Photosensitizing drugs loaded stable carrier-artificial oil bodies

Abstract

The photosensitizer mTHPC was loaded in oil body which significantly enhanced the nuclear localization of mTHPC in comparison to load in F68 micelle. Furthermore, in this study, the mTHPC was discovered in cellular nucleus of HeLa cells which were treated about 1 h. As the results, the cells treaded by mTHPC-loaded in oil body with light showed that the efficacy of PDT has better than F68 micelle, because the oil body enhanced the nuclear accumulation of mTHPC. Thus, it is suggest that the oil body held great promise for a PDT carrier in the future.