Alessia Argirò, Federica Colio, Manuel Garofalo, Simone Longhi, Luciano Potena, Giulia Saturi, Marco Allinovi, Alessio Aloisio, Aldostefano Porcari, Awais Sheikh, Marianna Fontana, Julian Gillmore, Pablo García-Pavía, Manuel Gómez Bueno, Silvia Menale, William E Moody, Caitlin Thornton, Lorena Herrador, José González-Costello, Fernando de Frutos, Concetta Di Nora, Igor Vendramin, Massimo Imazio, Marco Merlo, Gianfranco Sinagra, Marcus Anthony Urey, Quan M Bui, Ahmad Masri, Mohammad Alqabani, Zhongli Chen, Liang Chen, Alessio Gasperetti, Paolo Milani, Giovanni Palladini, Barbara Cattadori, Alberto Cipriani, Giulio Sinigiani, Gino Gerosa, Giuseppe Palmiero, Giuseppe Limongelli, Beatrice Musumeci, Giacomo Tini, Maurizio Pieroni, Federico Perfetto, Francesco Cappelli
{"title":"Multicenter cohort analysis of cardiac amyloidosis patients treated with heart transplant.","authors":"Alessia Argirò, Federica Colio, Manuel Garofalo, Simone Longhi, Luciano Potena, Giulia Saturi, Marco Allinovi, Alessio Aloisio, Aldostefano Porcari, Awais Sheikh, Marianna Fontana, Julian Gillmore, Pablo García-Pavía, Manuel Gómez Bueno, Silvia Menale, William E Moody, Caitlin Thornton, Lorena Herrador, José González-Costello, Fernando de Frutos, Concetta Di Nora, Igor Vendramin, Massimo Imazio, Marco Merlo, Gianfranco Sinagra, Marcus Anthony Urey, Quan M Bui, Ahmad Masri, Mohammad Alqabani, Zhongli Chen, Liang Chen, Alessio Gasperetti, Paolo Milani, Giovanni Palladini, Barbara Cattadori, Alberto Cipriani, Giulio Sinigiani, Gino Gerosa, Giuseppe Palmiero, Giuseppe Limongelli, Beatrice Musumeci, Giacomo Tini, Maurizio Pieroni, Federico Perfetto, Francesco Cappelli","doi":"10.1016/j.rec.2026.06.005","DOIUrl":"10.1016/j.rec.2026.06.005","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>To describe the clinical characteristics of patients with cardiac amyloidosis who have undergone heart transplantation (HT).</p><p><strong>Methods: </strong>This retrospective multicenter study involving 14 referral centers included 113 patients with cardiac amyloidosis who underwent HT: 57 with transthyretin amyloidosis (ATTR) (22 with wild-type ATTR and 35 with variant ATTR) and 56 with light chain amyloidosis (AL).</p><p><strong>Results: </strong>Compared with patients with ATTR, patients with AL amyloidosis showed more severe hemodynamic compromise before HT, with a lower cardiac index (1.7 L/min/m<sup>2</sup> [interquartile range, 1.4-2.0 L/min/m<sup>2</sup>] vs 1.9 L/min/m<sup>2</sup> [interquartile range, 1.6-2.4 L/min/m<sup>2</sup>]; P = .027) and higher right atrial pressure. Post-transplant infections occurred in 23 patients with ATTR (40%) and 24 with AL (43%). New-onset neuropathy occurred in 11% of patients, while neuropathy progression was more frequent in ATTR compared with AL (23% vs 7.1%; P = .044). Median follow-up was 4.6 years in ATTR and 5.4 years in AL. Five-year survival was similar in both groups (77% in AL vs 83% in ATTR). Sepsis was the leading cause of death (n = 11, 29% of deaths). Among patients with ATTR, 9 received tafamidis before HT and 7 after HT. Eight patients with ATTR received patisiran post-HT (1 pre-HT), and 3 received diflunisal post-HT. In AL, 70% received bortezomib-based therapy while 28% received daratumumab-based therapy. In AL, hematologic responses improved after HT, with the complete response rate increasing from 42% before HT to 54% after HT.</p><p><strong>Conclusions: </strong>HT is an effective treatment for carefully selected patients with cardiac amyloidosis, with comparable unadjusted survival between AL and ATTR. These findings warrant confirmation in prospective studies.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marina Botello-Marabotto, Mercè Comas, David Abbad-Gómez, Laia Domingo, Berta Ibáñez-Beroiz, Ibai Tamayo, Beatriz Poblador-Plou, Antonio Gimeno-Miguel, Máximo Redondo, María Padilla, Isabel Del Cura, Teresa Sanz, Antonio Díaz-Holgado, Helena Tizón-Marcos, Xavier Castells, María Sala
{"title":"Cardiology care, cardiovascular comorbidities and all-cause mortality in long-term breast cancer survivors: a retrospective cohort study.","authors":"Marina Botello-Marabotto, Mercè Comas, David Abbad-Gómez, Laia Domingo, Berta Ibáñez-Beroiz, Ibai Tamayo, Beatriz Poblador-Plou, Antonio Gimeno-Miguel, Máximo Redondo, María Padilla, Isabel Del Cura, Teresa Sanz, Antonio Díaz-Holgado, Helena Tizón-Marcos, Xavier Castells, María Sala","doi":"10.1016/j.rec.2026.06.003","DOIUrl":"10.1016/j.rec.2026.06.003","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Breast cancer survivors (BCS) have an elevated risk of cardiovascular disease (CVD), but standardized follow-up protocols remain limited. We aimed to describe cardiovascular comorbidities and the utilization of specialized health services, particularly cardiology services, among BCS, and to examine their association with mortality.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 6186 BCS diagnosed between 2000 and 2006 who survived at least 5 years after diagnosis. Participants were followed up from 2012 to 2016. Health care use and comorbidities obtained from electronic health records were analyzed. A multivariate time-dependent Cox proportional hazards model was used to assess the association between use of cardiology services and all-cause mortality.</p><p><strong>Results: </strong>A total of 43.6% of long-term BCS had CVD at the beginning of follow-up. Women with CVD were older (mean age 71.8 vs 62 years; P<.001) and had a substantially higher comorbidity burden than those without CVD (5.83 vs 1.96; P <.001). During follow-up, 781 BCS (12.6%) died. Nonsurvivors were older and had a greater and more severe baseline comorbidity burden than survivors. They also had higher rates of specialist visits. Use of cardiology services was associated with lower mortality, although the association did not reach statistical significance (HR, 0.84; 95%CI, 0.67-1.05; P=.12).</p><p><strong>Conclusions: </strong>The prevalence of CVD among BCS was high, although only 18.8% used cardiology services. Nonsurvivors had a higher CVD burden and severity, and showed greater use of health care services.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Alperi, Isaac Pascual, Víctor León, Iria Silva, Ismael Rivera-Diaz, Luis Zamayoa-Paz, Daniel Morena, Beatriz Nieves, Marcel Almendárez, Rut Álvarez, Ángela Herrero, Pablo Avanzas
{"title":"Transcatheter edge-to-edge tricuspid valve repair combining a late-generation 3-dimensional intracardiac echocardiography system with transesophageal guidance.","authors":"Alberto Alperi, Isaac Pascual, Víctor León, Iria Silva, Ismael Rivera-Diaz, Luis Zamayoa-Paz, Daniel Morena, Beatriz Nieves, Marcel Almendárez, Rut Álvarez, Ángela Herrero, Pablo Avanzas","doi":"10.1016/j.rec.2026.06.002","DOIUrl":"10.1016/j.rec.2026.06.002","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>The use of transcatheter tricuspid edge-to-edge repair (TEER) is growing steadily due to its minimally invasive nature. The VeriSight Pro 3D intracardiac echocardiography (ICE) catheter might help to increase procedural safety and improve procedural outcomes.</p><p><strong>Methods: </strong>In this prospective, single-center, observational study, we compared the procedural outcomes of tricuspid TEER guided by ICE plus transesophageal echocardiography (TEE) or by TEE alone. Lead-induced tricuspid regurgitation and combined mitral-tricuspid procedures were excluded. Primary events were those associated with procedural and early (30-day) safety.</p><p><strong>Results: </strong>A total of 45 consecutive patients were included (25 guided by TEE and 20 by ICE+TEE). There were no significant differences in baseline clinical and echocardiographic features. No mortality, stroke, major bleeding, or major vascular events occurred. ICE significantly decreased the fluoroscopy time (ICE+TEE vs TEE: 16.2 [8.9-26.0] minutes vs 26 [18.2-32.0] minutes; P=.003), radiation dose (ICE+TEE vs TEE: 782 [390-1040] mGy vs 1413 [960-1705] mGy; P=.002), and dose-area product (ICE+TEE vs TEE: 5855 [2675-9328] cGy cm<sup>2</sup> vs 12 120 [8670-15 080] cGy cm<sup>2</sup>; P=.004). Procedural time was also significantly decreased (ICE+TEE vs TEE: 55 [37-62] minutes vs 72 [50-80] minutes; P=.03). Optimal visualization of leaflet grasping and insertion was achieved in all ICE procedures.</p><p><strong>Conclusions: </strong>The addition of 3D ICE guidance to TEE during tricuspid TEER is associated with lower fluoroscopy time and radiation exposure compared with TEE, without any significant disadvantages regarding procedural safety. This study represents the first national experience with the novel VeriSight Pro 3D ICE catheter.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148253893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adriana Milena Jurado-Arenales, Paula S Bohórquez-Hernández, Edgar Fabián Manrique-Hernández, Maricel Licht-Ardila, Alexandra Hurtado-Ortiz, Luis Eduardo Echeverría-Correa
{"title":"Well-being and the invisible role of the family in patients with heart failure.","authors":"Adriana Milena Jurado-Arenales, Paula S Bohórquez-Hernández, Edgar Fabián Manrique-Hernández, Maricel Licht-Ardila, Alexandra Hurtado-Ortiz, Luis Eduardo Echeverría-Correa","doi":"10.1016/j.rec.2026.06.004","DOIUrl":"10.1016/j.rec.2026.06.004","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148253828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandro Carta-Bergaz, Roberto Gómez-Sánchez, Esteban González-Torrecilla, Pablo Ávila, Felipe Atienza, Ana González-Mansilla, Elena Rodríguez-González, Ángel Arenal
{"title":"Multispline catheter mapping of the coronary ostia to guide aortic root ablation.","authors":"Alejandro Carta-Bergaz, Roberto Gómez-Sánchez, Esteban González-Torrecilla, Pablo Ávila, Felipe Atienza, Ana González-Mansilla, Elena Rodríguez-González, Ángel Arenal","doi":"10.1016/j.rec.2026.05.006","DOIUrl":"10.1016/j.rec.2026.05.006","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Safe ablation of ventricular arrhythmias from the left ventricular outflow tract (LVOT) requires accurate coronary ostia localization, but conventional imaging adds procedural complexity, radiation, and cost. The aim of this study was to determine whether electroanatomic coronary ostial localization using multispline-based catheters reproduces computed tomography (CT)-defined ostial anatomy and could serve as an anatomic reference.</p><p><strong>Methods: </strong>Among 85 consecutive patients undergoing evaluation for LVOT ablation, 51 met the inclusion criteria and were prospectively enrolled in a 2-phase observational study: a CT-validated cohort (n=26) followed by a non-CT implementation cohort (n=25). Coronary ostia were identified electroanatomically using predefined protrusion criteria and compared with CT in a validation cohort. An exploratory electrocardiogram-based model was tested to predict ostial proximity.</p><p><strong>Results: </strong>Electroanatomic identification of the left coronary artery (LCA) ostium was achieved in all patients (100%; 95%CI, 93.0%-100%), and of the right coronary artery (RCA) in 73% (95% CI, 58.3%-84.1%). In the CT-validation cohort, electroanatomic and CT-derived ostial locations demonstrated excellent 3-dimensional concordance (LCA: 1.30±0.37 mm; RCA: 1.48±0.43 mm). In the subsequent implementation cohort, electroanatomic coronary localization was performed without systematic CT use. No ischemic clinical events occurred during 404 days of follow-up; CT in the validation cohort showed no coronary lesions. The exploratory electrocardiogram-based model suggested artery-specific variables for predicting coronary proximity.</p><p><strong>Conclusions: </strong>Electroanatomic mapping with spline-based catheters enables accurate coronary ostia localization during LVOT ablation, consistently for the LCA and in most cases for the RCA. These findings support its use as a feasible anatomical reference to inform procedural decision-making.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148228632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Williams Hinojosa, Daniel Rodríguez-Muñoz, Isabel López-Alacid, Fernando Arribas Ynsaurriaga, Alejandro Cruz-Utrilla, Pilar Escribano-Subías
{"title":"Atrial flutter ablation in pulmonary hypertension: a national referral center experience.","authors":"Williams Hinojosa, Daniel Rodríguez-Muñoz, Isabel López-Alacid, Fernando Arribas Ynsaurriaga, Alejandro Cruz-Utrilla, Pilar Escribano-Subías","doi":"10.1016/j.rec.2026.05.007","DOIUrl":"10.1016/j.rec.2026.05.007","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148228585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Antonio Fernández-Sánchez, Juan Emilio Alcalá-López, Juan Jiménez-Jaimez
{"title":"Extensive circumferential fatty infiltration of the left ventricle with an arrhythmic phenotype.","authors":"José Antonio Fernández-Sánchez, Juan Emilio Alcalá-López, Juan Jiménez-Jaimez","doi":"10.1016/j.rec.2026.04.008","DOIUrl":"10.1016/j.rec.2026.04.008","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}