Vojenske Zdravotnicke Listy最新文献

{"title":"METFORMIN MAY AMELIORATE INFLAMMATORY EVENTS OF IL-18 IN SOME INFLAMMATORY CONDITIONS","authors":"Ajil A. Alzamily, K. M. Obaid, Buthainah Al-Azzawi","doi":"10.31482/mmsl.2021.039","DOIUrl":"https://doi.org/10.31482/mmsl.2021.039","url":null,"abstract":"Background: Interleukin-18 (IL-18) belongs to the cytokine family IL-1. IL-18 is synthesized as inactive precursors which need to be processed into an active interleukin by the Caspase-1 enzyme. The role of IL-18 is implicated in several auto-immune disorders, myocardial function, emphysema, metabolic syndromes, psoriasis, bowel inflammation, sepsis, and acute kidney injury. IL-18 exhibits pro-inflammatory properties, such as increased cell adhesion molecules, nitric oxide production, enhancement of T-cell and natural killer cell maturation, and increasing the production of chemokines. This study was designed from November 2020 to February 2021 at Al-Shomali hospital, Babylon governorate, Iraq. This study aimed to assess the levels of IL-18 in patients with PCOS, T2DM and CAD before treatment with metformin and after metformin medication, and to evaluate the roles of IL-18 in the development of this disease. Materials and methods: The study design is a case-control study and patients are selected by simple randomization after diagnosis by a specialist based on clinical diagnosis and laboratory findings. An enzyme-linked immunosorbent test (ELISA) was used to estimate the level of serum IL-18 before and after metformin administration. A total of 300 patients were involved in this study, divided according to their chronic illness as 60 women with PCOS, 60 patients Type 2 diabetes mellitus (T2DM), 60 patients with myocardial infarction (MI), and 60 patients with T2DM and MI. In addition, 30 healthy people as a control group. Results: Before treatment with metformin, the results were exhibited a significant difference (P≤0.0001) in the concentrations of IL-18 in PCOS, T2DM, and patients with CAD as compared with control. While, after metformin treatment, a significant decrease (P≤0. 01, P≤0.0001 and P≤0.001) in IL-18 level in patients with PCOS and T2DM and CAD respectively as compared to before metformin treatment. Conclusion: Metformin administration reduces the inflammatory events of IL-18 in patients with T2DM and CAD and PCOS.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41749076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PEDIATRIC SUBTYPES OF VENTRICULAR SEPTAL DEFECTS WITH PERCENT CLOSURE AT IBN-SENA TEACHING HOSPITAL IN THE CITY OF MOSUL - IRAQ","authors":"B. S. Mustafa, Ayoub A. Al-bayati, Ghayth M Abdulrazzaq, M. Merkhan","doi":"10.31482/mmsl.2021.036","DOIUrl":"https://doi.org/10.31482/mmsl.2021.036","url":null,"abstract":"The ventricular septal defect (VSD) is a congenital lesion characterized by the presence of an opening between cardiac chambers. The treatment might involve medical therapy to control symptoms or in certain cases, surgical resuscitation might be required. Objectives: The study was conducted to establish a database about the prevalence and pattern of VSD and their prognosis in children referred to by echocardiography in Ibn-Sena Teaching Hospital over the period of March 2019 to January 2020. Method: The present study is a prospective descriptive study conducted on all patients diagnosed with cardiac lesions revealed by echocardiography. The sample included in the study involves newborns (day 1) to 14-years-old children. Result: Out of 500 children included in the study; most of these cases were cyanotic congenital heart lesions and out of which two-third were perimembranous defects. Conclusion: The study concluded a higher prevalence of non-cyanotic lesions and peri-membranous type is the commonest VSD lesion.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45296427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 AMONG A SAMPLE OF IRAQI PATIENTS WITH RHEUMATIC DISEASES: A MULTICENTER STUDY","authors":"F. Gorial, Ali Abdulrahman Younis, Ali Alkazzaz, Avin M. Arif Maroof, T. A. Qaradaghi, Chiman Hasan Mahmood, Mohamme H ALosami, D. Yasiry, Nabaa Ihsan Awadh, Marwa Moayad Younis, Farah J. Mahdi, Saad Waheed Mihan, Nizar A. Jassim","doi":"10.31482/mmsl.2021.038","DOIUrl":"https://doi.org/10.31482/mmsl.2021.038","url":null,"abstract":"Background: There are scarce data on disease characteristics and severity of coronavirus 2019 (COVID-19) among Iraqi patients with rheumatic diseases (RDs). In this study, we aimed to report the disease characteristics and variables associated with COVID-19 outcome among patients with RDs. Methods: Between October 2020 and April 2021, rheumatic diseases (RDs) patients with COVID-19 were registered from different centres in Iraq. The patient's demographics, rheumatological history, COVID-19 symptoms, severity, and management, if any, their disease progress and outcome have been assessed. Binary logistic regression analysis was performed to determine predictors of disease severity. Results: 253 patients were included in the study, and most were females. The commonest rheumatic disease was rheumatoid arthritis (RA), followed by systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS) (95, 52 and 20 patients respectively). It has been found that 50.6% of patients had mild COVID-19, and 49.4% had moderate disease;18% of patients required oxygen support, no patient was treated in hospital, and there was no reported death. Patients with moderate COVID-19 had significantly higher age than mild type (p= 0.022);with more BMI (p=0.03), more in the number of comorbidities (p<0.001), more steroids users (p=0.012), higher steroid dose (P=0.034), had longer steroid duration, longer duration of conventional disease-modifying antirheumatic drugs (cDMARDs) (p=0.018), and biologic Diseasemodifying Antirheumatic Drug (bDMARDs) in months (p=0.025). Increasing body mass index (BMI), duration of biological DMARDs use, and an increasing number of comorbidities were significant independent factors that increase the risk of having more severe COVID-19, (p<0.05). Conclusion: COVID-19 infection rheumatic patients tend to have mild-moderate disease course;BMI, duration of biological DMARDs use, and many comorbidities were significant independent factors that increase the risk of having more severe COVID-19,(p<0.05). © 2022, University of Defence, Faculty of Military Health Sciences. All rights reserved.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44482872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NANOEMULGEL AS A RECENT DRUG DELIVERY SYSTEM","authors":"Alaa R. Azeez, Myasar Alkotaji","doi":"10.31482/mmsl.2021.035","DOIUrl":"https://doi.org/10.31482/mmsl.2021.035","url":null,"abstract":"Every year many drug molecules discovered to be effective in treatment of many diseases, however not all of these drugs succeed in reaching the market. One of the main reasons for such failure is the lipophilicity or low water solubility of these chemicals which results in poor bioavailability. Nanoemulsion has the ability to deliver these drugs in an efficient way. Nanoemulsion, which is usually o/w emulsion can incorporate this lipophilic drug into nanolipoidal droplets. However, the difficulty in applying liquid dosage form can be overcome by using nanoemulgel system. Nanoemulgel considered as a suitable way to deliver lipophilic drugs through topical route. This review tries to highlight the importance of nanoemulgel as a drug delivery system. The components of the systems have been explored and the methods of preparations including high energy methods and low energy methods have been discussed. Different methods were used in characterization of such delivery system; all of these methods and techniques were reviewed briefly. Finally, the recent researches about different applications of emulgel in local delivery or systemic delivery has been discussed. To conclude, the nanoemulgel applications in drug delivery is very promising and many products will find their way to the markets soon.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42642620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF SYMMETRICAL AND ASYMMETRIC DIMETHYL-L-ARGININE AS BIOMARKERS IN DIALYSIS-DEPENDENT AKI PATIENTS","authors":"Mohammed KJ. Alnori, Muthear N. Dawood, M. A. Ajeel","doi":"10.31482/mmsl.2021.034","DOIUrl":"https://doi.org/10.31482/mmsl.2021.034","url":null,"abstract":"Introduction: Symmetrical and Asymmetric dimethyl-L-arginine were previously discovered in urine, the present study explored the link between acute kidney injury (AKI) and modulation in the level of these biomarkers. Methods: Ninety volunteers were recruited in the current study, sixty of them were dialysis-dependent AKI patients, their ages ranged between 29-70 years, 13 were diabetic and 47 were non-diabetics patients. Thirty healthy subjects were recruited as a control group. Blood urea, serum creatinine, uric acid, glucose, lipid profile, albumin, hemoglobin, levels were measured using an automated analyzer (SK3002b). Asymmetric dimethyl-L-arginine (ADMA) and symmetric dimethyl-L-arginine (SDMA) serum concentrations were measured using ELISA. Results: The findings of the current study demonstrated a significant decrease in hemoglobin and serum albumin levels alongside an increase in the serum creatinine, uric acid, and serum triglyceride (TG) in the patients when compared to the apparently healthy controls. Serum concentrations of ADMA and SDMA were significantly lower in healthy controls compared to the patients. Conclusion: These data confirm the assumption which assumes that both, ADMA and SDMA serum levels are sensitive markers of reduced renal function and serum SDMA is more sensitive than ADMA in dialysis-dependent AKI patients.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41392001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SMART HYDROGEL POLYMERS FOR DRUG DELIVERY","authors":"Z. Ali, Myasar Alkotaji","doi":"10.31482/mmsl.2021.032","DOIUrl":"https://doi.org/10.31482/mmsl.2021.032","url":null,"abstract":"Smart hydrogels are special type of hydrogels that undergo solution-gelation transition in response to alterations in the environment. Solution-gel transformation is brought about through either physical or chemical cross-linking that occur between the hydrogel chains. Various stimulating factors have been identified to be responsible for the change in the physical state of the intelligent hydrogel. The most important triggering factors are the temperature, pH, ions, electrical signalling, magnetic field, glucose, light and others. Each of these stimulating factors can trigger the swelling of the hydrogel through unique mechanism. Many of these triggering factors are characteristics of the biological systems which make the smart polymers quite beneficial for different biomedical applications. Numerous natural and synthetic polymers have been distinguished to act as smart materials. These polymers impressed the scientists to use them in many biomedical and industrial applications such as drug delivery systems, gene therapy applications, tissue engineering and many other applications.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44926754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METHODS OF IMMOBILIZATION OF MICROBIAL ENZYMES ON SOLID SURFACES AND THEIR USE","authors":"T. Válek, M. Pohanka","doi":"10.31482/mmsl.2021.033","DOIUrl":"https://doi.org/10.31482/mmsl.2021.033","url":null,"abstract":"","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47993369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"USUTU VIRUS, ANOTHER EMERGING MOSQUITO-BORNE PATHOGEN IN CENTRAL EUROPE","authors":"Jakub Vojtíšek, Radek Pečta, R. Kejíková, Z. Hubálek, S. Šikutová, I. Rudolf","doi":"10.31482/mmsl.2021.031","DOIUrl":"https://doi.org/10.31482/mmsl.2021.031","url":null,"abstract":"Usutu virus (USUV) je emergentní patogen přenášený komáry, taxonomicky náleží do rodu Flavivirus čeledi Flaviviridae. Tento původně africký arbovirus v roce 2001 způsobil hromadné hynutí ptactva v okolí Vídně a poté se rozšířil prakticky po celé střední, jižní a západní Evropě. USUV je primárně patogenní pro některé druhy pěvců, především kosy černé (Turdus merula), avšak patogenita byla prokázána i u řady jiných druhů, zejména z řádů dravců a sov. V posledních letech přibývá případů infekce u člověka. Cílem práce je podat ucelené informace o taxonomii viru, jeho genomu, životním cyklu včetně komářích vektorů a obratlovčích rezervoárů, endemickém výskytu v Africe i následném expanzivním šíření v Evropě, surveillanci v jednotlivých evropských státech, patogenitě viru pro obratlovce včetně popisu onemocnění, jež způsobuje, laboratorní diagnostice a dostupné léčbě.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45257049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MENTAL HEALTH CONSEQUENCES OF CLIMATE CHANGE FROM EUROPEAN PERSPECTIVE","authors":"O. Rydlo, V. Bostik","doi":"10.31482/mmsl.2021.037","DOIUrl":"https://doi.org/10.31482/mmsl.2021.037","url":null,"abstract":"Society, as much as an individual, has a certain capacity to cope with issues. The preparedness of the society for the issue significantly enhances the ability to overcome the issue with minimum possible harm. This article considers psychological consequences of climate change, the major challenge for society, from the perspective of European security. It proposes an increasement of aggressive behavior and intergroup hostility as a direct and indirect psychological consequence of climate change. In the final section, crisis intervention and de-securitization of climate change debate are considered to serve as mitigating factors for future development.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43984660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVALENCE OF ANEMIA AND ITS IMPACT ON THE QUALITY OF LIFE OF RENAL TRANSPLANT RECIPIENTS: A CROSS-SECTIONAL STUDY","authors":"S. Shilbayeh","doi":"10.31482/mmsl.2021.028","DOIUrl":"https://doi.org/10.31482/mmsl.2021.028","url":null,"abstract":"Background: Renal transplant patients show a high incidence of anemia, which is often responsible for cardiovascular morbidity and graft rejection. Anemia reportedly impacts the health-related quality of life (HRQoL); however, only a limited number of related studies have been conducted on renal transplant recipients. In this study, we estimated the prevalence of anemia and its effects on QoL of renal transplant patients in Saudi Arabia.","PeriodicalId":38749,"journal":{"name":"Vojenske Zdravotnicke Listy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42621347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}