Forum of Clinical Oncology最新文献_第7页

The Pharmacological Profile of Cyclin-dependent Kinase (CDK) 4/6 Inhibitors: Clinical Management of Toxicity and Drug Interactions Related to CDK 4/6 Inhibitor-based Treatment in Advanced/Metastatic Breast Cancer 细胞周期蛋白依赖性激酶(CDK) 4/6抑制剂的药理学特征:基于CDK 4/6抑制剂治疗晚期/转移性乳腺癌相关的毒性和药物相互作用的临床管理

Forum of Clinical Oncology Pub Date : 2019-12-01 DOI: 10.2478/fco-2019-0007

Tzelepi C. Vasiliki, Gogadis T. Aristeidis, Adamidis K. Christos, E. Timotheadou

引用次数: 5

Cancer Registry Report in Mansoura University Hospital, Egypt in 2015 2015年埃及曼苏拉大学医院癌症登记报告

Forum of Clinical Oncology Pub Date : 2019-12-01 DOI: 10.2478/fco-2019-0003

Niveen Abotouk

{"title":"Cancer Registry Report in Mansoura University Hospital, Egypt in 2015","authors":"Niveen Abotouk","doi":"10.2478/fco-2019-0003","DOIUrl":"https://doi.org/10.2478/fco-2019-0003","url":null,"abstract":"Abstract Background This study aimed to report a cancer registry in Clinical Oncology and Nuclear Medicine Department, Mansoura University Hospital in 2015. Patients and Methods All cancer patients who were registered in the department of Clinical Oncology and Nuclear Medicine, Mansoura University Hospital in the time period from January 1st, 2015 to December 31st, 2015, were enrolled in this study. The data in the outpatient clinic index including patient’s name, age, sex and diagnosis were collected. Results The included patients were 1146 males (43.7%) and 1474 females (56.3%), the male to female ratio was 1:1.3. The median age for patients was 54 years, and it ranged from 1.5 to 93 years. The median age at diagnosis for female and male patients was 52 years and 57 years, respectively. The most common sites for cancer in females were breast (47.2%), thyroid (7.6%), colon and rectum (5.7%), non-Hodgkin (3.6%), uterus, brain and then ovary. However, the most common cancer sites among males were bladder (9.7%), colon and rectum (9.2%), lung (8.5%), hepatobiliary region (7.9%), brain (6.6%), non-Hodgkin lymphoma (6.6%) and then prostatic cancer. Conclusion The current report provides a first cancer registry for this hospital based on data, to be further included in cancer statistics.","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"10 1","pages":"26 - 33"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42189665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Assessing the potential role of neutrophil elastase as a prognostic indicator in oral squamous cell carcinoma 评估中性粒细胞弹性蛋白酶作为口腔鳞状细胞癌预后指标的潜在作用

Forum of Clinical Oncology Pub Date : 2019-12-01 DOI: 10.2478/fco-2019-0004

P. Jaiswal, S. Kheur, Pratiksha G Mahajan, A. Thirumal Raj, Mamatha G. S. Reddy, Roopa Madalli, N. Gupta

{"title":"Assessing the potential role of neutrophil elastase as a prognostic indicator in oral squamous cell carcinoma","authors":"P. Jaiswal, S. Kheur, Pratiksha G Mahajan, A. Thirumal Raj, Mamatha G. S. Reddy, Roopa Madalli, N. Gupta","doi":"10.2478/fco-2019-0004","DOIUrl":"https://doi.org/10.2478/fco-2019-0004","url":null,"abstract":"Abstract Past decade has seen the advent of several prognosticators for oral squamous cell carcinoma (OSCC). Although TNM staging is still considered as the prognostic gold standard, it is not possible to obtain all the necessary information for a pathological TNM staging until excisional biopsy. Thus, it is necessary to identify features from the initial biopsy, which could aid in early prognostication. Aim To compare neutrophil elastase immuno-expression in oral squamous cell carcinoma patients with and without lymph node metastasis. Materials and Methods Archival specimens of 50 oral squamous cell carcinoma consisting of 25 cases with and 25 cases without lymph node metastasis were immuno-stained for neutrophil elastase. Results Statistically, a significant difference was noted in the neutrophil elastase staining between the 2 groups. 18 of the 25-oral squamous cell carcinoma cases with lymph node metastasis were positive and only 5 of the 25-oral squamous cell carcinoma cases without nodal involvement were positive. Conclusion Presence of neutrophil elastase in the lesional tissue is strongly associated with a lymph node involvement, and thus could serve as a prognostic factor for oral squamous cell carcinoma.","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"10 1","pages":"34 - 38"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46258884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Impact of cyclin D1 and DJ-1 on diagnosis, clinico-pathological features and outcome in prostate cancer and benign prostatic hyperplasia 细胞周期蛋白D1和DJ-1对前列腺癌和良性前列腺增生诊断、临床病理特征及预后的影响

Forum of Clinical Oncology Pub Date : 2019-12-01 DOI: 10.2478/fco-2019-0005

Amrallah A. Mohammed, Hania M. Ibrahim, Hanna A. Atwa, A. Elshentenawy, Amira S. Elwan

{"title":"Impact of cyclin D1 and DJ-1 on diagnosis, clinico-pathological features and outcome in prostate cancer and benign prostatic hyperplasia","authors":"Amrallah A. Mohammed, Hania M. Ibrahim, Hanna A. Atwa, A. Elshentenawy, Amira S. Elwan","doi":"10.2478/fco-2019-0005","DOIUrl":"https://doi.org/10.2478/fco-2019-0005","url":null,"abstract":"Abstract Background Disturbance in cell cycle regulatory genes is a common finding among many types of cancers. The aim of this study is to evaluate the role of cyclin D1 and DJ-1 in benign prostatic hyperplasia (BPH) and prostate cancer (PC). Method The current study enclosed 40 patients diagnosed with PC and 40 cases of BPH. The expression level of cyclin D1 and DJ-1 were evaluated by immunohistochemistry (IHC). Cyclin D1 scored depending on the percentage of stained nuclear tumor cells. While scoring of DJ-1 was based on intensity. The results were correlated with clinicopathological features and outcome. Results In the PC group, cyclin D1 was detected in 95% and overexpressed in 42.5%, DJ-1 was positively stained in 85% and overexpressed in 47.5%. Meanwhile, in the BPH group, cyclin D1 was not detected and DJ-1 stained in only 2.5%. There was a statistically significant difference in Gleason score (GS), tumor stage, size, and treatment failure (p =< 0.001). In the terms of PC diagnosis prediction, although cyclin D1 was more specific (100%), DJ-1 is more sensitive than cyclin D1 (80%, 70%, respectively) (p = 0.000). Conclusions Cyclin D1 and DJ-1 may emerge as a promising way for diagnosis of PC in certain circumstances, as the presence of insufficient tissue sampling, small foci of carcinoma or benign lesions mimic PC. This is in addition to the known role of cyclin D1 and DJ-1 in PC prognosis.","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"10 1","pages":"15 - 25"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43910382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

25th Hellenic conference of Clinical Oncology 第25届希腊临床肿瘤会议

Forum of Clinical Oncology Pub Date : 2019-04-01 DOI: 10.2478/fco-2019-0001

引用次数: 4

Unfolding Ariadne’s thread in the scientific publications’ labyrinth 在科学出版物的迷宫中展开阿里阿德涅的线索

Forum of Clinical Oncology Pub Date : 2018-12-01 DOI: 10.2478/FCO-2018-0006

M. Liontos, N. Tsoukalas

引用次数: 0

Clinical and biological implications of Hippo pathway dysregulation in sarcomas 肉瘤中Hippo通路失调的临床和生物学意义

Forum of Clinical Oncology Pub Date : 2018-12-01 DOI: 10.2478/fco-2018-0002

A. Kyriazoglou, R. Zakopoulou, F. Zagouri, A. Bamias, M. Dimopoulos

引用次数: 1

Analysis of KRAS and NRAS mutations in Greek patients with metastatic Colorectal Cancer (mCRC) on the registry of the Gastro-intestinal Cancer Study Group (GIC-SG) 希腊转移性癌症（mCRC）患者的KRAS和NRAS突变在胃肠道癌症研究组（GIC-SG）注册中的分析

Forum of Clinical Oncology Pub Date : 2018-12-01 DOI: 10.2478/fco-2018-0005

N. Gouvas, Telenia Kalambaliki, A. Voutsina, Z. Saridaki, M. Tzardi, A. Kalykaki, M. Sfakianaki, A. Athanasiadis, E. Xynos, I. Boukovinas, J. Souglakos

{"title":"Analysis of KRAS and NRAS mutations in Greek patients with metastatic Colorectal Cancer (mCRC) on the registry of the Gastro-intestinal Cancer Study Group (GIC-SG)","authors":"N. Gouvas, Telenia Kalambaliki, A. Voutsina, Z. Saridaki, M. Tzardi, A. Kalykaki, M. Sfakianaki, A. Athanasiadis, E. Xynos, I. Boukovinas, J. Souglakos","doi":"10.2478/fco-2018-0005","DOIUrl":"https://doi.org/10.2478/fco-2018-0005","url":null,"abstract":"Abstract Introduction Several studies show that mutational profiles could influence treatment decisions in patients with metastatic CRC (mCRC). KRAS mutational status was the first step in biomarkers development in the era of molecular targeted therapies. Recently, NRAS mutational status was identified as an independent prognostic factor for the response to treatment with anti-EGFR moAbs. The aim of this observational study was to assess the feasibility of the KRAS/NRAS mutational analysis in patients with metastatic colorectal cancer in Greece and to identify any correlations with known clinical characteristics and histopathologic features. Methods From January 2014 until September 2014 all patients registered to the GIC-SG database with newly diagnosed metastatic disease from colon or rectal cancer were included and tumor samples were analyzed for kras/nras mutations in 9 different certified laboratories in Greece. Results Samples from 510 patients were analyzed. Mutations’ distribution was as follows: 173 (33,9%) KRAS exon 2, 10 (2%) KRAS exon 3, 25 (4,9%) KRAS exon 4, 22 (4,3%) NRAS exon 2, 11 (2,2%) NRAS exon 3 and 3 (0,6%) NRAS exon 4. The only factor significantly associated with RAS mutational status was primary tumor location, with right sided tumors exhibiting higher rates of mutations. Discussion The incidence and distribution of KRAS or NRAS exon 2-4 mutations are in accordance with those reported in the literature. The most significant clinical or pathological parameter revealed from the analysis is the location of the primary tumor.","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"9 1","pages":"31 - 36"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44214475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Functional And Survival Outcome Of Egyptian Children And Adolescents With Malignant Bone Tumors: An Experience In A Setting Of Limited Health Resource 埃及儿童和青少年恶性骨肿瘤的功能和生存结局:在卫生资源有限的情况下的经验

Forum of Clinical Oncology Pub Date : 2018-12-01 DOI: 10.2478/fco-2018-0001

Mokhtar M Galila, E. Fatma, I. Sherif, Ragab Iman, Y. Khaled

{"title":"Functional And Survival Outcome Of Egyptian Children And Adolescents With Malignant Bone Tumors: An Experience In A Setting Of Limited Health Resource","authors":"Mokhtar M Galila, E. Fatma, I. Sherif, Ragab Iman, Y. Khaled","doi":"10.2478/fco-2018-0001","DOIUrl":"https://doi.org/10.2478/fco-2018-0001","url":null,"abstract":"Abstract Objective Evaluate outcome of paediatric malignant bone tumours at Ain Shams University, Egypt, from January 2003 to July 2016. Methods Retrospective data analysis regarding clinico-epidemiological aspects, treatment outcomes, survival analysis and musculoskeletal tumour society score (MSTS score). Results The study included 37 patients; 22 had Ewing sarcoma (ES) and 15 had osteosarcoma, male: female ratio 0.85:1, median ages of 11. The overall frequency was 2.3% among all cancers. There is wide range of time lag until diagnosis. Patients with ES were significantly younger than those with osteosarcoma were. Swelling was the most common presenting symptom and femur was the most common affected site. Fifteen patients fulfilled MSTS criteria; most of them had excellent MSTS score, which significantly affected by type of surgery. ES patients were treated with POG#9354/CCG#7942 protocols and osteosarcoma with CCG#7921 protocol. Limb salvage was the most common type for surgical local control. Most common cause of death was relapse, whereas infection was the most common complication of treatment. 1-year, 2-year, 3-year overall-survival of osteosarcoma were 93.3%, 40%, and 13.3% respectively and 77.3%, 40.9%, and 18.2% respectively for ES. 1-year, 2-year, 3-year event-free-survival were 80%, 40%, and 13.3% respectively and 72.7%, 22.7%, and 18.2% respectively for ES patients. Conclusion Although survival rates for malignant bone tumours are still unsatisfactory, the functional outcome of extremity tumours after limb salvage procedures is promising","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"9 1","pages":"3 - 9"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48679326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The outcome-based iCAN! / theyCAN! feedback paradigm differentiates strong and weak learning outcomes, learner diversity, and the learning outcomes of each learner: A shift to metacognitive assessment 基于结果的iCAN！/他们可以！反馈范式区分强势和弱势学习结果、学习者多样性以及每个学习者的学习结果：向元认知评估的转变

Forum of Clinical Oncology Pub Date : 2018-12-01 DOI: 10.2478/fco-2018-0004

I. Dimoliatis, I. Zerdes, A. Zampeta, Zoi Tziortzioti, E. Briasoulis, I. Souglakos

{"title":"The outcome-based iCAN! / theyCAN! feedback paradigm differentiates strong and weak learning outcomes, learner diversity, and the learning outcomes of each learner: A shift to metacognitive assessment","authors":"I. Dimoliatis, I. Zerdes, A. Zampeta, Zoi Tziortzioti, E. Briasoulis, I. Souglakos","doi":"10.2478/fco-2018-0004","DOIUrl":"https://doi.org/10.2478/fco-2018-0004","url":null,"abstract":"Abstract Background Can learning outcomes be transformed in useful tools revealing strong and weak learning outcomes, learners, teachers; reporting student self-assessment overestimation; informing formative feedback and summative examinations? Methods Based on the ESMO / ASCO global curriculum, 66 level-two learning outcomes were identified and transformed in the iCAN!-Oncology and theyCAN!-Oncology questionnaires, anonymously completed online, before and after teaching, by trainees and trainers respectively, in a five-day fulltime undergraduate oncology course. Results In total, students assessed themselves (iCAN!) with 55% before and 70% after the course (27% improvement); teachers assessed students (theyCAN!) with 43% before and 69% after (60% improvement). Twenty level-two learning outcomes (30%) were scored below the pass / fail cut-point by students while 46 (70%) by teachers, before the course; none after the course. Students assessed themselves the highest in “TNM system” before (81%) and after (82%), while the teachers assessed students so in “Normal cell biology” before (72%) and “Moral / ethical issues in clinical research” after (83%). The lowest assessed outcome was the “Research protocol” by students (28%) and teachers (18%) before, and the “Anticancer agents” after (54% by both). Individual students self-assessed themselves from 31% to 88% before, and from 54% to 88% after; individual teachers assessed students from 29% to 66% before, and from 55% to 94% after. The iCAN! / theyCAN! provided detailed individual student or teacher profile, tightfisted or generous. Conclusions The iCAN! / theyCAN! differentiate strong and weak learning outcomes, learners, teachers; reveal no student self-assessment overestimation; inform formative feedback and summative exams at a metacognitive level; generalize to any course and assessor; support evidence-based teaching and learning SWOT policy.","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"9 1","pages":"17 - 29"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49299152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1