S. Dakua, N. Navkar, J. Abi-Nahed, D. Groen, M. Bernabeu, M. Saghir, H. Kamel, A. Al-Ansari, P. Coveney
{"title":"Towards a computational system to support clinical treatment decisions for diagnosed cerebral aneurysms","authors":"S. Dakua, N. Navkar, J. Abi-Nahed, D. Groen, M. Bernabeu, M. Saghir, H. Kamel, A. Al-Ansari, P. Coveney","doi":"10.1109/MECBME.2014.6783259","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783259","url":null,"abstract":"Cerebral aneurysms are one of the prevalent and devastating cerebrovascular diseases of adult population worldwide. In most cases, it causes rupturing of cerebral vessels inside the brain, which leads to subarachnoid hemorrhage. In this work, we present a clinical workflow model to assist endovascular interventionists to select the type of stent-related treatment for cerebral aneurysms. The model pipeline includes data-acquisition, processing of aneurysm geometry and the simulation of blood flow. The preliminary results show the potential clinical value of the proposed computational workflow.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132663606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed ElMessidi, Sana Tmar-Ben Hamida, B. Ahmed, T. Penzel
{"title":"Accurate automatic identification of slow wave sleep using a single electro-oculogram channel","authors":"Mohamed ElMessidi, Sana Tmar-Ben Hamida, B. Ahmed, T. Penzel","doi":"10.1109/MECBME.2014.6783247","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783247","url":null,"abstract":"Diagnosis and treatment of sleep disorders require analysis of the sleep stages and patterns in the polysomnographic (PSG) signals recorded over several hours. Traditionally, sleep is monitored based on PSG signals that require several measurements collected from different locations on the head and the body. These signals are used to evaluate the sleep quantity and quality. However, the need for unobtrusive monitoring and convenience motivates a variety of alternative approaches focused on the minimization of a number of monitored physiological signals. Previous studies have shown that the quantity and length of slow wave sleep (SWS) periods during sleep are the major indicators of the sleep quality. The aim of this paper is to present a new automatic method to detect SWS epochs using a single-channel electro-oculography (EOG). This method is based on a simple rule based algorithm with an adaptive method to adjust thresholds. The new method is evaluated through 9 healthy subjects and the results are compared to the clinical visual scoring. The agreement of our detection method for the validation data was 90.0%, the sensitivity was 90.5% and the specificity was 89.9% and the kappa value was 0.74.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130864095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Approach for the evaluation of a KDD based DSS visual representations","authors":"Awatef Brahmi, Hela Ltifi, Mounir Ben Ayed","doi":"10.1109/MECBME.2014.6783272","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783272","url":null,"abstract":"Due to the progressing growth of temporal data, data analysis and exploration become more and more difficult task; particularly in the medical domain. For this reason, it seems important to use Decision Support System (DSS) based on the decisional tool Knowledge Discovery in Data (KDD) and the visualization techniques for assisting user to get and understand information. Our research is based on the visual representations of an existing KDD based DSS for the fight against nosocomial infections. In this paper, we are interested in proposing a method, focusing on the user evaluation of this system.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121588153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatma-Elzahraa Eid, Haitham A. Elmarakeby, L. Heath, M. Elhefnawi
{"title":"Human microRNAs targeting hepatitis C virus","authors":"Fatma-Elzahraa Eid, Haitham A. Elmarakeby, L. Heath, M. Elhefnawi","doi":"10.1109/MECBME.2014.6783236","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783236","url":null,"abstract":"microRNA (miRNA) is a post-transcriptional gene regulation mechanism that mediates sequence-specific degradation of the targeted RNA and thus provides an opportunity for the development of oligonucleotide-based drugs. Here, we propose a systematic approach for finding, selecting, and validating miRNAs that target conserved regions in the hepatitis C virus (HCV). Different factors, such as target conservation, target accessibility, miRNA and target RNA thermodynamics, are considered in our pipeline. The conservation profiles of six major genotypes of HCV have been analyzed and the potential conserved regions are selected for downstream analysis based on their entropy and length. An in silico protocol for predicting the miRNA targets in HCV highly conserved regions is devised, and a set of potential miRNAs is filtered and verified using different techniques. Some of the predicted miRNAs were previously experimentally validated, which gives support to our analysis.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"791 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114000275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Areen K. Al-Bashir, G. Hillman, M. Li, Y. Katkuri, V. Singh-Gupta, Yimin Shen, C. Yunker, E. Haacke
{"title":"New DCE-MRI parameters to quantify the vascular changes induced by sunitinib treatment in renal carcinoma tumors","authors":"Areen K. Al-Bashir, G. Hillman, M. Li, Y. Katkuri, V. Singh-Gupta, Yimin Shen, C. Yunker, E. Haacke","doi":"10.1109/MECBME.2014.6783195","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783195","url":null,"abstract":"To develop new dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) parameters to quantify the vascular effects of different doses of the antiangiogenic drug sunitinib on renal cell carcinoma (RCC) kidney tumors in mice. Mice bearing established RCC xenograft tumors were treated with sunitinib doses of 10, 20 or 40 mg/kg/day (SU10, SU20 or SU40 respectively) or treated with vehicle only (control). New DCE parameters, contrast agent uptake to the peak (AUCtp), time to peak concentration (TTP), washout slope (Nslope) and full width half maximum (FWHM), were obtained from T1-weighted images. These parameters were quantified for tumor-bearing kidneys and normal kidneys. Treatments with SU20 and SU40 caused increased perfusion in the tumor core compared to control and SU10. Kidney tumors treated with SU20 had an almost identical pattern of contrast agent uptake rate, peak and clearance as those observed in normal kidneys. The effect of SU20 on normal kidneys was milder than that observed with SU40. Treatment with SU40 caused increased contrast agent uptake by the cortex of the normal kidneys compared to the normal kidneys in control and SU10. FWHM also provided new information about the effect of different treatment doses and showed that kidney tumors treated with SU20 have almost the same values of FWHM as the normal kidneys in control mice. The new DCE parameters, including AUCtp, Nslope and FWHM, have the potential to give a precise description of the treatment effect not only in the whole mouse kidney but also in different regions inside the kidney.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"580 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115896914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low power CMOS neurochemical biosensor application in an implantable intelligent neurotrophic factor delivery hybrid microsystem for Parkinson's","authors":"M. Poustinchi, S. Musallam","doi":"10.1109/MECBME.2014.6783223","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783223","url":null,"abstract":"We have developed a low power neurotransmitter biosensor which can be applied in an implantable closed-loop CMOS neurotrophic factor delivery microsystem which by protecting the healthy neurons and restoring damaged ones can maintain therapeutic levels of chemical concentrations in the brain. The hybrid microsystem is composed of novel biosensor that can sense micromolar concentration of neurotransmitters (dopamine) and embedded negative feedback circuits that control the flow of pharmacological agents in micro fluidic channels. The focus of this manuscript is on sensing, control and decision making circuitry. It consists of a current conveyer, a low noise low power amplifier, an integrator and a comparator with offset cancelation. Circuit is fabricated in CMOS 0.18 um with low power consumption of 921 nW.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124169166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beaded elastic rods to simulate the diffusive dynamics of biofilament deformations","authors":"Nitish Ratan Appanasamy, Sachin Goyal","doi":"10.1109/MECBME.2014.6783209","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783209","url":null,"abstract":"The twisting and bending dynamics of bio-filaments such as DNA are crucial to their biological functions. The nature and time-scales of these deformations are not only influenced by the structural elasticity of the bio-filament but also by their diffusion mechanics. While the elastic rod theory is still evolving to model the structural elasticity with rigorous descriptions of contituive laws, beaded chain models have been very successful to simulate the diffusion mechanics. This paper presents a framework that merges the strengths of beaded chain models with an elastic rod model to simulate the diffusive deformations (twisting and bending) of stiff bio-filemants.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"11 21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116825861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Sefidgar, K. Raahemifar, H. Bazmara, M. Bazargan, S. Mousavi, M. Soltani
{"title":"Effect of remodeled tumor-induced capillary network on interstitial flow in cancerous tissue","authors":"M. Sefidgar, K. Raahemifar, H. Bazmara, M. Bazargan, S. Mousavi, M. Soltani","doi":"10.1109/MECBME.2014.6783242","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783242","url":null,"abstract":"Interstitial fluid flow has been studied by many cancer researchers for investigation on the effect of interstitial flow on drug delivery. This paper formulates blood flow through a capillary network induced by a solid tumor and fluid flow in a tumor's surrounding tissue and investigates the effects of consideration a remodeled network and adaptability of capillary on interstitial flow. Numerical results show that the prediction of interstitial pressure for the remodeled network shows a higher value compared to the rigid one. Results from interstitial fluid and blood distribution in normal and cancerous tissues have beneficial information about the prediction of successive drug delivery.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121232828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A performance comparison of hand motion EMG classification","authors":"Sungtae Shin, R. Tafreshi, R. Langari","doi":"10.1109/MECBME.2014.6783276","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783276","url":null,"abstract":"Powered prosthesis is of considerable value to amputees to enable them to perform their daily-life activities with convenience. One of applicable control signals for controlling a powered prosthesis is the myoelectric signal. A number of commercial products have been developed that utilize myoelectric control for powered prostheses; however, the functionality of these devices is still insufficient to satisfy the needs of amputees. For the purpose of a comparison, several electromyogram classification methods have been studied in this paper. The performance criteria included not only classification accuracy, but also repeatability and robustness of the classifier, training time for online training performance, and computational time for real-time operation were evaluated with seven classification algorithms. The study included five different feature sets with time-domain feature values and autoregressive model coefficients. In summary, the quadratic discriminant analysis showed a remarkable performance in terms of high classification accuracy, high robustness, and low computational time of training and classification from the experiment results.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128249253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taoufik Wassar, M. Franchek, K. Grigoriadis, Cedric Benkowski, Mehmet C. Kadipasaoglu, S. Parnis
{"title":"Heart assist devices: Modeling and diagnostics","authors":"Taoufik Wassar, M. Franchek, K. Grigoriadis, Cedric Benkowski, Mehmet C. Kadipasaoglu, S. Parnis","doi":"10.1109/MECBME.2014.6783241","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783241","url":null,"abstract":"In this paper, adaptive stead-state models are presented for axial flow-pumps used as heart assist devices. These models predict flow rate and power consumption of the pump based on the pressure differential (head) and impeller speed. The developed models are identified using system identification techniques on data obtained from a mock circulatory loop. The mock circulatory experiments include physiologic conditions ranging from a healthy heart function to heart failure. The online adaptive nature of these models is used to estimate effective blood viscosity in real-time. Additional mock circulatory loop experiments are performed to emulate flow obstruction at the pump outlet. Results show that the coefficients from the adapted models can be used to detect, identify and estimate the fault.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132167665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}