{"title":"Cluster analysis of the codon use frequency of MHC genes and genes coding for proteins with different fingerprints","authors":"Jianmin Ma, W. Gu, Tong Zhou, Xiao Sun, Zuhong Lu","doi":"10.1109/IEMBS.2001.1017394","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1017394","url":null,"abstract":"Summary form only received as follows: The relative synonymous codon use frequencies (RSCU) of 135 MHC genes from four mammal species are analyzed using hierarchical cluster method. The result suggests that gene function is the dominant factor that determines codon usage bias, while species is a minor factor that determines further difference in codon usage bias. RSCU values of 71 genes coding for proteins with two different fingerprints are also studied and these 71 genes can be clearly differentiated into two groups according to the difference in codon usage bias. This indicates that codon usage is closely related to protein high-level structure. The conclusion may be useful in gene classification and prediction of gene function and protein spatial structure.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"33 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123613821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Classification of respiratory sounds by using an artificial neural network","authors":"Z. Dokur, T. Ölmez","doi":"10.1109/IEMBS.2001.1019035","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019035","url":null,"abstract":"In this paper, a classification method for respiratory sounds (RSs) in patients with asthma and in healthy subjects is presented. A wavelet transform is applied to a window containing 256 samples. Elements of the feature vectors are obtained from the wavelet coefficients. The best feature elements are selected by using dynamic programming. A Grow and Learn (GAL) neural network is used for the classification. It is observed that RSs of patients (with asthma) and healthy subjects are successfully classified by the GAL network.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129578084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New denoising scheme for magnetic resonance spectroscopy signals","authors":"O. A. Ahmed","doi":"10.1109/IEMBS.2001.1017197","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1017197","url":null,"abstract":"A new scheme for denoising magnetic resonance spectroscopy signals is presented. The scheme is based on projecting noisy signals on different time-frequency domains, consecutively, and performing noise filtering operations in these domains according to the noise level. The evaluation of this scheme was performed using extensive simulation of magnetic resonance spectroscopy signals with different noise levels. It was observed that this scheme gives superior results that compensate for the excess computational requirements, especially for very low signal to noise ratio signals.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133305220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acupuncture-based biophysical frontiers of complementary medicine","authors":"D. Raković","doi":"10.1109/IEMBS.2001.1019091","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019091","url":null,"abstract":"In this paper biophysical bases and frontiers of the acupuncture-based complementary medicine are considered, and essential significance of its resonance microwave (MW)/ultralowfrequency (ULF) electromagnetic (EM)/ionic nature as well as the quantum-holographic \"electrooptical\" neural-network-like-function of the acupuncture system are pointed out, as supported by microwave resonance therapy (MRT) of the psychosomatically disordered acupuncture system. At the same time, the non-threshold gap-junction-based self-assembling of the acupuncture system presents an explanation for the extreme sensitivity of the organism upon the influences of weak external MW/ULF EM fields.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"11 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130300253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Automatic lumbar vertebrae segmentation in fluoroscopic images via optimised concurrent Hough transform","authors":"Yalin Zheng, M. S. Nixon, R. Allen","doi":"10.1109/IEMBS.2001.1017328","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1017328","url":null,"abstract":"We show how a new approach can automatically detect the positions and borders of vertebrae concurrently, relieving many of the problems experienced in other approaches. First, we use phase congruency to relieve the difficulty associated with threshold selection in edge detection of the illumination variant DVF images. Then, our new Hough transform approach is applied to determine the moving vertebrae, concurrently. We include optimisation via a genetic algorithm (as without it the extraction of moving multiple vertebrae is computationally daunting). Our results show that this new approach can indeed provide extractions of position and rotation which appear to be of sufficient quality to aid therapy and diagnosis of spinal disorders.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115825823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reduction of invasive tests in Chagasic patients with a modified self-organizing map","authors":"L. Marmol-Herrera, K. Warwick","doi":"10.1109/IEMBS.2001.1020537","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1020537","url":null,"abstract":"The applicability of AI methods to the Chagas' disease diagnosis is carried out by the use of Kohonen's self-organizing feature maps. Electrodiagnosis indicators calculated from ECG records are used as features in input vectors to train the network. Cross-validation results are used to modify the maps, providing an outstanding improvement to the interpretation of the resulting output. As a result, the map might be used to reduce the need for invasive explorations in chronic Chagas' disease.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"711 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115126791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Automatic grading of pathological images of prostate using multiwavelet transform","authors":"K.J. Khouzani, H. Soltanian-Zadeh","doi":"10.1109/IEMBS.2001.1017298","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1017298","url":null,"abstract":"Histological grading of pathological images is used to determine the level of malignancy of cancerous tissues. This task is done by pathologists. Pathologists are inconsistent in these judgments from day to day and from person to person. So the grades are very subjective and furthermore in some cases this is a difficult and time-consuming task. This paper presents a new method for automatic grading of pathological images of prostate based on the Gleason grading system. According to the Gleason grading system, each cancerous specimen is assigned one of five grades. In our method the decision is based on features extracted from the multiwavelet transform of images. Energy and entropy features are extracted from submatrices obtained in decomposition. Then a k-NN classifier is used to classify each image. We also used features extracted by wavelet packet and second order moments to compare various methods. Experimental results show the superiority of the multiwavelet transform compared to other techniques. For multiwavelets, critically sampled preprocessing outperforms repeated row preprocessing and has less sensitivity to noise. We also found that the first level of decomposition is very sensitive to noise and thus should not be used for feature extraction.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115294499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hybrid optimization for ultrasound and multimodal image registration","authors":"M. Wachowiak, R. Smolíková, Adel Said Elmaghraby","doi":"10.1109/IEMBS.2001.1017265","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1017265","url":null,"abstract":"Optimization of similarity metrics is an important component of many biomedical image registration applications that greatly affects registration outcome. Selection of an optimization approach is dependent on the modalities being registered, the characteristics of the similarity function, and available computational resources. This paper addresses optimization approaches for 2D and 3D rigid body intra- and multimodal ultrasound registration. Stochastic and direct techniques are compared for mutual information and correlation ratio functions. A new direct/stochastic hybrid approach based on the tabu search is also proposed. Visualization and experimental results suggest the usefulness of such an approach. Results also show that the tabu hybrid technique compares favorably with traditional techniques, based on accuracy and number of function evaluations.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115376232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Okamoto, Y. Soeta, S. Nakagawa, M. Tonoike, Y. Ando
{"title":"Analysis of MEG relating to subjective preference of visual motion stimuli","authors":"Y. Okamoto, Y. Soeta, S. Nakagawa, M. Tonoike, Y. Ando","doi":"10.1109/IEMBS.2001.1019021","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019021","url":null,"abstract":"The aim of this study is to identify the relationship between subjective preference and the human brain responses to visual motion under changing period. First, preference judgments using the paired-comparison method for sinusoidal movements of a single circular target in the horizontal direction were performed. Then, MEG data were recorded during presentations of the most preferred and the least preferred moving stimuli. From the initial delay range of the autocorrelation function (ACF) of the alpha wave, the effective duration (/spl tau//sub e/) was analyzed. Results show that the stimulus with most preferred periods has a greater value of /spl tau//sub e/ than that with least preferred periods at the occipital area, especially in the left hemisphere.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115455754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Frakes, C. Conrad, T. Healy, J. W. Monaco, M. Smith, J.T. Yoganathan, P. Ajit
{"title":"Application of an adaptive control grid interpolation technique to morphological vascular reconstruction: a component of a comprehensive surgical planning and evaluation tool","authors":"D. Frakes, C. Conrad, T. Healy, J. W. Monaco, M. Smith, J.T. Yoganathan, P. Ajit","doi":"10.1109/IEMBS.2001.1017314","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1017314","url":null,"abstract":"The total cavopulmonary connection (TCPC) is a palliative surgical repair performed on children with a single ventricle (SV) physiology. Much of the power produced by the resultant single ventricle pump is consumed in the systemic circulation. Consequently the minimization of power loss in the TCPC is imperative for optimal surgical outcome. As a component of a comprehensive surgical planning and evaluation tool we have developed a method of vascular morphology reconstruction based on adaptive control grid interpolation to function as a precursor to computational fluid dynamics (CFD) analysis aimed at quantifying power loss. Our technique combines positive aspects of optical flow-based and block-based motion estimation algorithms to accurately reconstruct vascular geometries with a minimal degree of computational complexity. Subsequent CFD simulations offer the pressure and velocity information necessary to quantify power loss in the TCPC on a pre and post-operative basis. Collectively these steps form a powerful tool for both surgical planning and evaluation aimed at producing optimal TCPC configurations for successful surgical outcomes. Both reconstruction and CFD components of the technique will be discussed.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115661385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}