2009 International Conference on Biomedical and Pharmaceutical Engineering最新文献

{"title":"An accurate and robust algorithm for detection of heart and respiration rates using an impulse based UWB signal","authors":"M. Baboli, A. Sharafi, A. Ahmadian, M. Nambakhsh","doi":"10.1109/ICBPE.2009.5384092","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384092","url":null,"abstract":"The purpose of this paper is to introduce an accurate algorithm to detect respiration rate and heart beat using an Ultra-Wideband (UWB) signal. One important issue to consider for obtaining precise results is the right selection of measurement parameters in UWB system. In this work the impact of these parameters in detecting respiration rate and heart beat are studied and the best values are suggested. The experiments are done using a UWB transceiver with 3.2GHz of bandwidth in a busy environment without any wave absorbent. The results of the experiments prove an accuracy of 98 % and 90% for detecting of respiration rate and heart beats, respectively. The robustness of the algorithm to environmental noise due to scattering effect is also studied by performing different experiments in two situations.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127439731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of portable ARM processor based ECG module for 12 lead ECG data acquisition and analysis","authors":"C. Ghule, D. Wakde, Gurjinder S. Virdi, Neeta R. Khodke","doi":"10.1109/ICBPE.2009.5384077","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384077","url":null,"abstract":"The progress in portable computing in the past few decades has provided the means with PC or customized microcomputer based instrumentation to develop solutions to biomedical problems that could not be approached before. Detection of irregularities in the rhythms of the heart using customized microcomputer based instruments is a growing field in medical research. This paper gives an emphasis on the development of a portable platform for real time analysis of ECG signal, which can be used for a regular observing device for home usage and at the same time as an advance warning device for heart abnormalities. This is done by transmitting the same data to the doctors' personal mobile or office using wireless protocol for remote monitoring and further diagnosis. It makes use of the analog to digital converter in order to interface it to the advance processor ARM LPC 2100 series to give 12 lead ECG output signal.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"127 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121925477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An alternative index for monitoring microcirculatory blood flow: The beat-to-beat microcirculatory blood flow variability","authors":"H. Hsiu, W. Hsu, Chia-Liang Hsu","doi":"10.1109/ICBPE.2009.5384107","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384107","url":null,"abstract":"Objective: Cardiovascular variability analysis, such heart rate variability or blood pressure variability, provides important information about activities of various regulatory mechanisms for the cardiovascular system. Aim of the present study is to use the laser Doppler flowmetry (LDF) measurement to study the correspondent changes between the beat-to-beat microcirculatory blood flow (MBF) and its variation (MBFV). Methods: 17 trials were performed on 5 male healthy volunteers. For each experiment, we applied local heating (LH) stimulation and recorded a 20-minute heating-effect data sequence. For each pulse, DCflux (average LDF flux) was calculated, and CV (coefficient of variation) of DCflux (DCCV) was then calculated to evaluate the beat-to-beat MBFV. Results: The slope between DCCV and DCflux was negative with R2 ≫0.7 (p≪0.01 by F-test). Conclusion: Our results suggest that by providing an alternative solution to overcome the major drawback for LDF measurement of lacking quantitative evaluation, MBFV parameters calculated from the beat-to-beat LDF waveform may have meaning in improving the evaluation for the LH response of the MBF perfusion.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126466227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic detection of the macula in the retinal fundus image by detecting regions with low pixel intensity","authors":"N. Tan, D. Wong, J. Liu, W. J. Ng, Z. Zhang, J.H. Lim, Z. Tan, Y. Tang, H. Li, S. Lu, T. Y. Wong","doi":"10.1109/ICBPE.2009.5384075","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384075","url":null,"abstract":"This paper proposes a method to detect the macula in the retinal fundus image automatically. The method makes use of the optic disc height obtained from the ARGALI to define the region of interest. Regions of dark spots are then detected by finding the coordinates with the lowest pixel intensity and determining the average pixel neighbourhood intensities. These regions are ranked to determine the region containing the macula. This algorithm was tested on 162 images, and an accuracy of 98.8% was achieved. The results are promising for further development and use of this method in AMD studies and physiology localization.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132202831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing hypothesis of some 2,4 -disubstituted-phenoxy acetic acid derivatives as a Crth2 receptor antagonist: A QSAR approach","authors":"A. Jain, R. Agrawal","doi":"10.1109/ICBPE.2009.5384069","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384069","url":null,"abstract":"In pursuit of better CRTh2 receptor antagonist agents, 2D-QSAR, 3D- QSAR studies were performed on a series of 2,4-disubstituted-phenoxy acetic acid derivatives. The best QSAR model was selected, having correlation coefficient R = 0.904, standard error of estimation SEE = 0.456 and cross validated squared correlation coefficient Q2 = 0.739. The predictive ability of the selected model was also confirmed by leave one out cross validation and by leave 33% out Q2 = 688. The QSAR model indicates that the descriptors (logP, SI3, LM, and DVZ). play an important role for the CRTh2 receptor antagonist activities. The kNN-MFA approach was used to generate models by all three different methods and predict the activity of test molecules through each of these models. The Q2, pred_r2, Vn and k value of kNN-MFA with SW, SA & GA were (0.8392, 0.7059, 2/2 ) (0.6725, 0.6716, 2/4 ) and (0.6832, 0.6716, 2/4 ) SW kNN-MFA method have better q2 (0.8392) and pred_r2 (0.7059) than other two methods, model validation correctly predicts activity 83.9% and 70.5% for the training and test set respectively. It uses 2 steric descriptors with 2 k nearest neighbor to evaluate activity of new molecule.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134377893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cardiovascular model for blood pressure control systems","authors":"P. C. A. Ang, B. W. Ang, K. Zhu","doi":"10.1109/ICBPE.2009.5384109","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384109","url":null,"abstract":"A cardiovascular model for blood pressure control system is developed in this paper. This model is used to simulate hypertensive patients in order to design control systems for regulation of blood pressure. The stability of the model is also investigated. The model can accurately represent human arterial blood pressure and therefore, the control system designed and simulated based on the model can be considered very near to clinical trial.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116036327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-recognition of DNA — From life processes to DNA computation","authors":"W. Benjamin","doi":"10.1109/ICBPE.2009.5384112","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384112","url":null,"abstract":"Ever since the first appearance of deoxyribose nucleic acid (DNA) in 1953, it has fascinated multitudes with its simplicity. With a modest syllabus of four nucleotides (adenine, thymine, cytosine and guanine), it codes for the complexity of life around us. In this paper, we investigate how the structure of DNA codes for life processes and how we can take advantage of its minuscule size, mechanism of self-recognition and self-assembly for ‘bottom-up’ nanotechnology. High hopes are also placed on miniaturizing present computing technology using DNA computing based on two fundamental features; massive parallelism of DNA strands and Watson-Crick complementarity. Advances in DNA-based computation and algorithmic assembly are then used to complement researches in DNA nanotechnology.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121724799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an ultrasound thrombolysis system for artificial hearts","authors":"S. Tsujimura, Y. Sankai","doi":"10.1109/ICBPE.2009.5384110","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384110","url":null,"abstract":"Thrombus formation in artificial hearts remains a key risk factor in the death of patients. Anticoagulant therapy is essential in patients with artificial hearts. However, thrombogenesis can also occur under anticoagulant therapy. Once thrombogenesis has begun, anticoagulant therapy cannot recover the thrombus-free state. Therefore, in order to prevent thrombogenesis in the artificial heart, we developed a prototype ultrasound thrombolysis system. The system is assumed to work continuously, dissolving micro thrombi before they can grow, thereby preventing the thrombogenesis. As a method of preventing thrombogenesis, we focused on the thrombolytic effect of ultrasound. We herein assume that three phenomena, namely, cavitation, acceleration, and acoustic streaming, can dissolve micro thrombi. Considering the specifications required for applying ultrasound thrombolysis in the artificial heart, the prototype ultrasound thrombolysis system consists primarily of piezoelectric vibrators for generating ultrasound and a driver unit. Two types of vibrator were prepared for two different ultrasound frequencies (23 and 220 kHz). Thrombolysis by cavitation was expected to occur at 23 kHz, and thrombolysis by acceleration was expected to occur at 220 kHz. The driver unit is composed of a switching circuit, an output transformer, and a matching circuit. In order to confirm thrombolysis using the developed system, a thrombolysis test was carried out in vitro. The thrombus was formed from human whole blood (Hematocrit: 46%) and was divided into three parts. These were placed into three disposable optical cells (samples A, B, and C) with saline. Two continuous ultrasound waves (Frequency: 23 and 220 kHz, Common Ultrasound Intensity: 1.2 W/cm2) were radiated for 30 minutes to samples A and B, respectively. For comparison, sample C was prepared without ultrasound. As a result, thrombolysis was observed visually in samples A and B. In conclusion, the developed ultrasound thrombolysis system was confirmed to provide two mechanisms for preventing thrombogenesis in the artificial heart.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129631728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of diffuse reflectance spectra of various skin conditions by principal component method","authors":"S. Prince, S. Malarvizhi","doi":"10.1109/ICBPE.2009.5384094","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384094","url":null,"abstract":"Different skin and sub-surface tissues have distinct or unique reflectance pattern which help us differentiate normal and cancerous tissues. Optical means of characterizing tissues have gained importance due to its noninvasive nature. Spectral characteristics of the components provide useful information to identify the components, because different chromophores have different spectroscopic responses to electromagnetic waves of a certain energy band.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":" 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120827557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An improved echo tracking algorithm for arterial distensibility measurements","authors":"J. Joseph, V. Jayashankar","doi":"10.1109/ICBPE.2009.5384091","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384091","url":null,"abstract":"Arterial distensibility is often measured by non-invasively detecting the change in artery diameter over a cardiac cycle. Traditional methods using B-mode images require considerable processing power and time. Here we present a method to extract the distensibility waveform from RF signals obtained by ultrasound interrogation of the carotid artery. We propose an automatic method that uses an adaptive threshold to track the desired number of echoes and measure the artery diameter accurately. The algorithm could be used along with single element transducer based ultrasound measurement systems as well as B-mode scanners. The performance is analyzed using data obtained using phantom models of the artery as well as from human volunteers.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132192045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}