JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik最新文献

EVALUASI IN VITRO-IN VIVO FILM TRANDERMAL DILTIAZEM HCL DENGAN PENINGKAT PENETRASI PEG 400 SEBAGAI ANTIHIPERTENSI 对维罗进体内的维托膜膜膜dilderazem HCL的评价，以及作为抗高血压药的佩格渗透增强剂的评价

JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik Pub Date : 2019-06-01 DOI: 10.31942/JIFFK.V16I01.2922

Yulias Ninik Windriyati, Risha Fillah Fithria, F. Kurniawati, Ulfatun Mukaromah

{"title":"EVALUASI IN VITRO-IN VIVO FILM TRANDERMAL DILTIAZEM HCL DENGAN PENINGKAT PENETRASI PEG 400 SEBAGAI ANTIHIPERTENSI","authors":"Yulias Ninik Windriyati, Risha Fillah Fithria, F. Kurniawati, Ulfatun Mukaromah","doi":"10.31942/JIFFK.V16I01.2922","DOIUrl":"https://doi.org/10.31942/JIFFK.V16I01.2922","url":null,"abstract":"ABSTRACTDiltiazem HCL is an antihypertensive that low oral bioavailability of 40%, so developed to transdermal preparations. A matrix type of transdermal patch of diltiazem HCl was prepared using polyvinyl alcohol and ethyl cellulose with PEG 400 as penetration enhancer. In vitro-in vivo evaluation were conducted to asses drug permeation through the skin and determine the effectiveness of transdermal film as an antihypertensive drug. Transdermal patches of diltiazem HCl were evaluated for physicochemical characteristics weight variation, thickness, folding endurance, moisture uptake, and drug content. In vitro permeation study was conducted using commercial semi permeable membrane in Franz diffusion cell. In vivo activity study was evaluated on male rat Wistar that induced NaCl with CODA non-invasive blood pressure method. Transdermal patches of diltiazem HCl were found no significant differences in terms of physicochemical characteristics. The in vitro skin permeation profiles showed increased flux values with the increase of PEG 400 as a penetration enhancer. The in vivo evaluation showed a reduction in systolic and diastolic blood pressure within one hour after the drug administration. Diltiazem HCl was able penetration into skin, absorbed in blood circulation and effective as antihypertensive via transdermal route.Keywords : antihypertension, diltiazem HCl, PEG 400, transdermal patch","PeriodicalId":383938,"journal":{"name":"JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik","volume":"37 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113993732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

RENDEMEN KITOSAN LIMBAH CANGKANG KERANG SIMPING (Amusium pleuronectes) DAN KERANG KEPAH (Polymesoda erosa) DARI KENDAL JAWA TENGAH 蚕食蚕蛹（胸膜蚕）和蚕蛹（啮蚀多孔虫）的研究报告

JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik Pub Date : 2019-06-01 DOI: 10.31942/JIFFK.V16I01.2931

A. Ariyanti, Eni Masruriati, Arin Widya Nuari, M. H. Y. Syahputra

引用次数: 1

EFEK ANTIDIARE EKSTRAK ETANOL DAUN PARIJOTO (Medinilla speciosa Blume) PADA MENCIT JANTAN GALUR BALB/C

JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik Pub Date : 2019-06-01 DOI: 10.31942/JIFFK.V16I01.2926

Yance Anas, Desi Rakhmawati, Layyinatul Fuadah, Nola Carina Rahayu

{"title":"EFEK ANTIDIARE EKSTRAK ETANOL DAUN PARIJOTO (Medinilla speciosa Blume) PADA MENCIT JANTAN GALUR BALB/C","authors":"Yance Anas, Desi Rakhmawati, Layyinatul Fuadah, Nola Carina Rahayu","doi":"10.31942/JIFFK.V16I01.2926","DOIUrl":"https://doi.org/10.31942/JIFFK.V16I01.2926","url":null,"abstract":"ABSTRACTParijoto is one of a rare plant species in Indonesia, and its leaves have traditionally been utilized to treat diarrhea in the area of Kudus Regency, Indonesia. Parijoto leaves contain active compounds of tannin and flavonoid which have antidiarrheal properties. This investigation intends to demonstrate the antidiarrheal effect of parijoto leaf ethanol extract (EEDP) on male Balb/C mice castor oil-induced diarrheal and reveal its antidiarrheal mechanism through antimotility and antisecretory testing. EEDP made by maceration method. The antidiarrheal effects of three series level EEDP (500; 1,000 and 2,000) mg / Kg BB tested on diarrhea mice induced by castor oil. Concurrently, the antimotility and antisecretory effects of EEDP investigated with the intestinal transit method and castor oil-induced enteropooling. The data in this study were the onset of diarrhea, the weight of liquid-formless stools (for 8 hours), the ratio of digestion tracts passed by norit markers, and the volume of intestinal contents. These data were analyzed statistically at the 95% confidence level. The examination presumed that EEDP was able to respite the onset of diarrhea and diminish the formation of liquid-formless feces in male Balb/C mice induced by castor oil. The antidiarrheal mechanism of EEDP also exhibited in this study through its effects as antimotility and antisecretory.Keywords: Parijoto leaf ethanol extract, antidiarrheal, antimotility, antisecretory","PeriodicalId":383938,"journal":{"name":"JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik","volume":"236 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122359684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

UJI AKTIVITAS ANTIDEPRESAN PERASAN RIMPANG TEMULAWAK (Curcuma xanthorrhiza, Roxb) TERHADAP MENCIT PUTIH JANTAN (Mus musculus) 对雄性小嘴(musculus, curonly xanthorrhiza, Roxb)的抗抑郁活性测试

JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik Pub Date : 2019-06-01 DOI: 10.31942/JIFFK.V16I01.2930

Dianita Kartikasari, Hairunisa Hairunisa, Emy Nadya Natasha

{"title":"UJI AKTIVITAS ANTIDEPRESAN PERASAN RIMPANG TEMULAWAK (Curcuma xanthorrhiza, Roxb) TERHADAP MENCIT PUTIH JANTAN (Mus musculus)","authors":"Dianita Kartikasari, Hairunisa Hairunisa, Emy Nadya Natasha","doi":"10.31942/JIFFK.V16I01.2930","DOIUrl":"https://doi.org/10.31942/JIFFK.V16I01.2930","url":null,"abstract":"ABSTRACTPrevention and treatment with synthetic antidepressants has many side effects that affect the central nervous system and usage must be under the supervision of a doctor. Whereas prevention and traditional medicine relatively do not cause side effects, are inexpensive, and easy to obtain. One example of traditional medicine from natural ingredients, which can provide an antidepressant effect is ginger rhizome. This research aims to determine whether ginger rhizome have antidepressant effects on male white mice. Antidepressant effect testing was carried out on male white mice (Mus musculus) using the forced swim test method. The part of the plant used is the rhizome of the ginger plant. Curcuma rhizome is made with juice and given orally with a concentration of 20%, 40%, and 60%. The negative control used is Na CMC 0.5%, while the positive control used, namely amitriptilyn. The parameters observed were the duration of immobility time, swimming time and climibing time (in seconds) which were calculated from minutes 3-6 for 6 minutes, and statistical tests were carried out with a confidence level of 95%. The results showed that at a concentration of 40% the curcuma rhizome juice had a significant value (p> 0.05) which means that there was no significant difference in antidepressant effect (%) from the juice of temulawak 56.31% and amitriptylin 78.78%Keywords: ginger rhizome, antidepressants, the forced swim test","PeriodicalId":383938,"journal":{"name":"JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116237881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IDENTIFIKASI DAN ISOLASI SENYAWA LIKOPEN DARI SEMANGKA (CITRULLUS LANATUS) 确定和分离西瓜的番茄番茄复合物(CITRULLUS LANATUS)

JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik Pub Date : 2019-06-01 DOI: 10.31942/JIFFK.V16I01.2933

Eva Monica, R. Rollando

{"title":"IDENTIFIKASI DAN ISOLASI SENYAWA LIKOPEN DARI SEMANGKA (CITRULLUS LANATUS)","authors":"Eva Monica, R. Rollando","doi":"10.31942/JIFFK.V16I01.2933","DOIUrl":"https://doi.org/10.31942/JIFFK.V16I01.2933","url":null,"abstract":"ABSTRACTLycopene is one of the phytochemical compounds of the carotenoid group, the main producer of red pigments found in watermelons. Watermelon is a round-shaped vines containing vitamin C and vitamin A and has high antioxidant levels. This study aims to identify lycopene compounds in watermelons. Extraction of watermelon flesh by maceration method. Identification of lycopene compounds with UV-Visibel spectrophotometry instrument followed by identification with the TLC method and fractionation of extracts using preparative TLC with chloroform: ethanol (1: 1) solvents, and identification of fractionation results with Fourier Transform Infrared Spectroscopy (FT-IR). The results of the identification of watermelon fruit extract using the TLC method obtained three spots and the results of UV-Vis spectrophotometry showed three peaks namely between 440-520 nm. The identification of fractionation of watermelon extract using FT-IR obtained a constituent group of lycopene structures, but did not show the R-CH = CH-R group that is owned by lycopene, whereas the results of the test with UV-Vis spectrophotometry appearing at 206 and 245 which indicate the presence of other compounds. From the results of the study it can be concluded that the testing of known extracts of watermelon fruit contains lycopene compounds, but the testing of lycopene identification on the results of fractionation of watermelon fruit extracts was not found with certainty the existence of lycopene because the FT-IR results were only shown and contained on the results UV-Vis spectrophotometry was found to be the wavelength of other compounds.keywords: Watermelon, Lycopene, UV-Vis Spectrophotometry, IR Spectrophotometry","PeriodicalId":383938,"journal":{"name":"JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114619329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

UJI AKTIVITAS PENINGKAT DAYA INGAT FRAKSI ETIL ASETAT EKSTRAK ETANOL BUAH KEMUKUS (Piper cubeba L. f) PADA MENCIT JANTAN GALUR BALB/C DENGAN METODE RADIAL ARM MAZE (RAM) 用镭射臂法(RAM)测试雄性乙醇初乙醇(Piper cubeba L。

JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik Pub Date : 2019-06-01 DOI: 10.31942/JIFFK.V16I01.2927

Junvidya Heroweti, Yance Anas, Idress Muhammed Hama

{"title":"UJI AKTIVITAS PENINGKAT DAYA INGAT FRAKSI ETIL ASETAT EKSTRAK ETANOL BUAH KEMUKUS (Piper cubeba L. f) PADA MENCIT JANTAN GALUR BALB/C DENGAN METODE RADIAL ARM MAZE (RAM)","authors":"Junvidya Heroweti, Yance Anas, Idress Muhammed Hama","doi":"10.31942/JIFFK.V16I01.2927","DOIUrl":"https://doi.org/10.31942/JIFFK.V16I01.2927","url":null,"abstract":"ABSTRACTNeurodegenerative is often associated with aging. The aging process will affect the decrease in nerve cells, especially brain nerve cells. Ethyl acetate fraction of kemukus fruit ethanol extract (FEAEE) of kemukus fruit has been investigated as a memory enhancer with the Morris water maze (MWM) method. One of the shortcomings of the Morris water maze method is that it causes stress in test animals, thus affecting their memory. This study aims to determine the memory enhancing activity of FEAEE of kemukus fruit with the radial arm maze method This research is an experimental study with pre and posttest matched control group design using 25 male mice, Balb/c strains divided into 5 groups. Mice group 1 as a negative control group were given a 1% CMC Na solution of 17.5 mg/mL. Group mice 2 - 5 were given FEAEE of kemukus fruit with doses of 63, 126, 252, and 504 mg/kgBB, respectively. Test material is given orally for 21 days. Observations were made on the frequency of mice passing the platform correctly and incorrectly and calculating memory scores using the radial arm maze (RAM) method. Differences in memory scores were analyzed by the Mann Whitney test. The results showed that FEAEE steamed fruit has memory enhancing activity. Memory activity was indicated at doses of 63 and 252 mg / kg.Keywords: steamed fruit (Piper cubeba, L. f), ethyl acetate fraction, memory score, radial arm maze","PeriodicalId":383938,"journal":{"name":"JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126539579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

EVALUASI SIFAT FISIKA KIMIA DAN TANGGAP RASA TABLET HISAP DEKOKTA DAUN MENGKUDU (Morinda citrifolia L.) DENGAN VARIASI PEMANIS 化学物理性质评估和吸收含淀粉片片的淀粉性。甜味剂的变化

JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik Pub Date : 2019-06-01 DOI: 10.31942/JIFFK.V16I01.2932

M. Rochman, Mufrod Mufrod, Feyzar Habib Reynaldo, Ayuk Siti Fatimah, Yayang Rusyta Dewi

{"title":"EVALUASI SIFAT FISIKA KIMIA DAN TANGGAP RASA TABLET HISAP DEKOKTA DAUN MENGKUDU (Morinda citrifolia L.) DENGAN VARIASI PEMANIS","authors":"M. Rochman, Mufrod Mufrod, Feyzar Habib Reynaldo, Ayuk Siti Fatimah, Yayang Rusyta Dewi","doi":"10.31942/JIFFK.V16I01.2932","DOIUrl":"https://doi.org/10.31942/JIFFK.V16I01.2932","url":null,"abstract":"ABSTRACTNoni leaf (Morinda citrofolia L.) has antioxidant compounds that can inhibit and counteract free radicals. Decocta Noni leaf to make more practice preparation of lozenges. This study aims to evaluate the physical chemical characteristics and taste response of lozenges with variations of sweeteners to cover the bitter taste of Noni leaves. Decocta mengkudu leaf is obtained by boiling at 90C for 30 minutes. Suction tablets made 9 formulas based on variations of sweeterners sucrose-water sweetener, sorbitol-sucrose-sugarcane water, and aspartame-sucrose-sugarcane water. The suction tablet is made by molding mixture method. Evaluation of physical chemical characteristics including hardness and solubility were analyzed statistically using one-way ANOVA with 95% confidence level, followed by tukey test, weight uniformity, taste response and thin layer chromatography analyzed descriptively. The results of the study was showed that influenced the increase in hardness and dissolution time and the results of the requirements physical lozenges The results of the TLC test of lozenges and decocytes showed an RF value close to Quercetin. The taste response test results showed formula I with variations of sugarcane-sucrose water sweetener, formula III with variations in sorbitol-sucrose-sugarcane-water sweetener and sugarcane water aspartame-sucrose was the most preferred by respondents of 85% - 95%.Keywords: leaf of morinda citrifolia l., lozenges, sorbitol, aspartame, sucrose, sugarcane water","PeriodicalId":383938,"journal":{"name":"JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124332443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

METODE ISOLASI YANG MUDAH DALAM ISOLASI SENYAWA β-KAROTEN DARI LABU KUNING (Cucurbita moschata Duch ex Poiret) 容易在与世隔绝的环境中茁壮成长的隔离方法化合物β-KAROTEN从南瓜(Cucurbita moschata Duch ex Poiret)

JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik Pub Date : 2019-06-01 DOI: 10.31942/JIFFK.V16I01.2924

Rollando Rollando, Muhammad Hilmi Afthoni

{"title":"METODE ISOLASI YANG MUDAH DALAM ISOLASI SENYAWA β-KAROTEN DARI LABU KUNING (Cucurbita moschata Duch ex Poiret)","authors":"Rollando Rollando, Muhammad Hilmi Afthoni","doi":"10.31942/JIFFK.V16I01.2924","DOIUrl":"https://doi.org/10.31942/JIFFK.V16I01.2924","url":null,"abstract":"ABSTRACTPumpkin (Cucurbita moschata Duch ex Poiret), a fruit that contains several compounds, has activities to protect the human body from free radicals. Provitamin A is recognized as an antioxidant compound. Antioxidants can protect the body’s damage caused by free radicals. The purpose of this study was to isolate beta carotene compounds and test the purity of beta carotene isolates obtained using DR-UV and infrared spectrophotometry. Pumpkin is extracted using acetone: petroleum ether with a ratio (1: 1). Identification of beta carotene from extracts was carried out using TLC with the mobile phase of ethanol: acetone: n-hexane with a ratio (2: 1: 1) and scan spectrum using a UV-Vis spectrophotometer. Beta carotene was identified as the result of TLC elution on UV 254 and 366 nm which showed 2 spots. Detection of beta carotene spectra was carried out in the range of 350 to 550 nm and obtained beta carotene peaks at wavelength x nm. The extract purification process was carried out using Preparative TLC with the mobile phase of ethanol: acetone: n-hexane with a ratio (2: 1: 1) and obtained isolates cleaned first using chloroform: methanol ratio of 1: 1. The isolates were dried and tested using DR-UV and infrared spectrophotometry. Isolates from Cucurbita moschataDuch ex Poiret extract) contain beta carotene, zeaxanthin.Keywords: pumpkin; beta carotene; isolation","PeriodicalId":383938,"journal":{"name":"JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125516002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AKTIVITAS INHIBISI ASETILKOLINESTERASE EMPAT JENIS SAYURAN SECARA IN VITRO 乙酰胆酯酶的四种蔬菜在体外抑制

JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik Pub Date : 2019-06-01 DOI: 10.31942/JIFFK.V16I01.2928

Maulita Cut Nuria, Elin Yulinah Sukandar, Asep Gana Suganda, Muhamad Insanu

{"title":"AKTIVITAS INHIBISI ASETILKOLINESTERASE EMPAT JENIS SAYURAN SECARA IN VITRO","authors":"Maulita Cut Nuria, Elin Yulinah Sukandar, Asep Gana Suganda, Muhamad Insanu","doi":"10.31942/JIFFK.V16I01.2928","DOIUrl":"https://doi.org/10.31942/JIFFK.V16I01.2928","url":null,"abstract":"ABSTRACTAcetylcholine is a conducting compound of nerve excitatory (neurotransmitter), while acetylcholinesterase is an enzyme that can hydrolyze the acetylcholine into choline and acetic acid. This reaction is needed so that the nerves can return to take a rest after the activation process, but it can cause damage to the cells in the brain. The most common case is dementia characterized by memory loss. The prevalence of this disease is lower in China and some other Asian countries compared to the United States. It supposed because food consumption commonly by Asians contain vegetables. Extracts derived from vegetables potentially inhibit the activity of acetylcholinesterase (AChE) enzyme which related to chemical contents of the plant. This research aims to investigate the inhibitory activity of acetylcholinesterase enzyme from 4 types of vegetables namely soybean sprouts (bean sprout of Glycine max (L.) Merr.), green bean sprouts (bean sprout of Vigna radiata), carrot (Daucus carota L.), and winged beans (Psophocarpus tetragonolobus (L.) DC.) by in vitro with the Ellman method. Total phenolic and flavonoids contents from fourth types of extracts were also determined. The winged beans extract had the smallest total phenolic and flavonoid contents, but the inhibitory activity against AChE was the biggest. The results showed that IC50 extract of winged beans was 893.86 μg/ml, IC50 carrot extract higher than 1500 μg/ml while the other extracts had no activity. The winged beans extract potential to be further developed as an inhibitor AChE.Keywords : inhibitor of acetylcholinesterase, IC50, vegetables","PeriodicalId":383938,"journal":{"name":"JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122004752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN SELADA ROMAINE (Lactuca sativa var. Longifolia) DAN DAUN SELADA KERITING (Lactuca sativa var. Crispa) BESERTA IDENTIFIKASI BEBERAPA SENYAWA ANTIOKSIDAN 检测罗马生菜(Lactuca sativa var. Longifolia)和卷莴苣(Lactuca sativa var. Crispa)的抗氧化剂和乙醇提取物的活性，并鉴定几种抗氧化剂化合物

JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik Pub Date : 2019-06-01 DOI: 10.31942/JIFFK.V16I01.2925

Maria Ulfah, Ady Laksono Putro, Efa Erfiana Safitri

{"title":"UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN SELADA ROMAINE (Lactuca sativa var. Longifolia) DAN DAUN SELADA KERITING (Lactuca sativa var. Crispa) BESERTA IDENTIFIKASI BEBERAPA SENYAWA ANTIOKSIDAN","authors":"Maria Ulfah, Ady Laksono Putro, Efa Erfiana Safitri","doi":"10.31942/JIFFK.V16I01.2925","DOIUrl":"https://doi.org/10.31942/JIFFK.V16I01.2925","url":null,"abstract":"ABSTRACTFree radicals are suspected as triggers of various degenerative diseases. Antioxidants are compounds that can counteract free radicals. This study aims to determine the antioxidant activity by DPPH method and analyze the active compounds contained in romaine lettuce extract (Lactuca sativa var Longifolia) and lactuca sativa var Crishpa lettuce extract (Lactuca sativa var Crishpa). Romaine lettuce and and lactuca sativa var Crishpa was done extraction with a maceration method using 70% as ethanol solvent. The concentration of extract used was 12.5; 25; 50; 100; 200 and 400 ppm and vitamin C concentrations as comparison was 0.5; 1; 1.5; 2; 2,5 and 3 ppm tested its antioxidant activity by DPPH method by spectrophotometry visible, until IC50 value was obtained. The identification of the active compound was performed by phytochemical screening and Thin Layer Chromatography (TLC). The results showed that romaine lettuce has IC50 value of 151,1515 ppm and lactuca sativa var Crishpa has IC50 value of 183,7560 ppm and vitamin C value was 1,7005 ppm. The chemical compounds contained in romaine ethanol extract and lactuca sativa var Crishpa lettuce extract are alkaloids, phenols and flavonoids.Keywords: Antioxidant, DPPH, IC50, TLC, Romaine, Lactuca sativa var Crishpa","PeriodicalId":383938,"journal":{"name":"JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117230298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0