Paediatrics and Child Health (United Kingdom)最新文献_第2页

Revolutionizing paediatric neurorehabilitation: integrating innovation and contemporary practice 革命性的儿科神经康复：整合创新和当代实践

Paediatrics and Child Health (United Kingdom) Pub Date : 2025-05-01 DOI: 10.1016/j.paed.2025.02.002

Vijay Palanivel, Tim Grove, Melanie Burrough

{"title":"Revolutionizing paediatric neurorehabilitation: integrating innovation and contemporary practice","authors":"Vijay Palanivel, Tim Grove, Melanie Burrough","doi":"10.1016/j.paed.2025.02.002","DOIUrl":"10.1016/j.paed.2025.02.002","url":null,"abstract":"<div><div>The field of paediatric neurorehabilitation is undergoing significant transformation, driven by evolving care pathways, innovative technologies, and a growing emphasis on addressing health disparities. Children and young people (CYP) with acquired brain injuries (ABI) benefit from rehabilitation that optimizes their participation in daily life across home, school, and community settings. This paper explores the changing landscape of paediatric neurorehabilitation and changing patterns of causes of brain injury in children. The discussion extends to health inequalities that affect access to care, underscoring the need for system-wide reforms to bridge disparities linked to socioeconomic, geographic, and cultural factors. The development of seamless, end-to-end service pathways, from acute care to specialist tertiary neurorehabilitation and onward community services, demonstrates the potential for integrated care to improve outcomes for CYP transitioning from hospital to home. Central to effective rehabilitation is personalized goal setting and high-intensity treatments, which enhance physical, cognitive, and social outcomes. Technological advancements, including virtual reality, robotics, and electrical muscle stimulation, are reshaping therapeutic approaches, increasing engagement, and fostering neuroplasticity. Findings advocate for ongoing research, investment in community services, and equitable application of emerging technologies. By prioritizing personalized care and addressing systemic barriers, the future of paediatric neurorehabilitation holds promise for improved long-term functional outcomes for children with ABI.</div></div>","PeriodicalId":38589,"journal":{"name":"Paediatrics and Child Health (United Kingdom)","volume":"35 5","pages":"Pages 134-139"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute neurological deficit: is it demyelination? Review of demyelinating disorders of the central nervous system 急性神经缺损：是脱髓鞘吗？中枢神经系统脱髓鞘疾病综述

Paediatrics and Child Health (United Kingdom) Pub Date : 2025-05-01 DOI: 10.1016/j.paed.2025.02.004

Yoshua C. Collins-Sawaragi, Evangeline Wassmer

引用次数: 0

Developmental and epileptic encephalopathies: the clinical approach to investigation and management 发展性和癫痫性脑病：临床方法的调查和管理

Paediatrics and Child Health (United Kingdom) Pub Date : 2025-05-01 DOI: 10.1016/j.paed.2025.02.007

Ogechukwu Okpala, Manali Chitre

{"title":"Developmental and epileptic encephalopathies: the clinical approach to investigation and management","authors":"Ogechukwu Okpala, Manali Chitre","doi":"10.1016/j.paed.2025.02.007","DOIUrl":"10.1016/j.paed.2025.02.007","url":null,"abstract":"<div><div>Epileptic encephalopathies (EE) and developmental and epileptic encephalopathies (DEE) are a group of severe brain disorders in which epileptic electrical discharge contributes to progressive psychomotor dysfunction. These include rare but important conditions such as neonatal epileptic encephalopathy, West, Dravet, Lennox Gastaut and Landau Kleffner syndromes. These conditions result in a characteristic cluster of clinical, EEG and aetiological features which together, help us understand the condition, use more targeted therapies and prognosticate with regards to progression with age. Electroencephalography (EEG) is crucial in determining the causative epilepsy syndrome. Since the availability of next generation sequencing, genetic testing has assumed increasing importance in the diagnosis of specific syndromes. Multidisciplinary support from medical, nursing and therapy teams is essential in helping these children reach the best of their abilities, skills and to optimize their long-term outcomes. In this article we describe some of the more commonly seen EE/DEE and discuss management and prognosis of these.</div></div>","PeriodicalId":38589,"journal":{"name":"Paediatrics and Child Health (United Kingdom)","volume":"35 5","pages":"Pages 163-170"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inherited white matter disorders in children 儿童遗传性白质紊乱

Paediatrics and Child Health (United Kingdom) Pub Date : 2025-05-01 DOI: 10.1016/j.paed.2025.02.008

Nee Na Kim, Asthik Biswas, Cheryl Hemingway

{"title":"Inherited white matter disorders in children","authors":"Nee Na Kim, Asthik Biswas, Cheryl Hemingway","doi":"10.1016/j.paed.2025.02.008","DOIUrl":"10.1016/j.paed.2025.02.008","url":null,"abstract":"<div><div>Inherited white matter disorders (IWMDs), otherwise known as leukodystrophies, represent a group of rare and heterogenous neurological conditions affecting the white matter of the central nervous system (CNS). With a wide range of differential diagnoses and associated medical complexities, they often pose a diagnostic challenge to clinicians. Rapid technological advancement including the availability of genetic investigations such as whole genome sequencing (WGS) is leading to an increasing number of patients with a confirmed genetic diagnosis. For the majority of IWMDs there is no specific treatment, and the focus of clinical management remains symptomatic and involves a multidisciplinary team and holistic approaches. Up until recently, only natural history trials were available, but now the focus is shifting to novel targeted therapies. Early diagnosis and prompt referral to specialized IWMD centers is crucial for optimum management of affected children or asymptomatic affected siblings. Collaborative efforts are needed to achieve two important goals 1) to establish international patient registries for long term natural history and recruitment to new treatment trials and 2) to encourage wider newborn screening programmes for early detection of these rare diseases at the asymptomatic stage. In this review, we aim to summarise the common clinical presentations, diagnostic investigations, management and prognosis of the more commonly encountered inherited white matter disorders in children.</div></div>","PeriodicalId":38589,"journal":{"name":"Paediatrics and Child Health (United Kingdom)","volume":"35 5","pages":"Pages 171-179"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurocutaneous syndromes: a multidisciplinary team approach 神经皮肤综合征：多学科团队方法

Paediatrics and Child Health (United Kingdom) Pub Date : 2025-05-01 DOI: 10.1016/j.paed.2025.02.006

Hanna Richardson, Rachel Gwynn, Parisha Chadha, Penny Andreou, Karen Ray, Clare Rapier, Catherine Swales, Sarah Aylett

引用次数: 0

Treatable movement disorders in children 儿童可治疗的运动障碍

Paediatrics and Child Health (United Kingdom) Pub Date : 2025-05-01 DOI: 10.1016/j.paed.2025.02.003

Gautam P Ambegaonkar

引用次数: 0

Neuroprotection in traumatic brain injury 外伤性脑损伤的神经保护

Paediatrics and Child Health (United Kingdom) Pub Date : 2025-04-19 DOI: 10.1016/j.paed.2025.04.001

Swathy Subhash, Shruti Agrawal

引用次数: 0

Childhood pneumonia: an update in the post-COVID-19 era 儿童肺炎：后covid -19时代的最新情况

Paediatrics and Child Health (United Kingdom) Pub Date : 2025-04-17 DOI: 10.1016/j.paed.2025.04.005

Shana Irvine, Peter Logan, Michael D Shields, Paddy McCrossan

引用次数: 0

Children with tracheostomies in the paediatric intensive care unit 在儿科重症监护室进行气管切开术的儿童

Paediatrics and Child Health (United Kingdom) Pub Date : 2025-04-17 DOI: 10.1016/j.paed.2025.04.004

Nicola Holt, Will Tremlett

引用次数: 0

Management of extubation failure on the paediatric intensive care unit 儿科重症监护室拔管失败的处理

Paediatrics and Child Health (United Kingdom) Pub Date : 2025-04-15 DOI: 10.1016/j.paed.2025.04.003

Deepika Puthucode, Patrick Davies

{"title":"Management of extubation failure on the paediatric intensive care unit","authors":"Deepika Puthucode, Patrick Davies","doi":"10.1016/j.paed.2025.04.003","DOIUrl":"10.1016/j.paed.2025.04.003","url":null,"abstract":"<div><div>Extubation failure is common in PICU especially in the current era when patients with multiple complexities can be of a significant challenge. Extubation failure is defined as inability to sustain spontaneous breathing after removal of artificial airway leading to the need for re-intubation within 48 hours of a planned extubation. The pathophysiology of extubation failure can be grouped under four categories: airway, muscular power, respiratory drive, and lung parenchymal pathologies with cardiopulmonary interactions. To achieve success and maintain extubation, it is important to identify risk factors contributing for failure and fix them, wean ventilation using appropriate weaning strategies and by stepwise process, assess readiness and extubate at the optimum time. Repeated extubation failures can also be complications increasing the risk of mortality and length of stay. Causes are diverse with clinical complexity, needing multidisciplinary team approach for a comprehensive management of extubation failure. The paediatric intensivist needs to recognize children at risk of extubation failure, make a comprehensive plan and intervene at the earliest opportunity to prevent further morbidity.</div></div>","PeriodicalId":38589,"journal":{"name":"Paediatrics and Child Health (United Kingdom)","volume":"35 6","pages":"Pages 203-207"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0