中华心血管病杂志最新文献

{"title":"[Guidelines for percutaneous coronary intervention (2025)].","authors":"","doi":"10.3760/cma.j.cn112148-20250422-00302","DOIUrl":"10.3760/cma.j.cn112148-20250422-00302","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"53 ","pages":"717-745"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert recommendations on clinical application of cardiac myosin inhibitor in patients with obstructive hypertrophic cardiomyopathy].","authors":"","doi":"10.3760/cma.j.cn112148-20241124-00730","DOIUrl":"10.3760/cma.j.cn112148-20241124-00730","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"53 ","pages":"746-756"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Impact of retinol-binding protein changes on tafamidis treatment response in patients with transthyretin cardiac amyloidosis].","authors":"M Wu, S Y Zhang, Y Lu, Z Tian, S Y Zhang","doi":"10.3760/cma.j.cn112148-20250310-00176","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20250310-00176","url":null,"abstract":"<p><p><b>Objective:</b> To explore the relationship between retinol-binding protein (RBP) levels and disease severity in patients with transthyretin cardiac amyloidosis (ATTR-CA), as well as its impact on therapeutic response to tafamidis. <b>Methods:</b> This retrospective study utilized data from the China National Rare Disease Registry System and included ATTR-CA patients treated with tafamidis between January 2018 and September 2022. Patients were stratified into two groups based on baseline RBP levels: the normal RBP group (≥36 mg/L) and the reduced RBP group (<36 mg/L). Baseline characteristics and clinical data after one year of treatment were collected and compared between the groups. Within the reduced RBP group, patients were further subclassified by changes in RBP levels after treatment (ΔRBP=post-treatment RBP-baseline RBP) into ΔRBP>0 and ΔRBP<0 subgroups. Worsening of global longitudinal strain (GLS) after treatment was defined as the primary outcome, logistic regression analysis was used to identify risk factors influencing therapeutic response to tafamidis in ATTR-CA patients. <b>Results:</b> A total of 52 ATTR-CA patients were included (aged (58.5±12.0) years, 46 males (88%)). Among 39 patients who completed one-year tafamidis treatment, no statistically significant difference was observed in RBP levels post-treatment versus baseline ((27.0±14.3) mg/L vs. (25.9±15.4) mg/L, <i>P</i>=0.261). Compared to the normal RBP group, the reduced RBP group had significantly higher estimated glomerular filtration rate-adjusted N-terminal pro-B-type natriuretic peptide levels (2 316.0 (1 161.5, 6 027.8) ng/L vs. 806.2 (349.5, 1 735.8) ng/L), higher left ventricular mass index ((164.4±46.5) g/m² vs. (123.9±31.8) g/m²), and lower left ventricular ejection fraction ((50.8±11.3)% vs. (58.8±6.2)%) (all <i>P</i><0.05). Among 31 patients in the reduced RBP group who completed one-year tafamidis treatment, 23 were classified as ΔRBP>0 and 8 as ΔRBP<0. The ΔRBP<0 group exhibited greater GLS worsening than the ΔRBP>0 group (0.7 (-0.1, 1.4)% vs. -0.4 (-1.4, 0.2)%, <i>P</i>=0.027). Multivariate logistic regression analysis revealed that ΔRBP<0 was an independent risk factor for GLS worsening (<i>OR</i>=8.584, <i>95%CI</i> 1.186-62.150, <i>P</i>=0.033) in ATTR-CA patients. <b>Conclusion:</b> ATTR-CA patients with reduced RBP levels exhibit more severe left ventricular structural and functional impairment compared to those with normal RBP levels. Decline in RBP during treatment (ΔRBP<0) is associated with poorer response to tafamidis treatment. Monitoring RBP dynamics may assist clinicians in assessing disease severity and therapeutic response in ATTR-CA patients.</p>","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"53 7","pages":"776-783"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Multi-modality imaging for the diagnosis of patient with IgG4-related coronary vasculitis: a case report].","authors":"R J Fan, Y D Wang, L J Fan, Y D Zhang, Z Wang, K Q Liu","doi":"10.3760/cma.j.cn112148-20240611-00326","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20240611-00326","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"53 7","pages":"813-816"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of blood pressure outcome on the risk of arteriosclerosis in non-hypertensive individuals].","authors":"Z X Kang, Q Xia, S W Kang, Z S Song, F Y Geng, Z Y Du, Z Huang, D D Zhao, Y Li","doi":"10.3760/cma.j.cn112148-20250121-00064","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20250121-00064","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the impact of blood pressure outcomes on the risk of arteriosclerosis in non-hypertensive populations. &lt;b&gt;Methods:&lt;/b&gt; This study was a retrospective cohort study. All data were derived from Kailuan Cohort. Non-hypertensive individuals who completed two brachial-ankle pulse wave velocity (baPWV) measurements between January 2014 and December 2019 (using the first measurement as the baseline and the second as the follow-up) were enrolled, and clinical data such as blood pressure and baPWV were collected. According to the blood pressure level at baseline and follow-up, participants were divided into new-onset hypertension group (no hypertension at baseline but diagnosed at follow-up) and non-hypertension group (no hypertension at both baseline and follow-up). Multiple linear regression and multivariate logistic regression were used to analyze the impact of new-onset hypertension on arteriosclerosis progression. Subgroup analysis further classified participants into six blood pressure transition categories: normal-maintained, normal-to-high-normal, normal-to-hypertensive, high-normal-to-normal, high-normal-maintained, and high-normal-to-hypertensive groups. Multivariate logistic regression analysis was used to assess the impact of different blood pressure outcomes on arteriosclerosis progression. &lt;b&gt;Results:&lt;/b&gt; A total of 7 049 participants were enrolled, with the age of (40.45±9.04) years, including 3 645 males (51.71%). There were 800 cases in the new-onset hypertension group and 6 249 individuals in the non-hypertension group. During follow-up, arteriosclerosis occurred in 2 154 cases (30.56%). Multivariable linear regression analysis revealed a positive correlation between new-onset hypertension and baPWV levels. The baPWV in the new-onset hypertension group was significantly higher by 63.94 cm/s compared to the non-hypertension group (&lt;i&gt;β&lt;/i&gt;=63.94, &lt;i&gt;P&lt;/i&gt;&lt;0.01). Additionally, the risk of arteriosclerosis in the new-onset hypertension group was 2.09 times that of the non-hypertension group (&lt;i&gt;OR&lt;/i&gt;=2.09, 95%&lt;i&gt;CI&lt;/i&gt;: 1.77-2.46, &lt;i&gt;P&lt;/i&gt;&lt;0.01). Subgroup analysis revealed significantly higher arteriosclerosis risks in normal-to-high-normal (&lt;i&gt;OR&lt;/i&gt;=1.65, 95%&lt;i&gt;CI&lt;/i&gt; 1.38-1.98, &lt;i&gt;P&lt;/i&gt;&lt;0.01), normal-to-hypertensive (&lt;i&gt;OR&lt;/i&gt;=2.47, 95%&lt;i&gt;CI&lt;/i&gt; 1.70-3.59, &lt;i&gt;P&lt;/i&gt;&lt;0.01), high-normal-maintained (&lt;i&gt;OR&lt;/i&gt;=1.50, 95%&lt;i&gt;CI&lt;/i&gt; 1.21-1.86, &lt;i&gt;P&lt;/i&gt;&lt;0.01), and high-normal-to-hypertensive groups (&lt;i&gt;OR&lt;/i&gt;=2.86, 95%&lt;i&gt;CI&lt;/i&gt; 2.20-3.73, &lt;i&gt;P&lt;/i&gt;&lt;0.01) than normal-maintained group, except for a non-significant difference in high-normal-to-normal group (&lt;i&gt;OR&lt;/i&gt;=0.95, 95%&lt;i&gt;CI&lt;/i&gt; 0.74-1.20, &lt;i&gt;P&lt;/i&gt;&gt;0.05). &lt;b&gt;Conclusion:&lt;/b&gt; Blood pressure outcome in non-hypertensive populations is closely related to arteriosclerosis risk. Progression to or maintenance of high-normal blood pressure or higher levels substantially increases arteriosclerosis risk, while regression from high-normal to normal blood pressure show","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"53 7","pages":"806-812"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Familial hypercholesterolemia caused by compound heterozygous variants in the LDLR gene: a case report].","authors":"K X Wang, Y L Ren, J R Zhang, X T Hou, X Y Li","doi":"10.3760/cma.j.cn112148-20250522-00389","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20250522-00389","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"53 7","pages":"816-819"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pericardial diseases: the missing piece in comprehensive prevention and treatment of cardiovascular diseases].","authors":"J X Song, S Sun, Y X Cui, H Chen","doi":"10.3760/cma.j.cn112148-20250314-00191","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20250314-00191","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"53 7","pages":"713-716"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research on the pattern and influencing factors of cardiometabolic multimorbidity in China].","authors":"Y F Wang, Z W Wang, C Y Zheng, X Wang, Y X Tian, X Cao, R H Feng","doi":"10.3760/cma.j.cn112148-20240509-00247","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20240509-00247","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the prevalence, comorbidity patterns, and associated factors of cardiometabolic multimorbidity (CMM) in China. <b>Methods:</b> From 2012 to 2015, a total of 34 994 residents aged ≥35 years were enrolled using a stratified multistage random sampling method across 31 provinces, autonomous regions, and municipalities in China. Data were collected through questionnaires, covering demographic characteristics, behavioral and lifestyle factors, and self-reported history of cardiometabolic diseases. CMM was defined as the coexistence of two or more cardiometabolic diseases in the same individual. Association rule analysis using the Apriori algorithm from the arules package was employed to identify strong CMM patterns. Multivariable logistic regression was employed to explore factors associated with CMM. <b>Results:</b> The mean age of the participants was 55.6 years. Among them, 15 926 were male (45.51%). The prevalence of cardiometabolic multimorbidity (CMM) was 11.25% (3 937/34 994). A total of 35 distinct CMM combinations (each with a frequency ≥10) were identified. The most prevalent dyad, triad, and tetrad comorbidity patterns were hypertension+hyperlipidemia (1 036 cases), hypertension+hyperlipidemia+diabetes (352 cases), and hypertension+stroke+hyperlipidemia+diabetes (54 cases), respectively. Nine strong CMM patterns were identified using the Apriori association rule algorithm. Multivariable logistic regression analysis showed that older age (≥70 years: <i>OR</i>=17.39,95%<i>CI</i> 13.92-21.71,<i>P</i><0.01), junior high school education (<i>OR</i>=1.31, 95%<i>CI</i> 1.17-1.48, <i>P</i><0.01), senior high school or above education (<i>OR</i>=1.45, 95%<i>CI</i> 1.27-1.65, <i>P</i><0.01), retirement (<i>OR</i>=3.09, 95%<i>CI</i> 2.76-3.46, <i>P</i><0.01), unemployment or being laid-off (<i>OR</i>=1.16, 95%<i>CI</i> 1.06-1.28, <i>P</i><0.01), a family history of cardiometabolic disease (<i>OR</i>=4.37, 95%<i>CI</i> 4.04-4.72, <i>P</i><0.01), regular smoking (<i>OR</i>=1.38, 95%<i>CI</i> 1.24-1.53, <i>P</i><0.05), and occasional smoking (<i>OR</i>=1.21, 95%<i>CI</i> 1.00-1.49, <i>P</i><0.01) were significantly associated with an increased risk of CMM. <b>Conclusion:</b> The prevalence of cardiometabolic multimorbidity in China is relatively high, with the most common comorbidity patterns involving combinations of hypertension and hyperlipidemia, often accompanied by diabetes and stroke. Older age, retirement status, smoking, and a family history of cardiovascular disease are associated with an increased risk of both single and multiple cardiometabolic conditions. Greater attention should be paid to individuals with a single cardiometabolic disorder due to their elevated risk of developing multimorbidity.</p>","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"53 7","pages":"792-798"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The clinical application of fractional flow reserve and Doppler flow velocity derived from optical coherence tomography in coronary artery disease].","authors":"L Zhao, L B Li, B Liu, Z H Wang, J P Wang, B Li, Z W Xu","doi":"10.3760/cma.j.cn112148-20241128-00742","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20241128-00742","url":null,"abstract":"<p><p><b>Objective:</b> To explore the diagnostic value of fractional flow reserve (FFR) based on optical coherence tomography (OCT) for coronary functional ischemia, and to investigate the feasibility of synchronously obtaining Doppler blood flow velocity information with the help of OCT technology. <b>Methods:</b> This study was a single-center, prospective, self-controlled clinical study on coronary heart disease patients who underwent OCT and FFR assessment at Department of Cardiology, the Second Hospital of Jilin University from January 2024 to February 2025. Linear regression analysis was used to evaluate the correlation and consistency between OCT-FFR and FFR. With FFR≤0.80 as the gold standard for judging whether the target vessel was ischemic, the diagnostic performance of OCT-FFR was evaluated, and the diagnostic value of OCT-FFR for significant coronary artery ischemia was assessed using subject operating characteristic curves. Blood flow OCT data were analyzed by Doppler processing algorithm to obtain information on coronary blood flow velocity. <b>Results:</b> A total of 31 vessels from 28 patients were analyzed, the correlation coefficient <i>r</i> between OCT-FFR and FFR of the 31 vessels was 0.84 (<i>P</i><0.001). With FFR as the gold standard to determine whether a coronary artery is ischemic, accuracy, sensitivity, specificity, positive predictive value, and negative predictive value for OCT-FFR was 93.55%, 75.00%, 100.00%, 1.00, 0.92. In clinical practice, Doppler OCT was used for the first time to obtain information on coronary blood flow velocity. <b>Conclusion:</b> OCT-FFR had an excellent correlation and consistency with FFR in judging whether there is coronary artery ischemia. The feasibility of the simultaneous acquisition of OCT-FFR and Doppler flow velocity information in coronary stenosis was preliminarily verified.</p>","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"53 7","pages":"799-805"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics and treatment outcomes in patients with recurrent pericarditis].","authors":"S Sun, M Zhao, Y X Cui, J Song, J T Chen, H Chen, J X Song","doi":"10.3760/cma.j.cn112148-20250210-00096","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20250210-00096","url":null,"abstract":"<p><p><b>Objective:</b> To summarize and analyze the clinical characteristics and treatment outcomes of patients with recurrent pericarditis. <b>Methods:</b> This observational study consecutively recruited patients with recurrent pericarditis who were hospitalized at Peking University People's Hospital between January 2017 and February 2024. Clinical characteristics and treatment outcomes were collected and summarized during follow-up. <b>Results:</b> A total of 8 recurrent pericarditis patients including 3 males were included, with an age of 34.0 (22.0, 39.5) years. In terms of clinical features, all patients presented with acute-onset severe chest pain, accompanied by fever in 7 and an audible pericardial friction rub in 2 patients. Electrocardiogram showed no diffuse ST-segment elevation or PR-segment depression in any patient. Echocardiography revealed pericardial effusion in all cases, with extensive fibrinous exudate and transient pericardial thickening observed in 6 patients. CT identified concurrent pleural and/or peritoneal effusions in 6 patients. All patients exhibited marked elevations in C-reactive protein, erythrocyte sedimentation rate and D-dimer levels. Whole-exome sequencing identified MEFV gene mutations associated with familial Mediterranean fever in 3 cases. Two patients developed cardiac tamponade requiring pericardiocentesis, which revealed hemorrhagic effusion. In the aspect of treatment outcomes, the time from recurrence to first confirmed diagnosis of recurrent pericarditis of this cohort was 14.5 (13.3, 19.5) d. Upon diagnosis, all patients promptly received standard anti-inflammatory therapy with ibuprofen and colchicine, achieving rapid relief. However, during a follow-up of 12.0 (6.0, 25.3) months, 3 patients experienced recurrence, and 2 developed transient constrictive pericarditis. <b>Conclusion:</b> Patients with recurrent pericarditis typically exhibit characteristic clinical presentations, laboratory abnormalities, imaging findings and potential genetic associations. Although standard anti-inflammatory therapy demonstrates favorable short-term efficacy, long-term management remains challenging due to the risks of recurrence and progression to constrictive pericarditis.</p>","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"53 7","pages":"769-775"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}