Romanian Journal of Diabetes, Nutrition and Metabolic Diseases最新文献_第3页

Modern Ways of Treatment of Metabolic Disorders in Women with Polycystic Ovarian Syndrome 多囊卵巢综合征女性代谢紊乱的现代治疗方法

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-09-01 DOI: 10.2478/rjdnmd-2019-0033

A. Urbanovych, K. Kozlovska, M. Urbanovych

引用次数: 2

Uncommon Manifestation of Hypoglycemia in a Patient with Insulinoma – A Case Report 胰岛素瘤患者低血糖的罕见表现- 1例报告

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-09-01 DOI: 10.2478/rjdnmd-2019-0035

N. Mîndrescu, G. Văcaru, L. Guja, R. D. Miulescu

{"title":"Uncommon Manifestation of Hypoglycemia in a Patient with Insulinoma – A Case Report","authors":"N. Mîndrescu, G. Văcaru, L. Guja, R. D. Miulescu","doi":"10.2478/rjdnmd-2019-0035","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0035","url":null,"abstract":"Abstract Insulinoma are insulin-secreting tumors of pancreatic origin that generates hypoglycemia by excessive secretion of insulin. Insulinoma is a rare disease ant the most tumors are benign, solitary and occur at intrapancreatic sites. Case report. A 42-year old Caucasian women was hospitalized at the “Prof. N.C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases Bucharest in April 2019 after an episode of hypoglycaemia remitted after intravenous glucose administration. Patient accused for about two weeks anxiety phenomena. At the time of admission in the hospital the patient was conscious in a good general condition. Paraclinical investigations revealed basal blood glucose 29 mg/dl, fasting insulin serum 87.7 µU/ml and pancreatic C-peptide-7.90 ng/ml. During hospitalization under strict glycaemic monitoring, the patient presented frequent asymptomatic hypoglycemic episodes that was remitted after intravenous glucose administration. Nuclear magnetic resonance highlighted a nodular lesion of the pancreas and in May 2019 the tumor resection was practiced. After surgery the blood glucose ranged between 86 mg/dl and 116 mg/dl. To mention that patient has a family history of diabetes and she’s obese. Conclusion. This case suggests that lack symptoms of hypoglycaemia may be present in patients with insulinoma. Diagnostic of insulinoma requires high clinical suspicions, accurate biochemical investigations and imaging techniques for the localization of the tumor and may represent a challenge in certain situations.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"327 - 330"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41782172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Different View to Older Diabetics: Management of Treatment According to Cognitive Functions 对老年糖尿病的不同看法:根据认知功能进行治疗

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-09-01 DOI: 10.2478/rjdnmd-2019-0024

R. Bahşi, D. Sürmeli, Tuğba Turgut, Hande Selvi Oztorun, Volkan Atmış, A. Yalçın, S. Aras, M. Varlı

引用次数: 0

The Qualitative and Quantitative Structure of Oral Microbiocenosis in Rats with Periodontitis in a Setting of Hyper- and Hypothyroidism 甲状腺功能亢进和甲状腺功能减退时牙周炎大鼠口腔微生物病的定性和定量结构

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-09-01 DOI: 10.2478/rjdnmd-2019-0030

V. Shcherba, I. Krynytska, M. Marushchak, M. Korda

{"title":"The Qualitative and Quantitative Structure of Oral Microbiocenosis in Rats with Periodontitis in a Setting of Hyper- and Hypothyroidism","authors":"V. Shcherba, I. Krynytska, M. Marushchak, M. Korda","doi":"10.2478/rjdnmd-2019-0030","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0030","url":null,"abstract":"Abstract Background and aims. Oral microbial flora is a highly sensitive indicator system producing qualitative and quantitative responses to changes in various individual organs and systems. The aim of study was to perform a comparative analysis of qualitative and quantitative structure of oral microbiocenosis in rats with comorbidity-free periodontitis and in animals with periodontitis in a setting of hyper- and hypothyroidism. Material and methods. Experimental studies were conducted on 48 mature male white rats. Samples for microbiological tests were taken from dental surfaces (on the border between hard tissue and gums in the interdental spaces). The isolated pure cultures were identified by their morphological, tinctorial, cultural and biochemical properties and the signs of pathogenecity. Results. We found that the oral dysbiosis occurring in a setting of periodontitis in rats is chiefly characterized by increased quantity of coccal forms and by increased candidal inoculation; these organisms cumulatively inhibit the growth of normal microbial flora, such as Lactobacilli, bacteroids and Bifidobacteria. Thyroid dysfunction exacerbates changes in the qualitative and quantitative structure of oral microbiocenosis. Conclusions. The periodontitis in a setting of thyroid dysfunction increases both the species variety and the quantitative counts of oral microbial flora, with predominance of such microbial organisms as Staph. aureus, E. coli, E. faecalis, Candida albicans and P. aeruginosa.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"293 - 304"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47381314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship Between Lipid Metabolism and The Level of Albuminuria with Single Nucleotide Polymorphism -204A>C [rs 3808607] CYP7A1 Gene in Patients with Type 2 Diabetes Mellitus and Diabetic Nephropathy 单核苷酸多态性-204A>C[rs3808607]CYP7A1基因与2型糖尿病和糖尿病肾病患者脂代谢和蛋白尿水平的关系

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-09-01 DOI: 10.2478/rjdnmd-2019-0026

Nadiia Demihova, Cherkashyna Lidiya, O. Chernatska, T. Mazur, Tetyana Aleksakhina, O. Demikhov

{"title":"The Relationship Between Lipid Metabolism and The Level of Albuminuria with Single Nucleotide Polymorphism -204A>C [rs 3808607] CYP7A1 Gene in Patients with Type 2 Diabetes Mellitus and Diabetic Nephropathy","authors":"Nadiia Demihova, Cherkashyna Lidiya, O. Chernatska, T. Mazur, Tetyana Aleksakhina, O. Demikhov","doi":"10.2478/rjdnmd-2019-0026","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0026","url":null,"abstract":"Abstract Background and aims. The purpose of our study was to determine the features of diabetic nephropathy, to identify the relationship between the level of albumin excretion, urine and lipid profile, genotype variants of the CYP7A1 gene in people with type 2 diabetes and diabetic nephropathy. Material and methods. Patients were divided into three groups. Normoalbinuria was detected in group I, and II - microalbuminuria, and III -macroalbuminuria. Determination of albumin to creatinine ratio was more accurate, although more expensive method. We examined single nucleotide polymorphism -204A> C [rs 3808607] of the promoter region of the CYP7A1 gene. Results. It was established that homozygotes by the major allele with genotype AA had lower values of albuminuria, atherogenic lipoproteins, total cholesterol, triglycerides and higher levels of anti-atherogenic lipoproteins than patients with AС and СС genotypes. Conclusion. The СС genotype was most unfavorable in the prognostic plan, since homozygotes for this minor allele were characterized by higher values of albuminuria, total cholesterol, triglycerides, and lower values of high-density lipoprotein","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"253 - 260"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48209337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Assessment of Long Term Metabolic Effects of Atypical Antipsychotics in Schizophrenia Patients 精神分裂症患者服用非典型抗精神病药物的长期代谢效应评估

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-09-01 DOI: 10.2478/rjdnmd-2019-0028

Nicolae-Marius Cason, P. Babeș, Enikő Béres, K. Babeș

{"title":"Assessment of Long Term Metabolic Effects of Atypical Antipsychotics in Schizophrenia Patients","authors":"Nicolae-Marius Cason, P. Babeș, Enikő Béres, K. Babeș","doi":"10.2478/rjdnmd-2019-0028","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0028","url":null,"abstract":"Abstract Background and aims. Patients with schizophrenia have a shorter life expectancy than normal population partially due to the metabolic side effects of antipsychotic treatment. The aim of this study is to evaluate the long-term evolution of the metabolic syndrome in chronic schizophrenia patients on fixed second generation antipsychotics (SGA). Material and method. The components of metabolic syndrome were evaluated repeatedly in a minimum 6 months and maximum 2 years follow-up period. The presence of metabolic syndrome (MetS) and metabolic risk scores (cMetS) according to National Cholesterol Education Program Adult Treatment Panel III were calculated and compared in time. In the prevalence, incidence and normalization logistic regression studies included all the known risk factors together with the follow-up period. Finally, all these rates were compared depending on the type of SGA. Results. Only cMetS, waist circumference and diastolic blood pressure presented significant increase in the follow-up period which was in average 385.5 days. The prevalence of MetS at base-line was 39.4%, which increased to 48.5% after the follow-up period. The calculated incidence of 30% was associated with a 23.1% rate of normalization. Logistic regression studies revealed as independent risk factors the age and base-line cMetS/weight for incidence and for normalization. In the aripiprazole group the normalization rate exceeded the incidence rate (33.3% vs 20%). Conclusions. The results emphasize the highly dynamic character of the metabolic syndrome even in chronic schizophrenia patients with fixed SGA regimen. The normalization of MetS is a possibility that should not ignored. The age and weight continue to remain independent risk factors, thus close monitoring in elderly and strict weight control plan are necessary. Aripiprazole showed better safety profile, but more extensive studies are required for definitive conclusions.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"267 - 277"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42009706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Lifestyle Medicine – New Concept, Innovative Discipline 生活方式医学——新概念，创新学科

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-09-01 DOI: 10.2478/rjdnmd-2019-0031

A. Hâncu

{"title":"Lifestyle Medicine – New Concept, Innovative Discipline","authors":"A. Hâncu","doi":"10.2478/rjdnmd-2019-0031","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0031","url":null,"abstract":"Abstract A large percentage 63% of premature deaths and chronic diseases could be prevented by adhering to healthy dietary patterns, being physically active and avoid smoking. The concept of lifestyle medicine introduced 20 years ago by Rippe is defined as the integration of modern lifestyle practices into evidence-based medicine, in order to lower risk factors or to be support for chronic therapies. A new taxonomy is proposed in lifestyle medicine, with determinants, as drivers for chronic diseases, anthropogens and metaflammation, the metabolic inflammatory state. Other possible determinants are proposed for lack os scope in life, estrangement and lost identity. Despite all health messages, healthy behaviors are exceptions, not the rule. It will be important in the future to change how practitioners will support individuals in their efforts to live healthier. More psychological and social factors should be analyzed. Many doctors are not self-confident with prescribing healthy lifestyle or nutritional recommendations. Creating a new discipline should foster development of preventive recommendations. General practitioners will need specific academic trainings to learn how to promote recommendations for lifestyle changes for health, for prevention and for diseases management, starting by adopting themselves healthy lifestyles.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"305 - 309"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41385135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetology & Cardiology: The Future is Now! 糖尿病和心脏病学:未来就是现在!

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-09-01 DOI: 10.2478/rjdnmd-2019-0022

B. Timar, D. Gaita

引用次数: 1

Highlighted of Ramadan Fasting on Diabetes-Study of Complications, Biochemical Aspects and Anthropometry 斋月禁食对糖尿病并发症、生化及人体测量的研究

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-09-01 DOI: 10.2478/rjdnmd-2019-0023

M. Bencharif, I. Sersar, M. Bentaleb, F. Z. Boutata, Y. Benabbas

{"title":"Highlighted of Ramadan Fasting on Diabetes-Study of Complications, Biochemical Aspects and Anthropometry","authors":"M. Bencharif, I. Sersar, M. Bentaleb, F. Z. Boutata, Y. Benabbas","doi":"10.2478/rjdnmd-2019-0023","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0023","url":null,"abstract":"Abstract Background and aims: The diabetic exempted from fasting by religion, wishing or not to observe the fast, is exposed like any other during Ramadan to a change in lifestyle. The objective of this study was to highlight the effects of Ramadan fasting on diabetes. Material and methods: Multicentre study on 899 diabetics was carried to collect data on the behaviour of diabetics with regard to the fast of Ramadan, biochemicals and anthropometry parameters. Results. The sample consists of 541 diabetic fasters (DTMF) and 358 no fasters. The causes of interruption of fasting were: hypoglycemia (82.4%), dehydration (44.5%), hyperglycemia (12.6%), high blood pressure (13.7%), loss of consciousness (8.3%). The risk factors related to fasting for DTMF were the type of diabetes and gender. Discussion and modifications about dietary, blood glucose monitoring and nutritional education sessions showed a protective effect against the occurrence of hypo and hyperglycemia and loss of consciousness. Decreasing differences were noted for Hb1Ac, LDL and Total-Cholesterol between before and after Ramadan. The weight of DTMF decreased in post-Ramadan (p=0.0000). Conclusion. There is a need to consider regular preventive measures based on public information on the effects of diabetes related complications and the benefits of a balanced diet combined with regular physical activity in nutrition education sessions.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"227 - 234"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45663721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evaluation of Pancreatic and Extra Pancreatic Effects of Branched Amino Acids 支链氨基酸对胰腺和胰腺外的影响评价

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-06-01 DOI: 10.2478/rjdnmd-2019-0021

Moath Alqaraleh, V. Kasabri, Sundus Al Alawi, Nihad Al-Othman

{"title":"Evaluation of Pancreatic and Extra Pancreatic Effects of Branched Amino Acids","authors":"Moath Alqaraleh, V. Kasabri, Sundus Al Alawi, Nihad Al-Othman","doi":"10.2478/rjdnmd-2019-0021","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0021","url":null,"abstract":"Abstract Background and aims: Leucine, Isoleucine, and Valine collectively known as Branched-chain amino acids (BCAAs), can be closely associated with metabolic dysregulates and with insulin resistance. We aimed to explore the role of BCAAs as potential treatment option for diabetes. Material and method: Bioassay the effect of BCAAs on MIN6 cell line on insulin secretion and pancreatic beta cells expansion, then were checked for inhibitory potential of pancreatic amylase, glucosidase and lipase as alternative approach for diabetes treatment. Results: BCAAs significantly enhance insulin secretion parallel to L-alanine efficacy. Furthermore, BCAAs obtain a dose dependent β-cell proliferation similar to glucagon-like peptide-1. Moreover, these acids could restore the secretory function of MIN6 β-cell despite stressful gluco-lipo-toxicity; separately or combined. Moreover, BCAAs exerted a dose dependent dual inhibition of amylase, glucosidase and lipase. Conclusions: Our current findings suggest that BCAAs supplementation may have a potential therapeutic effect against diabetes as insulin releasing agent and as specific inhibitors for both-amylase/α-amyloglucoside and lipase","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"199 - 209"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46605513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4