{"title":"负载稳定载体-人工油体的光敏药物","authors":"Yu-Chi Chiou, P. Lai","doi":"10.1109/ICBPE.2009.5384067","DOIUrl":null,"url":null,"abstract":"The photosensitizer mTHPC was loaded in oil body which significantly enhanced the nuclear localization of mTHPC in comparison to load in F68 micelle. Furthermore, in this study, the mTHPC was discovered in cellular nucleus of HeLa cells which were treated about 1 h. As the results, the cells treaded by mTHPC-loaded in oil body with light showed that the efficacy of PDT has better than F68 micelle, because the oil body enhanced the nuclear accumulation of mTHPC. Thus, it is suggest that the oil body held great promise for a PDT carrier in the future.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"32 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Photosensitizing drugs loaded stable carrier-artificial oil bodies\",\"authors\":\"Yu-Chi Chiou, P. Lai\",\"doi\":\"10.1109/ICBPE.2009.5384067\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The photosensitizer mTHPC was loaded in oil body which significantly enhanced the nuclear localization of mTHPC in comparison to load in F68 micelle. Furthermore, in this study, the mTHPC was discovered in cellular nucleus of HeLa cells which were treated about 1 h. As the results, the cells treaded by mTHPC-loaded in oil body with light showed that the efficacy of PDT has better than F68 micelle, because the oil body enhanced the nuclear accumulation of mTHPC. Thus, it is suggest that the oil body held great promise for a PDT carrier in the future.\",\"PeriodicalId\":384086,\"journal\":{\"name\":\"2009 International Conference on Biomedical and Pharmaceutical Engineering\",\"volume\":\"32 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2009 International Conference on Biomedical and Pharmaceutical Engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/ICBPE.2009.5384067\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2009 International Conference on Biomedical and Pharmaceutical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICBPE.2009.5384067","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The photosensitizer mTHPC was loaded in oil body which significantly enhanced the nuclear localization of mTHPC in comparison to load in F68 micelle. Furthermore, in this study, the mTHPC was discovered in cellular nucleus of HeLa cells which were treated about 1 h. As the results, the cells treaded by mTHPC-loaded in oil body with light showed that the efficacy of PDT has better than F68 micelle, because the oil body enhanced the nuclear accumulation of mTHPC. Thus, it is suggest that the oil body held great promise for a PDT carrier in the future.
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