Otorhinolaryngology Clinics最新文献

{"title":"The role of tympanotomy and mastoidectomy in the management of otogenic meningitis","authors":"F. Mammarella, A. Loperfido, C. Pianura, G. Stazi, L. Marchioni, G. Bellocchi","doi":"10.23736/s2724-6302.22.02413-6","DOIUrl":"https://doi.org/10.23736/s2724-6302.22.02413-6","url":null,"abstract":"","PeriodicalId":38742,"journal":{"name":"Otorhinolaryngology Clinics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82825136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of auditory brainstem response in Cornelia de Lange Syndrome","authors":"D. Troisi, P. De Luca, C. Cassandro, M. Ralli, P. Viola, A. Albera, F. Gioacchini, L. de Campora, D. Tassone, A. Scarpa","doi":"10.23736/s2724-6302.21.02396-3","DOIUrl":"https://doi.org/10.23736/s2724-6302.21.02396-3","url":null,"abstract":"","PeriodicalId":38742,"journal":{"name":"Otorhinolaryngology Clinics","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77977299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimal hearing loss in children: effect on speech in noise perception","authors":"C. Cassandro, M. Ralli, P. De Luca, A. Albera, Giulia Aschero, Silvano Lovallo, V. Landi, Irene Vernero, Diego Sammarco, Alessandra Manassero, A. Scarpa","doi":"10.23736/s2724-6302.21.02397-5","DOIUrl":"https://doi.org/10.23736/s2724-6302.21.02397-5","url":null,"abstract":"","PeriodicalId":38742,"journal":{"name":"Otorhinolaryngology Clinics","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85570764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological investigation of reparative processes in the area of the defect of cartilage tissue of the external ear of the rabbit after the local application of allogenic mesenchymal stem cells","authors":"Yuriy V. Minin, Anton F. Karas, Halyna A. Karas, T. Kucherenko, S. P. Chaika, P. Virych, N. Shuvalova, T. Y. Raskaliei","doi":"10.37219/2528-8253-2022-1-29","DOIUrl":"https://doi.org/10.37219/2528-8253-2022-1-29","url":null,"abstract":"Purpose: to study the features of the restoration of rabbits outer ear elastic cartilage tissue in the area of the defect after its filling with allogeneic mesenchymal stem cells (MSCs).\u0000Materials and methods: Studies were performed on 24 sexually mature rabbits. All animals under general anaesthesia underwent surgery to create a standardized linear defect and were divided into experimental (15 rabbits) and control (9 rabbits) groups. In the experimental group, the defect was filled with suspensions of MSCs in the amount of 5 million cells, and in the control group of cells was not introduced. MSCs were obtained from the\u0000umbilical cord of rabbits by the enzymatic method. After the first passage of the MSCs culture, was studied MSCs stem potential and tested ability to differentiating. Material for morphological studies was taken after 1, 2 and 3 months, cryostat sections were prepared hematoxylin-eosin and picrofuxin staining were performed according to van Gizon, as well as morphometry.\u0000Results: The introduction of suspensions of allogeneic MSCs in the experiment in the cartilage defect of the outer ear of rabbits causes healing with the activation of pre-existing embryonic cartilage cells, the appearance of cells in a state of division in the adjacent zone, activation of angiogenesis and promotes fibrotization with a predominance of loose connective tissue 1 month after surgery. After 3 months, a more pronounced activation of chondrogenesis is observed with the growth of chondrocytes and their increased number in lacunae, the appearance of isogenic groups of cells, which is combined with vascular activation and the growth of dense scar connective tissue,increased fibroblasts and the number of collagen fibers in the defect area, as well as in the absence of a complete restoration of the characteristic cartilage structure. At that time, in the control group, in the process of defect healing 1 month after the operation, along with the detection of a reduced zone of activation of cartilage chondrocytes and collagen fibers, the development of destructive-dystrophic processes of chondrocytes and the extracellular cartilage matrix was observed. The morphometry data quantitatively confirm a more pronounced activation of chondrogenesis in the areas adjacent to the cartilage defect under the conditions of MSC injection compared to the control. The difference is 20.8% 1 month after the operation and 14.2% 3 months later. The results obtained indicate the promise of using MSCs to activate reparative processes in the area of rabbits outer ear cartilage tissue defect.","PeriodicalId":38742,"journal":{"name":"Otorhinolaryngology Clinics","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81117015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of appeals of patients with sensorineural hearing loss to the otolaryngological department during 2015-2021","authors":"Margaryta R. Amirkhanova, Julia V. Dieeva","doi":"10.37219/2528-8253-2022-1-56","DOIUrl":"https://doi.org/10.37219/2528-8253-2022-1-56","url":null,"abstract":"Patients with perceptual hearing impairment occupy a significant place among patients of the otolaryngology department. They often have psycho-emotional disorders, social and family disorders. It is important to understand the etiopathogenesis of the disease. Some cases of sensorineural hearing loss (SHL) remain with an unknown etiopathogenetic mechanism of development, which requires more in-depth examination of patients.\u0000Aim: to analyze the number and character of appeals of patients with sensorineural hearing impairment to the otolaryngology department of the Alexander Clinical Hospital in Kyiv during 2015-2021.\u0000Methods and materials: We analysed 13,147 inpatients 'medical records, from which 1,138 patients' cards with perceptual hearing impairments were selected.\u0000Results: According to the analysis, the absolute and relative number of patients in the otolaryngology department of Alexander Clinical Hospital in Kyiv in 2020 and 2021 decreased significantly due to the temporary re-profiling of the otolaryngology department in these years for infectious patients with COVID-19. The most common changes in bone conduction according to audiometry occurred against the background of acute or exacerbation of chronic otitis media (509 cases). But this figure may be due to inflammatory changes, rather than true sensorineural hearing loss. 155 patients could not name a specific cause. These patients required further in-depth examination. In the third most frequent place indicated hypothermia, acute respiratory diseases (135 cases). In 106 patients, acute sensorineural hearing loss was caused by vascular disorders, and 11 patients reported emotional stress as the cause. Acute trauma caused perceptual disorders in 16, surgery in 3, neuroma in 1, barotrauma and rupture of the tympanic membrane in 7, the use of chemotherapy in 3 cases. The average interval between the onset of the first symptoms of SHL and hospitalization in the otolaryngology department of the Alexander Clinical Hospital in Kyiv for 2025-2021 was 8.19 days. The lowest interval was in 2016 – 7.5 days, the largest – 10 days in 2021. The average duration of inpatient treatment of patients for 2015-2021 was 9.4 days. The lowest figure was in 2020 – 8.1 days, the highest – 10.4 days in 2021. There were 495 patients with bilateral lesions and 354 patients with left lesions, 289 patients had lesions on the right side. 39 patients with SHL and type 2 diabetes mellitus had diabetes, 460 had tinnitus and 44 had vestibular disorders.\u0000Conclusions: Patients with acute sensorineural hearing loss receive inpatient treatment in the otolaryngology department than with the progression or exacerbation of the chronic form. Otitis media and acute respiratory diseases were the most common disorders of bone conduction, but not all of these cases can be interpreted as sensorineural hearing loss. The average interval for the study period between the onset of the first symptoms and the start of treatment was 8.19 days,","PeriodicalId":38742,"journal":{"name":"Otorhinolaryngology Clinics","volume":"1118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86473174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of patients with snoring and moderate obstructive sleep apnea","authors":"Yuriy V. Minin, T. Kucherenko","doi":"10.37219/2528-8253-2022-1-50","DOIUrl":"https://doi.org/10.37219/2528-8253-2022-1-50","url":null,"abstract":"Objective: To increase the effectiveness of treatment of patients with snoring and obstructive sleep apnea in the field of segmental narrowing of the upper respiratory tract.\u0000Materials and methods: 20 patients with complaints of constant snoring and sleep apnea were monitored.\u0000All patients underwent cardio-respiratory monitoring. To determine the levels of narrowing of the upper respiratory tract, changes in the intensity of the MR signal from the anatomical structures of the upper respiratory tract (VDS) of all patients selected for surgical treatment were studied, followed by determining the effect of therapy.\u0000Results: The paper presents the results of treatment of patients with moderate obstructive sleep apnea. All patients underwent clinical and radiological examination to determine the level of narrowing of the upper respiratory tract. With narrowing of the common nasal passages, retropalatinal and retroglossal areas of the pharynx, appropriate surgical correction of HF was performed.\u0000After 2 months, obstructive sleep apnea was absent in 55% of patients, the index of hypopnea (IG) did not exceed 10 episodes per hour with a duration of hypopnea up to 14 seconds and maximum desaturation of capillary blood (SpO2) up to 95%. No snoring was noted in 45% of patients in this group, while 15% of individuals reported silent snoring in the supine position and occasional snoring of low intensity.\u0000Tactics of surgical treatment of patients with snoring and OSAS of moderate severity, aimed at eliminating obstruction of the airway during sleep at all levels and requires an individualized approach.","PeriodicalId":38742,"journal":{"name":"Otorhinolaryngology Clinics","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84125668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All about otorrhoea","authors":"Fedir Yurochko, Dzwinka Kopanska","doi":"10.37219/2528-8253-2022-1-62","DOIUrl":"https://doi.org/10.37219/2528-8253-2022-1-62","url":null,"abstract":"Otorrhoea is a symptom of the presence or leakage of secretions (sulfur, blood, pus, mucus, cerebrospinal fluid or even saliva) from the ear. Otorrhea is an important symptom of ear disease, or may be a manifestation of the spread of diseases in the external auditory canal from the ear. The cause of otorrhoea can be determined in most cases after the history and examination of the patient. The most common causes of purulent otorrhoea are acute otitis externa or acute otitis media. Chronic otitis media with cholesteatoma should be remembered as a lifethreatening condition. Patients with otorrhoea are mostly outpatient and do not require inpatient treatment. Understanding the cause of otorrhoea will help establish the correct diagnosis and prescribe the right effective treatment.","PeriodicalId":38742,"journal":{"name":"Otorhinolaryngology Clinics","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72650114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indicators of rheoencephalography in recurrent acutraumatic lesions in real combat conditions","authors":"T. Shidlovskaya, T. Shidlovskaya, N. Kozak, K. V. Ovsyanik, L. Petruk","doi":"10.37219/2528-8253-2022-1-04","DOIUrl":"https://doi.org/10.37219/2528-8253-2022-1-04","url":null,"abstract":"Topicality: Recurrent acute trauma is common in patients who have received acutrauma in the combat zone. In such patients it is advisable to diagnose cerebral hemodynamic disorders for timely targeted medical care.\u0000Objectives of the study: The purpose of the work is to assess the quantitative and qualitative indicators of rheoencephalography in servicemen who received repeated acute trauma in real combat conditions.\u0000Materials and methods: We analysed the rheoencephalography of 52 patients with recurrent acute trauma and 15 healthy normal hearing subjects.\u0000Results: In the qualitative assessment of the rheograms of the examined patients, we found signs of cerebral circulatory disorders in both carotid (FM) and vertebrobasilar (OM) systems.\u0000In 28,3 % of the surveyed OOS fighters, we observed an increase in the tone of cerebral vessels with symptoms of angiospasm. Difficulty with venous outflow occurred in 72,1 % of cases in the carotid system and in 87,6 % - in the vertebrobasilar. Among the studied patients, we also often recorded a decrease in cerebral vascular tone (25,7 %) and cases of atonic curve (24,1 %). There was a significant proportion of patients with unstable vascular tone with a tendency to increase it 47,4 % or decrease 27,7 % in both cerebral circulatory systems. With regard to pulse blood supply, in patients with acutrauma were recorded (58,2 %) cases of its reduction in the carotid system and (89,7 %) in the vertebrobasilar basin. In the vertebrobasilar system, the asymmetry of REG curves (12,1 %) was also observed in real combat conditions.\u0000Analysis of quantitative indicators of REG in the carotid and vertebrobasilar systems in the subjects compared with the control group (K) revealed the following.\u0000In the examined patients there were changes in cerebral vascular tone and difficulty in venous outflow, as well as a decrease in pulse blood supply, as evidenced by significant changes in α, dichroic (DKI), diastolic (DSI) and rheographic (RI) indices of the REG curve. Thus, in the vertebrobasilar system, the value of Pi, which characterizes the pulse blood supply, was 0,57±0,04 (P<0,01) (at a rate of 1,19±0,03), and DKI was 59,63±1,18% (P<0,01) (at a rate of 51,2±1,4%).\u0000Thus, in patients with recurrent acute trauma there are severe disorders of cerebral circulation, especially\u0000in the vertebrobasilar basin.\u0000Conclusions: 1. According to rheoencephalography, fighters who received repeated acute trauma in the area of environmental protection have severe cerebrovascular disorders, with venous outflow difficulties, decreased pulse blood flow, tendency to decrease and unstable tone of cerebral vessels predominate.\u00002. Significant (P<0,05) deviations from the norm in the indicators of DKI, DSI and Ri, especially in the vertebrobasilar basin, take place in the examined fighters with repeated acute trauma. This indicates a pronounced violation of cerebral circulation, venous outflow and decreased pulse blood supply during repeated\u0000combat acutrau","PeriodicalId":38742,"journal":{"name":"Otorhinolaryngology Clinics","volume":"233 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83485258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern approach to the treatment of acute viral rhinosinusitis","authors":"S. Bezshapochny, O.R. Dzhirov, Olexander G. Podovzhny","doi":"10.37219/2528-8253-2022-1-73","DOIUrl":"https://doi.org/10.37219/2528-8253-2022-1-73","url":null,"abstract":"Relevance: Treatment of acute viral rhinosinusitis is one of the current problems of modern medicine. Coldrelated diseases are now receiving a lot of attention due to the worldwide pandemic SARS-CoV-2, the choice of therapy becomes a difficult task even for experienced physicians. The study provides an assessment of the efficacy of treatment of patients with acute viral rhinosinusitis with combined phytotherapeutic agents.\u0000Materials and methods: During the study, 54 patients were followed up and divided into 2 groups: the study group (28 patients) and the control group (26 patients). During treatment, patients in the control group received basic treatment, which included: Nasal cavity irrigation with an isotonic saline solution (0.9% NaCl solution) [4] by 2 doses into each nasal half 3 times a day, topical glucocorticosteroids (Mometasone furoate) by 2 doses into each nasal half 2 times a day. Patients in the study group received: \"Sinuvit\" complex phytopreparation by 2 capsules after meals 2 times a day, nasal cavity irrigation with isotonic saline solution (0,9% NaCl solution) by 2 doses into each nasal half 3 times a day, topical glucocorticosteroids (Mometasone furoate) by 2 doses into each nasal half 2 times a day. The results of treatment were evaluated by means of subjective and objective indicators.\u0000Results: Efficient symptom relief was found in the study group, reflected in improved patient well-being and renewed physiological function of the mucociliary apparatus.\u0000Conclusion: Based on the obtained results of the study and our previous experience in treatment of rhinosinusitis, we have made a conclusion about the effectiveness of the presented scheme of treatment with combined phytotherapeutic agents.","PeriodicalId":38742,"journal":{"name":"Otorhinolaryngology Clinics","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75439954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological evaluation of the effect of continuous direct electrostimulation with the help of the bioelectric system on the denervated circular musculature of the eye in case of experimental single facial nerve injury","authors":"A. Bobrov, Oleg M. Borisenko, Anastasia E. Pedachenko, T. Malysheva, Alexander V. Papp","doi":"10.37219/2528-8253-2022-1-11","DOIUrl":"https://doi.org/10.37219/2528-8253-2022-1-11","url":null,"abstract":"The use of direct electrical stimulation to produce shortening of the denervated circular oculus in experimental facial nerve palsy (FNP) allows for complete closure of the ocular slit.\u0000The aim of this study is to study morphological changes in the nerves under the influence of direct electrical stimulation with biphasic pulses over a long period of time.\u0000Materials and methods: A model of a single facial nerve injury with consequent paralysis of orbicularis oculi muscle was created in the experiment on 12 adult animals. The animals were divided into 2 groups: main and control. In the main group, the stimulating part of the bioelectric device for eye closure was implanted, after which the ability to work in real-time mode to perform long-duration stimulation of orbicularis oculi muscle was tested. The control group did not receive any effect effects on orbicularis oculi muscle. After 30 days, all the animals underwent orbicularis oculi muscle elimination on the side of the facial nerve palsy with the following morphological examination.\u0000Results: An intergroup comparative analysis using the nonparametric U-Mann-Whitney criterion for changes in the Ki-67 proliferation index revealed a statistically significant difference between the comparison group and the experimental group, that was affected by the electrical stimulation with the increase of the parameter for the group with electrical stimulation according to the control group from 28,3 (25,0; 30.8) to 30.9 (28.8; 33.3), or 1.1 times (p=0.04); Analysis of variation in mitochondrial photocurrent density revealed statistically significant differences between the control group and the experimental group, with the increase of this parameter for the group with electrical stimulation compared with the control group from 10.5 (6.3; 14.4) to 15.8 (12.8 17,6), i.e. by\u00001.5 times (p=0.0004); a statistically significant increase of the parameter for the group with electrical stimulation versus the control group from 48,9 (40,6; 63.0) to 64.4 (60.0; 72.4), i.e. by a factor of 1.3 (p = 0.00005).\u0000Conclusions: The assessment of the effects of electrostimulation on the musculoskeletal apparatus after neuroraphy (in the experiment) revealed structural and ultrastructural changes, indicating the increased morphofunctional activity of renewed regeneration of muscle fibers in the study under the influence of direct electrical stimulation. In addition, no specific pathological changes were detected under the influence of direct electrostimulation for 30 days.","PeriodicalId":38742,"journal":{"name":"Otorhinolaryngology Clinics","volume":"216 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75593558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}