Vojenske Zdravotnicke Listy最新文献_第8页

IMPACT OF ANTIDIABETIC DRUGS ON RISK AND OUTCOME OF COVID-19 INFECTION: A REVIEW 降糖药物对COVID-19感染风险和转归的影响

Vojenske Zdravotnicke Listy Pub Date : 2022-02-10 DOI: 10.31482/mmsl.2022.004

A. Zainal, M. Merkhan

{"title":"IMPACT OF ANTIDIABETIC DRUGS ON RISK AND OUTCOME OF COVID-19 INFECTION: A REVIEW","authors":"A. Zainal, M. Merkhan","doi":"10.31482/mmsl.2022.004","DOIUrl":"https://doi.org/10.31482/mmsl.2022.004","url":null,"abstract":"Based on many reports, an unmistakable link probably exists between diabetes mellitus and COVID-19. A major predisposing factor determining severity and mortality of COVID-19 is diabetes mellitus, diabetic patients were shown to be at higher risk for developing severe COVID-19 disease than non-diabetics;many recent studies reported a striking prevalence of DM in those diagnosed with COVID-19. Accordingly, antidiabetic drugs can possibly impact the clinical course and / or the outcome of this infection, either by alleviating diabetes-associated symptoms, minimizing its complications, or by mitigating or aggravating COVID-19 disease by effects independent from their direct antidiabetic effects. Several antidiabetic drug classes were shown to have varying effects, like blocking viral entry to cells, as well as having immunomodulatory, anti-inflammatory, antifibrotic, or cardioprotective effects;such effects could prove beneficial for COVID-19 patients. On the other hand, some antidiabetic agents may have adverse effects that aggravate patients’ condition like hypoglycemia, fluid retention, increased weight or lactic acidosis, which require special consideration in patient management. Some of the drugs were found in observational studies to either reduce mortality from COVID-19 or pose no harm, but more solid evidence from clinical trials is still lacking. © 2022, University of Defence, Faculty of Military Health Sciences. All rights reserved.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47724364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

ETANERCEPT IN PATIENTS WITH ANKYLOSING SPONDYLITIS: EFFECTIVENESS AND RATE OF RESPONSE 依那西普治疗强直性脊柱炎的疗效和有效率

Vojenske Zdravotnicke Listy Pub Date : 2022-02-02 DOI: 10.31482/mmsl.2022.001

Zahraa R. Albagoa, I. Thanoon, Faez Ibraheem Abdulla, A. Younis

{"title":"ETANERCEPT IN PATIENTS WITH ANKYLOSING SPONDYLITIS: EFFECTIVENESS AND RATE OF RESPONSE","authors":"Zahraa R. Albagoa, I. Thanoon, Faez Ibraheem Abdulla, A. Younis","doi":"10.31482/mmsl.2022.001","DOIUrl":"https://doi.org/10.31482/mmsl.2022.001","url":null,"abstract":"Introduction: “Ankylosing spondylitis (AS)” is an inflammatory disorder that affects the axial skeleton, peripheral joints, as well as entheses, resulting in significant disability. “Tumor necrosis factor-α (TNF-α)” inhibitors are regarded to be a helpful treatment for patients with active “AS”. This study aimed to investigate the effectiveness and response rate of “etanercept” in a group of patients with “ankylosing spondylitis” in Mosul, Iraq. Methods: A prospective, “open-labeled”, non-randomized 12 weeks study was undertaken on 43 participants with “ankylosing spondylitis” in the “Rheumatology unit” of “Ibn Sina Teaching Hospital”, and the diagnosis was made using the “modified New York criteria”. Participants were assessed at the outset of the study, week 4, and week 12 after receiving etanercept 50mg subcutaneously once weekly. The “Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)” was utilized to assess disease activity, while the “Bath Ankylosing Spondylitis Function Index” was utilized to assess functional status (BASFI) at baseline, 4 weeks, and 12 weeks. BASDAI 50 was used to assess the response rate. Results: Mean patients’ age was “36.6±8.47” years; men accounted for “90.7 %” of the cases, with the mean disease length being “9.6±5.90” years. A marked decrease in BASFI and BASDAI was found four and twelve weeks after commencing treatment compared to baseline (p=0.000). “BASDAI 50 %” response was fulfilled by 42.5 % of the participants after 4 weeks and by 65%% after 12 weeks of therapy with “etanercept”. There was a marked fall in the mean ESR and CRP after four and twelve weeks of “etanercept” therapy. Conclusion: In “AS” patients, once weekly “etanercept” 50 mg given subcutaneously for twelve weeks was an effective therapy.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43264989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

ECHOCARDIOGRAPHY IN FIRST-CONTACT CARE 超声心动图在初次接触护理中的应用

Vojenske Zdravotnicke Listy Pub Date : 2022-01-31 DOI: 10.31482/mmsl.2021.051

Petr Grenar, K. Medilek, Jiří Nový, J. Horáček, T. Kupsa, P. Skořepa, M. Jakl

引用次数: 1

EVALUATION OF ANTIMICROBIAL EFFECTS OF CITRUS PEEL EXTRACTS AND ITS SILVER NANOPARTICLES AGAINST MULTIPLE PATHOGENS 柑桔皮提取物及其纳米银对多种病原菌的抑菌效果评价

Vojenske Zdravotnicke Listy Pub Date : 2022-01-31 DOI: 10.31482/mmsl.2021.052

Maimonah Q. Yahya, Khadeeja Y. Abid

{"title":"EVALUATION OF ANTIMICROBIAL EFFECTS OF CITRUS PEEL EXTRACTS AND ITS SILVER NANOPARTICLES AGAINST MULTIPLE PATHOGENS","authors":"Maimonah Q. Yahya, Khadeeja Y. Abid","doi":"10.31482/mmsl.2021.052","DOIUrl":"https://doi.org/10.31482/mmsl.2021.052","url":null,"abstract":"The majority of nanomaterials have unique properties that make them helpful in a variety of biotechnology applications. The study assesses the phytochemical, antioxidant (using a DPPH radical scavenging assay) and antimicrobial activities and identifies minimum inhibitor concentrations of Citrus sinensis (orange), Citrus Limonum (lemon), and Citrus reticulata (tangerine) extracts and their silver nanoparticles. Fourier Transform Infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) was used to analyze the produced AgNPs. The synthesized AgNPs have a size of less than 100 nm according to SEM examination. Their DPPH radical scavenging activity and reducing power increased in a dose-dependent way that was more than that of their aqueous and alcoholic extracts. In comparison to Staphylococcus aureus and Candida albicans, silver nanoparticles were found to be more efficient towards Escherichia coli. Their activities were increased with increasing dosage. Whereas, no inhibition zones were conducted with the examined plain citrus peel extracts. This finding revealed that the biomolecules that cover nanoparticles can increase metal nanoparticles' biological activity and the organic AgNPs green alcoholic and aqueous extracts from orange, lemon, and tangerine peels could be used as a potential source of new antioxidant and antimicrobial agents.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43022093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

AFLATOXIGENIC FUNGI IN NUTS AND DRIED FRUITS IN MOSUL AND DUHOK CITY 摩苏尔和东北地区坚果和干果中的致黄真菌

Vojenske Zdravotnicke Listy Pub Date : 2022-01-26 DOI: 10.31482/mmsl.2021.049

Emanbellah Ramadan, N. Ramadan, A. Mohammed

{"title":"AFLATOXIGENIC FUNGI IN NUTS AND DRIED FRUITS IN MOSUL AND DUHOK CITY","authors":"Emanbellah Ramadan, N. Ramadan, A. Mohammed","doi":"10.31482/mmsl.2021.049","DOIUrl":"https://doi.org/10.31482/mmsl.2021.049","url":null,"abstract":"Introduction: The present study aims to determine the contamination of eighteen samples from different nuts and dried fruits from the markets of Mosul and Duhok city. Materials and Methods: This study included samples of local and imported nuts and dried fruits. Results: The study showed different genera of contaminant fungi such as Alternaria, Penicillium, and Aspergillus species which are very common fungi associated with samples. The most fungal contamination was found in pistachio and black raisins, followed by balahsisi, taffy raisins, yellow raisins, dried apricot and peanut with shell. A total of nine species of Aspergillus were isolated on (potato dextrose agar, malt extract agar and dichloran rose bengal agar) media A. niger, A. flavus, A. fumigatus, A. tamarii, A. aculeatus, A. parasiticus, A. oryzae, A. japonicus, A. ochraceus were detected from all types of nuts and dried fruits samples. The most frequent species were A. niger followed by A. flavus and A. fumigates with percentage frequencies of 45.2%, 20.3% and 13.9% respectively. The ability of toxicogenic fungi to produce AflatoxinB1 by ELISA test of Sunlong corporation in nuts and dried fruits samples ranged from 94.8 to 136.4 μg/kg, with the highest levels of ability to produce AflatoxinB1 in nuts samples (peanut with shell, sunflower seeds and walnut) at levels 135.8, 129.0, and 128.9 μg/kg respectively, while in dried fruits samples the highest ability to produce AflatoxinB1in dried apricot, taffy raisins and yellow raisins was at levels136.4,123.1 and 118.0 μg/kg, respectively. Conclusion: we conducted the fungal contamination and quantitative content of aflatoxin B1 in nuts and dried fruits notably those sold openly in food shops.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49585007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

STRATEGIES OF STRESS MANAGEMENT OF BURNOUT SYNDROME IN STUDENTS OF PREGRADUATE STUDY COURSE OF SOCIAL WORK 社会工作预修学生倦怠综合征的压力管理策略

Vojenske Zdravotnicke Listy Pub Date : 2022-01-25 DOI: 10.31482/mmsl.2022.003

A. Vosečková, Zuzana Truhlářová, P. Blažek

{"title":"STRATEGIES OF STRESS MANAGEMENT OF BURNOUT SYNDROME IN STUDENTS OF PREGRADUATE STUDY COURSE OF SOCIAL WORK","authors":"A. Vosečková, Zuzana Truhlářová, P. Blažek","doi":"10.31482/mmsl.2022.003","DOIUrl":"https://doi.org/10.31482/mmsl.2022.003","url":null,"abstract":"Za jeden z nejpodstatnějších iniciujících faktorů vývoje syndromu vyhoření je považováno působení chronického stresu. Studenti, kteří jsou vystaveni vysoké míře stresu a zároveň nedokáží využít vhodné strategie zvládání těchto zátěžových situací, bývají ohroženi rozvojem syndromu vyhoření již během studia. Předmětem této práce bylo prozkoumat blíže otázku stresu, a to v souvislosti se syndromem vyhoření, s důrazem na rozvoj tohoto jevu ve skupině pregraduálních studentů Ústavu sociální práce v Hradci Králové. Stejně jako posouzení souvislostí využití strategie zvládání stresu versus riziko vývoje syndromu vyhoření u studentů. Vzhledem k počtu respondentů není záměrem této studie zobecnění nalezených výsledků, ale snaha o hlubší pohled do této problematiky a aplikace získaných poznatků do výuky studentů oboru sociální práce. Pro vyhodnocení strategií zvládání stresu byl využit dotazník SVF 78, syndrom vyhoření byl posouzen dotazníkem Burnout Measure. Nejčastěji používanou strategií zvládání stresu byla perseverace. Řadíme ji do skupiny negativních strategií, jelikož přímo zhoršuje a prodlužuje stresovou reakci organismu na prožívající zátěž. V otázce vztahu mezi strategiemi zvládání a syndromem vyhoření se ukázala pozitivní korelace u negativních strategií zvládání stresu, jako jsou úniková tendence, perseverace, rezignace nebo sebeobviňování. Pozitivní korelace v těchto parametrech znamená, že studenti, kteří využívají tyto strategie zvládání stresu, mají větší míru ohrožení syndromem vyhoření. Negativní korelace byla nalezena u pozitivních strategií, mezi které patří odklon, náhradní uspokojení, kontrola situace, pozitivní sebeuspokojení. Celková míra korelace pro oba dotazníky byla 0,4 – 0,59.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45944761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVALUATION OF THE THERAPEUTIC EFFECTS OF COMBINED HYDROXYCHLOROQUINE AND AZITHROMYCINE IN PATIENTS WITH COVID-19 羟氯喹与阿奇霉素联合治疗新冠肺炎的疗效评价

Vojenske Zdravotnicke Listy Pub Date : 2022-01-13 DOI: 10.31482/mmsl.2021.045

Zeina A.Althanoon

{"title":"EVALUATION OF THE THERAPEUTIC EFFECTS OF COMBINED HYDROXYCHLOROQUINE AND AZITHROMYCINE IN PATIENTS WITH COVID-19","authors":"Zeina A.Althanoon","doi":"10.31482/mmsl.2021.045","DOIUrl":"https://doi.org/10.31482/mmsl.2021.045","url":null,"abstract":"Introduction: Coronavirus pandemic is currently a global health concern with no established treatment guidelines. The aim of the present study was to determine the therapeutic effectiveness of hydroxychloroquine combined with azithromycin in patients with positive coronavirus disease 2019 (COVID‐19) admitted to the hospital with severe dyspnea, as well as the incidence of occurrence of adverse effects. Methods: It was intended to utilize a retrospective clinical study of approximately 250 adult patients admitted to the ALSALAM Teaching Hospital in Mosul city with mild to moderate COVID-19 in order to evaluate treatment efficacy in combination with clinical and biochemical findings. Two groups were involved in the research. The first patient group consisted of 250 people who got hydroxychloroquine in conjunction with azithromycin, while the second untreated control group consisted of 100 individuals who received no medication as part of the research. Results: Baseline parameters (clinical and biochemical assays) did not vary substantially among the two groups. Patients in the treatment group were hospitalized at a rate of 30%, compared to 27% in the untreated control group (P<0.001). Between groups, there were no statistically significant changes in mortality, non-invasive oxygen demand, or hospitalization duration. Biochemical and Clinical outcomes were comparable between those receiving hydroxychloroquine with azithromycin and those do not receive any medication. Conclusion: This treatment regimen was shown to be not affective in mild to severe positve COVID-19 hospitalized patients and was associated with a small number of mild to moderate clinical adverse effects. © 2022, University of Defence, Faculty of Military Health Sciences. All rights reserved.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44747257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

PUBLIC LEADERSHIP'S MESSAGING DURING PUBLIC HEALTH CRISES - CHALLENGES AND OPPORTUNITIES FROM MASK-WEARING MESSAGING DURING THE COVID-19 PANDEMIC 公共卫生危机期间的公共领导信息——新冠肺炎大流行期间戴口罩信息带来的挑战和机遇

Vojenske Zdravotnicke Listy Pub Date : 2022-01-07 DOI: 10.31482/mmsl.2021.040

Zhayra Geraldine Garcia Escalona, V. Bostik

{"title":"PUBLIC LEADERSHIP'S MESSAGING DURING PUBLIC HEALTH CRISES - CHALLENGES AND OPPORTUNITIES FROM MASK-WEARING MESSAGING DURING THE COVID-19 PANDEMIC","authors":"Zhayra Geraldine Garcia Escalona, V. Bostik","doi":"10.31482/mmsl.2021.040","DOIUrl":"https://doi.org/10.31482/mmsl.2021.040","url":null,"abstract":"Given their primacy in discussions over public health measures throughout the COVID-19 pandemic, this paper focuses on leadership’s messages around masks and mask-wearing, aiming to emphasise the responsibility of leadership in the formation of norms during public health crises. It argues for the importance of robust messaging as a key factor in confidence building and public abidance to health measures, using the shortcomings in mask-wearing communication as a case study. For this purpose, the paper first discusses securitization theory and places it in the context of health to build on risk communication framework. Secondly, it examines the role of leadership and meaning-making in that process by discussing the WHO’s early mask guidance and consequent challenges at the state-level by political and health leadership. Lastly, the paper confirms the importance of citizenry’s successful reception of health guidance and outlines potential tactics to do so. Having discussed that, the paper addresses other hindrances to public health messaging and confidence-building that rest outside official communication, namely disinformation and misinformation but also negative non-discursive messaging. This, with the aim of building on available literature on the development of epidemiological response and management from a security lens. © 2022, University of Defence, Faculty of Military Health Sciences. All rights reserved.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42021641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SOLID LIPID NANOPARTICLES AS A PROMISING APPROACH FOR DELIVERY OF ANTICANCER AGENTS: REVIEW ARTICLE 固体脂质纳米粒子作为一种很有前途的抗癌药物递送方法&综述

Vojenske Zdravotnicke Listy Pub Date : 2021-12-27 DOI: 10.31482/mmsl.2021.042

Salam Shanta Taher, Z. A. Sadeq, K. Al-kinani, Zahraa Salim Alwan

{"title":"SOLID LIPID NANOPARTICLES AS A PROMISING APPROACH FOR DELIVERY OF ANTICANCER AGENTS: REVIEW ARTICLE","authors":"Salam Shanta Taher, Z. A. Sadeq, K. Al-kinani, Zahraa Salim Alwan","doi":"10.31482/mmsl.2021.042","DOIUrl":"https://doi.org/10.31482/mmsl.2021.042","url":null,"abstract":"Cancer disease has a complicated pathophysiology and is one of the major causes of death and morbidity. Classical cancer therapies include chemotherapy, radiation therapy, and immunotherapy. A typical treatment is chemotherapy, which delivers cytotoxic medications to patients to suppress the uncontrolled growth of cancerous cells. Conventional oral medication has a number of drawbacks, including a lack of selectivity, cytotoxicity, and multi-drug resistance, all of which offer significant obstacles to effective cancer treatment. Multidrug resistance (MDR) remains a major challenge for effective cancer chemotherapeutic interventions. The advent of nanotechnology approach has developed the field of tumor diagnosis and treatment. Cancer nanotechnology enables direct access to tumor cells, resulting in enhanced drug localization and cellular uptake. Since the early 1990’s, several solid lipid nanoparticle (SLN) or SLN-based systems for the delivery of cytotoxic drugs have been manufactured and tested with success. High shear homogenization, microemulsionbased SLN, Supercritical fluid technology, spray drying, and solvent emulsification/evaporation methods can all be used to successfully formulate SLN.There is great potential to enhance cancer chemotherapy by incorporating it into a solid lipid nanoparticle (SLN) drug delivery system. Improving tumor diffusivity, improvement of body distribution, and inhibiting MDR are the main attributes. This type of review article discusses advantages and disadvantages of SLNs, their production techniques, and their potential usage in the treatment of various cancers.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45474872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OVERVIEW OF VITAMIN D ROLE IN POLYCYSTIC OVARIAN SYNDROME 维生素D在多囊卵巢综合征中的作用综述

Vojenske Zdravotnicke Listy Pub Date : 2021-12-21 DOI: 10.31482/mmsl.2021.027

E. Sulaiman, S. Dhia, M. Merkhan

{"title":"OVERVIEW OF VITAMIN D ROLE IN POLYCYSTIC OVARIAN SYNDROME","authors":"E. Sulaiman, S. Dhia, M. Merkhan","doi":"10.31482/mmsl.2021.027","DOIUrl":"https://doi.org/10.31482/mmsl.2021.027","url":null,"abstract":"Vitamin D inadequacy is widespread in females with polycystic ovarian syndrome (PCOS), with blood values of 25-hydroxy vitamin D (25OHD) down to or less than 20 ng/ml in two-third of PCOS patients. Decreased 25OHD concentrations have been linked to insulin resistance, ovulatory and period abnormalities, lower pregnancy outcomes, and other indications of PCOS, according to epidemiological studies. There might be some, but inadequate, research that vitamin D supplements can help women with PCOS with menstruation disruption and insulin sensitivity. Vitamin D inadequacy may bestow to the exacerbation of PCOS, and vitamin D intake may be helpful in the treatment of this condition. However, the present evidence is insufficient, and further experimental investigations are in need to establish vitamin D supplementation's potential advantages in this population. Many investigators claimed a pertinency between vitamin D concentrations and PCOS, nevertheless, these researches bear rattle factors of conjoined with other disorders or ailments, such as obesity, diabetes, and hirsutism. In the view of this, the present review detailed the role of vitamin D inadequacy and related biomolecule abnormalities, including sex hormones, and insulin and we listed their psychological and cardiovascular encounter. We concluded that the correlation between vitamin D intake and mended PCOS prominence is dubious and no definite findings attained by studies conducted across multicentral laboratories.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48636698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12