobatics athletes. An online survey was conducted, and 108 participants of mature age (aged 21 to 35 for women and 22 to 35 for men) from Ukraine were selected. The study showed that 87.10% of participants experienced an injury during pole training at least once a year. Most respondents (82.40%) reported bruises, contusions, and soft tissue injuries. 30.55% of respondents reported muscle, tendon, and ligament injuries, 17.59% had joint injuries, and 21.29% had sprains or tears of ligaments. 11.11% of respondents suffered fractures or bone cracks. Only 5.60% had no experience of injury during pole trainings. 75.80% of respondents sometimes experience painful sensations in joints, ligaments, or soft tissues, while 16.70% claimed to feel them constantly. Injuries obtained during pole trainings were treated independently by 63.88% of respondents, 26.85% consulted a traumatologist, and 25% consulted a physical therapist or rehabilitation specialist. Only 3.70% required surgical intervention, and 23.14% sought help from a massage therapist. The most common cause of injury during pole acrobatics training was unsuccessful execution of an element (71.87%). 34.37% of respondents suffered injuries due to falling from the pole. The most common injuries were to the shoulders (48.1% of respondents), thighs (28.67%), wrists (27.75%), and knees (37.00%). 43.15% of respondents experienced injuries during flexibility exercises at least once. Injuries during dynamic combinations were experienced by 37.89% of respondents, 32.63% during strength lifts (flag, tulip lift), 26.31% during static strength tricks, 25.26% during catches, 17.89% during extreme acrobatic tricks (Devil Drop, Switch/Fonji, etc.), 15.78% during dismounts, 13.68% during balance exercises (handstands), 11.57% during pole climbs, 7.36% during spins, and 2.10% during pole mounts. According to most respondents, increasing the quantity and quality of safety mats, improving warm-up before training, and increasing the trainer's attention can reduce the risk of traumatic episodes. Athletes who do not pay attention to safety techniques are 13.19% more likely to get injured, while physical imbalances between the right and left sides of the body increase the risk of injury by 63.24%.\u0000\u0000Keywords: pole dance, pole sport, prevention, trauma.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75189366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actual problems of prevalence and treatment of deep bite with functional correction of the musculo-articular complex in the permanent bite","authors":"N.A. Kyrychenko","doi":"10.35339/ekm.2023.92.1.kyr","DOIUrl":"https://doi.org/10.35339/ekm.2023.92.1.kyr","url":null,"abstract":"The significant prevalence of deep bite and pathology of the musculo-articular complex dictates the need for a comprehensive study of this issue. A deep bite is diagnosing in about 78% of cases with vertical anomalies in the permanent bite. Also, according to the latest research, this pathology occurs most often in Europe, 37.4%. Deep bite is diagnosed more often among men. In addition, there is an increase in the prevalence of deep bite with age in adult patients. In addition, complaints about the musculo-articular complex have become more frequent: pain in the temporomandibular joints, muscle tension, teeth grinding, stronger clenching. All these factors dictate the need for a detailed study of this pathology. The article presents an analysis of modern domestic and foreign literature, which highlights the issues of prevalence, etiology, clinical manifestations, diagnostic criteria and classification of forms of deep bite, its impact on the musculo-articular complex and features of treatment of this pathology in the permanent bite. The reviewed scientific works offer different methods of diagnosis and treatment of deep bite. In particular, the methods of treatment depend on the etiology and nature of deep bite. Many scientific works associate the occurrence of musculo-articular disorders with deep bite in patients. The improvement of the condition of the muscle-articular complex after the orthodontic treatment is also determined. However, a consensus was not reached on this issue, so research continues. After the analysis of the scientific works of many authors from the PubMed database, the need for a more detailed study of the problem, diagnostic methods and the creation of algorithms for the treatment of deep bite with functional correction of the musculo-articular complex in the permanent bite is followed.\u0000\u0000Keywords: temporomandibular joint, orthodontical treatment tactics, treatment algorithms.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87131450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of index scores after complex treatment of periodontal diseases in persons with general somatic pathology","authors":"M. Shevchuk, R. Shkrebnyuk, V. Dyryk, O. Vynogradova, A.I. Sloboda","doi":"10.35339/ekm.2023.92.1.ssd","DOIUrl":"https://doi.org/10.35339/ekm.2023.92.1.ssd","url":null,"abstract":"The purpose of the study was to evaluate the effectiveness of the developed schemes of complex treatment and prevention of periodontal tissue diseases in patients with general somatic pathology according to the dynamics of periodontal and hygienic indices. Treatment was carried out in 134 patients with inflammatory and dystrophic-inflammatory diseases of the perio­dontium against the background of somatic pathologies: two developed schemes of complex treatment of periodontal diseases were used, taking into account the values of the CPITN index. All patients were divided into 2 groups: the main (73 (54.48 %) patients), whose treatment was carried out using the schemes developed by us, and the comparative (61 (45.52 %) patients), in whom the treatment of periodontal pathology was carried out according to generally accepted schemes. The dynamics of the values of PMA, OHI-S indices and the vacuum test of gingival capillary resistance were evaluated according to the method of Kulazhenko V.I. before the treatment of periodontal diseases, 3, 6 and 12 months after it. After 12 months of follow-up, the values of the PMA index remained significantly lower compared to the values before treatment, and the state of oral hygiene remained satisfactory in patients of both groups. In the examined main group, an increase in the time of formation of hematomas on the gums ((62.14±0.38) seconds) was observed by 1.15 times compared to the data before treatment, but in the patients of the comparison group, this indicator was lower than the initial data. Тhe patients of the main group showed an improvement in all index scores, while in the comparison group, the values of these indices were below the initial values. Treatment of periodontal disease with values of the CPITN index ≤ 2 and > 2 points against the background of general somatic pathology, with the use of schemes developed by us, contributed to the elimination of inflammation, improvement of oral hygiene and normalization of hemodynamics in the periodontal tissues, which was confirmed by the positive dynamics of index scores in the near and distant periods of observation.\u0000\u0000Keywords: treatment of periodontal diseases, somatic pathology, index assessment of periodontal status.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"439 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86853216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of the main properties of dental cements for permanent fixation of non-removable denture structures","authors":"I. Yanishen, R. Kuznetsov, O. Fedotova, A. Pohorila, M. Bohatyrenko","doi":"10.35339/ekm.2023.92.1.ykf","DOIUrl":"https://doi.org/10.35339/ekm.2023.92.1.ykf","url":null,"abstract":"The study was conducted to compare the main characteristics of dental cements for permanent fixation of fixed dentures. Some materials, formed by the reaction of weak polymeric acids with inorganic glass powder. Dental cements have a number of advantages: due to adhesion, the material \"join\" the surface of the abutment tooth and the inner surface of the artificial structure; some permanent cements slowly release fluoride ions over time to maintain dental health; they do not dissolve in the oral fluid. Despite the advantages, these materials need further improvement in their mechanical performance. Laboratory tests were carried out in the conditions of the accredited in the system of UKR-SEPRO and licensed research laboratory of JSC \"Stoma\". The following basic properties were studied: mixing time (Tm, s), curing time (Tc, s), film thickness (μm), compressive strength (MPa), acid solubility (mm/h), adhesion to metal/dentin (MPa). The process of mixing the components of the \"Compomer\" material is 2.5 s longer than that of \"Ketac Cem\" and 7.7 s longer than that of \"Fuji Plus\". In the case of the \"curing time\" indicator, the \"Fuji Plus\" material is significantly different, with a curing time that is 4.5 s faster than that of \"Ketac Cem\" and half the \"curing time\" compared to \"Compomer\". \"Ketac Cem\" has the lowest \"film thickness\" value – (21.8±0.8) μm, which significantly differs (p≤0.05) from the materials selected for the study. The study of the compression resistance of the cements revealed their full compliance with the standard value according to ISO-9917-1:2007. The acid solubility of the tested cements is at the level of (0.14÷0.29) mm/h. The adhesion index of the tested cements fully meets the requirements of international standards.\u0000\u0000Keywords: permanent cement, non-removable denture structures, properties, adhesion, international standards.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"47 22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77785055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and pathological differential diagnosis of localised granulomatous skin lesions","authors":"T. Shynkarenko","doi":"10.35339/ekm.2023.92.1.shy","DOIUrl":"https://doi.org/10.35339/ekm.2023.92.1.shy","url":null,"abstract":"Granulomas are focal infiltrates consisting mainly of macrophages or macrophage-derived cells (epithelioid, giant cells), chiefly in the case of impossibility or slow degradation of specific antigens. The variability of manifestations complicates the clinical and pathological diagnosis of granulomatous skin diseases due to individual patient reactivity and the specifics of often unidentified triggering factors. The mini-review analyses possible approaches to differentiating the most likely localised granulomatous lesions (granuloma annulare, sarcoidosis, tuberculides, leprosy, and lupus miliaris disseminates faciei) by providing recommendations on possible key clinical and histopathological characteristics. The review is illustrated by a case of a localized granulomatous lesion with features that are atypical but possible for some of the diseases discussed, with the most likely diagnosis of granuloma annulare (clinical course, localization, vertical infiltrates, destruction of elastic fibers, accumulation of mucin, solitary eosinophils). Pathologists need to consider different diagnostic approaches for different types of histological diagnoses, which may require opposite therapies. Therefore, the possibility of infection or foreign material in all types of granulomatous inflammation should be considered and PAS staining and polarized light microscopy should be recommended as basic steps in the examination. Special techniques such as Ziehl-Nielsen or Grocott methenamine silver should be also applied to identify the pathogen if necessary. It is essential to have enough tissue for histological examination, including immunohistochemical staining and polymerase chain reaction. Pathologists should not hesitate to ask for a larger tissue sample early in the disease if necessary.\u0000\u0000Keywords: tuberculoid granuloma, palisade granuloma, ring-shaped granuloma, granulomatosis of the skin, histochemistry, biopsy.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90881837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}