中华心血管病杂志最新文献

{"title":"[Advances in the integration of artificial intelligence and electrocardiogram for heart failure risk prediction, diagnosis, and treatment].","authors":"Q Li, W Dong","doi":"10.3760/cma.j.cn112148-20260721-00459","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260721-00459","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1223-1227"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Dual association of peripheral blood eosinophil count with high on-treatment platelet reactivity and long-term cardiac death in patients with coronary artery disease: a large-scale cohort study].","authors":"Z H Ke, K L Yan, D S Yuan, K X Zhang, M L Liu, F Y Xu, X F Tang, Y J Yang, J Q Yuan, X Y Zhao","doi":"10.3760/cma.j.cn112148-20260313-00166","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260313-00166","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the association of baseline peripheral blood eosinophil count with high on-treatment platelet reactivity and its clinical prognostic value in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI) and receiving clopidogrel. <b>Methods:</b> This was a single-center prospective cohort study. Consecutive patients with coronary artery disease who underwent PCI at Fuwai Hospital, Chinese Academy of Medical Sciences, between January and December 2013 were enrolled; those receiving dual antiplatelet therapy with aspirin and clopidogrel were included. Baseline data were collected, and platelet reactivity was assessed using thromboelastography. Patients were followed up for 5 years, with cardiac death as the endpoint. Baseline eosinophil count was analyzed as a continuous variable and was also categorized into quartiles (Q1-Q4). Multivariable logistic regression was used to analyze the association between eosinophil count and high on-treatment platelet reactivity. Multivariable restricted cubic spline models were used to analyze the dose-response relationship. Subgroup analyses and interaction tests were performed according to age, sex, diabetes, hypertension, acute coronary syndrome, body mass index, and high-sensitivity C-reactive protein levels. Multivariable Cox proportional hazards regression was used to assess the predictive value of eosinophil count for cardiac death. <b>Results:</b> A total of 6 524 patients were included. The mean age was (58.21±10.26) years, and 5 059 (77.54%) were male. Among them, 6 050 patients completed the 5-year follow-up, and 140 cardiac deaths (2.31%) occurred. Multivariable logistic regression analysis showed that peripheral blood eosinophil count was negatively associated with the risk of high on-treatment platelet reactivity (<i>OR</i>=0.94, 95%<i>CI</i>: 0.90-0.98, <i>P</i>=0.003). When analyzed as a categorical variable, compared with the lowest quartile group (Q1), the risk of high on-treatment platelet reactivity was lower in patients in the highest quartile group (Q4) (<i>OR</i>=0.77, 95%<i>CI</i>: 0.65-0.91, <i>P</i>=0.003). Multivariable restricted cubic spline analysis showed a linear negative correlation between eosinophil count and the risk of high on-treatment platelet reactivity (<i>P</i> for overall=0.012, <i>P</i> for nonlinearity=0.362). Further subgroup analysis showed that the above association remained consistent across clinical subgroups stratified by age, sex, diabetes, hypertension, acute coronary syndrome, body mass index, and high-sensitivity C-reactive protein levels (all <i>P</i> for interaction>0.05). Multivariable Cox regression analysis showed that peripheral blood eosinophil count was positively associated with the risk of cardiac death (<i>HR</i>=1.14, 95%<i>CI</i>: 1.07-1.21, <i>P</i><0.001). When analyzed as a categorical variable, compared with the Q1 group, the risk of cardiac death was higher in patients in the","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1172-1180"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Fabry disease and hypertrophic obstructive cardiomyopathy: from phenotypic mimicry to precision diagnosis and treatment].","authors":"T Liu, C H He, Y C Zhang, X Du, J Z Dong","doi":"10.3760/cma.j.cn112148-20260326-00202","DOIUrl":"10.3760/cma.j.cn112148-20260326-00202","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1238-1243"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mechanism by which disulfiram improves cardiac function in HFpEF rats via the GSDMD/Drp1 signaling pathway].","authors":"H F Wen, W D Li, X Y Shen, X L Jiang, Y Shen, W Zhang, J Zhang","doi":"10.3760/cma.j.cn112148-20260823-00530","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260823-00530","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the role of the gasdermin D (GSDMD)/dynamin-related protein 1 (Drp1) signaling pathway in cardiac injury and mitochondrial dynamic regulation in a rat model of heart failure with preserved ejection fraction (HFpEF). <b>Methods:</b> Twenty-four 8-week-old male Sprague-Dawley rats weighing 200-240 g were selected and randomly divided into four groups, with six rats per group: control group (regular chow and drinking water), HFpEF group (fed with 60% high-fat diet plus drinking water containing 0.5 g/L N<sup>ω</sup>-nitro-L-arginine methyl ester for 8 consecutive weeks), disulfiram group (intragastric administration of disulfiram at 50 mg·kg<sup>-</sup>¹·d<sup>-</sup>¹ on the basis of HFpEF modeling), and mitochondrial division inhibitor 1 (Mdivi-1) group (intragastric administration of Mdivi-1 at 30 mg·kg<sup>-</sup>¹·d<sup>-</sup>¹ on the basis of HFpEF modeling). H9C2 cardiomyoblasts were used for in-vitro experiments and assigned to four groups: normal cell group (cultured in routine complete medium with equal-volume vehicle), model group (treated with 12.5 mmol/L high glucose combined with 0.2 mmol/L palmitic acid for 12 h), disulfiram intervention group (40 μmol/L disulfiram added simultaneously with modeling), and Mdivi-1 intervention group (20 μmol/L Mdivi-1 added simultaneously with modeling). Echocardiography was performed to assess cardiac structure and function of rats in each group; a non-invasive blood pressure monitoring system was used to measure arterial blood pressure of rats; an exhaustive treadmill exercise test was performed to evaluate exercise tolerance of rats; HE, Masson, and wheat-germ agglutinin staining were used to assess myocardial histomorphology, collagen deposition, and cardiomyocyte cross-sectional area; Western blot was used to detect the expression levels of GSDMD, cleaved GSDMD, Drp1, mitofusin (MFN) 1 and MFN2 in rat myocardial tissues and H9C2 cardiomyoblasts; enzyme-linked immunosorbent assay (ELISA) was used to measure N-terminal pro-B-type natriuretic peptide and inflammatory factors, including interleukin (IL)-1β and IL-18 in rat myocardium; co-immunoprecipitation assay was performed to identify the interaction between GSDMD and Drp1 in myocardial tissues of HFpEF rats; immunohistochemical staining was used to determine myocardial GSDMD and Drp1 expression in rats. <b>Results:</b> Compared with the control group, the HFpEF group displayed a higher body weight ((364.50±20.98) g vs. (256.50±6.77) g), blood pressure (systolic blood pressure: (162.99±5.61) mmHg vs. (125.33±7.15) mmHg; diastolic blood pressure: (119.78±4.58) mmHg vs. (81.01±3.85) mmHg; 1 mmHg=0.133 kPa), left ventricular end-diastolic anterior wall thickness ((0.38±0.03) cm vs. (0.29±0.03) cm), left ventricular end-diastolic posterior wall thickness ((0.32±0.01) cm vs. (0.25±0.02) cm), left ventricular end-diastolic internal diameter ((0.78±0.03) cm vs. (0.67±0.01) cm), and the ratio of early diastolic mitr","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1154-1163"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cardiovascular-kidney-metabolic syndrome: past, present, and future].","authors":"Y Wang, Y F Guo","doi":"10.3760/cma.j.cn112148-20250805-00552","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20250805-00552","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1232-1237"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Applications and advances of LGE cardiac magnetic resonance imaging-based three-dimensional scar mapping in the evaluation of arrhythmogenic substrates].","authors":"Q Y Yang, C Han, M W Zheng, L W Liu","doi":"10.3760/cma.j.cn112148-20260214-00100","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260214-00100","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1244-1250"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Midterm outcomes of transcatheter edge-to-edge repair mitral valve guided solely by transesophageal echocardiography].","authors":"W Z Xing, Y Han, Y H Zhang, G Han, Z R Sun, L L Ben, S B Song, Z B Lang, G J Zhang, X B Pan, Y Han","doi":"10.3760/cma.j.cn112148-20260901-00550","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260901-00550","url":null,"abstract":"<p><p><b>Objective:</b> To preliminarily evaluate the efficacy and safety of transcatheter edge-to-edge repair of the mitral valve (MV-TEER) guided solely by transesophageal echocardiography (TEE). <b>Methods:</b> A total of 46 patients with mitral regurgitation who underwent MV-TEER guided solely by transesophageal echocardiography (TEE) at Central China Fuwai Hospital of Zhengzhou University from January 2023 to January 2024 were retrospectively enrolled. Follow-up was performed at 1, 3, 6, and 12 months after the procedure, including echocardiography, 6-minute walk test, New York Heart Association (NYHA) functional classification, and grading of mitral regurgitation severity. Hospitalization for heart failure, repeat mitral valve intervention, and all-cause mortality were recorded. The cumulative incidence of rehospitalization for heart failure was estimated using the Kaplan-Meier method. <b>Results:</b> The median age of the enrolled patients was 67.5 (59.0, 73.0) years, and 29 patients (63%) were male. MV-TEER was successfully performed under sole TEE guidance in all 46 patients. The median follow-up duration was 15.80 (12.63, 20.64) months. The 1-year rehospitalization rate for heart failure was 20%, and 1 patient died of malignant arrhythmia. There was no repeat mitral valve intervention. At 1 year after the procedure, the left ventricular end-systolic diameter decreased significantly from (47.17±11.31) mm to (39.71±7.44) mm (<i>P</i><0.05). The left ventricular end-systolic volume decreased from (87.02±20.63) ml to (72.18±17.30) ml (<i>P</i><0.05), and the left ventricular ejection fraction improved from (44.98±11.78)% to (51.84±10.03)% (<i>P</i><0.05). Five patients had mitral regurgitation grade 3+, while the remaining patients had grade less than 3+. Three patients were in NYHA functional class Ⅲ, 23 in class Ⅱ, and 19 in class Ⅰ. The 6-minute walk distance improved significantly from (298±78) m to (375±70) m (<i>P</i><0.05). <b>Conclusion:</b> It is preliminarily demonstrated that MV-TEER guided solely by TEE is safe and effective, and patients have favorable midterm outcomes.</p>","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1206-1211"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on non-invasive cardiac imaging for the evaluation of heart failure].","authors":"","doi":"10.3760/cma.j.cn112148-20260104-00006","DOIUrl":"10.3760/cma.j.cn112148-20260104-00006","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1132-1146"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Construction of a prediction model for in-hospital major adverse cardiovascular events after emergency percutaneous coronary intervention in patients with ST-elevation myocardial infarction].","authors":"Z X Guo, Y H Mi, M K Xin, X N He","doi":"10.3760/cma.j.cn112148-20260825-00532","DOIUrl":"https://doi.org/10.3760/cma.j.cn112148-20260825-00532","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To construct a machine-learning-based prediction model for in-hospital major adverse cardiovascular events (MACE) among patients with ST-elevation myocardial infarction (STEMI) after emergency percutaneous coronary intervention (PCI). &lt;b&gt;Methods:&lt;/b&gt; A total of 5829 patients with STEMI who underwent emergency PCI at the Emergency Critical Care Center of Beijing Anzhen Hospital, Capital Medical University, from January 1, 2015, to July 1, 2025, were enrolled. Patients were divided into the MACE group (524 cases) and the non-MACE group (5 305 cases) according to the occurrence of in-hospital MACE and were further divided into the training set (4 080 cases) and test set (1 749 cases) at a ratio of 7∶3. MACE included cardiogenic shock, severe heart failure, severe arrhythmia, acute stent thrombosis or recurrent acute myocardial infarction, non-fatal stroke, and cardiogenic death. Demographic data, lifestyle-related factors, past medical history, admission vital signs, laboratory test results within 24 hours after admission, echocardiographic parameters, Killip classification, and coronary interventional data were collected. Univariate analysis and Lasso regression were performed to select variables for model construction. Five machine-learning &lt;i&gt;algorithms,&lt;/i&gt; including support vector machine (SVM), logistic regression, random forest, naive Bayes&lt;i&gt;,&lt;/i&gt; and extreme gradient boosting (XGBoost)&lt;i&gt;,&lt;/i&gt; were used to construct prediction models for in-hospital MACE. The optimal model was selected based on the area under the receiver-operating characteristic curve (&lt;i&gt;AUC-ROC&lt;/i&gt;) and the area under the precision-recall curve (&lt;i&gt;AUPRC&lt;/i&gt;). Calibration curve and decision curve analysis were used to assess the probability calibration and clinical net benefit of the model. SHapley Additive exPlanations (SHAP) analysis was used to interpret the contribution of each feature. &lt;b&gt;Results:&lt;/b&gt; The patients were aged (58.1±12.3) years, and 4 875 (83.63%) were male. Fourteen variables were selected for model construction, including B-type natriuretic peptide, myoglobin, left ventricular ejection fraction, high-density lipoprotein cholesterol, high-sensitivity troponin I, triglycerides, triglyceride-glucose index, low-density lipoprotein cholesterol, glycated hemoglobin, creatine kinase-MB, smoking history, heart rate, Killip classification, and age. The XGBoost model yielded the best predictive performance, with an &lt;i&gt;AUC-ROC&lt;/i&gt; of 0.992 and an &lt;i&gt;AUPRC&lt;/i&gt; of 0.947, and exhibited favorable probability calibration and clinical net benefit. SHAP analysis demonstrated that the top five variables with the greatest contribution to model prediction were B-type natriuretic peptide, creatine kinase-MB, myoglobin, left ventricular ejection fraction, and triglyceride-glucose index. &lt;b&gt;Conclusions:&lt;/b&gt; Machine-learning prediction models for in-hospital MACE after emergency PCI in patients with STEMI were successfully constructed and internally v","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1190-1197"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of effort-related myocardial infarction with non-obstructive coronary arteries complicated by atrial fibrillation and cerebral infarction].","authors":"Q L Wang, X S Huang, S C Li","doi":"10.3760/cma.j.cn112148-20260104-00008","DOIUrl":"10.3760/cma.j.cn112148-20260104-00008","url":null,"abstract":"","PeriodicalId":38755,"journal":{"name":"中华心血管病杂志","volume":"54 10","pages":"1215-1217"},"PeriodicalIF":0.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}