中华心血管病杂志最新文献

{"title":"[Role of lymphatic network in cardiac repair post myocardial infarction].","authors":"J Q He, D L Zhang, C H Yan, Y L Han","doi":"10.3760/cma.j.cn112148-20260121-00053","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260121-00053","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 3","pages":"328-332"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Moderate-intensity statin plus ezetimibe: time to rethink it as an optimal initial lipid-lowering strategy].","authors":"S Li, H H Liu, J J Li","doi":"10.3760/cma.j.cn112148-20251226-00913","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20251226-00913","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 3","pages":"249-256"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The application of cardiopulmonary exercise test in heart failure with preserved ejection fraction].","authors":"M Y Liu, K Yang, W J Lu, P Xie","doi":"10.3760/cma.j.cn112148-20260120-00049","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260120-00049","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 3","pages":"343-348"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of left ventricular apical hypoplasia].","authors":"Y T Huang, L W Qiu, D Han, L Hua, Q Y Xi, X B Zhong, L Gao, H Zeng","doi":"10.3760/cma.j.cn112148-20260203-00075","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260203-00075","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 3","pages":"321-323"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The safety and efficacy of adeno-associated virus-mediated LDLR transfection in homozygous familial hypercholesterolemia].","authors":"G Gao, C B Xu, R F Li, T Zheng, J R Shao, X K Wang, P N Liu, G Wang, L X Jiang, G Qu, T Chen, J Q She, Y B Luo, Z Y Yuan, Y Wu","doi":"10.3760/cma.j.cn112148-20251115-00804","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20251115-00804","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the safety and efficacy of an adeno-associated virus vector carrying an optimized human low density lipoprotein receptor (LDLR) gene (NGGT006) in the treatment of homozygous familial hypercholesterolemia (HoFH) with LDLR mutations. <b>Methods:</b> This is an open-label, single-center, single-arm, non-randomized, investigator-initiated clinical trial. According to the dose-escalation principle, enrolled HoFH patients received a single injection of NGGT006 at three different doses: low dose (7.5×10¹² vg/kg), medium dose (1.5×10¹³ vg/kg), or high dose (3.0×10¹³ vg/kg). The primary endpoint of this study was the safety of NGGT006 treatment, evaluated by the incidence of drug-related adverse events and serious adverse events, and the efficacy of NGGT006 treatment, assessed by percentage and absolute changes in low density lipoprotein-cholesterol (LDL-C) levels. The early results of the first 3 patients after NGGT006 therapy in a 64-week follow-up were reported. <b>Results:</b> The 3 patients were aged 29 to 33 years, including 2 males, and the baseline serum LDL-C levels ranged from 8.95 to 11.17 mmol/L. No effective reduction in LDL-C levels was observed in patients 1 and 2, who were treated with low dose and medium dose of NGGT006, respectively. Patient 3 treated with a high dose of NGGT006 showed a rapid and persistent decrease in LDL-C levels. At the 64-week follow-up, the LDL-C level reduced from 11.17 mmol/L to 0.28 mmol/L, with a relative change of 97.49% compared with baseline. During the entire follow-up period, there were no serious adverse events in any of the patients. Only adverse events graded 2 or lower occurred, such as liver enzyme elevation and mild fever. <b>Conclusions:</b> NGGT006 gene therapy is generally safe and well-tolerated in HoFH patients with LDLR mutations. High-dose NGGT006 treatment can significantly reduce LDL-C levels. Further research is needed to evaluate its long-term efficacy.</p>","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 3","pages":"266-272"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Impact of cumulative atherogenic index of plasma exposure on the risk of new-onset cardiovascular disease in middle-aged and young populations].","authors":"Y X Chen, H M Liu, H Y Zhao, S H Liu, M X Wang, L Q Liu, J R Liu, H X Li, S L Wu, Y T Wu","doi":"10.3760/cma.j.cn112148-20251130-00838","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20251130-00838","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the association between baseline cumulative atherogenic index of plasma and the risk of new-onset cardiovascular disease in middle-aged and young populations. &lt;b&gt;Methods:&lt;/b&gt; A total of 35 212 populations under 60-years old with complete physical examination in 2006 and 2010 from the Kailuan Study were retrospectively enrolled. Complete atherogenic index of plasma data were extracted and populations were grouped by cumulative atherogenic index of plasma quartile: Q1 group (&lt;-0.80, &lt;i&gt;n&lt;/i&gt;=8 803), Q2 group (-0.80-&lt;-0.19, &lt;i&gt;n&lt;/i&gt;=8 803), Q3 group (-0.19-&lt;0.49, &lt;i&gt;n&lt;/i&gt;=8 803), Q4 group (≥0.49, &lt;i&gt;n&lt;/i&gt;=8 803). The study subjects were followed up, with the endpoint defined as the occurrence of new-onset cardiovascular disease, defined as myocardial infarction and stroke. The follow-up period began after the physical examination in 2010 and ended at the date of the endpoint event or December 31, 2022, whichever came first. Cox proportional hazard regression model was used to analyze the impact of cumulative atherogenic index of plasma on the risk of new-onset cardiovascular disease and its subtypes, with trend tests conducted. Stratification was performed based on hypertension status, diabetes status, and low-density lipoprotein cholesterol (LDL-C) levels (&lt;3.4 mmol/L or ≥3.4 mmol/L) to examine multiplicative interactions with the cumulative atherogenic index of plasma, and Cox proportional hazards regression analysis was subsequently conducted. &lt;b&gt;Results:&lt;/b&gt; Among 35 212 participants, 26 636 (75.6%) were male, with an age of (45.4±8.3) years. Cardiovascular disease occurred in 2 075 cases (5.9%), of which 390 (1.1%) had myocardial infarction and 1 725 (4.9%) had stroke. During a follow-up of (11.5±2.0) years, the incidence densities of new-onset cardiovascular disease from Q1 to Q4 groups were 3.08, 4.70, 5.55 and 7.23 per 1 000 person-years, respectively. Cox proportional hazard regression model showed that, compared with the Q1 group, after adjusting for confounding factors, the &lt;i&gt;HRs&lt;/i&gt;(95%&lt;i&gt;CIs&lt;/i&gt;) of cardiovascular disease in Q2, Q3 and Q4 groups were 1.27 (1.10-1.48), 1.33 (1.14-1.56), 1.43 (1.19-1.72), respectively, the differences were statistically significant (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). The risk of cardiovascular disease showed an increasing trend across the Q1 to Q4 groups (&lt;i&gt;P&lt;/i&gt;&lt;sub&gt;trend&lt;/sub&gt;&lt;0.001). In the endpoint-specific analyses for myocardial infarction and stroke, stroke demonstrated a similar trend (&lt;i&gt;P&lt;/i&gt;&lt;sub&gt;trend&lt;/sub&gt;=0.002), while no statistically significant difference was observed for myocardial infarction (&lt;i&gt;P&lt;/i&gt;&lt;sub&gt;trend&lt;/sub&gt;=0.465). Subgroup analysis showed that there were potential multiplicative interactions between different levels of LDL-C, the presence or absence of hypertension or diabetes, and the cumulative atherogenic index of plasma (all &lt;i&gt;P&lt;/i&gt; for interaction&lt;0.05). In a low-risk population with LDL-C&lt;3.4 mmol/L, non-hypertensive, or non-diabetic, the cardi","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 3","pages":"273-282"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of myocardial work in patients with mitral valve prolapse and severe regurgitation: predictive value for prolonged postoperative ICU stay].","authors":"C H Gu, C Y Cui, C H Wei, H F Liu, Y L Ma, J J Yuan, X Q Tian","doi":"10.3760/cma.j.cn112148-20260202-00074","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260202-00074","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To quantitatively evaluate left ventricular myocardial work in patients with mitral valve prolapse with severe regurgitation (MVPSR) and normal left ventricular ejection fraction (LVEF) using pressure-strain loop (PSL) technology, and explore its predictive value for the duration of patients' postoperative stay in the intensive care unit (ICU). &lt;b&gt;Methods:&lt;/b&gt; MVPSR patients with normal LVEF who were treated at Fuwai Huazhong Cardiovascular Hospital from May 2023 to June 2025 were included as the MVPSR group. All patients underwent cardiac valve repair or valve replacement surgery and underwent echocardiography before surgery. Subjects who were matched for gender, age, body mass index as well as comorbidities, and underwent echocardiography during the same period, and were excluded from MVPSR were selected as the non-MVPSR group. Left ventricular global longitudinal strain, longitudinal strain peak time dispersion and global work index, global work efficiency (GWE), global constructive work, global wasted work, as well as the longitudinal strain and work parameters for each segment (basal, mid, and apical segments) were assessed using PSL technology. The duration of ICU stay for patients in the MVPSR group after mitral valve surgery were recorded, and a prolonged ICU stay was defined as a duration &gt;48 hours. The differences in left ventricular myocardial work parameters between the two groups were compared, and the impact of GWE on the duration of patients' early postoperative ICU stay was analyzed using a multifactor linear regression model. Receiver operating characteristic curve analysis was applied to evaluate the predictive performance of GWE for prolonged ICU stay. &lt;b&gt;Results:&lt;/b&gt; There were 80 patients in the MVPSR group, aged (58.9±12.3) years, including 61 males. There were 58 patients in the non-MVPSR group, including 31 healthy subjects, aged (54.8±15.3) years, including 36 males. The postoperative ICU stay time in the MVPSR group was (37.0±16.8) hours. Compared with the non-MVPSR group, the MVPSR group had lower global work index, GWE and global constructive work, and higher global wasted work; the work efficiency and constructive work in the basal, intermediate and apical segments were all lower, and the wasted work was higher; the longitudinal strain and work index in the basal segment were both lower (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). The results of the multi-factor linear regression model analysis showed that GWE was an independent influencing factor for postoperative ICU stay duration in MVPSR patients (&lt;i&gt;β&lt;/i&gt;=-2.89, 95%&lt;i&gt;CI&lt;/i&gt; -5.43--0.34, &lt;i&gt;P&lt;/i&gt;=0.030). The area under the curve for GWE in predicting prolonged ICU stay time was 0.850 (95%&lt;i&gt;CI&lt;/i&gt; 0.729-0.970). The receiver operating characteristic curve showed that the optimal cutoff value for GWE for predicting prolonged ICU stay was 92.5%, namely GWE≤92.5% predicting prolonged stay in ICU, with a sensitivity of 76.2% and a specificity of 82.4%. &lt;b&gt;Conclusions:","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 3","pages":"289-296"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Essentials and considerations for outpatient genetic counseling for inherited cardiovascular diseases].","authors":"M M Zuo, K Hong","doi":"10.3760/cma.j.cn112148-20251209-00860","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20251209-00860","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 3","pages":"360-364"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on cardiovascular risk assessment and prevention in adult exercise rehabilitation].","authors":"","doi":"10.3760/cma.j.cn112148-20251212-00871","DOIUrl":"10.3760/cma.j.cn112148-20251212-00871","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 2","pages":"134-145"},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on multidisciplinary collaborative screening and diagnostic pathway for transthyretin amyloidosis].","authors":"","doi":"10.3760/cma.j.cn112148-20250813-00571","DOIUrl":"10.3760/cma.j.cn112148-20250813-00571","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 2","pages":"146-156"},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}