Forum of Clinical Oncology最新文献_第8页

Trismus and reduced quality of life in patients with oral squamous cell carcinoma, who received post-operative radiotherapy alone or combined with chemotherapy 术后单独放疗或联合化疗的口腔鳞状细胞癌患者的牙关紧闭和生活质量下降

Forum of Clinical Oncology Pub Date : 2017-06-30 DOI: 10.1515/fco-2015-0023

Evangelos Galitis, V. Droukas, M. Tzakis, Vassileios Psarras, D. Galiti, E. Kyrodimos, M. Trichas, A. Psyrri, N. Papadogeorgakis, M. Kouri, E. Belli, V. Kouloulias

{"title":"Trismus and reduced quality of life in patients with oral squamous cell carcinoma, who received post-operative radiotherapy alone or combined with chemotherapy","authors":"Evangelos Galitis, V. Droukas, M. Tzakis, Vassileios Psarras, D. Galiti, E. Kyrodimos, M. Trichas, A. Psyrri, N. Papadogeorgakis, M. Kouri, E. Belli, V. Kouloulias","doi":"10.1515/fco-2015-0023","DOIUrl":"https://doi.org/10.1515/fco-2015-0023","url":null,"abstract":"Abstract Background Patients, who receive radiotherapy (RT) for head and neck cancer, develop chronic functional abnormalities and survive with reduced quality of life. Purpose We aimed to study patients with oral cancer, who received post-operative radiotherapy or chemoradiotherapy. Patients Ten patients (mean age 63.8 years) were included. Methods Oral mucositis, pain and xerostomia, maximum mouth opening (MMO) and functional abnormalities before and after RT were recorded. The 35 mm MMO or less was accepted as trismus. Patients completed the EORTC QLQ C-30 and Head/Neck35 questionnaires. Results Mean RT dose was 64.3 Gray. Six patients received chemoradiotherapy. Severe mucositis, pain and xerostomia were recorded in 6 and 5 patients respectively. MMO was reduced in all patients. The mean MMO (34 mm) reached the level of trismus. The total number of symptoms increased from 3.1 to 6.3 in C-30 and from 3.1 to 8.8 per patient in the H/N35. Severe fatigue, pain, limitations at work, weakness, sad feelings, family problems, sleeping problems, anorexia, financial difficulties, tense/irritable, constipation, nausea, vomiting and depression were most often reported with C-30. Most patients reported low to moderate quality of life. Severe oral, jaw and neck pain, swallowing problems, taste alterations, sticky saliva, dry mouth, coarseness, dental problems, feeling sick and reduced interest in life/sex were the most common symptoms reported with N/H35. Conclusions The observed trismus, 2- to 3-fold increase of symptoms and poorer quality of life highlighted the need for support of oral cancer patients, who receive postoperative radiotherapy or chemoradiotherapy.","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"8 1","pages":"29 - 36"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/fco-2015-0023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48350376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The Role of Genetics in Sporadic GEP-NETs: A Comprehensive Review of the Literature 遗传学在散发性GEP-NETs中的作用：文献综述

Forum of Clinical Oncology Pub Date : 2017-06-30 DOI: 10.1515/fco-2017-0001

G. Fotopoulos, I. Vathiotis, G. Nikou, K. Syrigos

引用次数: 0

Is postoperative radioactive iodine associated with a survival advantage among… 术后放射性碘与患者的生存优势有关吗…

Forum of Clinical Oncology Pub Date : 2017-06-30 DOI: 10.1515/fco-2015-0027

R. Hamed

{"title":"Is postoperative radioactive iodine associated with a survival advantage among…","authors":"R. Hamed","doi":"10.1515/fco-2015-0027","DOIUrl":"https://doi.org/10.1515/fco-2015-0027","url":null,"abstract":"Abstract Aim This trial aimed to determine wether postoperative radioactive iodine(RAI) associated with a survival benefit among intermediate-risk Papillary Thyroid Cancer patients or not. Methods this study is a retrospective study of intermediate-risk papillary thyroid cancer patients that were treated with or without post operative RAI from 1st January 2002 till 1st January 2012. Overall survival (OS) and multivariate regression analyses were measured for all patients. Results 100 patients were included in this trial : 70 patients received postoperative RAI and 30 patients did not. The mean follow-up time was 7.1 (4.8 -15.1 years), and a median survival time could not be estimated. Overall survival at 10 years was 96% in the RAI vs 93% in the group without RAI (P < .001). RAI reduced risk of death by a 27% [hazard risk (HR) 0.73, confidence interval (CI) 0.64 - 0.84, P < .001]. Older patient age, male gende, larger tumor size, multifocal tumors, lymph node metastases, aggressive histology, vascular invasion, positive surgical margin, minimal extrathyroidal extension and absence of postoperative RAI were accompanied by compromised OS (all P ≤ .001). Conclusion This representative study addresses the survival advantage of RAI for with intermediate risk PTC patients but conducting of large prospective randomized controlled trial is still warranted.","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"8 1","pages":"23 - 27"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46732923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing an algorithm for the management of Renal Cell Carcinoma: focus on metastatic disease 发展肾细胞癌管理的算法:聚焦于转移性疾病

Forum of Clinical Oncology Pub Date : 2017-06-30 DOI: 10.1515/fco-2015-0025

A. Kyriazoglou, I. Dimitriadis, A. Bamias

引用次数: 1

Targeting Bruton Tyrosine Kinase: A novel strategy in the treatment of B-cell lymphomas 靶向布鲁顿酪氨酸激酶:治疗b细胞淋巴瘤的新策略

Forum of Clinical Oncology Pub Date : 2017-06-30 DOI: 10.1515/fco-2015-0026

R. Sklavenitis-Pistofidis, T. Koletsa, A. Lazaridou, A. Goulas

引用次数: 0

Cardiotoxicity of the adjuvant trastuzumab in a Saudi population: clinical experience of a single institution 辅助曲妥珠单抗在沙特人群中的心脏毒性:单一机构的临床经验

Forum of Clinical Oncology Pub Date : 2016-06-01 DOI: 10.1515/fco-2016-0007

R. Hamed, K. Salim, A. Alzahrani, S. Elsamany

{"title":"Cardiotoxicity of the adjuvant trastuzumab in a Saudi population: clinical experience of a single institution","authors":"R. Hamed, K. Salim, A. Alzahrani, S. Elsamany","doi":"10.1515/fco-2016-0007","DOIUrl":"https://doi.org/10.1515/fco-2016-0007","url":null,"abstract":"Abstract Purpose Adjuvant trastuzumab is currently an internationally standard for the treatment of localised breast cancer that over express HER2 with the most adverse effect being cardiotoxicity. We conducted this study to evaluate the cardiac safety of trastuzumab in clinical practice. Methods This study is a retrospective observational single institutional study conducted in the Oncology Center of King Abdulla Medical City (KAMC), Makkah, Saudi Arabia, from June 2011 to January 2014. We evaluated the incidence of cardio toxicity and associated risk factors during adjuvant trastuzumab treatment. Results Of 57 patients, 20 patients (35%) exhibited cardiotoxicity. About 14% of patients had drop of left ventricular ejection fraction (LVEF) below 50%, whilst 10% and 15% drop of LVEF below their baseline levels were found in 30% and 5% of patients, respectively. About 98.3% of our patients have completed treatment, of whom 21% had a provisional interruption because of a fall in LVEF. A definitive trastuzumab discontinuation has been made in 1.75% of cases because of a nonregressive reduction in LVEF. Analysis of risk factors related to trastuzumab cardio toxicity found that patients older than 40 years were more likely to develop cardio toxicity compared to those younger than 40 years. This difference was statistically significant (p = 0.042). Conclusion In our study, the cardiac safety seems comparable with the literature data. Trastuzumab-related cardiotoxicity is manifested by an asymptomatic decrease in the LVEF and less commonly by clinical heart failure. Most instances are transient, asymptomatic and reversible.","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"7 1","pages":"1 - 6"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67375204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Metabolic syndrome and Cancer: Do they share common molecular pathways? 代谢综合征和癌症:它们有共同的分子途径吗?

Forum of Clinical Oncology Pub Date : 2016-06-01 DOI: 10.1515/fco-2016-0006

E. Veniou, I. Sofatzis, I. Kalantzis, M. Karakosta, M. Logothetis, E. Lianos, N. Ziras

{"title":"Metabolic syndrome and Cancer: Do they share common molecular pathways?","authors":"E. Veniou, I. Sofatzis, I. Kalantzis, M. Karakosta, M. Logothetis, E. Lianos, N. Ziras","doi":"10.1515/fco-2016-0006","DOIUrl":"https://doi.org/10.1515/fco-2016-0006","url":null,"abstract":"Abstract Metabolic syndrome, a clustering of risk factors including obesity, has emerged as a global health plague. A lot of epidemiological and clinical evidence suggests that the metabolic syndrome is linked not only to cardiovascular diseases and diabetes mellitus type 2 but also to cancer development and progression. In this review the potential mechanisms tying the metabolic syndrome with cancer are presented. The role of insulin resistance and hyperinsulinemia, the activation of insulin-like growth factor-1 (IGF-1) pathway, and the induction of cytotoxic products are highlighted. Subsequent effects leading to oxidative stress, release of lipokines with signaling properties by adipocytes, development of a sustained systemic inflammation, production of inflammatory cytokines, and establishment of a tumorigenic environment are also discussed. The importance of the metabolic syndrome and obesity coupled with the deeper understanding of the underlying molecular mechanisms has trigger intensive clinical research with an aim to prevent the risk of cancer and improve outcomes. Moreover, the need for lifestyle changes with increased physical activity and improved dietary quality has been emerged as urgent health priority.","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"7 1","pages":"15 - 7"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67375601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

BRCA1/2 associated cancer susceptibility: a clinical overview BRCA1/2相关癌症易感性:临床综述

Forum of Clinical Oncology Pub Date : 2016-06-01 DOI: 10.1515/fco-2015-0022

G. Lypas

{"title":"BRCA1/2 associated cancer susceptibility: a clinical overview","authors":"G. Lypas","doi":"10.1515/fco-2015-0022","DOIUrl":"https://doi.org/10.1515/fco-2015-0022","url":null,"abstract":"Abstract The most frequently identified genetic cause of breast cancer is the germline mutation of BRCA1 and 2 genes. The carriers of these mutations are at high risk for breast and ovarian cancers and increased risk for pancreatic and prostate cancers. Personal and family history are routinely used to identify individuals at risk for carrying such mutations. Genetic counselling is required to guide them through genetic testing and risk management. Positive testing corresponds to a deleterious mutation, whereas negative testing is considered as uninformative; variants of unknown clinical significance are also classified as uninformative. The most effective risk reduction strategy involves bilateral prophylactic mastectomy and bilateral salpingo-oophorectomy, eliminating 90% of breast and 97% of ovarian cancer risks, respectively. Before and until such surgery, surveillance with physical examination, mammography and magnetic resonance mammography, starting at 25–30 years of age, are recommended for the early diagnosis of breast cancer; semi-annual surveillance with physical examination, transvaginal ultrasound and serum CA-125 is recommended for women who have not had prophylactic surgery. Carriers diagnosed with breast cancer run a high risk for a new breast primary and this information should be used accordingly. PARP inhibitors is a new class of antineoplastic agents, already approved for advanced BRCA1/2 mutant (germline or somatic) ovarian cancer. Multigene panel testing may follow a negative BRCA genetic test, often identifying other genetic causes of cancer, expanding its role in oncology. Further adoption of PARP inhibitors, refinement in estimation of BRCA-associated cancer risks and wider population testing, through NGS technology, may become available in the near future.","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"7 1","pages":"16 - 24"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67375178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Reinstating endogenous antitumor immunity: The concept of therapeutic management of cancer 恢复内源性抗肿瘤免疫:癌症治疗管理的概念

Forum of Clinical Oncology Pub Date : 2016-03-01 DOI: 10.1515/fco-2016-0005

N. Pistamaltzian, S. Perez, C. Baxevanis

引用次数: 0

Overview and management of toxicities of immune checkpoint-blocking drugs 免疫检查点阻断药物的毒性概述及处理

Forum of Clinical Oncology Pub Date : 2016-03-01 DOI: 10.1515/fco-2016-0004

P. Economopoulou, A. Psyrri

引用次数: 1