中华心血管病杂志最新文献

{"title":"[Clinical characteristics and prognosis of patients with atrial functional mitral regurgitation].","authors":"P W Wang, M H Lin, Y L Wei, Y M Liu, S X Zheng, J F Wang, Q Qiu","doi":"10.3760/cma.j.cn112148-20260901-00549","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260901-00549","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinical characteristics and prognosis of atrial functional mitral regurgitation (AFMR). <b>Methods:</b> This was a single-center retrospective study. Patients hospitalized at Sun Yat-sen Memorial Hospital of Sun Yat-sen University between January 2020 and March 2022 and diagnosed with significant functional mitral regurgitation were enrolled. According to the type of regurgitation, patients were divided into the AFMR group and the ventricular functional mitral regurgitation (VFMR) group. Clinical and echocardiographic data were compared between the two groups. The patients were followed up until April 2024. The primary endpoint was all-cause mortality, and the secondary endpoint was the composite of cardiac death and hospitalization for heart failure. Survival was compared between the two groups using Kaplan-Meier survival curves. Cox proportional hazards regression analysis was performed to identify factors associated with all-cause mortality in patients with functional mitral regurgitation. <b>Results:</b> The study cohort consisted of 269 patients, with a median age of 66.0 (57.5, 76.0) years, among whom 172 (63.9%) were male. Patients were divided into the AFMR group (<i>n=</i>61, 22.7%) and the VFMR group (<i>n</i>=208, 77.3%)<i>.</i> Compared with the VFMR group, the AFMR group had a higher proportion of female patients, older age, a higher prevalence of atrial fibrillation, lower prevalences of coronary artery disease, fewer patients with heart failure symptoms, and a lower proportion of prior visits to cardiovascular departments (all <i>P</i><0.05). Compared with the VFMR group, the AFMR group demonstrated significantly larger anteroposterior left atrial diameter, right atrial transverse diameter, and right ventricular transverse diameter, along with a higher LVEF and a higher prevalence of moderate or greater tricuspid regurgitation (all <i>P</i><0.05). The follow-up duration was 24.6 (5.8, 37.6) months. The AFMR group exhibited lower all-cause mortality (21.3% (13/61) vs. 38.9% (81/208), <i>P=</i>0.011) and a lower rate of the composite endpoint of cardiac death and heart failure hospitalization (24.6% (15/61) vs. 42.8% (89/208), <i>P=</i>0.010) than the VFMR group. Kaplan-Meier survival analysis also revealed that the AFMR group had a higher cumulative event-free survival rate than the VFMR group (<i>P</i><sub>log-rank</sub>=0.002)<i>.</i> Multivariate Cox proportional-hazards regression analysis demonstrated that age (<i>HR</i>=1.038, 95%<i>CI</i> 1.019-1.057, <i>P</i><0.001<i>),</i> cerebrovascular disease (<i>HR</i>=2.014, 95%<i>CI</i> 1.200-3.382, <i>P</i>=0.008), AFMR (<i>HR</i>=0.341, 95%<i>CI</i> 0.175-0.667, <i>P</i>=0.002), and moderate or greater tricuspid regurgitation (<i>HR</i>=2.297, 95%<i>CI</i> 1.467-3.596, <i>P</i><0.001) were independent predictors of all-cause mortality in patients with functional mitral regurgitation. <b>Conclusions:</b> Compared with VFMR, AFMR is more co","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1181-1189"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the role and mechanism of junctophilin-2 in arrhythmias].","authors":"Y Q Yan, S P Dang, R X Wang","doi":"10.3760/cma.j.cn112148-20260703-00434","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260703-00434","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1228-1231"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Fabry disease misdiagnosed as obstructive hypertrophic cardiomyopathy: a case report].","authors":"Y Wang, Y C Zhang, L Zhao, H Wang, Y L Wang, J Lyu, J Z Dong, X Du","doi":"10.3760/cma.j.cn112148-20260521-00334","DOIUrl":"10.3760/cma.j.cn112148-20260521-00334","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1212-1215"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Two-dimensional speckle-tracking echocardiography in radiotherapy-related right heart dysfunction and analysis of associated risk factors].","authors":"R Liu, L A Xu, Z Q Zhao, R L Han","doi":"10.3760/cma.j.cn112148-20260811-00507","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260811-00507","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the impact of radiotherapy on right ventricular function using two-dimensional speckle-tracking echocardiography (2D-STE) in patients with thoracic tumors, and to identify factors associated with radiotherapy-induced right ventricular dysfunction. <b>Methods:</b> Patients who received thoracic radiotherapy at the Fourth Hospital of Hebei Medical University between May 2021 and May 2022 were enrolled in this study. 2D-STE examinations were performed before, during (upon completion of half of the prescribed radiotherapy dose), and after radiotherapy (1 to 2days after the end of radiotherapy). The 2D-STE evaluation parameters included left ventricular global longitudinal strain (LVGLS) and right ventricular free wall longitudinal strain (RVFWLS). The difference between post-treatment RVFWLS and the baseline value (ΔRVFWLS) and the percentage change in RVFWLS were calculated. Right ventricular dysfunction was defined as a right ventricular fractional area change (FAC)<35% or tricuspid annular systolic peak velocity at the right ventricular free wall<10 cm/s. Multiple linear regression analysis was performed to investigate the associations of age, cardiac volume, radiotherapy parameters, and other factors with ΔRVFWLS and the percentage change in RVFWLS. Receiver operating characteristic (ROC) curve analysis was used to assess the predictive performance of the relevant factors for right ventricular dysfunction, and the Kaplan-Meier method was adopted for survival analysis. <b>Results:</b> A total of 40 patients were enrolled in this study, including 22 males, with a median age of 61.0 years. Compared with baseline, right ventricular FAC ((45.48±4.67)% vs. (51.75±6.55)%, <i>P</i><0.05), LVGLS ((-16.83±2.99)% vs. (-18.85±3.00)%, <i>P</i><0.05), and RVFWLS ((-25.69±2.29)% vs. (-28.86±1.26)%, <i>P</i><0.05) decreased during treatment. These parameters remained lower than the baseline levels after treatment (all <i>P</i><0.05). Multiple linear regression analysis demonstrated that mean heart dose (MHD) and patient age were linearly correlated with ΔRVFWLS and the percentage change in RVFWLS (all <i>P</i><0.05). ROC curve analysis revealed that the area under the curve (<i>AUC</i>) of MHD for predicting right ventricular dysfunction was 0.984, with a cut-off value of 2 020 cGy; the <i>AUC</i> for patient age was 0.766, with a cut-off value of 56.5 years. The median follow-up duration was 82days, and 11 (28%) patients developed right ventricular dysfunction. The Kaplan-Meier survival curve indicated that the cumulative incidence of endpoint events was higher in patients aged ≥56.5 years than in those aged <56.5 years (<i>P</i><sub>log-rank</sub>=0.020). The cumulative incidence of endpoint events was higher in patients with an MHD ≥2 020 cGy than in those with an MHD <2 020 cGy <i>(P</i><sub>log-rank</sub><0.001)<i>.</i> <b>Conclusions:</b> 2D-STE allows early detection of right ventricular dysfunction. Patient age and MHD","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1198-1205"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The predictive value of left ventricular strain on cardiac magnetic resonance for adverse events in children and adolescent patients with hypertrophic cardiomyopathy].","authors":"X R Chen, X Ma, A X Zhang, Y Tang, K Yang, X Y Chen, S H Zhao","doi":"10.3760/cma.j.cn112148-20260612-00396","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260612-00396","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the role of left ventricular global longitudinal strain (GLS) derived from cardiac magnetic resonance (CMR) feature-tracking in evaluating left ventricular systolic function in children and adolescents with primary hypertrophic cardiomyopathy (HCM), as well as its prognostic value for adverse cardiovascular events and heart failure-related events. <b>Methods:</b> This was a single-center retrospective cohort study. Patients with primary HCM aged ≤21 years who underwent standard CMR examination at Fuwai Hospital, Chinese Academy of Medical Sciences, between January 2010 and December 2018 were included. Baseline clinical and CMR data were collected, and follow-up was completed. The primary endpoint was composite adverse cardiovascular events, and the secondary endpoint was heart failure-related events. Patients were divided into the event group and the non-event group according to whether the primary endpoint occurred. Multivariate Cox proportional-hazards regression models were used to identify independent factors associated with composite adverse cardiovascular events and heart failure-related events. Using the cohort median left ventricular GLS of -9.2% as the cut-off value, patients were stratified into the preserved GLS group (≤-9.2%) and the impaired GLS group (>-9.2%). Kaplan-Meier survival curves were plotted, and the log-rank test was performed to compare survival differences between groups. <b>Results:</b> A total of 249 children and adolescents with HCM were included, aged (14.81±3.71)years, of whom 163 were males (65.5%). The follow-up duration was (66.59±33.00)months. Composite endpoint events occurred in 37 patients, including 17 heart failure-related events and 20 sudden cardiac death events; 212 patients remained event-free. After adjusting for confounders such as left ventricular ejection fraction and history of unexplained syncope, multivariate Cox regression demonstrated that the percentage of late gadolinium enhancement (LGE) and left ventricular GLS were independently associated with composite adverse cardiovascular events (left ventricular GLS: <i>HR</i>=1.18, 95%<i>CI</i> 1.04-1.35, <i>P</i>=0.014; LGE extent: <i>HR</i>=1.12, 95%<i>CI</i> 1.06-1.18,<i>P</i><0.001) and heart failure-related events (left ventricular GLS: <i>HR</i>=1.52, 95%<i>CI</i> 1.18-1.96, <i>P</i>=0.001; LGE extent: <i>HR</i>=1.14, 95%<i>CI</i> 1.04-1.24, <i>P</i>=0.003). Kaplan-Meier analysis revealed that patients with impaired left ventricular GLS had lower cumulative event-free survival for both composite adverse cardiovascular events and heart failure-related events compared with those with preserved GLS (log-rank all <i>P</i><0.001). <b>Conclusions:</b> CMR feature-tracking can effectively assess left ventricular systolic function in children and adolescents with primary HCM. Left ventricular GLS and LGE percentage are independently associated with the risk of adverse cardiovascular events and heart failure-rela","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1147-1153"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[AI-driven heart failure risk prediction and early precision management strategies].","authors":"Y Y Li, H Wang, J F Yang","doi":"10.3760/cma.j.cn112148-20260721-00460","DOIUrl":"10.3760/cma.j.cn112148-20260721-00460","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1218-1222"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Fluid intake in patients with heart failure: should it be restricted or liberalized?]","authors":"Z Fang, J Zhang","doi":"10.3760/cma.j.cn112148-20260429-00277","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260429-00277","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1127-1131"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The incidence and 1-year prognosis of heart failure following myocardial infarction during hospitalization in patients with first STEMI].","authors":"Y Zhang, S Wang, W Yang, D D Qi, Z Y Zhu, X P Wang, G X Yan, C Y Gao","doi":"10.3760/cma.j.cn112148-20260514-00314","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260514-00314","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the incidence of in-hospital heart failure (HF) following myocardial infarction (MI) and 1-year mortality in patients with first ST-segment elevation myocardial infarction (STEMI), and to compare the 1-year mortality risk among different types of HF. <b>Methods:</b> Data were derived from the Henan STEMI registry, which was a multicentre, prospective, observational study in central China. After excluding patients with a history of MI or HF, patients with first STEMI were divided into the HF and non-HF groups according to the occurrence of in-hospital HF. Based on the left ventricular ejection fraction (LVEF) measured on the last echocardiogram during hospitalization, patients with HF were classified into HF with preserved ejection fraction (HFpEF, LVEF≥50%), HF with mildly reduced ejection fraction (HFmrEF, LVEF 41%-49%), HF with reduced ejection fraction (HFrEF, LVEF≤40%), and HF with missing LVEF. Survival analysis was performed using the Kaplan-Meier method, and differences between groups were assessed with the log-rank test. Multivariate Cox frailty models were used to analyze the associations of HF status (present vs. absent) and different LVEF subgroups with 1-year mortality, using the non-HF group as the reference. <b>Results:</b> A total of 4 737 patients with first STEMI were included in the final analysis, with a median age of 62.8 (52.4, 70.8) years, of whom 1 158 (24.4%) were female. During hospitalization, 1 978 cases (41.8%) developed HF following MI, including 268 (13.5%) with HFrEF, 309 (15.6%) with HFmrEF, 707 (35.7%) with HFpEF, and 694 (35.1%) with missing LVEF. A total of 3 967 (83.7%) patients completed the 1-year follow-up. The 1-year mortality was significantly higher among STEMI patients complicated by HF than in those without (23.3% (391/1 680) vs. 5.8% (132/2 287), log-rank <i>P</i><0.001). Specifically, the rates were 29.6% (67/226) for HFrEF, 20.8% (53/255) for HFmrEF, 11.7% (72/615) for HFpEF and 34.1% (199/584) for HF with missing LVEF. Multivariate Cox frailty models identified in-hospital HF following MI as a risk factor for 1-year mortality (<i>HR</i>=2.13, 95%<i>CI</i>: 1.70-2.67). Notably, HFpEF was associated with the lowest risk of 1-year mortality (<i>HR</i>=1.59, 95%<i>CI</i>: 1.16-2.17), while the HF group with missing LVEF carried the highest risk (<i>HR</i>=2.49, 95%<i>CI</i>: 1.91-3.26). <b>Conclusions:</b> The incidence of HF following first STEMI during hospitalization was 41.8%, with a corresponding 1-year mortality of 23.3%. In-hospital HF following MI is a risk factor for 1-year mortality in patients with STEMI. Prognosis differed notably across HF subgroups: HFpEF was associated with the lowest risk, whereas patients with missing LVEF had the worst outcome.</p>","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1164-1171"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Genetic mechanisms and clinical significance of drug-induced long QT syndrome].","authors":"Z W Cao, R R Bai, R Wan, K Hong","doi":"10.3760/cma.j.cn112148-20260703-00435","DOIUrl":"10.3760/cma.j.cn112148-20260703-00435","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 9","pages":"1121-1126"},"PeriodicalIF":0.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Metabolic mechanisms of exercise for mitigating vascular aging].","authors":"B Y Huang, C S Yu, Y Zhang, S Yang, L Wang","doi":"10.3760/cma.j.cn112148-20260420-00252","DOIUrl":"10.3760/cma.j.cn112148-20260420-00252","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 9","pages":"1095-1102"},"PeriodicalIF":0.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}