2009 International Conference on Biomedical and Pharmaceutical Engineering最新文献

{"title":"Noise reduction in DEXA image based on system noise modeling","authors":"J. Kwon, S. Cho, Y. Ahn, Yong Man Ro","doi":"10.1109/ICBPE.2009.5384080","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384080","url":null,"abstract":"Denoising X-ray image is an important preprocessing process to measure BMD (Bone Mineral Density) correctly. In this paper, we deal with denoising X-ray image in DEXA (Dual-Energy X-ray Absorptiometry) system. Image noise in DEXA is modeled by separating source and detector noises. Using the noise model in DEXA, a noise reduction method is proposed. The proposed denoising method consists of Wiener filter to reduce the detector noise, and logarithmic scale-wavelet BayesShrink filter to reduce the source noise. Experimental results verified the proposed DEXA noise model and showed that the proposed noise reduction method outperformed the conventional method.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116423148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of a novel magnetic stimulation system: Magnetic harmonic multi-cycle stimulation (MHMS)","authors":"S. Goetz, T. Weyh, H. Herzog","doi":"10.1109/ICBPE.2009.5384111","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384111","url":null,"abstract":"Magnetic stimulation is nowadays a standard instrument in research as well as clinical applications. But available systems still have some vital problems; these include the extreme energetic ineffectiveness and the poor flexibility of stimulation properties. In the following text we analyse a new degree of freedom for stimulation devices in the time domain. This approach owes its high potential from the simplicity to implement this feature in existing commercial systems. A similar principle has already been applied for a stimulation device long time ago, but was intentionally overdamped to mimic a monophasic system and therefore energetically meaningless. For the current work, the alternative design was implemented into a sophisticated simulation model to predict its properties. A substantial benefit is for instance the feasibility to lower the threshold of the required current within the stimulation coil for creating nervous action potentials dramatically. Accordingly, the energetic impact with its even quadratic relation to the amplitude and especially the reduction of the coil heating are remarkable. The opportunity to control the nervous reaction more precisely and to gain access to the field of more complex spiking patterns is another special attribute. The realization of the concept seems reasonably simple, whereas the impact was found to be enormous. But this shall not block the view of the fact that the discovery and the explanation needs a change of thinking about the stimulating effect of inductive stimulation.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125884601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photosensitizing drugs loaded stable carrier-artificial oil bodies","authors":"Yu-Chi Chiou, P. Lai","doi":"10.1109/ICBPE.2009.5384067","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384067","url":null,"abstract":"The photosensitizer mTHPC was loaded in oil body which significantly enhanced the nuclear localization of mTHPC in comparison to load in F68 micelle. Furthermore, in this study, the mTHPC was discovered in cellular nucleus of HeLa cells which were treated about 1 h. As the results, the cells treaded by mTHPC-loaded in oil body with light showed that the efficacy of PDT has better than F68 micelle, because the oil body enhanced the nuclear accumulation of mTHPC. Thus, it is suggest that the oil body held great promise for a PDT carrier in the future.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125534037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of plant Macaranga peltata for its antioxidant, antimicrobial and cytotoxicity activity","authors":"M. Verma, P. Raj, H. Chandrasekhar, J. Rao, N. Udupa","doi":"10.1109/ICBPE.2009.5384086","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384086","url":null,"abstract":"The plant Macaranga peltata (Euphorbiaceae) leaves and stem bark was tested for its in vitro antioxidant, antimicrobial and cytotoxicity activity using different methods. In vitro anti oxidant activity Stem Bark extract showed Inhibitory concentration 50 % (IC50) value of 10.13 than the Leaf extract IC50=14.85 for DPPH Assay. Standard Ascorbic acid showed IC50=7.28. For ABTS free radical scavenging activity Leaf extract IC50=7.61 showed better activity than the Stem Bark extract IC50=9.77. Standard anti-oxidant Ascorbic acid showed IC50=11.76. The Nitric Oxide Radical inhibition activity was better shown by Stem Bark extract IC50=573.39 than Leaf extract IC50⇒1000. Whereas IC50 value for the standard anti-oxidant Ascorbic acid was 127.16. Scavenging of Superoxide radical by Alkaline DMSO method i.e. NBT Assay showed better activity for Leaf extract IC50=54.12 than Stem Bark extract IC50=55.52. But both Stem Bark and Leaf extract showed very good activity for NBT Assay and their IC50 values were very close to the Standard anti-oxidant Rutin IC50=49.73. In anti microbial activity MIC for Leaf extract was between 62.5µg/ml to 125µg/ml for Escherichia coli, 125µg/ml to 250µg/ml for Pseudomonas aeruginosa, 62.5µg/ml to 125µg/ml for Bacillus subtilis and 31.25µg/ml to 62.5µg/ml for Staphylococcus aureus. Whereas MIC for Stem Bark extract was between 500µg/ml to 1000µg/ml for Escherichia coli, 250µg/ml to 500µg/ml for Pseudomonas aeruginosa, 62.5µg/ml to 125µg/ml for Bacillus subtilis and 62.5µg/ml to 125µg/ml for Staphylococcus aureus. Ciprofloxacin used as standard antibiotic showed MIC between 1.953 µg/ml to7.813 µg/ml for all four bacterial strains. Cytotoxicity of Macaranga peltata Leaf and Stem Bark extracts was tested on Human Liver Cancer cell line HepG2. Four concentrations (1000µg/ml, 500µg/ml, 250µg/ml and 125µg/ml) of both extract were tested for the activity by MTT assay. Both Leaf and Stem Bark extracts showed very good cytotoxicity activity and their CTC50 value was 51.07 µg/ml and 22.32 µg/ml respectively.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129022836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study on blood flow rate measurement using intravascular catheter","authors":"Seng Sing Tan, C. M. Lam, W. E. Lim","doi":"10.1109/ICBPE.2009.5384073","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384073","url":null,"abstract":"Measurement of blood flow rate is essential in assessing the cardiovascular status of patients with coronary artery diseases during treatments. It provides feedback and monitors any improvements in the vascular system after the cardiovascular surgery. This paper presents the latest development of a new approach to measure blood flow rate using a catheter involving the concept of heat exchanger. In the study, an intravascular catheter is inserted into a simulated blood stream and a heat transfer element attached at the distal end extracts a small amount of heat from blood to the cooling fluid in the heat transfer element. We can correlate the blood flow rate to the change of the outlet temperature of the cooling fluid. In this approach, we can determine the cardiac output without the need for introduction of saline solution or other substance into patient body. Unlike Swan-Ganz catheter, it does not alter the blood temperature. Consequently, it is repeatable without any possible adverse effects due to altering blood composition or heating in the vascular system. In this experimental study, we have done the comparison between different designs and settings, and confirmed that this approach has a great potential to be an effective way of measuring blood flow rate as, well as cardiac output.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128077452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of hearing disorder by multi-band entropy cepstrum extraction from infant's cry","authors":"Mahmoud Mansouri Jam, H. Sadjedi","doi":"10.1109/ICBPE.2009.5384066","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384066","url":null,"abstract":"Infant's cry is a multimodal behavior that contains a lot of information about the infant, particularly, information about the health of the infant. In this paper a new feature in infant cry analysis is presented for recognition two groups: infants with hearing disorder and normal infants, by Mel frequency multi-band entropy cepstrum extraction from infant's cry. Signal processing stage is included by silence elimination, filtering, pre-emphasizing and feature extraction. After taking Fourier transform, spectral entropy was computed as single feature for all of cry sample. In classifying stage, by training artificial neural network, correction rate of recognition was obtained 73.6%. In order to enhancement in results, we used Mel filter bank. Entropy of each sub-band constitutes elements of next feature vector. By applying Discrete Cosine Transform (DCT) over logarithm of this vector, new feature vector were obtained, we named them MFECs. By MFECs vectors we achieved 88.3% of correction rate. So, MFECs are convenient features to classify cry of infants with hearing disorder from normal infants.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"98 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133894941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using survival models to analyze the effects of social attributes on length of stay of stroke patients","authors":"C. Kwoh, K. Lee, T. Le","doi":"10.1109/ICBPE.2009.5384062","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384062","url":null,"abstract":"Hospital length of stay (LOS) is a widely accepted indicator of hospital activity and performance of clinical care. We have collected and analyzed data on LOS of 4,086 stroke patients discharged from the Singapore General Hospital (SGH) for the duration 2004–2007. We chose to study stroke patients' data because stroke is an important chronic disease which requires significant social support and healthcare resources. We used survival analysis to study the effects of social attributes on LOS, using discharge from hospital as the time to event. Gender, age, ethnicity and subsidy status were studied as covariates. We discovered that old age increases the probability of long stay. Indian race decreases the probability of stay while Other makes the patient stay longer as compared to Chinese. Patients who were not fee-subsidized have lower chances of stay than those who were. Gender and Malay race did not have a significant effect on the stay probability. The effects of ethnicity and paying status on LOS reflect the influences of cultural environment and socioeconomic status. This demonstrates the importance of social determinants on healthcare and their consequent effects on the utilization of healthcare resources.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"221 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132475659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro screening and docking study of fosinopril and its analogs","authors":"S. Kini, J. Chaudhary, S. Arora","doi":"10.1109/ICBPE.2009.5384099","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384099","url":null,"abstract":"Hypertension is the most common cardiovascular disease. The prevalence of hypertension increases with advancing age; for example, about 50% of people between the ages of 60 and 69 years old have hypertension, and the prevalence is further increased beyond age of 70. Many angiotensin converting enzyme (ACE) inhibitors are known to be useful in the treatment of hypertension.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125380602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new wavelet based algorithm for estimating respiratory motion rate using UWB radar","authors":"M. Baboli, S. Ghorashi, N. Saniei, A. Ahmadian","doi":"10.1109/ICBPE.2009.5384095","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384095","url":null,"abstract":"UWB signals have become attractive for their particular advantage of having narrow pulse width which makes them suitable for remote sensing of vital signals. In this paper a novel approach to estimate periodic motion rates, using Ultra Wide Band (UWB) signals is proposed. The proposed algorithm which is based on wavelet transform is used as a non-contact tool for measurement of respiration motion rate. Compared with traditional contact measurement devices, experimental results utilizing a 3.2 GHz bandwidth transceiver, demonstrate 99% similar results. The standard deviation of the proposed algorithm for 30 independent experiments has obtained 19% for respiration motion.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121627856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive measurement of blood flow using magnetic disturbance method","authors":"C. T. Phua, Gaelle Lissorgues","doi":"10.1109/ICBPE.2009.5384098","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384098","url":null,"abstract":"Current laser Doppler method of blood flow sensing requires optical contact to the skin, tend to be bulky and have performance subjective to body fluids (e.g. blood, perspiration) and environmental contaminants (e.g. mud, water). This paper proposes a novel method of noninvasive acquisition of blood flow by measuring the magnetic disturbance created due to blood flowing through a localized magnetic field. The proposed system employs a GMR based magnetic sensor and magnet of 3 mm radius, placed on a major blood vessel. The magnetic field generated by the magnet acts both as the biasing field for the sensor and also the uniform magnetic flux for blood flow disturbance. As such, the system is compact, operates at room temperature and is able to sense through clothing. The signal acquired from the magnetic and optical methods are compared using the post-occlusive reactive hyperaemia test, where measurement results on 6 different healthy subjects are found to have error of less than 5%, showing the successful use of the magnetic method to measure blood flow.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116627479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}