Pedro Caravaca Pérez, Ignacio Fernández-Herrero, José Jesús Broseta, Nikein Ibarra-Márquez, Zorba Blázquez-Bermejo, Juan Carlos López-Azor, César Del Castillo Gordillo, Marta Cobo Marcos, Javier de Juan Bagudá, María Dolores García Cosío, Ana García-Álvarez, Marta Farrero, Juan F Delgado
{"title":"Impact of natriuresis on worsening renal function during episodes of acute heart failure.","authors":"Pedro Caravaca Pérez, Ignacio Fernández-Herrero, José Jesús Broseta, Nikein Ibarra-Márquez, Zorba Blázquez-Bermejo, Juan Carlos López-Azor, César Del Castillo Gordillo, Marta Cobo Marcos, Javier de Juan Bagudá, María Dolores García Cosío, Ana García-Álvarez, Marta Farrero, Juan F Delgado","doi":"10.1016/j.rec.2024.07.006","DOIUrl":"10.1016/j.rec.2024.07.006","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Worsening renal function (WRF) is a frequent complication in acute heart failure (AHF) with a controversial prognostic value. We aimed to study the usefulness of natriuresis to evaluate WRF.</p><p><strong>Methods: </strong>We conducted an observational, prospective, multicenter study of patients with AHF who underwent a furosemide stress test. The patients were classified according to whether WRF was present or absent and according to the median natriuretic response. The main endpoint was the combination of mortality, rehospitalization due to HF, and heart transplant at 6 months of follow-up.</p><p><strong>Results: </strong>One hundred and fifty-six patients were enrolled, and WRF occurred in 60 (38.5%). The patients were divided into 4 groups: a) 47 (30.1%) no WRF/low UNa (UNa ≤ 109 mEq/L); b) 49 (31.4%) no WRF/high UNa (UNa >109 mEq/L); c) 31 (19.9%) WRF/low UNa and d) 29 (18.6%) WRF/high UNa. The parameters of the WRF/low UNa group showed higher clinical severity and worse diuretic and decongestive response. The development of WRF was associated with a higher risk of the combined event (HR, 1.88; 95%CI, 1.01-3.50; P=.046). When stratified by natriuretic response, WRF was associated with an increased risk of adverse events in patients with low natriuresis (HR, 2.28; 95%CI, 1.15-4.53; P=.019), but not in those with high natriuresis (HR, 1.18; 95%CI, 0.26-5.29; P=.826).</p><p><strong>Conclusions: </strong>Natriuresis could be a useful biomarker for interpreting and prognosticating WRF in AHF. WRF is associated with a higher risk of adverse events only in the context of low natriuresis.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optical coherence tomography-guided versus intravascular ultrasound-guided percutaneous coronary intervention in patients with acute myocardial infarction","authors":"","doi":"10.1016/j.rec.2023.11.014","DOIUrl":"10.1016/j.rec.2023.11.014","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>Optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) yields clinical outcomes comparable to intravascular ultrasound (IVUS)-guided PCI in patients with stable ischemic heart disease. However, there is a scarcity of data comparing the clinical outcomes of OCT-guided and IVUS-guided PCI in the setting of acute myocardial infarction (AMI). We sought to compare the clinical outcomes of OCT-guided vs IVUS-guided PCI for patients with AMI in the era of second-generation drug-eluting stent (DES).</p></div><div><h3>Methods</h3><p>We identified 5260 consecutive patients who underwent PCI with a second-generation DES for AMI under IVUS<span> or OCT guidance from pooled data derived from a series of Korean AMI registries between 2011 and 2020. The primary endpoint was the 1-year rate of target lesion failure, defined as a composite of cardiac death, target vessel myocardial infarction, or ischemia-driven target lesion revascularization.</span></p></div><div><h3>Results</h3><p>A total of 535 (10.2%) and 4725 (89.8%) patients were treated under OCT and IVUS guidance, respectively. The 1-year target lesion failure rates were comparable between the OCT and IVUS groups before and after propensity score matching (hazard ratio, 0.92; 95%CI, 0.42-2.05, <em>P</em> <!-->=<!--> <!-->.84). The OCT utilization rate did not exceed 5% of total patients treated with second-generation DES implantation during the study period. The primary factors for the selection of OCT over IVUS were the absence of chronic kidney disease, non-left main vessel disease, single-vessel disease, stent diameter <<!--> <!-->3<!--> <!-->mm, and stent length ≤ 25<!--> <!-->mm.</p></div><div><h3>Conclusions</h3><p>OCT-guided PCI in patients with AMI treated with a second-generation DES provided comparable clinical outcomes for 1-year target lesion failure compared with IVUS-guided PCI.</p></div>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"77 8","pages":"Pages 607-617"},"PeriodicalIF":7.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dexmedetomidine mitigates acute kidney injury after coronary artery bypass grafting: a prospective clinical trial","authors":"","doi":"10.1016/j.rec.2024.02.005","DOIUrl":"10.1016/j.rec.2024.02.005","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>To evaluate the impact of dexmedetomidine impact on cardiac surgery-associated acute kidney injury (CSA-AKI), kidney function, and metabolic and oxidative stress in patients undergoing coronary artery bypass grafting with heart-lung machine support.</p></div><div><h3>Methods</h3><p>A randomized double-masked trial with 238 participants (50-75 years) undergoing coronary artery bypass grafting was conducted from January 2021 to December 2022. The participants were divided into Dex (n<!--> <!-->=<!--> <!-->119) and NS (n = 119) groups. Dex was administered at 0.5 mcg/kg over 10<!--> <!-->minutes, then 0.4 mcg/kg/h until the end of surgery; the NS group received equivalent saline. Blood and urine were sampled at various time points pre- and postsurgery. The primary outcome measure was the incidence of CSA-AKI, defined as the occurrence of AKI within 96<!--> <!-->hours after surgery.</p></div><div><h3>Results</h3><p>The incidence of CSA-AKI was significantly lower in the Dex group than in the NS group (18.26% vs 32.46%; <em>P</em> <!-->=<!--> <!-->.014). Substantial increases were found in estimated glomerular filtration rate value at T4–T6 (<em>P</em> <!--><<!--> <!-->.05) and urine volume 24<!--> <!-->hours after surgery (<em>P</em> <!--><<!--> <!-->.01). Marked decreases were found in serum creatinine level, blood glucose level at T1–T2 (<em>P</em> <!--><<!--> <!-->.01), blood urea nitrogen level at T3–T6 (<em>P</em> <!--><<!--> <!-->.01), free fatty acid level at T2–T3 (<em>P</em> <!--><<!--> <!-->.01), and lactate level at T3–T4 (<em>P</em> <!--><<!--> <!-->.01).</p></div><div><h3>Conclusions</h3><p>Dex reduces CSA-AKI, potentially by regulating metabolic disorders and reducing oxidative stress.</p><p>Registered with the Chinese Clinical Study Registry (No. ChiCTR2100051804).</p></div>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"77 8","pages":"Pages 645-655"},"PeriodicalIF":7.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to levosimendan predicts response to cardiac contractility modulation therapy: a pilot study","authors":"","doi":"10.1016/j.rec.2024.02.012","DOIUrl":"10.1016/j.rec.2024.02.012","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"77 8","pages":"Pages 703-705"},"PeriodicalIF":7.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preprocedural transthoracic echocardiography for predicting outcomes of transcatheter edge-to-edge repair for chronic primary mitral regurgitation","authors":"","doi":"10.1016/j.rec.2023.12.001","DOIUrl":"10.1016/j.rec.2023.12.001","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>Limited data exist on the prognostic usefulness of transthoracic echocardiography preceding MitraClip for chronic primary mitral regurgitation (MR). We evaluated the predictive ability of transthoracic echocardiography in this setting.</p></div><div><h3>Methods</h3><p>A total of 410 patients (median age, 83 years, 60.7% males) were included in the study. The primary outcome was the 1-year composite of all-cause mortality or heart failure hospitalization. Secondary endpoints encompassed individual elements of the primary outcome, the persistence of significant functional impairment or above-moderate MR at 1 year, and above-mild MR at 1-month.</p></div><div><h3>Results</h3><p>The only parameter associated with the risk of the primary outcome was a ventricular end systolic diameter index of ≥<!--> <!-->2.1 cm/m<sup>2</sup>, corresponding to the cohort's 4th quartile (HR, 2.44; 95%CI, 1.09-4.68; <em>P</em> <!-->=<!--> <!-->.022). Concurrently, higher left atrial volume index (LAVi) and a mid-diastolic medial-lateral mitral annular diameter (MAD) equal to or above the cohort's median of 32.2<!--> <!-->mm were linked to a higher probability of death and heart failure hospitalization, respectively. LAVi of ≥ 60<!--> <!-->mL/m<sup>2</sup>, above-mild mitral annular calcification, and above-moderate tricuspid regurgitation conferred higher odds of functional class III-IV or above-moderate MR persistence. All variables except LAVi and MAD, as well as indexed mid-diastolic medial-lateral MAD of ≥ 20.2<!--> <!-->mm/m<sup>2</sup> and mitral effective regurgitant orifice area of ≥ 0.40 cm<sup>2</sup>, were associated with greater-than-mild MR at 1 month.</p></div><div><h3>Conclusions</h3><p>Preprocedural increased indexed left heart dimensions, mainly left ventricular end-systolic diameter index, MAD, mitral annular calcification, mitral effective regurgitant orifice area, and tricuspid regurgitation mark a less favorable course post-MitraClip for chronic primary MR.</p></div>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"77 8","pages":"Pages 621-631"},"PeriodicalIF":7.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gore atrial septal occluder devices as an option in patients with nickel allergy","authors":"","doi":"10.1016/j.rec.2024.02.007","DOIUrl":"10.1016/j.rec.2024.02.007","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"77 8","pages":"Pages 697-699"},"PeriodicalIF":7.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dilated cardiomyopathy associated with cardiotoxicity due to consumption of energy drinks","authors":"","doi":"10.1016/j.rec.2024.02.018","DOIUrl":"10.1016/j.rec.2024.02.018","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"77 8","pages":"Pages 699-700"},"PeriodicalIF":7.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140771732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Practical approach for atrial cardiomyopathy characterization in patients with atrial fibrillation","authors":"","doi":"10.1016/j.rec.2024.02.009","DOIUrl":"10.1016/j.rec.2024.02.009","url":null,"abstract":"<div><p>Atrial fibrillation (AF) causes progressive structural and electrical changes in the atria that can be summarized within the general concept of atrial remodeling. In parallel, other clinical characteristics and comorbidities may also affect atrial tissue properties and make the atria susceptible to AF initiation and its long-term persistence. Overall, pathological atrial changes lead to atrial cardiomyopathy with important implications for rhythm control. Although there is general agreement on the role of the atrial substrate for successful rhythm control in AF, the current classification oversimplifies clinical management. The classification uses temporal criteria and does not establish a well-defined strategy to characterize the individual-specific degree of atrial cardiomyopathy. Better characterization of atrial cardiomyopathy may improve the decision-making process on the most appropriate therapeutic option. We review current scientific evidence and propose a practical characterization of the atrial substrate based on 3 evaluation steps starting with a clinical evaluation (step 1), then assess outpatient complementary data (step 2), and finally include information from advanced diagnostic tools (step 3). The information from each of the steps or a combination thereof can be used to classify AF patients in 4 stages of atrial cardiomyopathy, which we also use to estimate the success on effective rhythm control.</p></div>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"77 8","pages":"Pages 656-666"},"PeriodicalIF":7.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1885585724000720/pdfft?md5=c39642f504f42b1be071ce79b000fca4&pid=1-s2.0-S1885585724000720-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chronic fibrothrombotic deposits: a cause or consequence of pulmonary hypertension?","authors":"","doi":"10.1016/j.rec.2023.12.005","DOIUrl":"10.1016/j.rec.2023.12.005","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"77 8","pages":"Page 707"},"PeriodicalIF":7.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnosis and treatment of myocarditis and inflammatory cardiomyopathy. Consensus document of the SEC-Working Group on Myocarditis","authors":"","doi":"10.1016/j.rec.2024.02.022","DOIUrl":"10.1016/j.rec.2024.02.022","url":null,"abstract":"<div><p>Myocarditis is defined as myocardial inflammation and its etiology is highly diverse, including infectious agents, drugs, and autoimmune diseases. The clinical presentation also varies widely, extending beyond the classic clinical picture of acute chest pain, and includes cases of cardiomyopathy of unknown cause whose etiology may be inflammatory. Because certain patients may benefit from targeted treatments, the search for the etiology should begin when myocarditis is first suspected. There remain several areas of uncertainty in the diagnosis and treatment of this disease. Consequently, this consensus document aims to provide clear recommendations for its diagnosis and treatment. Hence, a diagnostic algorithm is proposed, specifying when non-invasive diagnosis with cardiac MR is appropriate vs a noninvasive approach with endomyocardial biopsy. In addition, more novel aspects are discussed, such as when to suspect an underlying genetic etiology. The recommendations cover the management of myocarditis and inflammatory cardiomyopathy, both for general complications and specific clinical entities.</p></div>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"77 8","pages":"Pages 667-679"},"PeriodicalIF":7.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141048345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}