Effect of remodeled tumor-induced capillary network on interstitial flow in cancerous tissue

Abstract

Interstitial fluid flow has been studied by many cancer researchers for investigation on the effect of interstitial flow on drug delivery. This paper formulates blood flow through a capillary network induced by a solid tumor and fluid flow in a tumor's surrounding tissue and investigates the effects of consideration a remodeled network and adaptability of capillary on interstitial flow. Numerical results show that the prediction of interstitial pressure for the remodeled network shows a higher value compared to the rigid one. Results from interstitial fluid and blood distribution in normal and cancerous tissues have beneficial information about the prediction of successive drug delivery.