Tokai Journal of Experimental and Clinical Medicine最新文献_第3页

Involvement of Impaired Angiogenesis and Myelosuppression in Antiresorptive-agent Related Osteonecrosis of the Jaw Mouse Model. 抗吸收剂相关性颌骨骨坏死小鼠模型中血管生成受损和骨髓抑制的参与。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-04-20

Hisao Igarashi, Satoru Nishizawa, Takeshi Miyamoto, Atsuhiko Hikita, Kazuto Hoshi

{"title":"Involvement of Impaired Angiogenesis and Myelosuppression in Antiresorptive-agent Related Osteonecrosis of the Jaw Mouse Model.","authors":"Hisao Igarashi, Satoru Nishizawa, Takeshi Miyamoto, Atsuhiko Hikita, Kazuto Hoshi","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To explore the involvement of bone marrow cells and angiogenesis in the pathogenesis of antiresorptive agent-related osteonecrosis of the jaw (ARONJ).Methods: We performed micro-computed tomography (CT) and histological analyses in an ARONJ mouse model generated using bisphosphonate (BP) and cyclophosphamide (CY).Results: Micro-CT analysis showed that BP and CY inhibited osteoneogenesis in the extraction socket. Histological analysis at 3 days after tooth extraction showed inhibition of vascular endothelial cell and mesenchymal stem cell mobilization into the extraction socket. When neovascularization of the extraction fossa was observed from as early as 1 day after extraction, it occurred predominantly in the area adjacent to the extraction fossa and close to the bone marrow cavity. In addition, the extraction fossa communicated with the adjacent bone marrow via the vasculature. Histological evaluation of the alveolar bone marrow around the extraction socket showed a decrease in bone marrow cells in the BP + CY group.Conclusion: Both inhibition of angiogenesis and suppression of bone marrow cell mobilization are involved in the pathogenesis of ARONJ.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"48 1","pages":"22-31"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Involved in the Choice Between Thoracic and Abdominal Deep Inspiration Breath Holds During Left Breast Cancer Radiotherapy. 左乳腺癌放疗中胸腹深吸气屏气选择的影响因素。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-04-20

Tatsuya Mikami, Yoshitsugu Matsumoto, Yuri Toyoda, Tsuyoshi Takazawa, Yoji Nakano, Tomomi Katsumata, Toshihisa Kuroki, Tsuyoshi Fukuzawa, Ryuta Nagao, Takeshi Akiba, Akitomo Sugawara

{"title":"Factors Involved in the Choice Between Thoracic and Abdominal Deep Inspiration Breath Holds During Left Breast Cancer Radiotherapy.","authors":"Tatsuya Mikami, Yoshitsugu Matsumoto, Yuri Toyoda, Tsuyoshi Takazawa, Yoji Nakano, Tomomi Katsumata, Toshihisa Kuroki, Tsuyoshi Fukuzawa, Ryuta Nagao, Takeshi Akiba, Akitomo Sugawara","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: Deep inspiration breath hold (DIBH) is used with adjuvant radiation therapy after left breast cancer surgery to reduce radiation dose to the heart. In this study we determined whether thoracic DIBH (T-DIBH) or abdominal DIBH (A-DIBH) should be selected based on patient background.Methods: Three-dimensional conformal radiation therapy plans were created under the same conditions using free breathing (FB), T-DIBH, and A-DIBH CT scans of patients who had previously undergone treatment at our hospital.Results: A-DIBH decreased the left lung dose compared to FB. In comparing T-DIBH and A-DIBH, the heart maximum and left lung doses were significantly lower in A-DIBH. The differences in the heart mean dose (Dmean) between FB, and T-DIBH and A-DIBH were correlated with the cardiothoracic ratio, heart volume, and left lung volume. The difference in the heart Dmean and the left lung dose of T-DIBH and A-DIBH correlated with the forced vital capacity (FVC).Conclusions: A-DIBH is preferable over T-DIBH with respect to the heart and left lung doses; however, with respect to the heart Dmean, T-DIBH was more effective in reducing the dose in some cases, and the FVC was a relevant factor in this study.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"48 1","pages":"13-21"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Medical Treatment for Aortoesophageal Fistula after Thoracic Endovascular Aortic Repair. 胸主动脉腔内修复术后主动脉食管瘘的成功治疗。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-04-20

Shinichiro Shimura, Hidekazu Furuya, Shigeto Odagiri, Sohsyu Kotani, Kimiaki Okada, Keisuke Ozawa, Akiyoshi Yamamoto, Goro Kishinami, Takuto Naiki, Masaomi Yamaguchi, Kenji Kuwaki, Yasunori Cho

引用次数: 0

Malignant Lymphoma with the MRI Findings Mimicking Inflammatory Disease: A Case Report. 恶性淋巴瘤的MRI表现与炎性疾病相似:1例报告。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-04-20

Kosuke Saito, Fumiyuki Goto, Hikaru Yamamoto, Shoji Kaneda, Akihiro Sakai, Koji Ebisumoto, Daisuke Maki, Hiroaki Iijima, Aritomo Yamazaki, Toshihide Inagi, Kenji Okami

{"title":"Malignant Lymphoma with the MRI Findings Mimicking Inflammatory Disease: A Case Report.","authors":"Kosuke Saito, Fumiyuki Goto, Hikaru Yamamoto, Shoji Kaneda, Akihiro Sakai, Koji Ebisumoto, Daisuke Maki, Hiroaki Iijima, Aritomo Yamazaki, Toshihide Inagi, Kenji Okami","doi":"","DOIUrl":"","url":null,"abstract":"Magnetic resonance imaging (MRI) is a more useful diagnostic modality for detecting paranasal tumors compared with computed tomography (CT). We encountered a case of malignant lymphoma of the maxillary sinus. Although CT findings suggested malignancy, MRI findings indicated an inflammatory disease. The patient was a 51-year-old man with a chief complaint of right maxillary toothache. Edema in the right middle meatus and bloody rhinorrhea were observed. CT revealed r ight maxillary s inus shadow with partial bone loss, suggesting malignancy. However, MRI performed two weeks later showed an internal homogeneous lesion with neither contrast effect, nor invasion outside the maxillary sinus. The patient also had no fever, weight loss, or night sweats. Additionally, no palpable cervical lymphadenopathy was observed. Endoscopic sinus surgery was performed to confirm the diagnosis. Upon opening the maxillary sinus, highly viscous retention and a large amount of yellowish-white debris were observed. Allergic fungal rhinosinusitis was suspected. However, histopathological analysis of the debris established a diagnosis of malignant lymphoma. The debris exhibited pathological findings of necrosis. The patient remained in remission after undergoing radiochemotherapy. Malignant lymphomas of the paranasal sinuses, which have a minimal tendency for invasion but with considerable predominance of necrosis, may be diagnosed as an inflammatory disease, based on MRI findings. In cases in which a thorough physical examination could not rule out malignant lymphomas, an endoscopic biopsy should be immediately considered.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"48 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Palatal Pleomorphic Adenoma Complicated by Dysphagia: A Case Report. 腭大多形性腺瘤合并吞咽困难1例。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-04-20

Rena Kojima, Yuji Koyama, Yoshihide Ota, Hiroshi Yamazaki, Ken-Ichi Aoyama, Akihiro Kaneko

引用次数: 0

Retroperitoneal Hematoma During Prophylactic Dose of Heparin Therapy for Coronavirus Disease 2019. 2019冠状病毒病预防剂量肝素治疗期间腹膜后血肿

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-04-20

Naoki Okada, Kyoko Niimi, Yoshino Asami, Shigeaki Hattori, Hiroto Takiguchi, Naoki Hayama, Yoko Ito, Tsuyoshi Oguma, Shun Ono, Koichiro Asano

引用次数: 0

Effect on Heart and Lung Doses Reduction of Abdominal and Thoracic Deep Inspiratory Breath-hold Assuming Involved-field Radiation Therapy in Patients with Simulated Esophageal Cancer. 模拟食管癌患者腹、胸深吸气屏气介入野放射治疗对心肺剂量减少的影响。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-04-20

Eride Mutu, Takeshi Akiba, Yoshitsugu Matsumoto, Etsuo Kunieda, Ryuta Nagao, Tsuyoshi Fukuzawa, Tomomi Katsumata, Toshihisa Kuroki, Tatsuya Mikami, Yoji Nakano, Shigeto Kabuki, Natsumi Futakami, Takafumi Nemoto, Yuri Toyoda, Tsuyoshi Takazawa, Akitomo Sugawara

{"title":"Effect on Heart and Lung Doses Reduction of Abdominal and Thoracic Deep Inspiratory Breath-hold Assuming Involved-field Radiation Therapy in Patients with Simulated Esophageal Cancer.","authors":"Eride Mutu, Takeshi Akiba, Yoshitsugu Matsumoto, Etsuo Kunieda, Ryuta Nagao, Tsuyoshi Fukuzawa, Tomomi Katsumata, Toshihisa Kuroki, Tatsuya Mikami, Yoji Nakano, Shigeto Kabuki, Natsumi Futakami, Takafumi Nemoto, Yuri Toyoda, Tsuyoshi Takazawa, Akitomo Sugawara","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: The purpose of this study was to evaluate the lung and heart doses in volumetric-modulated arc therapy (VMAT) using involved-field irradiation in patients with middle-to-lower thoracic esophageal cancer during free breathing (FB), abdominal deep inspiratory breath-hold (A-DIBH), and thoracic DIBH (T-DIBH) images.Methods: Computed tomography images of A-DIBH, T-DIBH, and FB from 25 patients with breast cancer were used to simulate patients with esophageal cancer. The irradiation field was set at an involved-field, and target and risk organs were outlined according to uniform criteria. VMAT optimization was performed, and lung and heart doses were evaluated.Results: A-DIBH had a lower lung V20 Gy than FB and a lower lung V40 Gy, V30 Gy, V20 Gy than T-DIBH. The heart all dose indices were lower in T-DIBH than FB, and the heart V10 Gy was lower in A-DIBH than FB. However, the heart Dmean was comparable with A-DIBH and T-DIBH.Conclusions: A-DIBH had significant dose advantages for lungs compared to FB and T-DIBH, and the heart Dmean was comparable to T-DIBH. Therefore, when performing DIBH, A-DIBH is suggested for radiotherapy in patients with middle-to-lower thoracic esophageal cancer, excluding irradiation of the prophylactic area.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"48 1","pages":"32-37"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case of Pilomatricoma After Coronavirus Disease 2019 Vaccination. 2019冠状病毒病疫苗接种后毛瘤1例。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-04-20

Manabu Nakazono, Mayu Kawai, Akiko Mizukami, Akio Kondoh, Hanako Yamaoka, Tomotaka Mabuchi

引用次数: 0

A Case of Disseminated Cutaneous Sporotrichosis Mimicking Sarcoidosis, that Required Four Biopsies to Diagnose. 弥散性皮肤孢子菌病样结节病1例，需4次活检诊断。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-04-20

Michio Tokuyama, Hanako Yamaoka, Shiho Tamiya, Tomotaka Mabuchi

{"title":"A Case of Disseminated Cutaneous Sporotrichosis Mimicking Sarcoidosis, that Required Four Biopsies to Diagnose.","authors":"Michio Tokuyama, Hanako Yamaoka, Shiho Tamiya, Tomotaka Mabuchi","doi":"","DOIUrl":"","url":null,"abstract":"A 69-year-old Japanese woman visited Tokai University Oiso hospital with cutaneous ulcers on her left upper arm that appeared in January 2013, and on her right nose that appeared in December of 2013. Neither the two biopsies and tissue culture from the arm lesion nor the biopsy and tissue culture from the nose lesion detected any organism. In December of 2013, she was diagnosed as cutaneous sarcoidosis at Oiso hospital and treated with oral prednisolone for six months, however, did not show improvement. In June of 2014, third skin biopsy and culture from her left upper arm was done at our hospital, and also could not detect any organism. After six months of continuing treatment with oral steroids and steroid injections, the cutaneous ulcers became enlarged, with purulent exudate, requiring a fourth skin biopsy and culture from left upper arm, which finally detected Sporotrichosis. After one-month administration of itraconazole, in January of 2015, cutaneous ulcers of both the arm and nose shrunk. Sporotrichosis mimics sarcoidosis as well as other skin conditions clinically and histologically, therefore recognizing the importance of carrying out multiple skin biopsies and cultures are imperative to prevent misdiagnosis and improper treatments and possible dissemination.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"48 1","pages":"5-9"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical glucocorticoids іn dermatological practice: the problem of efficiency and safety 外用糖皮质激素<s:1>皮肤科实践:有效性和安全性问题

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-03-31 DOI: 10.35339/ekm.2023.92.1.ifd

T. Iermolenko, О. Faizullin, O. Doroshenko

{"title":"Topical glucocorticoids іn dermatological practice: the problem of efficiency and safety","authors":"T. Iermolenko, О. Faizullin, O. Doroshenko","doi":"10.35339/ekm.2023.92.1.ifd","DOIUrl":"https://doi.org/10.35339/ekm.2023.92.1.ifd","url":null,"abstract":"The problem of choosing the optimal glucocorticoids for topical use regularly arises for any physician involved in the treatment of dermatological diseases. When solving this problem, the doctor should take into account the nature, severity and localization of the pathological process, the patient's age, as well as the potency and the safety profile of the drug itself. One of the most common approaches to making the optimal choice of glucocorticoids for topical use, which is designed to reduce potential risks, involves administration the least active drugs at the beginning of the treatment, if they are ineffective, they switch to the use of more active drugs, and further the most active drugs. An obvious disadvantage of this approach is the duration of the procedure of the empirical selection of the drug, which can significantly impede treatment. The emergence of VI generation glucocorticoids, such as mometasone furoate, methylprednisolone aceponate and prednicarbate. The therapeutic potential of these drugs combines high activity and safety of use. It has changed the situation significantly and helped to solve the problem of the safe use of glucocorticoid drugs in pediatric and geriatric practice for the treatment of severe forms of dermatological diseases wich requires administration of the active glucocorticoids. The paper contains an overview of the main classification systems that are applied to glucocorticoids intended for use in dermatological practice, and a short analysis of literary data regarding the experience of the clinical use of VI generation glucocorticoids. The article also contains a retrospective overview of development of main approaches to improving the pharmacotherapeutic properties of topical glucocorticoids. Special attention is paid on the analysis of the influence of peculiarities of the chemical structure of drugs into pharmacokinetic and pharmacodynamic parameters. Keywords: corticosteroid-responsive dermatoses, mometasone furoate, methylprednisolone aceponate, prednicarbate.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77265867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0